CN101732555A - Medicament for treating cold cough and chronic bronchitis - Google Patents
Medicament for treating cold cough and chronic bronchitis Download PDFInfo
- Publication number
- CN101732555A CN101732555A CN201010105176A CN201010105176A CN101732555A CN 101732555 A CN101732555 A CN 101732555A CN 201010105176 A CN201010105176 A CN 201010105176A CN 201010105176 A CN201010105176 A CN 201010105176A CN 101732555 A CN101732555 A CN 101732555A
- Authority
- CN
- China
- Prior art keywords
- fine powder
- medicine
- powder
- medicament
- chronic bronchitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a medicament for treating cold cough and chronic bronchitis, which adopts the technical scheme that the medicament comprises the following components in part by weight: 30 to 70 parts of unibract fritillary bulb, 30 to 70 parts of platycodon root, 200 to 500 parts of loquat leaf, 0.2 to 0.6 part of menthol and 0.5 to 5 parts of almond essence; and a method for preparing granular formulations of the medicament comprises the steps of: in the medicaments, pulverizing the unibract fritillary bulb into fine powder in an ultramicro mode; pulverizing the platycodon root into fine powder in an ultramicro mode and sieving the powder with a 200-mesh sieve; decocting platycodon root coarse powder and the loquat leaf by adding water, then uniformly mixing the mixture and the platycodon root fine powder, drying and porphyrizing, adding the unibract fritillary bulb fine powder into the mixture, and uniformly mixing to prepare granules; and drying the granules, adding the almond essence, the menthol and starch, uniformly mixing and encapsulating. The medicament has the advantages of treating cough yellow sputum or unsmooth expectoration, throat gall, chest distress and swelling pain, cold cough and chronic bronchitis which are caused by wind-heat affecting lung and fire transmission from internal depression. The extracted medicament is prepared into formulations such as capsules or soft capsules, micro-capsules or pills, is convenient for popular use, and reduces paraesthesia during administration.
Description
Technical field
The present invention relates to a kind of medicine, especially a kind of medicine for the treatment of cold cough and chronic bronchitis.
Background technology
There is very abundant pools of traditional Chinese medicine in China, but awaits to discover and use.The a lot of original very effective prescription system prescriptions of China, because of being subjected to the influence of factors such as technology of preparing, preparation technology and dosage form packing, greatly overslaugh in the sale of international market, the research of improvement raising pharmacy new technique novel form also is imminent for this reason.With regard to ordinary preparations such as syrup, bigger again on dose, take very inconvenience.The patient who becomes the patient simultaneously and have diabetes avoids and takes medicine, and its range of application is restricted, and the Chinese medicine that has also exists foreign odor, and the drug volatilization effect is fast, and drug effect is not lasting, shortcomings such as quality instability.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of cold cough and chronic bronchitis.The present invention will solve existing manufacturing process and dosage form is taken inconvenience, hinders characteristic medicine and moves towards domestic market and international market, makes diabetics because medicine contains the problem that sugar can not be taken.
Technical scheme of the present invention is: a kind of medicine for the treatment of cold cough and chronic bronchitis, this medicine component by weight are: 30-70 part Bulbus Fritillariae Cirrhosae, 30-70 part Radix Platycodonis, 200-500 part Folium Eriobotryae, 0.2-0.6 part Mentholum, 0.5-5 part almond essence; This medicine process for producing granula is: above medical material, and the Bulbus Fritillariae Cirrhosae superfine powder is broken into fine powder; The Radix Platycodonis superfine powder is broken into fine powder, crosses 200 mesh sieves; Gained coarse powder and Folium Eriobotryae added 10 times of water gagings decoction secondaries after the Radix Platycodonis micronizing was sieved, and each 1 hour, gradation filtered, merging filtrate left standstill 12 hours, got the clear paste of supernatant concentration to relative density 1.20～1.25 under 60 ℃, with Radix Platycodonis fine powder mixing, drying, porphyrize, add the Bulbus Fritillariae Cirrhosae fine powder, mixing is made granule, dry, add almond essence, Mentholum, starch, mixing incapsulates.
The invention has the advantages that: cough expectorant Huang or ungratifying ejection of phlegm due to a kind of treatment wind-heat invading the lung of this medicine, stagnation of fire in the interior, laryngopharynx swelling and pain, distending pain uncomfortable in chest, cold cough and chronic bronchitis.The medicine that refines is made capsule or dosage forms such as soft capsule, microcapsule or drop pill, be convenient to the use of popularity, reduced different sense when taking medicine, this product preparation has not only brought superiority to the patient, and has also brought the advantage of market sale for pharmacy corporation.
Micronizing improves the dissolution rate of active component in the medicine, and increase the biological utilisation amount of medicine: the overwhelming majority such as Chinese crude drug and food come from animals and plants.Generally speaking, effective medicinal components mainly is present in the cell, and under the undamaged situation of cell, effective ingredient just can be utilized after having only permeate through cell membranes (wall).After Chinese medicine carries out micronizing, can realize the crude drug cell breaking cellular wall.Its intracellular effective ingredient is exposed after cell wall breaking, so drug effect is greatly improved, and onset speed is fast.Particularly the medical material of quality hard and compact enters cell interior very long process and obstacle with the active ingredient stripping owing to can exempt solvent penetration cell wall behind the micronizing breaking cellular wall, therefore has the probability that more helps shortening extraction time, reduces consumption.Powder body after the micronizing has some special physicochemical properties that general granule does not have, as fine solubility, dispersibility, adsorptivity, chemical reactivity etc.In Chinese medicine extraction, the stripping of its effective ingredient need be passed through processes such as infiltration, swelling, infiltration and diffusion.The utilization of superfine communication technique can make effective ingredient stripping resistance reduce on the one hand, and on the other hand, the material of miniaturization has very strong surface adsorption power, affinity, dispersibility and dissolubility, thereby has improved the dissolution rate and the dissolution rate of effective ingredient.Experiment showed, that the cell grade superfine communication technique can obviously improve extraction ratio in the extraction of middle pharmaceutically active ingredient, particularly more obvious for the raising of macromolecular components extraction ratio.
The cell yardstick of plant and animal is generally at 8-901 μ m.The fineness of Chinese traditional powder is generally in the fine powder level at present, and particle diameter contains a certain amount of breaking cellular wall cell at 125-150 μ m in the Chinese medicine fine powder, but reaches the level of cell grade micropowder far away.The cell grade micropowder is broken to be meant that with animal-plant kind crude drug cell breaking cellular wall be the comminution process of purpose, uses modern superfine communication technique, crude drug can be crushed to 5-101 μ m.Under this fineness condition, sporoderm-broken rate 〉=95% of general crude drug cell.Can see the medicine organizational structure during compound recipe common flour electron microscope observation, superfine powder has been difficult to see complete cell, can only see cell debris.Adopt the super fine technology that the effective ingredient in the medical material is come out preferably, and no longer need the saturating wall (film) by in the past to discharge, thereby it is rapider that medicine is played a role.Specific surface area increases greatly after the drug micronization, thereby helps the dissolving and the absorption of medicine.
In addition, the particle diameter of medicine is thin more, and then its surface area is big more, helps the stripping of effective ingredient more.Chinese medicine ultra-fine powder is because its fine size, and surface area increases, and porosity increases, and can disperse preferably, be dissolved in the gastro-intestinal Fluid, and increase with the contact area of gastrointestinal mucosa, thereby help the absorption of medicine, improves the bioavailability of medicine.
Chinese medicine is after micronizing, and the external stripping index of medicine obviously improves the size of drug particle and the structure of powder body is the key factor that influences drug dissolution.After Chinese medicine was handled through micronizing, its granularity is fine and even more, and specific surface area increases, and porosity increases, and is easy to stripping.In addition, Chinese medicine after micronizing, cell wall breaking, the stripping resistance of effective ingredient reduces in the born of the same parents, dissolution rate increases.After the broken processing of Chinese medicine ultra-fine powder, medicine stripping index obviously improves
The favourable ten retains biological activity compositions of micronizing, improve drug effect: in the micronizing process, can not produce superheating phenomenon through control, even can under low temperature state, carry out, well and pulverizing speed are fast, help keeping the bioactive ingredients and the various nutritional labeling of non-refractory, thereby improve drug effect such as Margarita, add trade union with traditional method and destroy its part composition, and under the cryogenic conditions about-67 ℃, carry out micronizing, can more intactly keep effective ingredient, strengthen its function in delaying senility.Ganoderma contains rich in amino acid and trace element, has the activate immunity function, antitumor, and effects such as antithrombotic, after the micronizing, the curative effect performance is more complete;
The micronizing conservation, be convenient to use: Chinese medicine is after micronizing, and available smaller dose obtains former prescription curative effect, general medicine can no longer pass through lixiviate, processing such as decoction after micronizing, reduce loss of active ingredients in the production link, maximally utilised raw material
The specific embodiment
A kind of medicine for the treatment of cold cough and chronic bronchitis adopts: 65g Bulbus Fritillariae Cirrhosae, 65g Radix Platycodonis, 430g Folium Eriobotryae, 0.5g Mentholum.Above medical material, the Bulbus Fritillariae Cirrhosae superfine powder is broken into fine powder; The Radix Platycodonis superfine powder is broken into fine powder, crosses 200 mesh sieves, gets 48g, and is standby; Gained coarse powder and Folium Eriobotryae added 10 times of water gagings decoction secondaries after the Radix Platycodonis micronizing was sieved, and each 1 hour, gradation filtered, merging filtrate left standstill 12 hours, got the clear paste of supernatant concentration to relative density 1.20～1.25 (60 ℃), with Radix Platycodonis fine powder mixing, drying, porphyrize, add the Bulbus Fritillariae Cirrhosae fine powder, mixing is made granule, drying adds almond essence, Mentholum, starch, mixing, incapsulate, make 1000, promptly.
Claims (2)
1. medicine for the treatment of cold cough and chronic bronchitis, it is characterized in that: this medicine component by weight is:
Bulbus Fritillariae Cirrhosae 30-70 Radix Platycodonis 30-70 Folium Eriobotryae 200-500
Mentholum 0.2-0.6 almond essence 0.5-5
This medicine process for producing granula is: above medical material, and the Bulbus Fritillariae Cirrhosae superfine powder is broken into fine powder; The Radix Platycodonis superfine powder is broken into fine powder, crosses 200 mesh sieves; Gained coarse powder and Folium Eriobotryae added 10 times of water gagings decoction secondaries after the Radix Platycodonis micronizing was sieved, and each 1 hour, gradation filtered, merging filtrate left standstill 12 hours, got the clear paste of supernatant concentration to relative density 1.20～1.25 under 60 ℃, with Radix Platycodonis fine powder mixing, drying, porphyrize, add the Bulbus Fritillariae Cirrhosae fine powder, mixing is made granule, dry, add almond essence, Mentholum, starch, mixing incapsulates.
2. according to the described a kind of medicine for the treatment of cold cough and chronic bronchitis of claim 1, it is characterized in that: this medicine component by weight is:
Bulbus Fritillariae Cirrhosae 65 Radix Platycodoniss 65 Folium Eriobotryaes 430 Mentholums 0.5 almond essence 0.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010105176A CN101732555A (en) | 2010-02-03 | 2010-02-03 | Medicament for treating cold cough and chronic bronchitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010105176A CN101732555A (en) | 2010-02-03 | 2010-02-03 | Medicament for treating cold cough and chronic bronchitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101732555A true CN101732555A (en) | 2010-06-16 |
Family
ID=42456923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010105176A Pending CN101732555A (en) | 2010-02-03 | 2010-02-03 | Medicament for treating cold cough and chronic bronchitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101732555A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991773A (en) * | 2010-11-10 | 2011-03-30 | 胡枝清 | Loquat extract extracted from loquat pulp and preparation method thereof |
| CN102813800A (en) * | 2011-06-08 | 2012-12-12 | 刘青梅 | Fritillaria lozenge and preparation method thereof |
| CN105362855A (en) * | 2015-02-04 | 2016-03-02 | 徐应乐 | Plaster for treating wind heat cough of children |
| CN105878700A (en) * | 2016-04-29 | 2016-08-24 | 江西南昌济生制药厂 | Bulbus Fritillariae Cirrhosae and loquat capsules and preparation method and application thereof |
-
2010
- 2010-02-03 CN CN201010105176A patent/CN101732555A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991773A (en) * | 2010-11-10 | 2011-03-30 | 胡枝清 | Loquat extract extracted from loquat pulp and preparation method thereof |
| CN101991773B (en) * | 2010-11-10 | 2013-01-02 | 胡枝清 | Loquat extract extracted from loquat pulp and preparation method thereof |
| CN102813800A (en) * | 2011-06-08 | 2012-12-12 | 刘青梅 | Fritillaria lozenge and preparation method thereof |
| CN105362855A (en) * | 2015-02-04 | 2016-03-02 | 徐应乐 | Plaster for treating wind heat cough of children |
| CN105878700A (en) * | 2016-04-29 | 2016-08-24 | 江西南昌济生制药厂 | Bulbus Fritillariae Cirrhosae and loquat capsules and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103655639A (en) | Spirulina tablet, and preparation method thereof | |
| CN100546571C (en) | Sangju effervescent tablet for treating common cold | |
| CN100556401C (en) | Effervescence tablet for cold | |
| CN101007071A (en) | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology | |
| CN102772440A (en) | Processing method of ultra-micro wall-breaking oral-tablet decoction pieces by traditional Chinese medicines | |
| CN101732555A (en) | Medicament for treating cold cough and chronic bronchitis | |
| TWI549700B (en) | Panax notoginseng broken wall preparation | |
| CN101757057B (en) | Whiteflower leadword root chewable tablet | |
| CN103610659A (en) | Allicin medicinal composition and preparation method thereof | |
| CN104224858B (en) | Cordyceps militaris microcapsules, preparation and preparation method thereof | |
| CN100542520C (en) | Lonicera and Forsythia effervescent | |
| CN102727556A (en) | Throat-clearing traditional Chinese medicine buccal tablet and preparation method thereof | |
| CN100496515C (en) | Ring form effervescence dosage and preparation method thereof | |
| CN102462740B (en) | Pharmaceutical composition for relieving alcoholism and protecting liver and preparation method thereof | |
| CN113398185B (en) | Moistureproof five-flavor disinfection beverage granules and preparation method thereof | |
| CN101590108B (en) | Method for changing viscosity of Magnolia extract | |
| CN100546570C (en) | Effervescence tablet for treating wind-cold type cold | |
| CN101455773B (en) | China root greenbrier dispersible tablet and preparation method thereof | |
| CN100551360C (en) | Isatis root effervescence tablet and preparation method thereof | |
| CN101269123A (en) | Secondary development novel technique for thirst eliminating capsule for lowering blood sugar | |
| KR100735904B1 (en) | Tablet composition containing extract of natural herbal plants and its manufacturing process | |
| CN101190251A (en) | Rhodiola rosea chewable tablets and preparation method and application thereof | |
| CN101152424A (en) | Pharmaceutical composition of snake bile and tendril-leaved fritillary bulb, and preparations of the same | |
| CN103099825A (en) | Novel cordyceps sinensis capsule and preparation method thereof | |
| CN100542522C (en) | Antivirus effervescence tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20100616 |