CN107551038A - A kind of medical mouthwash and preparation method thereof - Google Patents
A kind of medical mouthwash and preparation method thereof Download PDFInfo
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- CN107551038A CN107551038A CN201710940055.4A CN201710940055A CN107551038A CN 107551038 A CN107551038 A CN 107551038A CN 201710940055 A CN201710940055 A CN 201710940055A CN 107551038 A CN107551038 A CN 107551038A
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Abstract
A kind of medical mouthwash and preparation method thereof, its raw material include following components：Chinese medicine extract, sodium fluoride, glycerine, xylitol, Tea Polyphenols, sorbic acid, deionized water, flavor enhancement and styptic；First, the mouthfeel of medical mouthwash can be improved by flavor enhancement being added in invention raw material, and oral cavity can be made to keep refrigerant sense, pain of alleviation；Cyclodextrin in flavor enhancement can embed bitter taste in Chinese medicine extract；Casoid flour in flavor enhancement can react to form complex compound with polyphenol compositions in Chinese medicine extract, so as to reduce the contact area of sialoprotein in polyphenol compositions and oral cavity, can remove bitterness sense；Secondly, raw material of the present invention adds styptic energy antibiotic and sterilizing, can quick-acting haemostatic powder；Meanwhile the lidocaine in styptic, local anaesthesia can be played a part of, drug effect is fast, does not also have excitant to Stomatocyte and tissue, so as to the pain of reduction of patient.
Description
Technical field
The present invention relates to a kind of medical mouthwash and preparation method thereof, belongs to Iatrochemistry product technical field.
Background technology
With the development of economic society and the raising of living standards of the people, the diet structure of people is also changing, with
Corresponding all kinds of mouth diseases it is also more and more common.At present, the incidence of disease of stomatopathy is high, and the species of mouth disease also has very
It is more, such as the canker sore patient of canker sore, pharyngitis, laryngitis, tonsillitis and gingivitis etc., especially recurrent, have
The characteristics of cyclical recurrent, the work and life of people are had a strong impact on, the preventing and treating of oral disease and the protection of tooth seem outstanding
To be important.Therefore, increasing people uses mouthwash now, but traditional mouthwash still has many problems, first, mouth
Feel very poor, there is bitter taste, there is very strong excitant to oral mucosa；Secondly, it is impossible to stop blooding, it is impossible to alleviate reduction of patient
Pain.
The content of the invention
In view of the shortcomings of the prior art, the invention provides a kind of medical mouthwash and preparation method thereof.
In order to achieve the above objects and other related objects, technical scheme provided by the invention is：A kind of medical mouthwash, institute
Stating the composition of raw materials of medical mouthwash includes the raw material of following parts by weight：Chinese medicine extract 6-9 parts, sodium fluoride 2-4 parts, glycerine 3-
6 parts, xylitol 4-7 parts, Tea Polyphenols 2-5 parts, sorbic acid 0.5-0.9 parts, deionized water 55-60 parts, flavor enhancement 1.2-1.5 parts and
Styptic 0.02-0.03 parts.
Preferably technical scheme is：The preparation method of the Chinese medicine extract：By honeysuckle, cordate houttuynia, maidenhair and five
Gall nut co-grinding adds the water that quality is 3 ~ 5 times of powder gross mass into powder, 30 ~ 50min of boiling at 85-100 DEG C,
The filtrate being filtrated to get is Chinese medicine extract.
Preferably technical scheme is：The flavor enhancement by menthol, cyclodextrin and casoid flour according to mass ratio 2.5 ~
3.5:0.8~1.2:1 mixes.
Preferably technical scheme is：The styptic is by alum and lidocaine according to mass ratio 1.5 ~ 2.5:1 mixing and
Into.
Preferably technical scheme is：Honeysuckle, cordate houttuynia, maidenhair and gallic mass ratio are 5 ~ 10：1：1：1.
In order to achieve the above objects and other related objects, technical scheme provided by the invention is：A kind of medical mouthwash
Preparation method, comprise the following steps：
The first step：Deionized water is poured into the container sterilized, be heated to 85 ~ 95 DEG C, then glycerine is sequentially added into container
And xylitol, stir to xylitol and dissolve, obtain the blending ingredients A of no particulate matter；
Second step：Blending ingredients A is cooled to 45 ~ 55 DEG C, sodium fluoride, sorbic acid, flavor enhancement are sequentially added into the container
And styptic, after stirring, obtain the blending ingredients B of no particulate matter；
3rd step：Blending ingredients B is cooled to 22 ~ 28 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols are added into container, after stirring
Produce medical mouthwash.
Preferably technical scheme is：The pH value of the medical mouthwash is 6.7-7.1.
Because above-mentioned technical proposal is used, the present invention this have the advantage that compared with prior art：
1st, the mouthfeel of medical mouthwash can be improved by flavor enhancement being added in raw material of the present invention, and oral cavity can be made to keep refrigerant sense, alleviate pain
Bitterly；Cyclodextrin in flavor enhancement can embed bitter taste in Chinese medicine extract；Casoid flour energy and Chinese medicine extract in flavor enhancement
Middle polyphenol compositions react to form complex compound, so as to reduce the contact surface of sialoprotein in polyphenol compositions and oral cavity
Product, can remove bitterness sense, casein can also improve the stability of medical mouthwash in addition.
2nd, raw material of the present invention adds styptic energy antibiotic and sterilizing, can quick-acting haemostatic powder；Meanwhile the lidocaine in styptic,
Local anaesthesia can be played a part of, drug effect is fast, does not also have excitant to Stomatocyte and tissue, so as to the pain of reduction of patient
Sense.
Embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this implementation
Content disclosed by example understands other advantages and effect of the present invention easily.
Embodiment 1：A kind of medical mouthwash and preparation method thereof
A kind of medical mouthwash, its composition of raw materials is by weight：6 parts of Chinese medicine extract, 2 parts of sodium fluoride, 4 parts of glycerine, xylose
0.02 part of 4 parts of alcohol, 2 parts of Tea Polyphenols, 0.5 part of sorbic acid, 55 parts of deionized water, 1.3 parts of flavor enhancement and styptic.
A kind of medical mouthwash, its preparation method comprise the following steps：
A, deionized water is poured into the container sterilized, is heated to 90 DEG C, then glycerine and xylitol are sequentially added into container,
Stirring is abundant to dissolving, and obtains without granular blending ingredients A；
B, blending ingredients A is cooled to 50 DEG C, sodium fluoride, sorbic acid, flavor enhancement and styptic is sequentially added into container, stirred
It is abundant to dissolving, obtain without granular blending ingredients B；
C, blending ingredients B is cooled to 25 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols is added into container, stirring is abundant to dissolving, i.e.,
Medical mouthwash can be made；
D, pH value and appearance test, pH value 7, qualified Hou Zhuan bottle encapsulation process are carried out.
Preferred embodiment is：The preparation method of the Chinese medicine extract：By honeysuckle, cordate houttuynia, maidenhair and five
Gall nut co-grinding adds the water that quality is 4 times of powder gross mass, boiling 45min, is filtrated to get at 90 DEG C into powder
Filtrate is Chinese medicine extract.By weight, honeysuckle, cordate houttuynia, maidenhair and gallic mass ratio are 6：1：1：1.
Preferred embodiment is：The flavor enhancement is by menthol, cyclodextrin and casoid flour according to mass ratio 3:1:1 is mixed
Conjunction forms.
Preferred embodiment is：The styptic is by alum and lidocaine according to mass ratio 2:1 mixes.
1st, 20 canker sore patients are asked take the medical mouthwash of the preparation of embodiment 1, once a day, one time 20 milli
Rise, adhere to taking 15 days, paid a return visit after 15 days, it is found that 18 human mouths do not have phenomenon of bleeding, ulcer symptoms have mitigated.
2nd, ask 20 patients for having oral problem take the medical mouthwash of the preparation of embodiment 1, it is found that 16 people feel
Mouthwash does not have bitterness sense.
First, the mouthfeel of medical mouthwash can be improved by flavor enhancement being added in the raw material of the present embodiment, and oral cavity can be made to keep clear
Cool feeling, pain of alleviation；Cyclodextrin in flavor enhancement can embed bitter taste in Chinese medicine extract；Casoid flour in flavor enhancement can be with
Polyphenol compositions react to form complex compound in Chinese medicine extract, so as to reduce sialoprotein in polyphenol compositions and oral cavity
Contact area, bitterness sense can be removed, casein can also improve the stability of medical mouthwash in addition.Secondly, the present embodiment
Raw material adds styptic energy antibiotic and sterilizing, can quick-acting haemostatic powder；Meanwhile the lidocaine in styptic, local anaesthesia can be played
Effect, drug effect is fast, does not also have excitant to Stomatocyte and tissue, so as to the pain of reduction of patient.
Embodiment 2：A kind of medical mouthwash and preparation method thereof
A kind of medical mouthwash, its composition of raw materials is by weight：7 parts of Chinese medicine extract, 2.5 parts of sodium fluoride, 3 parts of glycerine, wood
0.023 part of 5 parts of sugar alcohol, 3 parts of Tea Polyphenols, 0.6 part of sorbic acid, 57 parts of deionized water, 1.2 parts of flavor enhancement and styptic.
A kind of medical mouthwash, its preparation method comprise the following steps:
A, deionized water is poured into the container sterilized, is heated to 90 DEG C, then glycerine and xylitol are sequentially added into container,
Stirring is abundant to dissolving, and obtains without granular blending ingredients A；
B, blending ingredients A is cooled to 50 DEG C, sodium fluoride, sorbic acid, flavor enhancement and styptic is sequentially added into container, stirred
It is abundant to dissolving, obtain without granular blending ingredients B；
C, blending ingredients B is cooled to 25 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols is added into container, stirring is abundant to dissolving, i.e.,
Medical mouthwash can be made；
D, pH value and appearance test, qualified Hou Zhuan bottle encapsulation process are carried out.
1st, 20 canker sore patients are asked take the medical mouthwash of the preparation of embodiment 2, once a day, one time 20 milli
Rise, adhere to taking 15 days, paid a return visit after 15 days, it is found that 19 human mouths do not have phenomenon of bleeding, ulcer symptoms have mitigated.
2nd, ask 20 patients for having oral problem take the medical mouthwash of the preparation of embodiment 2, it is found that 17 people feel
Mouthwash does not have bitterness sense.
Embodiment 3：A kind of medical mouthwash and preparation method thereof
A kind of medical mouthwash, its raw material is by weight：8 parts of Chinese medicine extract, 3.5 parts of sodium fluoride, 6 parts of glycerine, xylitol 6
Part, 5 parts of Tea Polyphenols, 0.8 part of sorbic acid, 58 parts of deionized water, 1.4 parts of flavor enhancement and 0.027 part of styptic.
A kind of medical mouthwash, its preparation method comprise the following steps:
A, deionized water is poured into the container sterilized, is heated to 90 DEG C, then glycerine and xylitol are sequentially added into container,
Stirring is abundant to dissolving, and obtains without granular blending ingredients A；
B, blending ingredients A is cooled to 50 DEG C, sodium fluoride, sorbic acid, flavor enhancement and styptic is sequentially added into container, stirred
It is abundant to dissolving, obtain without granular blending ingredients B；
C, blending ingredients B is cooled to 25 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols is added into container, stirring is abundant to dissolving, i.e.,
Medical mouthwash can be made；
D, pH value and appearance test, qualified Hou Zhuan bottle encapsulation process are carried out.
1st, 20 canker sore patients are asked take the medical mouthwash of the preparation of embodiment 3, once a day, one time 20 milli
Rise, adhere to taking 15 days, paid a return visit after 15 days, it is found that 18 human mouths do not have phenomenon of bleeding, ulcer symptoms have mitigated.
2nd, ask 20 patients for having oral problem take the medical mouthwash of the preparation of embodiment 3, it is found that 16 people feel
Mouthwash does not have bitterness sense.
1st, 20 canker sore patients are asked take the medical mouthwash of the preparation of embodiment 3, once a day, one time 20 milli
Rise, adhere to taking 15 days, paid a return visit after 15 days, it is found that 18 human mouths do not have phenomenon of bleeding, ulcer symptoms have mitigated.
2nd, ask 20 patients for having oral problem take the medical mouthwash of the preparation of embodiment 3, it is found that 19 people feel
Mouthwash does not have bitterness sense.
Embodiment 4：A kind of medical mouthwash and preparation method thereof
A kind of medical mouthwash, its raw material is by weight：9 parts of Chinese medicine extract, 4 parts of sodium fluoride, 5 parts of glycerine, xylitol 7
Part, 4 parts of Tea Polyphenols, 0.9 part of sorbic acid, 60 parts of deionized water, 1.5 parts of flavor enhancement and 0.03 part of styptic.
A kind of medical mouthwash, its preparation method comprise the following steps:
A, deionized water is poured into the container sterilized, is heated to 90 DEG C, then glycerine and xylitol are sequentially added into container,
Stirring is abundant to dissolving, and obtains without granular blending ingredients A；
B, blending ingredients A is cooled to 50 DEG C, sodium fluoride, sorbic acid, flavor enhancement and styptic is sequentially added into container, stirred
It is abundant to dissolving, obtain without granular blending ingredients B；
C, blending ingredients B is cooled to 25 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols is added into container, stirring is abundant to dissolving, i.e.,
Medical mouthwash can be made；
D, pH value and appearance test, qualified Hou Zhuan bottle encapsulation process are carried out.
1st, 20 canker sore patients are asked take the medical mouthwash of the preparation of embodiment 4, once a day, one time 20 milli
Rise, adhere to taking 15 days, paid a return visit after 15 days, it is found that 17 human mouths do not have phenomenon of bleeding, ulcer symptoms have mitigated.
2nd, ask 20 patients for having oral problem take the medical mouthwash of the preparation of embodiment 4, it is found that 18 people feel
Mouthwash does not have bitterness sense.
Embodiment 5：A kind of medical mouthwash and preparation method thereof
A kind of medical mouthwash, the composition of raw materials of the medical mouthwash include the raw material of following parts by weight：Chinese medicine extract 7
Part, 4 parts of sodium fluoride, 6 parts of glycerine, 4 parts of xylitol, 5 parts of Tea Polyphenols, 0.9 part of sorbic acid, 58 parts of deionized water, 1.3 parts of flavor enhancement
With 0.03 part of styptic.
Preferred embodiment is：The preparation method of the Chinese medicine extract：By honeysuckle, cordate houttuynia, maidenhair and five
Gall nut co-grinding adds the water that quality is 5 times of powder gross mass, boiling 30min, is filtrated to get at 100 DEG C into powder
Filtrate be Chinese medicine extract.
Preferred embodiment is：The flavor enhancement is by menthol, cyclodextrin and casoid flour according to mass ratio 2.5:
1.2:1 mixes.
Preferred embodiment is：The styptic is by alum and lidocaine according to mass ratio 2.5:1 mixes.
Preferred embodiment is：Honeysuckle, cordate houttuynia, maidenhair and gallic mass ratio are 8：1：1：1.
In order to achieve the above objects and other related objects, technical scheme provided by the invention is：A kind of medical mouthwash
Preparation method, comprise the following steps：
The first step：Deionized water is poured into the container sterilized, be heated to 95 DEG C, then glycerine and wood are sequentially added into container
Sugar alcohol, stir to xylitol and dissolve, obtain the blending ingredients A of no particulate matter；
Second step：Blending ingredients A is cooled to 55 DEG C, sodium fluoride, sorbic acid, flavor enhancement are sequentially added into the container and is stopped
Blood agent, after stirring, obtain the blending ingredients B of no particulate matter；
3rd step：Blending ingredients B is cooled to 22 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols are added into container, after stirring i.e.
Obtain medical mouthwash.
Preferred embodiment is：The pH value of the medical mouthwash is 7.1.
Embodiment 6：A kind of medical mouthwash and preparation method thereof
A kind of medical mouthwash, the composition of raw materials of the medical mouthwash include the raw material of following parts by weight：Chinese medicine extract 9
Part, 2 parts of sodium fluoride, 5 parts of glycerine, 5 parts of xylitol, 5 parts of Tea Polyphenols, 0.5 part of sorbic acid, 60 parts of deionized water, 1.5 parts of flavor enhancement
With 0.03 part of styptic.
Preferred embodiment is：The preparation method of the Chinese medicine extract：By honeysuckle, cordate houttuynia, maidenhair and five
Gall nut co-grinding adds the water that quality is 3 times of powder gross mass, boiling 50min, is filtrated to get at 85 DEG C into powder
Filtrate is Chinese medicine extract.
Preferred embodiment is：The flavor enhancement is by menthol, cyclodextrin and casoid flour according to mass ratio 2.5:
0.8:1 mixes.
Preferred embodiment is：The styptic is by alum and lidocaine according to mass ratio 1.5:1 mixes.
Preferred embodiment is：Honeysuckle, cordate houttuynia, maidenhair and gallic mass ratio are 8：1：1：1.
In order to achieve the above objects and other related objects, technical scheme provided by the invention is：A kind of medical mouthwash
Preparation method, comprise the following steps：
The first step：Deionized water is poured into the container sterilized, be heated to 95 DEG C, then glycerine and wood are sequentially added into container
Sugar alcohol, stir to xylitol and dissolve, obtain the blending ingredients A of no particulate matter；
Second step：Blending ingredients A is cooled to 45 DEG C, sodium fluoride, sorbic acid, flavor enhancement are sequentially added into the container and is stopped
Blood agent, after stirring, obtain the blending ingredients B of no particulate matter；
3rd step：Blending ingredients B is cooled to 22 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols are added into container, after stirring i.e.
Obtain medical mouthwash.
Preferred embodiment is：The pH value of the medical mouthwash is 6.7.
As described above is only to explain the preferred embodiments of the invention, is not intended to tool to do any shape to the present invention
Limitation in formula, therefore all have any modification or change for making the relevant present invention under identical spirit, it should all wrap
Include the invention is intended to the category protected.
Claims (6)
- A kind of 1. medical mouthwash, it is characterised in that：The composition of raw materials of the medical mouthwash includes the raw material of following parts by weight： Chinese medicine extract 6-9 parts, sodium fluoride 2-4 parts, glycerine 3-6 parts, xylitol 4-7 parts, Tea Polyphenols 2-5 parts, sorbic acid 0.5-0.9 Part, deionized water 55-60 parts, flavor enhancement 1.2-1.5 parts and styptic 0.02-0.03 parts.
- 2. medical mouthwash according to claim 1, it is characterised in that：The preparation method of the Chinese medicine extract：By gold Honeysuckle flower, cordate houttuynia, maidenhair and Chinese gall co-grinding add the water that quality is 3 ~ 5 times of powder gross mass into powder, 30 ~ 50min of boiling at 85-100 DEG C, the filtrate being filtrated to get are Chinese medicine extract.
- 3. medical mouthwash according to claim 1, it is characterised in that：The flavor enhancement is by menthol, cyclodextrin and junket Albumen powder is according to mass ratio 2.5 ~ 3.5:0.8~1.2:1 mixes.
- 4. medical mouthwash according to claim 1, it is characterised in that：The styptic by alum and lidocaine according to Mass ratio 1.5 ~ 2.5:1 mixes.
- A kind of 5. preparation method of medical mouthwash, it is characterised in that：The composition of raw materials of the medical mouthwash will using right The composition of raw materials described in 1 ~ 4 any claim is sought, preparation method comprises the following steps：The first step：Deionized water is poured into the container sterilized, be heated to 85 ~ 95 DEG C, then glycerine is sequentially added into container And xylitol, stir to xylitol and dissolve, obtain the blending ingredients A of no particulate matter；Second step：Blending ingredients A is cooled to 45 ~ 55 DEG C, sodium fluoride, sorbic acid, flavor enhancement are sequentially added into the container And styptic, after stirring, obtain the blending ingredients B of no particulate matter；3rd step：Blending ingredients B is cooled to 22 ~ 28 DEG C, traditional Chinese medicine extraction night and Tea Polyphenols are added into container, after stirring Produce medical mouthwash.
- 6. the preparation method of medical mouthwash according to claim 5, it is characterised in that：The pH value of the medical mouthwash For 6.7-7.1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710940055.4A CN107551038A (en) | 2017-10-11 | 2017-10-11 | A kind of medical mouthwash and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710940055.4A CN107551038A (en) | 2017-10-11 | 2017-10-11 | A kind of medical mouthwash and preparation method thereof |
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| CN107551038A true CN107551038A (en) | 2018-01-09 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516003A (en) * | 2020-12-18 | 2021-03-19 | 上海杜可生物科技有限公司 | Use of cyclodextrin for inhibiting growth of oral bacteria |
| CN113633574A (en) * | 2021-08-23 | 2021-11-12 | 合肥赛为智慧医疗有限公司 | Anti-caries mouthwash and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800261A (en) * | 2015-05-15 | 2015-07-29 | 大连大学 | Clove compound mouthwash |
| CN106309325A (en) * | 2016-09-29 | 2017-01-11 | 青岛海之源智能技术有限公司 | Antibacterial and anti-inflammatory mouthwash and preparation method thereof |
-
2017
- 2017-10-11 CN CN201710940055.4A patent/CN107551038A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800261A (en) * | 2015-05-15 | 2015-07-29 | 大连大学 | Clove compound mouthwash |
| CN106309325A (en) * | 2016-09-29 | 2017-01-11 | 青岛海之源智能技术有限公司 | Antibacterial and anti-inflammatory mouthwash and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 颜霞等主编: "《血液病白问百答》", 30 June 2014, 军事医学科学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516003A (en) * | 2020-12-18 | 2021-03-19 | 上海杜可生物科技有限公司 | Use of cyclodextrin for inhibiting growth of oral bacteria |
| CN113633574A (en) * | 2021-08-23 | 2021-11-12 | 合肥赛为智慧医疗有限公司 | Anti-caries mouthwash and preparation method thereof |
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Application publication date: 20180109 |