CN102698241A - Chinese medicinal composition with alcoholism alleviating function and preparation method and application thereof - Google Patents
Chinese medicinal composition with alcoholism alleviating function and preparation method and application thereof Download PDFInfo
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- CN102698241A CN102698241A CN2012102173792A CN201210217379A CN102698241A CN 102698241 A CN102698241 A CN 102698241A CN 2012102173792 A CN2012102173792 A CN 2012102173792A CN 201210217379 A CN201210217379 A CN 201210217379A CN 102698241 A CN102698241 A CN 102698241A
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Abstract
The invention provides a Chinese medicinal composition, which is used for fulfilling the aim of alleviating alcoholism by normalizing the middle-warmer, eliminating dampness, regulating liver and alleviating alcoholism. For fulfilling the aim, active ingredients contained in the Chinese medicinal composition are prepared from the following raw materials in parts by weight: 10-30 parts of chrysanthemum, 10-30 parts of kudzuvine root, 5-15 parts of dried ginger, 10-20 parts of mung bean, 10-30 parts of orange peel, 10-30 parts of amomum fruit, 10-20 parts of white hyacinth bean, 10-30 parts of buckwheat, 10-30 parts of mulberry and 10-30 parts of pawpaw, and a corresponding preparation method is adopted. The Chinese medicinal composition has an alcoholism alleviating function.
Description
Technical field
The present invention relates to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine composition with antialcoholism action.
Background technology
Relieving the effect of alcohol is the people to be waken up come from drunk state, recovers consciousness or possessiveness.Usually not that nature is clear-headed, but adopt certain mode to relieve the effect of alcohol fast, play time-saving purpose, reduce the purpose of ethanol human harm.Antialcoholic drug totally can be divided into two kinds of chemical drugs, Chinese medicine preparation, and its sober-up function has relation with property of medicine speed.Comparatively speaking, chemical drugs at antialcoholic simultaneously, can cause the metabolism burden and produce injury in various degree liver, kidney.And the alcohol-neutralize healthy product of integration of edible and medicinal herbs neither can produce any side effect, and can play a part to repair nutrition to impaired liver cell, and is safe and reliable, therefore, obtained the favor of increasing expert and consumer.
Summary of the invention
Goal of the invention:, the object of the present invention is to provide a kind of Chinese medicine composition with antialcoholism action in order to address the above problem.
Another object of the present invention is to provide a kind of Chinese medicine composition method for preparing and application with antialcoholism action.
Technical scheme: the objective of the invention is to realize through following scheme:
A kind of Chinese medicine composition with antialcoholism action, its contained active component is prepared from the following raw materials in part by weight proportioning: Flos Chrysanthemi 10-30 part, Radix Puerariae 10-30 part, Rhizoma Zingiberis 5-15 part, Semen phaseoli radiati 10-20 part, Pericarpium Citri Reticulatae 10-30 part, Fructus Amomi 10-30 part, Semen Lablab Album 10-20 part, Semen Fagopyri Esculenti 10-30 part, Fructus Mori 10-30 part, Fructus Chaenomelis 10-30 part.
Above-mentioned Chinese medicine composition with antialcoholism action, its contained active component is prepared from the following raw materials in part by weight proportioning: 20 parts of Flos Chrysanthemis, 20 parts of Radix Puerariaes, 10 parts of Rhizoma Zingiberiss, 15 parts in Semen phaseoli radiati, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Fructus Amomis, 15 parts of Semen Lablab Albums, 20 parts in Semen Fagopyri Esculenti, 20 parts in Fructus Mori, 20 parts of Fructus Chaenomeliss.
Above-mentioned Chinese medicine composition with antialcoholism action, dosage form are granule, tablet, oral liquid, capsule.
Above-mentioned method with Chinese medicine composition of antialcoholism action, preparation process is: Flos Chrysanthemi, Radix Puerariae, Rhizoma Zingiberis, Semen phaseoli radiati, Pericarpium Citri Reticulatae, Fructus Amomi, Semen Lablab Album, Semen Fagopyri Esculenti, Fructus Mori and the Fructus Chaenomelis medical material of getting recipe quantity merge decocte with water twice, collecting decoction; Relative density is 1.10-1.20 when being concentrated into 65 ℃, adds ethanol and makes the percent by volume that contains the alcohol amount reach 65-85%, stirs, and leaves standstill; Filter, relative density was 1.20-1.30 and reclaims ethanol when filtrate decompression was concentrated into 65 ℃, got concentrated solution; Add adjuvant and water, be prepared into oral liquid, or with the concentrated solution spray drying; Be ground into dry extract, add adjuvant, process granule, tablet or capsule.
Above-mentioned method for preparing with Chinese medicine composition of antialcoholism action, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
Above-mentioned method for preparing with Chinese medicine composition of antialcoholism action, the spray drying condition is: EAT is 100-120 ℃, and leaving air temp is 80-90 ℃, and temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, spray velocity is 5-10ml/s.
Find that through animal experiment study Chinese medicine composition of the present invention has good antialcoholism action.Therefore, the present invention also provides the purposes of aforementioned pharmaceutical compositions, the application of promptly above-mentioned Chinese medicine composition in medicine is relieved the effect of alcohol in preparation.
Beneficial effect:
1, sees Fructus Chaenomelis suppressing the hyperactive liver Shujin in the side among the we, stomach function regulating removing dampness from theory of Chinese medical science; The Semen Lablab Album invigorating the spleen and regulating the stomach, removing damp-heat is monarch drug altogether.The Radix Puerariae relieving restlessness of relieving the effect of alcohol, promoting the production of body fluid to quench thirst; Flos Chrysanthemi heat clearing away suppressing the hyperactive liver is all ministerial drug.Pericarpium Citri Reticulatae, Fructus Amomi circulation of qi promoting removing dampness and middle preventing or arresting vomiting; Fructus Mori YIN nourishing tonifying liver; The Semen phaseoli radiati heat-clearing and toxic substances removing; Semen Fagopyri Esculenti sending down the abnormal ascending QI removing food stagnancy; Rhizoma Zingiberis dampness warming middle-JIAO, the strongly fragrant the turbid descending of row is adjuvant drug.All medicine compatibilities are played regulating the liver and spleen (stomach) altogether, and removing dampness is relieved the effect of alcohol, the merit of stopping nausea and vomiting by lowering the adverse flow of QI.
2, the present invention writes out a prescription reasonable in designly, and compatibility is rigorous.
3, the present invention consists of the dietotherapeutic kind, has no side effect low price.
The specific embodiment
Below through the embodiment form; Foregoing of the present invention is remake further detailed description; But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following instance, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, combine the specific embodiment, the present invention further specified as follows:
Listed weight proportion takes by weighing raw material required for the present invention in the according to the form below, unit: part
| Flos Chrysanthemi | Radix Puerariae | Rhizoma Zingiberis | Semen phaseoli radiati | Pericarpium Citri Reticulatae | Fructus Amomi | Semen Lablab Album | Semen Fagopyri Esculenti | Fructus Mori | Fructus Chaenomelis | |
| 1 | 10 | 30 | 5 | 20 | 10 | 30 | 20 | 10 | 30 | 10 |
| 2 | 20 | 20 | 10 | 15 | 20 | 20 | 15 | 20 | 20 | 20 |
| 3 | 30 | 10 | 15 | 10 | 30 | 10 | 10 | 30 | 10 | 30 |
Semen phaseoli radiati and Semen Fagopyri Esculenti are raw-food material among the present invention, and (formal name used at school: Fagopyrum esculentum) be the plant of buckwheat, all the other raw materials are all selected the Chinese Pharmacopoeia kind for use to Semen Fagopyri Esculenti.
2, preparation embodiment
More than proportioning raw materials is an example in the table, may further comprise the steps:
The preparation of granule:
Get Flos Chrysanthemi 30g, Radix Puerariae 10g, Rhizoma Zingiberis 15g, Semen phaseoli radiati 10g, Pericarpium Citri Reticulatae 30g, Fructus Amomi 10g, Semen Lablab Album 10g, Semen Fagopyri Esculenti 30g, Fructus Mori 10g and Fructus Chaenomelis 30g medical material and mixing, decocte with water twice adds 8 times of amounts that water is medical material weight for the first time, decocts 1h; Add for the second time 6 times of amounts that water is medical material weight, decoct 1h, collecting decoction filters; Filtrating is concentrated into relative density 1.10 (65 ℃), adds an amount of ethanol and makes and contain alcohol amount (volume fraction) and reach 65%, stirs; Left standstill 24 hours, and filtered, filtrate recycling ethanol also is concentrated into relative density 1.20 (65 ℃); Get concentrated solution, spray-dried (condition is that EAT is 100 ℃, and leaving air temp is 80 ℃; Temperature of charge is 70 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), be ground into dry extract, add suitable dextrin again, with an amount of 80% ethanol moistening, the system soft material is crossed 14 mesh sieves and is granulated, 50-80 ℃ of drying, 60 order granulate get granule.
The preparation of tablet:
Get Flos Chrysanthemi 10g, Radix Puerariae 30g, Rhizoma Zingiberis 5g, Semen phaseoli radiati 20g, Pericarpium Citri Reticulatae 10g, Fructus Amomi 30g, Semen Lablab Album 20g, Semen Fagopyri Esculenti 10g, Fructus Mori 30g and Fructus Chaenomelis 10g medical material and mixing, decocte with water twice adds 10 times of amounts that water is medical material weight for the first time, decocts 1.5h; Add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction filters; Filtrating is concentrated into relative density 1.15 (65 ℃), adds an amount of ethanol and makes and contain alcohol amount (volume fraction) and reach 75%, stirs; Left standstill 24 hours, and filtered, filtrate recycling ethanol also is concentrated into relative density 1.25 (65 ℃); Get concentrated solution, spray-dried (condition is that EAT is 110 ℃, and leaving air temp is 90 ℃; Temperature of charge is 80 ℃, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), be ground into dry extract, add appropriate amount of starch again, mix homogeneously, with an amount of 80% ethanol moistening, the system soft material is crossed 30 mesh sieves and is granulated, in 70～80 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, packing, outer package, it is qualified to inspect by ready samples, gets finished product.
The preparation of oral liquid:
Get Flos Chrysanthemi 20g, Radix Puerariae 20g, Rhizoma Zingiberis 10g, Semen phaseoli radiati 15g, Pericarpium Citri Reticulatae 20g, Fructus Amomi 20g, Semen Lablab Album 15g, Semen Fagopyri Esculenti 20g, Fructus Mori 20g and Fructus Chaenomelis 20g medical material and mixing, decocte with water twice adds 12 times of amounts that water is medical material weight for the first time, decocts 2h; Add for the second time 10 times of amounts that water is medical material weight, decoct 2h, collecting decoction filters; Filtrating is concentrated into relative density 1.20 (65 ℃), adds an amount of ethanol and makes and contain alcohol amount (volume fraction) and reach 85%, stirs; Left standstill 24 hours, and filtered, filtrate recycling ethanol also is concentrated into relative density 1.30 (65 ℃); Get concentrated solution, add an amount of sucrose and water, get the oral liquid finished product.
The preparation of capsule:
Get Flos Chrysanthemi 20g, Radix Puerariae 20g, Rhizoma Zingiberis 10g, Semen phaseoli radiati 15g, Pericarpium Citri Reticulatae 20g, Fructus Amomi 20g, Semen Lablab Album 15g, Semen Fagopyri Esculenti 20g, Fructus Mori 20g and Fructus Chaenomelis 20g medical material and mixing, decocte with water twice adds 10 times of amounts that water is medical material weight for the first time, decocts 1.5h; Add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction filters; Filtrating is concentrated into relative density 1.15 (65 ℃), adds an amount of ethanol and makes and contain alcohol amount (volume fraction) and reach 75%, stirs; Left standstill 24 hours, and filtered, filtrate recycling ethanol also is concentrated into relative density 1.25 (65 ℃); Get concentrated solution, spray-dried (condition is that EAT is 120 ℃, and leaving air temp is 90 ℃; Temperature of charge is 90 ℃, and atomizing pressure is 0.4 MPa, and spray velocity is 7.5ml/s.), be ground into dry extract, cross sieve No. 6, reinstall No. 1 capsule get final product finished product.
3. to drunk mice ethanol tolerance time and the influence of length of one's sleep experiment
3.1 laboratory animal: 20 of ICR male mices, body weight 18-22g (Nanjing Medical University's Experimental Animal Center, the animal quality certification number: SCXK (Soviet Union) 2008-0004).
3.2 experiment medicine: Chinese medicine composition oral liquid of the present invention, by above-mentioned oral liquid embodiment method preparation, promptly get Flos Chrysanthemi 20g, Radix Puerariae 20g, Rhizoma Zingiberis 10g, Semen phaseoli radiati 15g, Pericarpium Citri Reticulatae 20g, Fructus Amomi 20g, Semen Lablab Album 15g, Semen Fagopyri Esculenti 20g, Fructus Mori 20g and Fructus Chaenomelis 20g medical material and mix twice of decocte with water; Add for the first time 12 times of amounts that water is medical material weight, decoct 2h, add 10 times of amounts that water is medical material weight for the second time, decoct 2h; Collecting decoction filters, and filtrating is concentrated into relative density 1.20 (65 ℃), adds an amount of ethanol and makes and contain alcohol amount (volume fraction) and reach 85%; Stir, left standstill 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.30 (65 ℃); Get concentrated solution, add an amount of sucrose and water, get 10 of oral liquids; Specification: 10ml/ props up (being equivalent to contain crude drug 18g), Nanjing University of Traditional Chinese Medicine's self-control, lot number: 20120211.
3.3 experimentation
Be divided into 2 groups at random: matched group, of the present invention group, 10 every group.Each is organized mice and feeds with standard feed, freely drinks water, and adaptability is fed and begun test after 3 days.Matched group is irritated stomach and is given normal saline 0.1ml/10g body weight; Of the present invention group gives oral liquid 0.1ml/10g body weight of the present invention, and continuous three days, each organized mice fasting 12h; Matched group is irritated stomach and is given normal saline 0.1ml/10g body weight; Of the present invention group gives oral liquid 0.1ml/10g body weight of the present invention, behind the 25min, irritates stomach and gives 56% ethanol 16ml/kg body weight.The time that stomach gives ethanol irritated in record, observes and the time of record mice righting reflex loss and the time that righting reflex recovers.Tolerance time (drunk time)=righting reflex loss time-give the wine time; The length of one's sleep=righting reflex recovery time-righting reflex loss time.The result sees table 1.
Table 1. the present invention is to drunk mice ethanol tolerance time and the influence of the length of one's sleep
| Group | Number of animals (only) | Tolerance time (min) | The length of one's sleep (min) |
| Contrast | 10 | 22.2±13.8 | 416.5±188.9 |
| The present invention | 10 | 44.4±16.5 * | 223.7±103.3 * |
Annotate:
*P＜0.05 is compared with matched group
Last table is visible, and the present invention can obviously prolong the tolerance time of drunk mice to ethanol, curtails sleep, and has antialcoholism action.
Claims (7)
1. Chinese medicine composition with antialcoholism action; It is characterized in that its contained active component is prepared from the following raw materials in part by weight proportioning: Flos Chrysanthemi 10-30 part, Radix Puerariae 10-30 part, Rhizoma Zingiberis 5-15 part, Semen phaseoli radiati 10-20 part, Pericarpium Citri tangerinae 10-30 part, Fructus Amomi 10-30 part, Semen Lablab Album 10-20 part, Semen Fagopyri Esculenti 10-30 part, Fructus Mori 10-30 part, Fructus Chaenomelis 10-30 part.
2. the Chinese medicine composition that has antialcoholism action according to claim 1; It is characterized in that its contained active component is prepared from the following raw materials in part by weight proportioning: 20 parts of Flos Chrysanthemis, 20 parts of Radix Puerariaes, 10 parts of Rhizoma Zingiberiss, 15 parts in Semen phaseoli radiati, 20 parts of Pericarpium Citri tangerinaes, 20 parts of Fructus Amomis, 15 parts of Semen Lablab Albums, 20 parts in Semen Fagopyri Esculenti, 20 parts in Fructus Mori, 20 parts of Fructus Chaenomeliss.
3. the Chinese medicine composition that has antialcoholism action according to claim 1 is characterized in that dosage form is granule, tablet, oral liquid, capsule.
4. a method for preparing the Chinese medicine composition that has antialcoholism action according to claim 1 is characterized in that preparation process is: get Flos Chrysanthemi, Radix Puerariae, Rhizoma Zingiberis, Semen phaseoli radiati, Pericarpium Citri tangerinae, Fructus Amomi, Semen Lablab Album, Semen Fagopyri Esculenti, Fructus Mori and the merging of Fructus Chaenomelis medical material of recipe quantity, twice of decocte with water; Collecting decoction, relative density is 1.10-1.20 when being concentrated into 65 ℃, adds ethanol and makes the percent by volume that contains the alcohol amount reach 65-85%; Stir, leave standstill, filter; Relative density was 1.20-1.30 and reclaims ethanol when filtrate decompression was concentrated into 65 ℃, concentrated solution, add adjuvant and water is prepared into oral liquid; Or with the concentrated solution spray drying; Be ground into dry extract, add adjuvant, process granule, tablet or capsule.
5. according to the said method for preparing with Chinese medicine composition of antialcoholism action of claim 4, it is characterized in that decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
6. according to the said method for preparing of claim 4 with Chinese medicine composition of antialcoholism action; It is characterized in that; Said spray drying condition is: EAT is 100-120 ℃, and leaving air temp is 80-90 ℃, and temperature of charge is 70-90 ℃; Atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
7. the Chinese medicine composition that has antialcoholism action according to claim 1 has the application in the antialcoholism action medicine in preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104273285A (en) * | 2014-10-11 | 2015-01-14 | 辛如才 | Traditional Chinese medicine tea for alleviating hangover |
| CN105434584A (en) * | 2014-09-26 | 2016-03-30 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition with hangover alleviating efficacy and preparation method thereof |
| CN106389765A (en) * | 2016-10-19 | 2017-02-15 | 南京康凯生物科技有限公司 | Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1085086A (en) * | 1992-09-29 | 1994-04-13 | 张界夫 | A kind of prescription of sober-up oral medicine and preparation method |
| CN1104510A (en) * | 1993-12-28 | 1995-07-05 | 龚枫砰 | Spirit companion |
| CN1108553A (en) * | 1994-03-17 | 1995-09-20 | 李玉芹 | Product for dispelling the effects of alcohol |
| CN1341449A (en) * | 2001-09-30 | 2002-03-27 | 陈新 | Perlingual sweets for relieving acute alcoholism and its preparation method |
| CN101028500A (en) * | 2007-03-21 | 2007-09-05 | 孙喜灵 | Two-purpose food with appetising and sobering-up functions and its production |
-
2012
- 2012-06-28 CN CN2012102173792A patent/CN102698241A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085086A (en) * | 1992-09-29 | 1994-04-13 | 张界夫 | A kind of prescription of sober-up oral medicine and preparation method |
| CN1104510A (en) * | 1993-12-28 | 1995-07-05 | 龚枫砰 | Spirit companion |
| CN1108553A (en) * | 1994-03-17 | 1995-09-20 | 李玉芹 | Product for dispelling the effects of alcohol |
| CN1341449A (en) * | 2001-09-30 | 2002-03-27 | 陈新 | Perlingual sweets for relieving acute alcoholism and its preparation method |
| CN101028500A (en) * | 2007-03-21 | 2007-09-05 | 孙喜灵 | Two-purpose food with appetising and sobering-up functions and its production |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434584A (en) * | 2014-09-26 | 2016-03-30 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition with hangover alleviating efficacy and preparation method thereof |
| CN104273285A (en) * | 2014-10-11 | 2015-01-14 | 辛如才 | Traditional Chinese medicine tea for alleviating hangover |
| CN106389765A (en) * | 2016-10-19 | 2017-02-15 | 南京康凯生物科技有限公司 | Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof |
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Application publication date: 20121003 |