CN106581166A - Anti-fatigue food, health product or pharmaceutical composition - Google Patents
Anti-fatigue food, health product or pharmaceutical composition Download PDFInfo
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- CN106581166A CN106581166A CN201611151290.5A CN201611151290A CN106581166A CN 106581166 A CN106581166 A CN 106581166A CN 201611151290 A CN201611151290 A CN 201611151290A CN 106581166 A CN106581166 A CN 106581166A
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- extract
- chaga
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- mulberries
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- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 26
- 239000000284 extract Substances 0.000 claims abstract description 100
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses an anti-fatigue food, health product or pharmaceutical composition. The anti-fatigue food, health product or pharmaceutical composition comprises, by weight, 8-12 parts of Ganoderma lucidum extract, 4-6 parts of Sporophorum Phellini Igniarii extract, 4-6 parts of Inonotus obliquus extract and 4-6 parts of Fructus Mori extract. The anti-fatigue food, health product or pharmaceutical composition has the advantages that active ingredients such as polysaccharides and terpenes of Ganoderma lucidum, Sporophorum Phellini Igniarii, Inonotus obliquus and Fructus Mori are extracted maximally through unique extraction technologies, the efficacy or health effects of the Ganoderma lucidum, the Sporophorum Phellini Igniarii, the Inonotus obliquus and the Fructus Mori are given to maximal play, and accordingly bioavailability is improved, and consumption of crude medicinal materials of the Ganoderma lucidum, the Sporophorum Phellini Igniarii, the Inonotus obliquus and the Fructus Mori is reduced correspondingly; the anti-fatigue food, health product or pharmaceutical composition is excellent in anti-fatigue efficacy, is precise and appropriate in compatibility of the ingredients to achieve synergistic effect, and is remarkably superior to single ingredient in efficacy.
Description
Technical field
The present invention relates to application of the glossy ganoderma in pharmacy and functional food and field of health care food, more particularly to a kind of tool
There are food, health products or pharmaceutical composition of anti-fatigue effect and preparation method thereof.
Background technology
Due to the naturally-aged of operating pressure, family burden and human organ, usually make one to feel health very much not
As before, easily tired.Conventional Chinese medicine clinically antifatigue at present has wilsonii, American Ginseng, ginseng, rhodiola root, pseudo-ginseng etc..
Red ganoderma also known as red sesame, it is warm in nature.Smell is bitter flat nontoxic, cures mainly knot, the beneficial motive in the heart.Red ganoderma title glossy ganoderma among the people
Grass.Polyporaceae, is a kind of medicinal fungi.With tonifying middle-Jiao and Qi, enriching yin is strong, strengthen the body resistance to consolidate the constitution, promote longevity the effects such as.Glossy ganoderma
Main chemical compositions are polysaccharide and triterpenes, and triterpenes components are complicated, the report glossy ganoderma such as Zeng Xiangli contain 122 kinds of triterpenes into
Point, wherein main is 37 kinds of ganoderic acid.Have been demonstrated that GL-B class has antitumor, immunological regulation, hypoglycemic, drop blood
Fat, anti-oxidant and anti-ageing pharmacological action of waiting for a long time, ganodenic acid has anti-HIV-1 and HIV-1 proteinase activities, liver protection, antitumor
With the pharmacologically active such as anti AIDS virus.The research such as relevant effective component of glossy ganoderma extraction process is in the ascendant, is so far still state
The inside and outside important topic attracted attention.To obtain highly purified effective component of glossy ganoderma, recent domestic scholar to glossy ganoderma effectively into
The extraction purification technology divided carries out numerous studies.Now its main research progress is made into one to summarize, to researching and developing for further
Glossy ganoderma provides reference frame.
Phellinus, is a kind of fungi, is gained the name because parasitizing mulberry tree.Fructification stockless, the flat hemispherical of cap or the shape of a hoof, wood
Matter, it is shallow liver brown to lead or black.Also there is growth on the trunks such as poplar, willow, birch, oak.According to analysis, the composition of Phellinus is extremely
Complexity, in addition to containing a large amount of polysaccharose substances, also containing beta glucan, chitin（Shitosan）, heteroglycan（It is pectin, hemicellulose, many
The dietary fibers such as uronic acid）Deng composition, play the role of to promote harmful substance and Cholesterol Excretion in enteron aisle.Additionally, Phellinus is also
With anti-aging, the pharmacological actions such as cholesterol, protect liver and anti-cirrhosis are reduced, and these pharmacological actions exactly enjoy pharmaceutical industry
Favor.
CHAGA, calls Inonotus obliquus, is a kind of medicinal fungi being grown on silver birch.It is the health care of 21 century
Property food.It has treatment diabetes, anti-aging, improves and prevents anaphylaxis cortex etc. to act on.
Mulberries, the ripening fruits of mulberry tree, mulberry fruit is sweet in flavor and cold in property, with work(such as liver-kidney tonifying, fluid dryness, UFA eyesights
Effect.
Existing Phellinus glossy ganoderma based food, health products or pharmaceutical composition, content mostly is that Phellinus and/or glossy ganoderma is direct
Phellinus glossy ganoderma fine powder after crushing, and or routine among the people cook, be absorbed by organisms profit because its active ingredient is difficult to be completely dissolved
With bioavilability is low, effect is bad.Equally, Ganodenna Lucidum P.E, phellinus linteus extract, CHAGA extract and mulberries are had no
Extract is combined the report in anti-fatigue health-product containing or medicine.A few taste natural drug compatibilities are used, original drug effect can be played
Or what kind of drug effect occurs and change, it will be understood by those skilled in the art that being difficult to expect.
The content of the invention
In view of above-mentioned deficiency, it is an object of the invention to provide a kind of active constituent content is high, it is oral after be easy to absorb profit
With the food with anti-fatigue effect, health products or pharmaceutical composition and preparation method thereof.
In order to achieve the above object, present invention employs technical scheme below, the consumption of each component of the present invention be also through
Inventor is groped to summarize what is drawn in a large number, food that each component consumption is prepared in the range of following weight, health products or
Pharmaceutical composition is respectively provided with good curative effect：
A kind of food with anti-fatigue effect, health products or pharmaceutical composition, its raw material by following weight proportion component group
Into：
Red ganoderma extract 8-12 parts, phellinus linteus extract 4-6 parts, CHAGA extract 4-6 parts, mulberries extract 4-6 part.
Further, the food with anti-fatigue effect, health products or pharmaceutical composition be by following raw material medicaments by
Weight is made：10 parts of red ganoderma extract, 5 parts of phellinus linteus extract, 5 parts of CHAGA extract, 5 parts of mulberries extract.
Above-mentioned each raw material is integration of drinking and medicinal herbs material, you can use as medicine or health products, can act also as food and uses.
Described food, health products or pharmaceutical composition, are extracted by red ganoderma extract, phellinus linteus extract, CHAGA
Thing, mulberries extract are active component, add the oral administration agent that pharmaceutically conventional auxiliary material or complementary composition is prepared from
Type.
The formulation is selected from oral liquid, beverage, granule, pulvis, pill, tablet, medicinal tea or capsule.
The preparation method of a kind of food, health products or pharmaceutical composition is comprised the following steps：
（1）The preparation of red ganoderma extract：Red ganoderma is weighed, is crushed, with the ethanol of volumetric concentration 95% feed liquid mass ratio 1 is pressed:5-
10 hours of reflux extraction 1-3, obtain primary extract；Primary extract is centrifuged into 5min under the conditions of 2500rpm to obtain
Clear liquid is extract；Taking extract carries out silica gel column chromatography, and silica gel consumption is 20-30 times of extract quality, uses volume ratio
For 5:1 chloroform-methanol mixed liquor is eluted, and obtains eluate, with 50 DEG C of evaporated under reduced pressure 2-3 hours of Rotary Evaporators, is obtained
To Ganodenna Lucidum P.E；
（2）The preparation of phellinus linteus extract：Phellinus is taken, volume ratio 1 is added after being crushed:2 ethyl acetate and 60% ethanol, plus
Circumfluence distillation 3 times, first time 1-3 hour, second and third time difference 1-2 hours, filtrate merges to obtain extract I, the dregs of a decoction
Add 65% ethanol, heating and refluxing extraction 3 times, first time 1-1.5 hour, second and third time difference 0.5-1 hours, filtrate
Merge to obtain extract II, merge extract I and II, be condensed into extract, with 65% ethanol extract is dissolved, using nonpolar or
Low pole macroreticular resin is separated to it, first with water elution, obtains eluent I；Then with 60%-70% ethanol elutions, then with
90%-95% ethanol elutions, obtain eluent II, reclaim, and reduced pressure concentration and then vacuum freeze drying, crush 100 mesh sieves, obtain final product mulberry
Yellow extract；
（3）The preparation of CHAGA extract：CHAGA is taken, is crushed, with drinking water 0.5-1 hours are soaked, be subsequently adding CHAGA
The cellulase of weight 0.4-1.0%, with salt acid for adjusting pH value to 4.0-6.0, ultrasonic wave added enzymolysis 15-45min；Enzyme digestion reaction
Afterwards feed liquid is warming up to into 90-110 DEG C, is gone out enzyme 1-5 minutes, filtered, filtrate is standby, the filter residue of gained is extracted into two with ethanol solution
It is secondary：It is heated to micro-boiling, refluxing extraction 1-2 hour；Filter, filter residue is standby；Merge filtrate twice, reclaim filtrate decompression after ethanol
Concentration and then vacuum freeze drying, 100 mesh sieves were crushed, obtained final product CHAGA extract；
（4）The preparation of Fructus Mori extract：Mulberries are taken, in the ethanol solution with the 75-90% of 10 times of weight 60-90min is impregnated,
Extracted with the power ultrasonic of 3000-4000W under conditions of 40-45 DEG C and filtered after 30-40min；Filter residue is again with the 60- of 10 times of weight
75% ethanol solution ultrasonic extraction, condition ibid, filter, merge twice filtrate it is standby, filtrate concentration after vacuum freeze drying,
100 mesh sieves were crushed, mulberries extract was obtained；
（5）By formula ratio mixing Ganodenna Lucidum P.E, phellinus linteus extract, CHAGA extract and mulberries extract, pharmacy is added
Upper conventional auxiliary material or complementary composition prepare formulation.
Above-mentioned formulation can be prepared as pulvis.
Present invention also offers above-mentioned food, health products or pharmaceutical composition prepare antifatigue food, health products or
Purposes in medicine.
The beneficial effects of the present invention is：
The present invention extracts to greatest extent the effective active in glossy ganoderma, Phellinus, CHAGA, mulberries by unique extraction process
Composition, such as polysaccharide, terpene isoreactivity composition, play to greatest extent glossy ganoderma, Phellinus, CHAGA, the drug effect of mulberries or health care work(
Effect, improves bioavilability, correspondingly reduces glossy ganoderma, Phellinus, CHAGA, the consumption of mulberries primary crude drug.
Another significance of the present invention is, for some abnormal precious Chinese medicines, by medicinal material by unique extraction
Technique, makes extract for preparing the formulation of high-load, can make the effective simulation traditional Chinese medical science tradition decoction of medicinal ingredients of modern formulation, favorably
Develop in the modernization of Chinese medicine is promoted.
Research shows that the present composition has excellent anti-fatigue effect, and present composition compatibility is precise and appropriate, plays
Synergy, drug activity is substantially better than each single raw material.
Obviously, the above of the invention, according to the ordinary technical knowledge and means of this area, without departing from this
Under the premise of bright above-mentioned basic fundamental thought, the modification of other various ways can also be made, is replaced or is changed.
Specific embodiment
Below we will the invention will be further elaborated with reference to specific embodiment.
Embodiment 1
Food with anti-fatigue effect, health products or pharmaceutical composition：
（1）The preparation of red ganoderma extract：Red ganoderma is weighed, is crushed, with the ethanol of volumetric concentration 95% feed liquid mass ratio 1 is pressed:5
2 hours of reflux extraction, obtain primary extract；Primary extract is centrifuged into 5min under the conditions of 2500rpm and obtains supernatant
As extract；Taking extract carries out silica gel column chromatography, and silica gel consumption is 20 times of extract quality, is 5 with volume ratio:1
Chloroform-methanol mixed liquor is eluted, and obtains eluate, with 50 DEG C of Rotary Evaporators evaporated under reduced pressure 2 hours, obtains glossy ganoderma extraction
Thing；
（2）The preparation of phellinus linteus extract：Phellinus is taken, volume ratio 1 is added after being crushed:2 ethyl acetate and 60% ethanol, plus
Circumfluence distillation 3 times, 2 hours for the first time, for the second time with difference 1 hour for the third time, filtrate merged to obtain extract I, and the dregs of a decoction are added
65% ethanol, heating and refluxing extraction 3 times, 1 hour for the first time, for the second time with difference 0.5 hour for the third time, filtrate merges must extract
Liquid II, merges extract I and II, is condensed into extract, extract is dissolved with 65% ethanol, using nonpolar or low pole macropore
Resin is separated to it, first with water elution, obtains eluent I；Then with 70% ethanol elution, then with 90% ethanol elution, obtain
Eluent II, reclaims, and reduced pressure concentration and then vacuum freeze drying, crushes 100 mesh sieves, obtains final product phellinus linteus extract；
（3）The preparation of CHAGA extract：CHAGA is taken, is crushed, soaked 1 hour with drinking water, be subsequently adding CHAGA weight
0.5% cellulase, with salt acid for adjusting pH value to 5.0, ultrasonic wave added enzymolysis 30min；Feed liquid is warming up to after enzyme digestion reaction
100 DEG C, go out enzyme 3 minutes, filters, and filtrate is standby, and the filter residue of gained is extracted twice with ethanol solution：Micro-boiling is heated to, is flowed back
Extract 1 hour；Filter, filter residue is standby；Merge filtrate twice, reclaim and do filtrate reduced in volume and then vacuum refrigeration after ethanol
It is dry, 100 mesh sieves were crushed, obtain final product CHAGA extract；
（4）The preparation of Fructus Mori extract：Mulberries are taken, 80min is impregnated with the 75% of 10 times of weight ethanol solution, at 45 DEG C
Under the conditions of extracted with the power ultrasonic of 3000W and filtered after 35min；Filter residue is carried again with the 75% of 10 times of weight ethanol solution ultrasound
Take, condition ibid, filter, merge twice filtrate it is standby, filtrate concentration after vacuum freeze drying, crushed 100 mesh sieves, obtain mulberries
Extract；
（5）Count by weight ratio, take 2 parts of Ganodenna Lucidum P.Es, 1 portion of phellinus linteus extract, 1 part of CHAGA extract and 1 portion of mulberry
Shen extracts are well mixed, and then make pulvis with dextrin.Contain Ganodenna Lucidum P.E 100mg, phellinus linteus extract in every gram of pulvis
50mg, CHAGA extract 50mg and mulberries extract 50mg, daily 1g, once a day, warm water takes.
Embodiment 2
Food with anti-fatigue effect, health products or pharmaceutical composition：
Red ganoderma extract, phellinus linteus extract, CHAGA extract, the preparation method of mulberries extract are simply red with embodiment 1
Ganodenna Lucidum P.E, phellinus linteus extract, CHAGA extract, the amount ratio of mulberries extract are 4:3:3:3, it is and pharmaceutically conventional
Auxiliary material or complementary composition make pulvis, oral liquid, beverage, granule, pill, tablet, medicinal tea or capsule.
Embodiment 3
Food with anti-fatigue effect, health products or pharmaceutical composition：
Red ganoderma extract, phellinus linteus extract, CHAGA extract, the preparation method of mulberries extract are simply red with embodiment 1
Ganodenna Lucidum P.E, phellinus linteus extract, CHAGA extract, the amount ratio of the amount ratio of mulberries extract are 3:1:1:1, with pharmacy
Upper conventional auxiliary material or complementary composition make pulvis, oral liquid, beverage, granule, pill, tablet, medicinal tea or capsule.
Beneficial effect of the present invention with anti-fatigue effect is proved below by way of concrete pharmacodynamics test.
Test example：Food of the present invention, health products or pharmaceutical composition are to Mouse Weight, walking weight load, serum urea
The impact of nitrogen, hepatic glycogen blood lactase acid.
Inventor is by red ganoderma extract, phellinus linteus extract, CHAGA extract, mulberries extract folk prescription and reality
Apply food of the example 1 with anti-fatigue effect, health products or pharmaceutical composition（Compounding powder）Mouse anti-reflecting fatigue effect pharmacology examination
Comparative study confirmation is tested, the embodiment 1 has food, health products or the pharmaceutical composition of anti-fatigue effect（Compounding powder）For
It is antifatigue with more significantly pharmacologically active.
1. test material：
Medicine：
The food with anti-fatigue effect, health products or drug regimen medicinal powder prepared by embodiment 1（Contain in every gram of pulvis
Ganodenna Lucidum P.E 100mg, phellinus linteus extract 50mg, CHAGA extract 50mg and mulberries extract 50mg）.
Single red ganoderma extract powder：With reference to the preparation method of embodiment 1, every gram of pulvis is equivalent to extract containing red ganoderma
250mg。
Single phellinus linteus extract pulvis：With reference to the preparation method of embodiment 1, every gram of pulvis is equivalent to containing phellinus linteus extract
250mg。
Single CHAGA extract powder：With reference to the preparation method of embodiment 1, every gram of pulvis is equivalent to extract containing CHAGA
250mg。
Single mulberries extract pulvis：With reference to the preparation method of embodiment 1, every gram of pulvis is equivalent to containing mulberries extract
250mg。
2. test method：
Mouse 120 is taken, is divided into five groups：Test group（Administration：Composition pulvis obtained by embodiment 1）, red ganoderma group（Give
Medicine：Single red ganoderma extract powder）, Phellinus group（Administration：Single phellinus linteus extract pulvis）, CHAGA group（Administration：Single is white
Birch young pilose antler extract powder）, mulberries group（Administration：Single mulberries extract pulvis）；Dosage 20mg/kgBW, uses 0.5%CMC-
Na is made into suspension, and once, blank group only uses 0.5%CMC-Na gavages to daily gavage, after 30 days, to Mouse Weight, swimming with a load attached to the body
Swimming time, serum urea nitrogen, the impact of hepatic glycogen blood lactase acid are tested.
The impact of 1.1 pairs of Mouse Weights：
Impact of the table 1 to Mouse Weight（X±SD）
From table 1, orally administration mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group pulvis be after 30 days, respectively
The body weight of group mouse compares, and there are no significant for difference（P>0.05）.Therefore each group pulvis has no adverse effects to the body weight of mouse.
The impact of 1.2 pairs of mice burden swimming time.
Impact of 2 beverages of table to the mice burden swimming time（X±SD）
From table 2, orally administration mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group pulvis be after 30 days, Jing
Mouth gives mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group and compares with blank group, and walking weight load has
Conspicuousness（P<0.05）.Test group composition pulvis（Compound）Compared to red ganoderma group, Phellinus group, CHAGA group, mulberries group energy
Significantly extend the walking weight load to mouse.
The impact of serum urea nitrogen level after 1.3 pairs of mouse swimming.
Impact of the table 3 to serum urea nitrogen level after mouse swimming（X±SD）
From table 3, orally administration mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group pulvis are tried after 30 days
Test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group to compare with blank group, serum urea nitrogen content has conspicuousness（P<
0.05）.Test group composition pulvis（Compound）Can significantly reduce compared to red ganoderma group, Phellinus group, CHAGA group, mulberries group tired
Labor mice serum urea nitrogen is produced.
The impact of 1.4 pairs of mouse hepatic glycogen contents
Impact of the table 4 to mouse hepatic glycogen content（X±SD）
From table 4, orally administration mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group pulvis are tried after 30 days
Test a group composition pulvis（Compound）Mouse hepatic glycogen can be significantly improved compared to red ganoderma group, Phellinus group, CHAGA group, mulberries group
Content.
The impact of blood lactase acid value after 1.5 pairs of mouse swimming.
Impact of the table 5 to blood lactase acid value after mouse swimming（X±SD）
From table 5, orally administration mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group pulvis are tested after 30 days
Group composition pulvis（Compound）Blood after mouse swimming can be significantly reduced compared to red ganoderma group, Phellinus group, CHAGA group, mulberries group
Lactic acid TG-AUC.
As can be seen here, food, health products or drug regimen medicinal powder tool alleviates the work(of physical fatigue obtained in embodiment 1
Effect.
Conclusion：Orally administration mouse test group, red ganoderma group, Phellinus group, CHAGA group, mulberries group pulvis are tested after 30 days
Group composition pulvis（Compound）Compare compared to red ganoderma group, Phellinus group, CHAGA group, mulberries group, the negative of mouse can be extended
Weight swimming time（P ＜ 0.05）, reduce tired mice serum urea nitrogen and produce（P ＜ 0.01）, improve mouse hepatic glycogen content
（P ＜ 0.05）, reduce swimming after blood lactase acid TG-AUC（P ＜ 0.01)；Tested each group increases without bad shadow to Mouse Weight
Ring.Therefore under identical dosage, food of the present invention, health products or pharmaceutical composition（Compound）Anti-fatigue effect is substantially better than list
Herbal medicine, illustrates pharmaceutical composition of the present invention, by the mutual compatibility of four tastes difference Chinese medicine, meets traditional Chinese medical theory, plays
Synergistic function, obtains the effect for more preferably alleviating physical fatigue.
Claims (7)
1. a kind of food with anti-fatigue effect, health products or pharmaceutical composition, it is characterised in that：Its raw material is by following weight
The component composition of proportioning：
Red ganoderma extract 8-12 parts, phellinus linteus extract 4-6 parts, CHAGA extract 4-6 parts, mulberries extract 4-6 part.
2. food according to claim 1, health products or pharmaceutical composition, it is characterised in that：Its raw material is by following weight
The component composition of proportioning：
10 parts of red ganoderma extract, 5 parts of phellinus linteus extract, 5 parts of CHAGA extract, 5 parts of mulberries extract.
3. food according to claim 1 and 2, health products or pharmaceutical composition, it is characterised in that：It is carried by red ganoderma
It is active component to take thing, phellinus linteus extract, CHAGA extract, mulberries extract, adds the auxiliary material or auxiliary pharmaceutically commonly used
The oral administration formulation that property composition is prepared from.
4. food according to claim 3, health products or pharmaceutical composition, it is characterised in that：The formulation is selected from oral
Liquid, beverage, granule, pulvis, pill, tablet, medicinal tea or capsule.
5. a kind of preparation method of the food, health products or pharmaceutical composition as described in claim 1-4 any one, its feature
It is that the preparation method includes：
（1）The preparation of red ganoderma extract：Red ganoderma is weighed, is crushed, with the ethanol of volumetric concentration 95% feed liquid mass ratio 1 is pressed:5-
10 hours of reflux extraction 1-3, obtain primary extract；Primary extract is centrifuged into 5min under the conditions of 2500rpm to obtain
Clear liquid is extract；Taking extract carries out silica gel column chromatography, and silica gel consumption is 20-30 times of extract quality, uses volume ratio
For 5:1 chloroform-methanol mixed liquor is eluted, and obtains eluate, with 50 DEG C of evaporated under reduced pressure 2-3 hours of Rotary Evaporators, is obtained
To Ganodenna Lucidum P.E；
（2）The preparation of phellinus linteus extract：Phellinus is taken, volume ratio 1 is added after being crushed:2 ethyl acetate and 60% ethanol, plus
Circumfluence distillation 3 times, first time 1-3 hour, second and third time difference 1-2 hours, filtrate merges to obtain extract I, the dregs of a decoction
Add 65% ethanol, heating and refluxing extraction 3 times, first time 1-1.5 hour, second and third time difference 0.5-1 hours, filtrate
Merge to obtain extract II, merge extract I and II, be condensed into extract, with 65% ethanol extract is dissolved, using nonpolar or
Low pole macroreticular resin is separated to it, first with water elution, obtains eluent I；Then with 60%-70% ethanol elutions, then with
90%-95% ethanol elutions, obtain eluent II, reclaim, and reduced pressure concentration and then vacuum freeze drying, crush 100 mesh sieves, obtain final product mulberry
Yellow extract；
（3）The preparation of CHAGA extract：CHAGA is taken, is crushed, with drinking water 0.5-1 hours are soaked, be subsequently adding CHAGA
The cellulase of weight 0.4-1.0%, with salt acid for adjusting pH value to 4.0-6.0, ultrasonic wave added enzymolysis 15-45min；Enzyme digestion reaction
Afterwards feed liquid is warming up to into 90-110 DEG C, is gone out enzyme 1-5 minutes, filtered, filtrate is standby, the filter residue of gained is extracted into two with ethanol solution
It is secondary：It is heated to micro-boiling, refluxing extraction 1-2 hour；Filter, filter residue is standby；Merge filtrate twice, reclaim filtrate decompression after ethanol
Concentration and then vacuum freeze drying, 100 mesh sieves were crushed, obtained final product CHAGA extract；
（4）The preparation of Fructus Mori extract：Mulberries are taken, in the ethanol solution with the 75-90% of 10 times of weight 60-90min is impregnated,
Extracted with the power ultrasonic of 3000-4000W under conditions of 40-45 DEG C and filtered after 30-40min；Filter residue is again with the 60- of 10 times of weight
75% ethanol solution ultrasonic extraction, condition ibid, filter, merge twice filtrate it is standby, filtrate concentration after vacuum freeze drying,
100 mesh sieves were crushed, mulberries extract was obtained；
（5）By formula ratio mixing Ganodenna Lucidum P.E, phellinus linteus extract, CHAGA extract and mulberries extract, pharmacy is added
Upper conventional auxiliary material or complementary composition prepare formulation.
6. preparation method according to claim 5, it is characterised in that：The formulation is pulvis.
7. food, health products or pharmaceutical composition described in claim 1-6 any one are preparing antifatigue food, health products
Or the purposes in medicine.
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