CN102813800A - Fritillaria lozenge and preparation method thereof - Google Patents
Fritillaria lozenge and preparation method thereof Download PDFInfo
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- CN102813800A CN102813800A CN2011101543232A CN201110154323A CN102813800A CN 102813800 A CN102813800 A CN 102813800A CN 2011101543232 A CN2011101543232 A CN 2011101543232A CN 201110154323 A CN201110154323 A CN 201110154323A CN 102813800 A CN102813800 A CN 102813800A
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- bulbus fritillariae
- fritillariae uninbracteatae
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- fritillaria
- powder
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Abstract
The invention relates to fritillaria lozenge and a preparation method thereof. The fritillaria lozenge comprises, by weight, 20-40 parts of fritillaria powder, 40-60 parts of sweetener, 5-10 parts of binder, 5-10 parts of effervescing agent and 0.5-1.5 parts of wetting agent. The preparation method includes: superfine grinding the fritillaria into powder, sequentially and evenly mixing with xylitol, wetting agent, lubricant binder and effervescing agent, preparing the mixed powder into particles, adding the particles into a master mixing machine to tablet the particles. By the superfine grinding, absorption and utilization rate of effective components in the fritillaria are improved. In addition, the fritillaria lozenge is novel in prescription, reasonable in combination, simple in process, fine in taste, easy to absorb, convenient to carry and store, quite worthy to be developed, applied and popularized, and widely applicable to modern Chinese traditional medicine and food enterprises.
Description
Technical field
The present invention relates to the Chinese medicine health care product field, be specifically related to a kind of Bulbus Fritillariae Uninbracteatae buccal tablet and preparation method thereof.
Background technology
Bulbus Fritillariae Uninbracteatae is a herbaceos perennial, is one of important Chinese crude drug of China, its bulb hyoscine; The merit that relieving cough and resolving phlegm, heat clearing away eliminating stagnation are arranged is pressed the different of the place of production and kind, and Bulbus Fritillariae Uninbracteatae has the branch of Bulbus Fritillariae Cirrhosae and Bulbus Fritillariae Thunbergii; Especially the Bulbus Fritillariae Thunbergii price is low; Cultivated area is big, and a large amount of Japan, Korea S, Southeast Asia, Hong Kong and Taiwan and the American-European Chinese of part compact communities of exporting occupy an important position in China's agricultural production gross output value and foreign exchange earning.
Bulbus Fritillariae Uninbracteatae contains bioactive substance, and particularly the Bulbus Fritillariae Uninbracteatae alkaloid has " effects such as clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, eliminating stagnation ", and clinical phlegm-heat cough, the vexed expectorant of face of being used for is controlled scrofula and sore swollen toxin.Be used for the treatment of thyroid tumor etc. in recent years again.SARS is between the emergence period, because it has original curative effect to pneumonopathy, Bulbus Fritillariae Uninbracteatae was once becoming easy-to-sell goods.
Bulbus Fritillariae Uninbracteatae is as medicated diet; It generally is the use of pulverizing; Like the patent No. is the Chinese patent " a kind of production technology of Bulbus Fritillariae Cirrhosae powder " of CN201010259485.8, is the qualified Bulbus Fritillariae Cirrhosae raw material that buying is come, remove impurity; Clean then, dry, sterilize, be ground into satisfactory microgranule, packing, cartonning at last.It is also bad that but this Bulbus Fritillariae Uninbracteatae powder is prone to the moisture absorption and takes inconvenience, mouthfeel.
Micronizing: be meant that utilizing machinery or hydrokinetic method to overcome the solid interior cohesiveness makes it broken, thereby the material particles more than 3 millimeters is crushed to the operating technology of 10-25 micron.Be after the seventies in 20th century, for a kind of material that the development that adapts to modern high technology produces is processed new and high technology.Ultramicro powder is the final products of micronizing, has the unexistent special physicochemical property of general granule, like fine solubility, dispersibility, adsorptivity, chemical reactivity etc.Ultramicro powder has been widely used in many fields such as food, chemical industry, medicine, cosmetics pesticide.
Effervescent tablet is a kind of novel tablet of external in recent years Application and Development.The difference of it and conventional tablet just is that it also contains effervescent, when effervescent tablet is put into drinking-water or is sucked, and under the effect of effervescent, the carbon dioxide that produces during disintegration of tablet, making to suck or wash by water has when drinking
Soda popAs aesthetic feeling.The present invention intends the Bulbus Fritillariae Uninbracteatae series products of a kind of novelty on the basis of effervescent tablet, develop, to the added value that promotes the Bulbus Fritillariae Uninbracteatae series products, the deep development of Bulbus Fritillariae Uninbracteatae and the extraction of active substance are had sizable meaning.
Summary of the invention
Technical problem to be solved by this invention be provide to the above-mentioned state of the art a kind of mouthfeel good, be prone to absorb, Bulbus Fritillariae Uninbracteatae buccal tablet easy to carry.
Second technical problem to be solved by this invention be a kind of mouthfeel good, be prone to absorb, the method for preparing of Bulbus Fritillariae Uninbracteatae buccal tablet easy to carry, have the advantages that the preparation process is simple, effective force composition utilization rate is high.
The present invention solves the technical scheme that above-mentioned first technical problem adopts: a kind of Bulbus Fritillariae Uninbracteatae buccal tablet is characterized in that said Bulbus Fritillariae Uninbracteatae buccal tablet comprises each component of the following stated mass ratio:
Ultra micro Bulbus Fritillariae Uninbracteatae powder body 20～40, sweeting agent 40～60, bonding agent 5～10, effervescent 5～10, lubricant 0.5～1.5, parts by weight.
Said effervescent is sodium bicarbonate and organic acid (as: citric acid, tartaric acid, citric acid or fumaric acid etc.), and said sweeting agent adopts sorbitol, and sorbitol has the algefacient mouthfeel, wets one's whistle, and said binding agent adopts gelatinized starch to stick with paste.Said wetting agent adopts 65～75% ethanol; Said lubricant adopts magnesium stearate.
The present invention solves above-mentioned second technical scheme that technical problem adopted: a kind of method for preparing of Bulbus Fritillariae Uninbracteatae buccal tablet is characterized in that may further comprise the steps:
1) micronizing: use super micron mill Bulbus Fritillariae Uninbracteatae is ground into powder, fineness of powder is more than 400 orders;
2) allotment: with 20～40 parts of ultra micro Bulbus Fritillariae Uninbracteatae powder body, 40～60 parts of sweeting agents, 0.5～1.5 part of lubricant, mix homogeneously;
3) make soft material: the adding wetting agent behind mix homogeneously, the adjustment humidity of materials, and with 5～10 parts of allotments of bonding agent, the granulation of sieving, granular size reaches 16～18 orders;
4) drying: above-mentioned soft material is put into baking oven, oven dry, the control moisture is 2.5～3.5%;
5) sneak into 5～10 parts of effervescents at last, granulate, tabletting are finished product;
Adopt mass fraction.
Before said micronizing, Bulbus Fritillariae Uninbracteatae is pulverized and concocts, pulverize (1): with pulverizer the Bulbus Fritillariae Uninbracteatae bulb is ground into powder;
(2) Bulbus Fritillariae Uninbracteatae is concocted: content of starch accounts for 80% of whole bulb in the Bulbus Fritillariae Uninbracteatae, pass through high-temperature maturing, otherwise can influence effective ingredient utilization and the drug effect of Bulbus Fritillariae Uninbracteatae.The Bulbus Fritillariae Uninbracteatae concocting method be Bulbus Fritillariae Uninbracteatae at 1～2 hour postcooling of 90～100 ℃ of dryings, reach the requirement that Bulbus Fritillariae Uninbracteatae is passed through the no white heart of degree, no hard-core;
As preferably, said effervescent is sodium bicarbonate and organic acid; Said sweeting agent adopts sorbitol; Said binding agent adopts gelatinized starch to stick with paste; Said lubricant adopts magnesium stearate; (v) % ethanol that said wetting agent adopts 65～75.
Compared with prior art; The invention has the advantages that: Bulbus Fritillariae Uninbracteatae is processed into powder through micronizing processes buccal tablet again; Improved the absorption rate of effective ingredient in the Bulbus Fritillariae Uninbracteatae, and be difficult for the moisture absorption, in the process of buccal; Can directly be absorbed the loss that has been produced when having avoided effective ingredient to absorb by the oral mucosa through organs such as human intestines and stomach and livers; Simultaneously in the component of buccal tablet, added the sorbitol sweeting agent, sorbitol has low, the anticariogenic characteristics of heat, can not make the diabetes blood sugar increasing, has mouthfeel refrigerant, that wet one's whistle simultaneously; Simultaneously in the component of buccal tablet, add effervescent, made mouthfeel good.The present invention is a kind of novel tablet of on the effervescent tablet basis, developing, and prescription is novel, and compatibility is reasonable, and the aesthetic feeling as rolling is arranged in the time of in the inlet; And preparation technology is simple, the active ingredient absorption rate is high, and the product mouthfeel is good, easy to be absorbed and the storing that is easy to carry, and has the Application and Development promotional value, can be adaptable across modern Chinese medicine and food enterprise.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
A kind of method for preparing of Bulbus Fritillariae Uninbracteatae buccal tablet, technological process is: the Bulbus Fritillariae Uninbracteatae → pulverizing → process of preparing Chinese medicine → micronizing → ultra micro Bulbus Fritillariae Uninbracteatae powder body → allotment → granulation → drying → tabletting → Bulbus Fritillariae Uninbracteatae buccal tablet → packing.Specifically may further comprise the steps:
(1) pulverizes: the Bulbus Fritillariae Uninbracteatae bulb is ground into powder with pulverizer;
(2) Bulbus Fritillariae Uninbracteatae is concocted: content of starch accounts for 80% of whole bulb in the Bulbus Fritillariae Uninbracteatae, pass through high-temperature maturing, otherwise can influence effective ingredient utilization and the drug effect of Bulbus Fritillariae Uninbracteatae.The Bulbus Fritillariae Uninbracteatae concocting method be Bulbus Fritillariae Uninbracteatae at 1～2 hour postcooling of 90～100 ℃ of dryings, reach the requirement that Bulbus Fritillariae Uninbracteatae is passed through the no white heart of degree, no hard-core;
(3) micronizing: use super micron mill Bulbus Fritillariae Uninbracteatae is ground into powder, fineness of powder is more than 400 orders; Like 500 orders, 600 orders etc.;
(4) allotment: by weight umber with 20～40 parts of ultra micro Bulbus Fritillariae Uninbracteatae powder body, 40～60 parts of sweeting agents, 0.5～1.5 part of magnesium stearate lubricant, mix homogeneously;
(5) make soft material: the adding 65～75 behind mix homogeneously (v) % ethanol is adjusted humidity of materials, and sticks with paste allotment with 5～10 parts of gelatinized starches of bonding agent, the granulation of sieving, and granular size reaches the 16-18 order;
(6) drying: above-mentioned soft material is put into baking oven, oven dry, the control moisture is at 2.5～3.5 (wt) %;
(7) sneak into 5～10 parts of effervescents (sodium bicarbonate and organic acid) at last, granulate, tabletting are finished product, adopt mass fraction.
Embodiment 1
Bulbus Fritillariae Uninbracteatae micronizing fineness is reached 400 orders, prepare burden and mix homogeneously, add 7.5 parts of an amount of wetting agent and bonding agents, sieve, granulate granular size 16-18 order according to the mass ratio of 40 parts of ultra micro Bulbus Fritillariae Uninbracteatae powder body, 60 parts of xylitol, 1.5 parts of magnesium stearate; The grain that will wet is put into baking oven, and oven dry makes moisture 3%, and the grain that drying is good sieves again, make material become size evenly, do not have glutinous connecting block, be easy to the granule of tabletting, sneak into 7.5 parts of effervescents; With the material behind the granulate, be the Bulbus Fritillariae Uninbracteatae buccal tablet at last, adopt mass fraction with the tablet machine tablet forming.
Embodiment 2
Bulbus Fritillariae Uninbracteatae micronizing fineness is reached 500 orders, prepare burden and mix homogeneously, add 6 parts of an amount of wetting agent and bonding agents, sieve, granulate granular size 16-18 order according to the mass ratio of 30 parts of ultra micro Bulbus Fritillariae Uninbracteatae powder body, 50 parts of xylitol, 1 part of magnesium stearate; The grain that will wet is put into baking oven, and oven dry makes moisture 3%, and the grain that drying is good sieves again, make material become size evenly, do not have glutinous connecting block, be easy to the granule of tabletting, sneak into 7 parts of effervescents; With the material behind the granulate, be the Bulbus Fritillariae Uninbracteatae buccal tablet at last, adopt mass fraction with the tablet machine tablet forming.
Embodiment 3
Bulbus Fritillariae Uninbracteatae micronizing fineness is reached 600 orders, prepare burden and mix homogeneously, add 5 parts of an amount of wetting agent and bonding agents, sieve, granulate granular size 16-18 order according to the mass ratio of 20 parts of ultra micro Bulbus Fritillariae Uninbracteatae powder body, 40 parts of xylitol, 0.5 part of magnesium stearate; The grain that will wet is put into baking oven, and oven dry makes moisture 3%, and the grain that drying is good sieves again, make material become size evenly, do not have glutinous connecting block, be easy to the granule of tabletting, sneak into 10 parts of effervescents; With the material behind the granulate, be the Bulbus Fritillariae Uninbracteatae buccal tablet at last, adopt mass fraction with the tablet machine tablet forming.
The Bulbus Fritillariae Uninbracteatae buccal tablet that makes is carried out quality testing, and product quality meets following index:
(1) organoleptic indicator
Color and luster: be creamy white;
Outward appearance: the tablet profile is neat, smooth surface
Mouthfeel: sweet and sour taste has the Bulbus Fritillariae Uninbracteatae local flavor.
(2) physical and chemical index: moisture≤5.0%;
(3) microbiological indicator
Total plate count (cfu/g)≤5000, coliform (MPN/100g)≤30; Pathogenic bacterium must not detect.
(4) shelf life of products
Under the room temperature, 12 months shelf-lifves.
The result shows:
1. Bulbus Fritillariae Uninbracteatae buccal tablet of the present invention adopts superfine communication technique, has improved the absorption rate of Bulbus Fritillariae Uninbracteatae effective ingredient greatly;
2. prescription is novel, and compatibility is reasonable, and the aesthetic feeling as rolling is arranged when making in the inlet;
3. add xylitol and have low, the anticariogenic characteristics of heat, can not make the diabetes blood sugar increasing, have mouthfeel refrigerant, that wet one's whistle simultaneously.
4. product is a tablet, has overcome the problem of the easy moisture absorption caking of powder body, and storing is easy to carry.
Claims (6)
1. Bulbus Fritillariae Uninbracteatae buccal tablet is characterized in that said Bulbus Fritillariae Uninbracteatae buccal tablet comprises each component of the following stated mass ratio:
Ultra micro Bulbus Fritillariae Uninbracteatae powder body 20～40, sweeting agent 40～60, bonding agent 5～10, effervescent 5～10, lubricant 0.5～1.5, mass fraction.
2. Bulbus Fritillariae Uninbracteatae buccal tablet according to claim 1 is characterized in that said effervescent is sodium bicarbonate and organic acid; Said sweeting agent adopts sorbitol; Said binding agent adopts gelatinized starch to stick with paste; Said lubricant adopts magnesium stearate.
3. the method for preparing of a Bulbus Fritillariae Uninbracteatae buccal tablet is characterized in that may further comprise the steps:
1) micronizing: use super micron mill the Bulbus Fritillariae Uninbracteatae pulverizing is obtained ultra micro Bulbus Fritillariae Uninbracteatae powder body, powder fineness is more than 400 orders;
2) allotment: with 20～40 parts of ultra micro Bulbus Fritillariae Uninbracteatae powder body, 40～60 parts of sweeting agents, 0.5～1.5 part of lubricant, mixing;
3) make soft material: the adding wetting agent behind mix homogeneously, the adjustment humidity of materials, and through the allotment of 5～10 parts of gelatinized starches pastes of bonding agent, the granulation of sieving, granular size reaches 16～18 orders;
4) drying: above-mentioned soft material is put into baking oven, oven dry, the control moisture is at 2.5～3.5 (wt) %;
5) sneak into 5～10 parts of effervescents at last, granulate, tabletting are finished product;
Adopt mass fraction.
4. method for preparing according to claim 3 is characterized in that said wetting agent (the v) % ethanol that adopts 65～75.
5. method for preparing according to claim 3 is characterized in that said effervescent is sodium bicarbonate and organic acid; Described sweeting agent adopts sorbitol; Said binding agent adopts gelatinized starch to stick with paste; Said lubricant adopts magnesium stearate.
6. method for preparing according to claim 3; It is characterized in that before the said micronizing Bulbus Fritillariae Uninbracteatae being pulverized and concocting; Pulverize and with pulverizer the Bulbus Fritillariae Uninbracteatae bulb is ground into powder exactly; The process of preparing Chinese medicine be with Bulbus Fritillariae Uninbracteatae at 1～2 hour postcooling of 90～100 ℃ of dryings, reach the requirement that Bulbus Fritillariae Uninbracteatae is passed through the no white heart of degree, no hard-core.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101543232A CN102813800A (en) | 2011-06-08 | 2011-06-08 | Fritillaria lozenge and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101543232A CN102813800A (en) | 2011-06-08 | 2011-06-08 | Fritillaria lozenge and preparation method thereof |
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| CN102813800A true CN102813800A (en) | 2012-12-12 |
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| CN2011101543232A Pending CN102813800A (en) | 2011-06-08 | 2011-06-08 | Fritillaria lozenge and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432308A (en) * | 2013-08-17 | 2013-12-11 | 广州市云桥生物科技有限公司 | Composition consisting of effective traditional Chinese medicine parts and used for treating benign thyroid tumor |
| CN107836623A (en) * | 2017-10-10 | 2018-03-27 | 西华大学 | Konjac glucomannan effervescent tablet based on biological desulphurization and superfine grinding and preparation method thereof |
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| CN1682697A (en) * | 2005-02-08 | 2005-10-19 | 江中药业股份有限公司 | Effervescent lozenge and its preparing process |
| CN1824141A (en) * | 2005-12-23 | 2006-08-30 | 贵州渝生制药有限公司 | Preparation method of cough suppressing phlegm transforming medicine |
| CN1973884A (en) * | 2006-12-07 | 2007-06-06 | 李永胜 | Bobei throat-fitting buccal tablet |
| CN101322798A (en) * | 2008-07-31 | 2008-12-17 | 佛山冯了性药业有限公司 | Snake bile and Sichuan fritillaria bulb lozenge and preparation thereof |
| CN101732555A (en) * | 2010-02-03 | 2010-06-16 | 江西南昌济生制药厂 | Medicament for treating cold cough and chronic bronchitis |
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2011
- 2011-06-08 CN CN2011101543232A patent/CN102813800A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682697A (en) * | 2005-02-08 | 2005-10-19 | 江中药业股份有限公司 | Effervescent lozenge and its preparing process |
| CN1824141A (en) * | 2005-12-23 | 2006-08-30 | 贵州渝生制药有限公司 | Preparation method of cough suppressing phlegm transforming medicine |
| CN1973884A (en) * | 2006-12-07 | 2007-06-06 | 李永胜 | Bobei throat-fitting buccal tablet |
| CN101322798A (en) * | 2008-07-31 | 2008-12-17 | 佛山冯了性药业有限公司 | Snake bile and Sichuan fritillaria bulb lozenge and preparation thereof |
| CN101732555A (en) * | 2010-02-03 | 2010-06-16 | 江西南昌济生制药厂 | Medicament for treating cold cough and chronic bronchitis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432308A (en) * | 2013-08-17 | 2013-12-11 | 广州市云桥生物科技有限公司 | Composition consisting of effective traditional Chinese medicine parts and used for treating benign thyroid tumor |
| CN107836623A (en) * | 2017-10-10 | 2018-03-27 | 西华大学 | Konjac glucomannan effervescent tablet based on biological desulphurization and superfine grinding and preparation method thereof |
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Application publication date: 20121212 |