CN106389765A - Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof - Google Patents
Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/42—Heating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a traditional Chinese medicine composition capable of dispelling effect of alcohol. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-30 parts of Oxytropis kansuensis, 10-20 parts of polygonum capitatum, 20-30 parts of passiflora cochinchinensis, 10-20 parts of cassia seeds, 10-30 parts of waxgourd peels, 10-30 parts of rhizoma dioscoreae, 10-30 parts of radix puerariae, 5-15 parts of flowers of kudzuvine and 5-15 parts of semen hoveniae. Capsules, tablets and granules are prepared through carrying out mixing by adopting a specific granule stirrer and carrying out granulating according to the conventional method. The traditional Chinese medicine is good in content uniformity and has the action of dispelling the effect of alcohol.
Description
Technical field
The invention belongs to Chinese medicine health care product technical field, particularly to a kind of Anti-alcoholism Chinese medicinal composition.
Background technology
According to scientist's research, daily 80-150 gram of Chinese liquor of drink, hepatic injury can be caused within continuous 5 years.A large amount of drink Chinese liquor 20 years
More than, the people of 40%-50% can occur liver cirrhosis, and the 200 grams of continuities of Chinese liquor of daily drink may occur in which fatty liver in 10 years.Ethanol is to liver
Damaging action mainly caused by ethanol itself and its metabolite acetaldehyde.A large amount of gatherings of ethanol and acetaldehyde can reduce hepatocyte
The biological activity of interior each enzyme, impact sugar, fat and protein homergy, change membrane structure, cause liver cell destruction,
Lipidosiss, even hepatic fibrosis, liver cirrhosis.According to statistics, 86% be addicted to drink personage all with excessive phlegm, pharyngitis, cough, halitosis,
Nausea, retch, weak, dizzy headache, insomnia, sensation of oppression over the chest with shortness of breath, gastrointestinal upset, the easily symptom such as fatigue, and these symptoms are exactly
The omen of multiple chronic diseases, therefore, hangover-alleviating health-care products application and give birth to.Chinese medicinal alcoholism-relieving health promoting product kind in the market
Various, but mostly all made with medicine, large side effects or poor taste, uniformity of dosage units is bad, when clinically patient takes usually
Produce some side effect.
Content of the invention
In order to overcome the deficiencies in the prior art, the present invention is changed to adjuvant screening, process optimization and equipment by lot of experiments
Enter, there is provided a kind of Anti-alcoholism Chinese medicinal composition, uniformity of dosage units is good, preparation process is simple.
The object of the present invention is achieved like this：
A kind of Anti-alcoholism Chinese medicinal composition, it is prepared from by following raw materials in part by weight proportioning：Herba Oxytropis Kansuensiss 20-30 part, stone
Folium illicii Lanceolati 10-20 part, Herba passiflorae cochinchinensiss 20-30 part, Semen Cassiae 10-20 part, Exocarpium Benincasae 10-30 part, Rhizoma Dioscoreae 10-30 part, Radix Puerariae 10-30
Part, Flos puerariae lobatae 5-15 part, Japanese raisintree fruit 5-15 part.
Described Anti-alcoholism Chinese medicinal composition, it is prepared from by following raw materials in part by weight proportioning：25 parts of Herba Oxytropis Kansuensiss, Herba Polygoni Capitati
15 parts, 25 parts of Herba passiflorae cochinchinensiss, 15 parts of Semen Cassiae, 20 parts of Exocarpium Benincasae, 20 parts of Rhizoma Dioscoreae, 20 parts of Radix Puerariae, 10 parts of Flos puerariae lobatae, 10 parts of Japanese raisintree fruit.
Described Anti-alcoholism Chinese medicinal composition, dosage form is granule, tablet, capsule.
Described Anti-alcoholism Chinese medicinal composition, preparation method step is：Take Herba Oxytropis Kansuensiss, Herba Polygoni Capitati, Herba passiflorae cochinchinensiss, Semen Cassiae, winter
Melon skin, Rhizoma Dioscoreae, Radix Puerariae, Flos puerariae lobatae, Japanese raisintree fruit medical material merge, and add water to cook twice, collecting decoction, relative density when being concentrated into 65 DEG C
For 1.10-1.20, plus ethanol makes the percent by volume of alcohol content reach 65-85%, stirring, and standing filters, filtrate reduced in volume is extremely
When 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, obtains concentrated solution, concentrated solution is spray-dried, add adjuvant, in granule
Stirrer for mixing uniformly, is pelletized according to a conventional method, is made capsule, tablet, granule.
Described Anti-alcoholism Chinese medicinal composition, in preparation method, decocting condition is：8-12 times adding water as medical material weight for the first time
Amount, decocts 1-2h, the 6-10 times amount adding water for the second time as medical material weight, decocts 1-2h.
Described Anti-alcoholism Chinese medicinal composition, in preparation method, spray drying condition is：Inlet temperature is 100-120 DEG C, air-out
Temperature is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
Described Anti-alcoholism Chinese medicinal composition, Particle mixer in preparation method, including base, it is arranged on stirring on described base
Mix cylinder, be provided with stirring motor, the main shaft of described stirring motor and the described bottom wall central phase stirring cylinder in described base
Connect, the diapire in described mixing drum body is provided with stirring mast, be vertically uniformly provided with the side wall of described stirring cylinder
At least two cavitys, are provided with L-type material casting plate in described cavity, and the corner of described L-type material casting plate is connected to by rotary shaft
In cavity and the outboard end of described L-type material casting plate stretches in described mixing drum body, it is provided with material casting motor in described cavity,
The main shaft of described material casting motor is provided with and compresses eccentric, the medial extremity of described L-type material casting plate and the side of described cavity
It is provided with stress spring, the described wheel side compressing eccentric is pressed between L-type material casting plate medial extremity and cavity side walls between wall,
It is additionally provided with support rod on described base, regulation vertical slot is provided with described support rod, in described regulation vertical slot, be provided with elevator,
It is provided with lift cylinder between described elevator and described regulation vertical slot, be provided with electric rotating machine in described elevator, described
The main shaft of electric rotating machine is provided with column spinner, and described column spinner stretches in described mixing drum and described when described elevator declines
Column spinner is staggered setting with stirring mast.
Described Anti-alcoholism Chinese medicinal composition, is provided with sealing gasket at the opening of described cavity, and described rotary shaft is wrapped in described close
In packing.
Described Anti-alcoholism Chinese medicinal composition, described column spinner is provided with stirring palpus, is provided with the roof of described stirring cylinder
Charging aperture and feeding detection mouth.
Application in preparing Sobering-up Chinese medicine for the described Anti-alcoholism Chinese medicinal composition.
Herba Oxytropis Kansuensiss are the herb of leguminous plant Herba Oxytropis Kansuensiss.Removing toxic substances doctor's skin ulcer, diuresis of stopping blooding.Control various internal hemorrhages.
Herba Polygoni Capitati is the herb of polygonaceae plant Herba Polygoni Capitati.Classification system Polygonum capitatum Buch detoxifies, and dissipates
The stasis of blood, inducing diuresis for treating stranguria syndrome.Control dysentery, pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.The present invention is with complete
Grass is used as medicine.
Herba passiflorae cochinchinensiss are Passifloraceae Passiflora plant Herba passiflorae cochinchinensiss Passiflora cochinchinensis Spreng.,
Herb is used as medicine.Whole year can adopt, and clean chopping, dry.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For venom, Stomach duodenum is burst
Infectionss；Panaris, carbuncle sore are controlled in external.
Compared with prior art, FUFANG LIXUEPING PIAN according to the present invention has technique effect beneficial as follows：
(1) uniformity of dosage units is good.(2) preparation process is simple, structure is simple, is provided with L-type material casting plate, and it passes through when using
Compressing eccentric cooperation stress spring can make L-type material casting plate rotate centered on rotary shaft, thus by mixing drum interior part medicine
Thing throws to the center of mixing drum, and is additionally provided with column spinner, by the reverse rotation of column spinner and mixing drum, can will be in L
The bottom medicine agitation of type material casting plate, the medicine decline such that it is able to make L-type material casting back is stirred by column spinner, thus significantly
Improve stirring efficiency, and be not easy occur stirring dead angle, solve conventional art medicine agitating device stirring have dead angle and
The low technical deficiency of stirring efficiency, stability in use is good and strong applicability.(3) Herba Oxytropis Kansuensiss of the present invention, Herba Polygoni Capitati, Herba passiflorae cochinchinensiss solution
Poison, dissipating blood stasis, inducing diuresis for treating stranguria syndrome is monarch drug, and Semen Cassiae, Exocarpium Benincasae, Rhizoma Dioscoreae alcoholic intoxication are ministerial drug, and Radix Puerariae, Flos puerariae lobatae, Japanese raisintree fruit make for assistant
Medicine, has antialcoholism action jointly.
Brief description
Fig. 1 is the structural representation of Particle mixer
Specific embodiment
Form is described in further detail to the above of the present invention again by the following examples, but should not manage this
Solve the scope for the above-mentioned theme of the present invention and be only limitted to Examples below, all belonged to based on the technology that the above of the present invention is realized
In the scope of the present invention.
1st, combine specific embodiment, the present invention is further described as follows：
According to the form below, listed weight proportion weighs needed raw material of the present invention, unit：g
| Herba Oxytropis Kansuensiss | Herba Polygoni Capitati | Herba passiflorae cochinchinensiss | Semen Cassiae | Exocarpium Benincasae | Rhizoma Dioscoreae | Radix Puerariae | Flos puerariae lobatae | Japanese raisintree fruit | |
| Embodiment 1 | 20 | 20 | 20 | 20 | 10 | 30 | 10 | 15 | 5 |
| Embodiment 2 | 25 | 15 | 25 | 15 | 20 | 20 | 20 | 10 | 10 |
| Embodiment 3 | 30 | 10 | 30 | 10 | 30 | 10 | 30 | 5 | 15 |
2. prepare embodiment
Taking upper table Central Plains material proportioning as a example, comprise the following steps：
Embodiment 1：Weigh medical material by upper table and mix, add water to cook twice, 8 times adding water for the first time as medical material weight
Amount, decocts 1h, 6 times amount adding water for the second time as medical material weight, decocts 1h, collecting decoction, filtration, filtrate is concentrated into relative density
1.10 (65 DEG C), plus ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stirring, stands 24 hours, filtration, filtrate reclaims second
Alcohol is simultaneously concentrated into the extractum of relative density 1.20 (65 DEG C), and spray-dried (condition is 100 DEG C for inlet temperature, leaving air temp
For 80 DEG C, temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), it is ground into dry extract, add
Adjuvant, mix homogeneously in Particle mixer, pelletize according to a conventional method, make granule.
Above-mentioned Particle mixer, is shown in Fig. 1, including including base 1, is arranged on the stirring cylinder 2 on described base 1, in institute
State and in base 1, be provided with stirring motor 3, the main shaft of described stirring motor 3 is connected with the bottom wall central of described stirring cylinder 2,
Diapire in described stirring cylinder 2 is provided with stirring mast 4, is vertically uniformly provided with least in the side wall of described stirring cylinder 2
Two cavitys 5, are provided with L-type material casting plate 6 in described cavity 5, and the corner of described L-type material casting plate 6 is connected to by rotary shaft 7
In cavity 5 and the outboard end of described L-type material casting plate 6 stretches in described stirring cylinder 2, it is provided with material casting in described cavity 5 and drives
Motor 8, is provided with the main shaft of described material casting motor 8 and compresses eccentric 9, the medial extremity of described L-type material casting plate 6 with described
Be provided with stress spring 10 between the side wall of cavity 5, the described wheel side compressing eccentric 9 be pressed on L-type material casting plate 6 medial extremity with recessed
Between the side wall of chamber 5, when using, the wheel side activity compressing eccentric is pressed on the end of L-type material casting plate, so that L-type material casting
The end of plate is rotated centered on rotary shaft and stretches stress spring makes it store power, when rotating to the concave edge compressing eccentric, L
The end of type material casting plate resets under the pulling of stress spring, so that medical material is thrown to and stirred by the plate body movement being in mixing drum
Mix the center of cylinder, described base 1 is additionally provided with support rod 11, regulation vertical slot 12 is provided with described support rod 11, described
Adjust in vertical slot 12 and be provided with elevator 13, between described elevator 13 and described regulation vertical slot 12, be provided with lift cylinder 14,
It is provided with electric rotating machine 15 in described elevator 13, column spinner 16, described column spinner are provided with the main shaft of described electric rotating machine 15
16 stretch in described mixing drum 2 when described elevator 13 declines and described column spinner 16 and stirring mast 4 stagger setting.In order to
Facilitate column spinner to enter mixing drum, the top cover of mixing drum can be opened after loading column spinner, then top cover is covered.
It is provided with sealing gasket 17 at the opening of described cavity 5, described rotary shaft is wrapped in described sealing gasket.
Described column spinner is provided with stirring palpus 18, is provided with charging aperture 19 and feeding detection on the roof of described stirring cylinder
Mouth 20.Using stirring palpus, because it is flexible material, so not interfering with the normal material casting operation of L-type material casting plate.
Embodiment 2：Weigh medical material by upper table and mix, add water to cook twice, 10 times adding water for the first time as medical material weight
Amount, decocts 1.5h, 8 times amount adding water for the second time as medical material weight, decocts 1.5h, collecting decoction, filtration, filtrate is concentrated into relatively
Density 1.15 (65 DEG C), plus ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stands 24 hours, filtration, filtrate is returned
Receive ethanol and be concentrated into the extractum of relative density 1.25 (65 DEG C), spray-dried (condition is 120 DEG C for inlet temperature, air-out
Temperature is 90 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5/s.), it is ground into dry extract,
Add adjuvant, mix homogeneously in Particle mixer, pelletize according to a conventional method, make tablet.
Particle mixer is ibid.
Embodiment 3：Weigh medical material by upper table and mix, add water to cook twice, 10 times adding water for the first time as medical material weight
Amount, decocts 1.5h, 8 times amount adding water for the second time as medical material weight, decocts 1.5h, collecting decoction, filtration, filtrate is concentrated into relatively
Density 1.15 (65 DEG C), plus ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stands 24 hours, filtration, filtrate is returned
Receive ethanol and be concentrated into the extractum of relative density 1.25 (65 DEG C), spray-dried (condition is 120 DEG C for inlet temperature, air-out
Temperature is 90 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 7.5/s.), it is ground into dry extract,
Add adjuvant, mix homogeneously in Particle mixer, pelletize according to a conventional method, make capsule.
Particle mixer is ibid.
Comparative example 4：Make tablet with embodiment 2, using general Particle mixer.
3. uniformity of dosage units experiment
Content and content uniformity determination all by Chinese Pharmacopoeia two method operations of version in 2010, measures in Tablets
The content of puerarin.High-efficient liquid phase chromatogram condition is Agilent ZORBAX SB C18 chromatographic column (4.6mm × 150mm, 5 μm),
Mobile phase is methanol-water (27: 73), Detection wavelength 274nm, flow velocity 1.0ml/min, 25 DEG C of column temperature.Respectively Example 2 and right
Carry out the assay of puerarin than ten tablets of embodiment 4, find that the puerarin content in embodiment 2 is 0.23-
0.25%, the puerarin content in comparative example 4 is 0.05-0.38%, illustrates that embodiment 2 makes the tablet content uniformity
Good.
4. the impact of pair alcohol user's ethanol in blood content
Study subject：Select 50 healthy adults as study subject, men and women half and half.Test method：By study subject
Random point two groups, every group of 25 people, men and women half and half.Before drinking, 30min takes the tablet of embodiment 1 as experimental group respectively.The
Two groups as a control group, does not take any antialcoholic drugs before drinking.Study subject everyone drink 52 ° of Chinese liquor 250mL；30 minutes with
Afterwards, all study subject ethanol in blood contents are detected.Result such as following table.
Study subject ethanol in blood content (mg/100ml)
| Ethanol content | |
| Embodiment 2 | 46.91±4.48 |
| Embodiment 4 | 89.32±12.29 |
Drunk after medicine of the present invention in more direct alcohol user's blood it will be seen that drinking by the detection data of upper table
Ethanol content substantially reduces, and shows that medicine of the present invention has the effect quickly relieved the effect of alcohol.Meanwhile, drunk by observing two groups of experimenters
Body-feeling after 52 ° of Chinese liquor, finds that the beverage alcohol user drinking the present invention does not occur the phenomenon vomitted after drinking substantially, and straight
Meeting alcohol user has obvious sticky feeling, and has 2 vomiting phenomenon occurs.In addition, experiment also confirms that, the medicine of the present invention exists
Take after drinking, it may have antialcoholism action well.As before wine, 30min combines and takes after drinking, then dispelling effects of alcohol is more preferably；And it is male
Female the old and the young are all suitable.
Claims (10)
1. a kind of Anti-alcoholism Chinese medicinal composition is it is characterised in that it is prepared from by following raw materials in part by weight proportioning：Herba Oxytropis Kansuensiss
20-30 part, Herba Polygoni Capitati 10-20 part, Herba passiflorae cochinchinensiss 20-30 part, Semen Cassiae 10-20 part, Exocarpium Benincasae 10-30 part, Rhizoma Dioscoreae 10-30 part,
Radix Puerariae 10-30 part, Flos puerariae lobatae 5-15 part, Japanese raisintree fruit 5-15 part.
2. Anti-alcoholism Chinese medicinal composition as claimed in claim 1 it is characterised in that it prepared by following raw materials in part by weight proportioning and
Become：25 parts of Herba Oxytropis Kansuensiss, 15 parts of Herba Polygoni Capitati, 25 parts of Herba passiflorae cochinchinensiss, 15 parts of Semen Cassiae, 20 parts of Exocarpium Benincasae, 20 parts of Rhizoma Dioscoreae, Radix Puerariae 20
Part, 10 parts of Flos puerariae lobatae, 10 parts of Japanese raisintree fruit.
3. Anti-alcoholism Chinese medicinal composition as claimed in claim 1 is it is characterised in that dosage form is granule, tablet, capsule.
4. Anti-alcoholism Chinese medicinal composition as claimed in claim 1 is it is characterised in that preparation method step is：Take Herba Oxytropis Kansuensiss, Shi Mang
Grass, Herba passiflorae cochinchinensiss, Semen Cassiae, Exocarpium Benincasae, Rhizoma Dioscoreae, Radix Puerariae, Flos puerariae lobatae, Japanese raisintree fruit medical material merge, and add water to cook twice, collecting decoction,
When being concentrated into 65 DEG C, relative density is 1.10-1.20, plus ethanol makes the percent by volume of alcohol content reach 65-85%, stirring, quiet
Put, filter, filtrate reduced in volume to relative density when 65 DEG C is 1.20-1.30 and reclaims ethanol, obtains concentrated solution, concentrated solution is sprayed
Mist is dried, and adds adjuvant, mix homogeneously in Particle mixer, pelletizes according to a conventional method, make capsule, tablet, granule.
5. Anti-alcoholism Chinese medicinal composition as claimed in claim 4 it is characterised in that in preparation method decocting condition be：For the first time
The 8-12 times amount adding water as medical material weight, decocts 1-2h, the 6-10 times amount adding water for the second time as medical material weight, decocts 1-2h.
6. Anti-alcoholism Chinese medicinal composition as claimed in claim 4 it is characterised in that in preparation method spray drying condition be：Enter
Air temperature is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa,
Spray velocity is 5-10ml/s.
7. Anti-alcoholism Chinese medicinal composition as claimed in claim 4 is it is characterised in that Particle mixer in preparation method, including base,
Be arranged on the stirring cylinder on described base, be provided with stirring motor in described base, the main shaft of described stirring motor with described
The bottom wall central of stirring cylinder is connected, and is provided with stirring mast, in described stirring cylinder on the diapire in described mixing drum body
Side wall in be vertically uniformly provided with least two cavitys, be provided with L-type material casting plate in described cavity, the turning of described L-type material casting plate
It is connected in cavity by rotary shaft at angle and the outboard end of described L-type material casting plate stretches in described mixing drum body, in described sky
Intracavity is provided with material casting motor, is provided with and compresses eccentric on the main shaft of described material casting motor, described L-type material casting plate
It is provided with stress spring, the described wheel side compressing eccentric is pressed in L-type material casting plate between the side wall of medial extremity and described cavity
Between side and cavity side walls, described base is additionally provided with support rod, regulation vertical slot is provided with described support rod, described
Adjust in vertical slot and be provided with elevator, be provided with lift cylinder between described elevator and described regulation vertical slot, in described elevator
Inside it is provided with electric rotating machine, the main shaft of described electric rotating machine is provided with column spinner, described column spinner is when described elevator declines
Stretch in described mixing drum and described column spinner and stirring mast stagger setting.
8. according to claim 4 Anti-alcoholism Chinese medicinal composition it is characterised in that being provided with sealing gasket at the opening of described cavity, institute
State rotary shaft to be wrapped in described sealing gasket.
9. Anti-alcoholism Chinese medicinal composition stirs palpus it is characterised in that described column spinner is provided with according to claim 4, described
The roof of stirring cylinder is provided with charging aperture and feeding detection mouth.
10. application in Sobering-up Chinese medicine for the Anti-alcoholism Chinese medicinal composition as claimed in claim 1.
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| CN201610911207.3A CN106389765A (en) | 2016-10-19 | 2016-10-19 | Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212254A (en) * | 2022-08-15 | 2022-10-21 | 贵州医科大学 | Application of polygonum capitatum in preparation of anti-liver injury medicine |
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| CN102698241A (en) * | 2012-06-28 | 2012-10-03 | 南京中医药大学 | Chinese medicinal composition with alcoholism alleviating function and preparation method and application thereof |
| CN105943514A (en) * | 2016-06-22 | 2016-09-21 | 南京华宽信息咨询中心 | Glipizide tablets for treating diabetes and preparation method thereof |
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2016
- 2016-10-19 CN CN201610911207.3A patent/CN106389765A/en not_active Withdrawn
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|---|---|---|---|---|
| CN102698241A (en) * | 2012-06-28 | 2012-10-03 | 南京中医药大学 | Chinese medicinal composition with alcoholism alleviating function and preparation method and application thereof |
| CN105943514A (en) * | 2016-06-22 | 2016-09-21 | 南京华宽信息咨询中心 | Glipizide tablets for treating diabetes and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115212254A (en) * | 2022-08-15 | 2022-10-21 | 贵州医科大学 | Application of polygonum capitatum in preparation of anti-liver injury medicine |
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