CN101007071A - Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology - Google Patents
Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology Download PDFInfo
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- CN101007071A CN101007071A CNA2006100417829A CN200610041782A CN101007071A CN 101007071 A CN101007071 A CN 101007071A CN A2006100417829 A CNA2006100417829 A CN A2006100417829A CN 200610041782 A CN200610041782 A CN 200610041782A CN 101007071 A CN101007071 A CN 101007071A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention relates to a process for preparing Chinese medicinal composition for the treatment of chronic enteritis, gastritis and bacillary dysentery, which is prepared from Chinese herbal materials including hairy euphorbia, Chinese knotweed and iron holly bark through steps of grinding, grilling, merging grilling liquid, concentrating into electuary, drying and granulating.
Description
One, technology art field
The present invention relates to a kind of Chinese medicine and preparation technology thereof, specifically a kind of Chinese medicine and preparation technology thereof who treats acute and chronic intestinal, gastritis and bacillary dysentery belongs to technical field of Chinese medicines, comprises preparation technology.
Two, background technology
Treatment by Chinese herbs gastroenteritis and bacillary dysentery have a long history in China, because China's Chinese herbal medicine resource is very abundant, it is convenient to pluck, processing is concocted simple, toxic and side effects is less relatively, be not easy recurrence after curing with Chinese medicine, therefore adopt the acute and chronic gastroenteritis of treatment by Chinese herbs, and bacillary dysentery can both be accepted by broad masses of the people.Capsule or film coated tablet are the pharmaceutical formulations of using always, according to the relevant Medicine Act regulation of China, dosage changing form is as a kind of new drug research, and name of product of the present invention is that original dosage form of flying upward gastroenteritis capsule or Film coated tablets is to fly upward gastroenteritis sheet (sugar-coat), has listed national patent medicine standard promulgated by the ministries or commissions of the Central Government in.The technology characteristics of former dosage form (coated tablet) is: three flavor Chinese medicines, and Cortex Ilicis Rotundae is partly pulverized, and all the other decoctings extract, concentrate drying, mixing granulation, tabletting adds multiple adjuvant, forms through multiple coatings.This dosage form is ancient conventional dosage forms, fly upward the gastroenteritis sheet because the various adjuvants of interpolation occupy 1/3rd to 1/2nd of Chinese medicine weight with what this technology was produced, having increased the weight of Chinese medicine, particularly Pulvis Talci greatly is hydrophobic auxiliary, and disintegrate was slow after medicine entered digestive tract, absorb slow, onset is slow, and medicine effectively loss is many, and effective ingredient absorbs few, the bioavailability of Chinese medicine is reduced, therapeutic effect is had certain influence.In addition, the coated tablet production cycle is longer relatively, increases the factors of instability easily, becomes damp and rotten easily during storage, and weight is bigger, and packing and transportation are all inconvenient.What traditional handicraft was produced flies upward the gastroenteritis tablet owing to generally be added with sugar, perishable adhesion, and it is just more unfavorable to health particularly to take this tablet Chinese medicine for the people who suffers from hyperglycemia and diabetes.So tablet is compared with Film coated tablets with capsule and is had huge defective.Changing dosage form is an invention greatly in development of Chinese herb products field, and therefore, we improve the existing technology of this product with modern technologies, form new dosage form, and the control criterion that improves the quality is simultaneously ensured the quality of products, and improves drug effect, to adapt to patient's needs.
Three, summary of the invention
Purpose of the present invention is exactly many in order to solve the adjuvant composition that above-mentioned Chinese medicine added when producing conventional tablet, weight is big, it is slow to take the back disintegrate, drug absorption is insufficient, not thorough, it is slow to treat acute and chronic stomach, enteritis and bacillary dysentery onset, takes taboo many (hyperglycemia patient is avoided usefulness), thereby a kind of new form of Chinese drug and preparation technology are provided.
For achieving the above object, the present invention can realize by following scheme:
A kind of Chinese medicine for the treatment of acute and chronic intestinal, gastritis and bacillary dysentery, it is that the dosage form that its raw material of making effective ingredient is made by weight is capsule, Film coated tablets by 2280 parts of raw material Ramulus et Folium Bauhiniae Faberi, 1140 parts of Herb Polygoni Chinensiss, 580 parts of Chinese medicines of making by weight of Cortex Ilicis Rotundae.
Produce the Chinese medicine that capsule of the present invention or Film coated tablets are used for the treatment of acute and chronic intestinal, gastritis and bacillary dysentery, its preparation technology is prepared from by following method:
Getting in the prescription three flavor medicines is up to the standards standby respectively: get Cortex Ilicis Rotundae earlier and be ground into fine powder for 124 parts, cross the 100-300 mesh sieve, and standby; 2280 parts of 456 parts of all the other Cortex Ilicis Rotundaes and Ramulus et Folium Bauhiniae Faberi, the Herb Polygoni Chinensis decocts twice for 1140 parts, adding for the first time the 8-12 times of decocting that mixes raw material of Chinese medicine weight boiled 2 hours, adding for the second time the 6-10 times of decocting that mixes raw material of Chinese medicine weight boiled 1 hour, collecting decoction, filter, being condensed into relative density is 1.20-1.40 (60 ℃) thick paste, or relative density is 1.05-1.15 (60 a ℃) clean copy, again with standby rescuing than answering fine powder to mix, make soft material, cross the 12-14 mesh sieve, dry under 60-80 ℃ of ambient temperature, with 14 mesh sieve granulate, add appropriate amount of auxiliary materials stearic acid or Pulvis Talci or micropowder silica gel or 30 POVIDONE K 30 BP/USP 30 or amylodextrin or beta cyclodextrin, 1000 capsules of packing into are packed promptly.
Get Cortex Ilicis Rotundae and be ground into fine powder for 124 parts, cross 100 mesh sieves, standby; All the other rescue than answer 456 parts with 2280 parts of Ramulus et Folium Bauhiniae Faberi, the Herb Polygoni Chinensis decocts twice for 1140 parts, adding for the first time the 8-12 times of decocting that mixes raw material of Chinese medicine weight boiled 2 hours, adding for the second time the 6-10 times of decocting that mixes raw material of Chinese medicine weight boiled 1 hour, collecting decoction, filter, be condensed into relative density 1.05-1.15 (60 ℃) thick paste, standby Cortex Ilicis Rotundae crude drug in whole is mixed with it, make soft material, cross 14 mesh sieves, in temperature is 60-70 ℃ of oven dry down, 1000 of tablettings are sprayed on tabletting by an amount of gastric solubleness acrylic resin and HPMC (mark Chinese name), the film-coat that the zein mixing is used or made separately promptly.
Adopt wet granulation to be condensed into the thick paste that density is 1.20-1.40 (60 ℃) in the technology, adopt one-step palletizing, it is 1.05-1.15 (60 ℃) that clear paste is concentrated into density.
Granulate dusting, inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃, and in wet granulation, hybrid medicine maintains the temperature to keep under 60-70 ℃ the environment and was drying to obtain in 4-5 hour.
The dosage form of the Chinese medicine made from the above-mentioned raw materials prescription is capsule or Film coated tablets.
The advantage that the present invention is compared with prior art had is: existing relatively this dosage form of tablet science, and preparation technology is simpler, and is with short production cycle, easy and simple to handle, rate of drying is fast, and disintegration time is short, the absorbance height, therapeutic effect is faster, product stability increases, and particle weight is light, swallows conveniently, cheap for manufacturing cost, cost of transportation reduces.Considerably less to the adjunct ingredient that Chinese medicine adds, in capsule formulation, do not increase the weight of Chinese medicine substantially, making the Film coated tablets sheet heavily increases seldom, do not contain sugar, the people who suffers from hyperglycemia and diabetes is taken without any taboo, the patient crowd who takes this Chinese medicine is increased greatly, better remove the patient suffering, satisfy and ensure people's medication demand.
Four, body embodiment
Treat the Chinese medicine of acute and chronic intestinal, gastritis and bacillary dysentery, make raw materials of effective components and form and to be by weight:
Ramulus et Folium Bauhiniae Faberi 2280g Herb Polygoni Chinensis 1140g Cortex Ilicis Rotundae 580g.
The dosage form of making Chinese medicine with the effective ingredient of above-mentioned prescription is 1000 of the capsule of pharmacopeia regulation or Film coated tablets, and name of product is decided to be " flying upward the gastroenteritis capsule " or " flying upward the gastroenteritis Film coated tablets ", according to being the name of raw material Ramulus et Folium Bauhiniae Faberi.
Production is flown upward the gastroenteritis capsule or is flown upward the preparation technology that the gastroenteritis Film coated tablets taked:
Embodiment one: three flavor Chinese medicines standby through after the assay was approved in the material composition, wherein get Cortex Ilicis Rotundae 124 and be ground into fine powder, cross 100 mesh sieves, standby; All the other are rescued than decocting with other two flavor Chinese medicine Ramulus et Folium Bauhiniae Faberi, Herb Polygoni Chinensis's mixing and water adding, adding for the first time 10 times of decoctings that mix Chinese medicine weight boiled 2 hours, adding for the second time 8 times of decoctings that mix Chinese medicine weight boiled 1 hour, collecting decoction, filter, it is 1.20-1.40 (60 ℃) thick paste that filtrate is concentrated into density, adds above-mentioned standby Cortex Ilicis Rotundae fine powder and is mixed, and temperature is dry under the environment between 60 ℃-70 ℃, pulverize, cross 100 mesh sieves, moistening with the spraying of 60% ethanol, the system soft material makes granule, dry, granulate is up to the standards, and is standby.
Embodiment two: three flavor Chinese medicines are standby through after the assay was approved in the material composition; wherein get Cortex Ilicis Rotundae 124g and be ground into fine powder; cross 100 mesh sieves; standby; all the other Cortex Ilicis Rotundaes and other two flavor Chinese medicine Ramulus et Folium Bauhiniae Faberi and Herb Polygoni Chinensis's mixing and water adding decoct; adding for the first time 10 times of decoctings that mix Chinese medicine weight boiled 2 hours; adding for the second time 8 times of decoctings that mix Chinese medicine weight boiled 1 hour; collecting decoction filters, and it is 1.05-1.15 (60 ℃) clear paste that filtrate is concentrated into relative density; add that above-mentioned standby to rescue than answering the crude drug fine powder be the granulation of dusting of female powder; carry out one-step palletizing with one-step-granulating method, granulate, it is standby to be up to the standards.
Implementation method three: the granule of preparation in treating excess syndrome applying method one or the implementation method two, add the appropriate amount of auxiliary materials mixing, the Capsules of packing into is made 1000 capsules.
Embodiment four: treating excess syndrome is executed in mode one or the embodiment two granule of preparation, adds an amount of magnesium stearate and be mixed in its granule, and tabletting is made 1000 of diaphragms promptly.
Utilize the one-step-granulating method inlet temperature to be 160-180 ℃ in technology, leaving air temp is 80-100 ℃.
Particle drying keeps the drying baker temperature between 60-70 ℃ in the technology.
Can use any or multiple in magnesium stearate, Pulvis Talci, micropowder silica gel, beta cyclodextrin, dextrin, starch, the polyvidone etc. when dividing encapsulated or tabletting in the technology.
In the technology during Film coated tablets coating earlier with IV gastric solubility acrylic acid resin or with the mixed liquor of zein different proportion as film coating.
The quality control of this product mainly is a microscopical identification, thin layer differentiates and assay 2 aspects that the control that has also increased heavy metal and arsenic salt is limited the quantity of, and heavy metal must not surpass 10/1000000ths, arsenic salt must not surpass 2/1000000ths, and content has increased the assay of Ramulus et Folium Bauhiniae Faberi.
Claims (5)
1, a kind of Chinese medicine and preparation technology thereof who treats acute and chronic intestinal, gastritis and bacillary dysentery, it is by 2280 parts of raw material Ramulus et Folium Bauhiniae Faberi, 1140 parts of Herb Polygoni Chinensiss, 580 parts of Chinese medicines of making by weight of Cortex Ilicis Rotundae, it is characterized in that: making the dosage form that the raw material of effective Chinese medicine ingredients makes by weight is capsule, Film coated tablets.
2, a kind of Chinese medicine and preparation technology thereof who treats acute and chronic intestinal, gastritis and bacillary dysentery according to claim 1 is characterized in that being formed by following prepared;
Getting in the prescription three flavor medicines is up to the standards standby respectively: get Cortex Ilicis Rotundae earlier and be ground into fine powder for 124 parts, cross the 100-300 mesh sieve, and standby; 2280 parts of 456 parts of all the other Cortex Ilicis Rotundaes and Ramulus et Folium Bauhiniae Faberi, the Herb Polygoni Chinensis decocts twice for 1140 parts, adding for the first time the 8-12 times of decocting that mixes raw material of Chinese medicine weight boiled 2 hours, adding for the second time the 6-10 times of decocting that mixes raw material of Chinese medicine weight boiled 1 hour, collecting decoction, filter, being condensed into relative density is 1.20-1.40 (60 ℃) thick paste, or relative density is 1.05-1.15 (60 a ℃) clean copy, again with standby rescuing than answering fine powder to mix, make soft material, cross the 12-14 mesh sieve, dry under 60-80 ℃ of ambient temperature, with 14 mesh sieve granulate, add appropriate amount of auxiliary materials stearic acid or Pulvis Talci or micropowder silica gel or 30 POVIDONE K 30 BP/USP 30 or amylodextrin or beta cyclodextrin, 1000 capsules of packing into are packed promptly.
3, a kind of Chinese medicine and preparation technology thereof who treats acute and chronic intestinal, gastritis and bacillary dysentery according to claim 1 is characterized in that: get Cortex Ilicis Rotundae and be ground into fine powder for 124 parts, cross 100 mesh sieves, and standby; All the other rescue than answer 456 parts with 2280 parts of Ramulus et Folium Bauhiniae Faberi, the Herb Polygoni Chinensis decocts twice for 1140 parts, adding for the first time the 8-12 times of decocting that mixes raw material of Chinese medicine weight boiled 2 hours, adding for the second time the 6-10 times of decocting that mixes raw material of Chinese medicine weight boiled 1 hour, collecting decoction, filter, be condensed into relative density 1.05-1.15 (60 ℃) thick paste, standby Cortex Ilicis Rotundae crude drug in whole is mixed with it, make soft material, cross 14 mesh sieves, in temperature is 60-70 ℃ of oven dry down, 1000 of tablettings are sprayed on tabletting by an amount of gastric solubleness acrylic resin and HPMC, the film-coat that the zein mixing is used or made separately promptly.
4, according to claim 2 or 3 described a kind of Chinese medicine and preparation technologies that treat acute and chronic intestinal, gastritis and bacillary dysentery, it is characterized in that: adopt wet granulation to be condensed into the thick paste that density is 1.20-1.40 (60 ℃) in the technology, adopt one-step palletizing, it is 1.05-1.15 (60 ℃) that clear paste is concentrated into density.
5, according to claim 2 or 3 described a kind of Chinese medicine and preparation technologies thereof that treat acute and chronic intestinal, gastritis and bacillary dysentery, it is characterized in that: in the granulation of dusting, inlet temperature is 160-180 ℃, leaving air temp is 80-100 ℃, in wet granulation, hybrid medicine maintains the temperature to keep under 60-70 ℃ the environment and was drying to obtain in 4-5 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100417829A CN101007071A (en) | 2006-01-27 | 2006-01-27 | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100417829A CN101007071A (en) | 2006-01-27 | 2006-01-27 | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology |
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| CN101007071A true CN101007071A (en) | 2007-08-01 |
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| CNA2006100417829A Pending CN101007071A (en) | 2006-01-27 | 2006-01-27 | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178749A (en) * | 2010-12-31 | 2011-09-14 | 史志辉 | Chinese medicinal composition and preparation method thereof |
| CN103212003A (en) * | 2013-05-16 | 2013-07-24 | 黎秋萍 | Medicine and food capable of treating hot and damp diarrhea |
| CN103494893A (en) * | 2013-09-30 | 2014-01-08 | 黎秋萍 | Footbath powder capable of resolving toxin with clear coolness |
| CN104208037A (en) * | 2013-05-30 | 2014-12-17 | 北京长城制药厂 | Method for preventing traditional Chinese medicine capsule from absorbing moisture |
| CN104435129A (en) * | 2013-07-23 | 2015-03-25 | 佛山市顺德区宝铜金属科技有限公司 | Fresh flower foot massage product canned in bamboo tube |
| CN105012443A (en) * | 2015-08-19 | 2015-11-04 | 韦爱小 | Traditional Chinese medicine for treating gastritis |
| CN107308221A (en) * | 2017-07-07 | 2017-11-03 | 陕西君碧莎制药有限公司 | Fly upward new application of the enterogastritis capsule in treatment pelvic inflammatory sequelae |
| CN107961239A (en) * | 2017-12-18 | 2018-04-27 | 陕西君碧莎制药有限公司 | A kind of three pharmaceutical composition and its application in terms of enterogastritis is treated |
-
2006
- 2006-01-27 CN CNA2006100417829A patent/CN101007071A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178749A (en) * | 2010-12-31 | 2011-09-14 | 史志辉 | Chinese medicinal composition and preparation method thereof |
| CN103212003A (en) * | 2013-05-16 | 2013-07-24 | 黎秋萍 | Medicine and food capable of treating hot and damp diarrhea |
| CN104208037A (en) * | 2013-05-30 | 2014-12-17 | 北京长城制药厂 | Method for preventing traditional Chinese medicine capsule from absorbing moisture |
| CN104435129A (en) * | 2013-07-23 | 2015-03-25 | 佛山市顺德区宝铜金属科技有限公司 | Fresh flower foot massage product canned in bamboo tube |
| CN104435129B (en) * | 2013-07-23 | 2017-01-11 | 佛山市顺德区宝铜金属科技有限公司 | Fresh flower foot massage product canned in bamboo tube |
| CN103494893A (en) * | 2013-09-30 | 2014-01-08 | 黎秋萍 | Footbath powder capable of resolving toxin with clear coolness |
| CN105012443A (en) * | 2015-08-19 | 2015-11-04 | 韦爱小 | Traditional Chinese medicine for treating gastritis |
| CN107308221A (en) * | 2017-07-07 | 2017-11-03 | 陕西君碧莎制药有限公司 | Fly upward new application of the enterogastritis capsule in treatment pelvic inflammatory sequelae |
| CN107308221B (en) * | 2017-07-07 | 2020-10-20 | 陕西君碧莎制药有限公司 | New application of Feiyang gastroenteritis capsule in treating pelvic inflammatory sequelae |
| CN107961239A (en) * | 2017-12-18 | 2018-04-27 | 陕西君碧莎制药有限公司 | A kind of three pharmaceutical composition and its application in terms of enterogastritis is treated |
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Open date: 20070801 |