CN108524374A - It is a kind of for the toothpaste and its manufacturing method of a variety of oral problems and application - Google Patents
It is a kind of for the toothpaste and its manufacturing method of a variety of oral problems and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention relates to oral hygienes, and in particular to a kind of for the toothpaste and its manufacturing method of a variety of oral problems and application.The present invention is directed to the toothpaste of a variety of oral problems, includes 0.4 2% Cortex Ilicis Rotundae extract, can make the oral care products such as toothpaste, mouthwash, spraying.The composition of the present invention or the oral care product containing the present composition can be used for treating stomatitis, periodontitis, canker sore, prevent plaque from being formed, and prevent decayed tooth, reduce oral cavity various problems.
Description
Technical field
The present invention relates to oral hygienes, and in particular to a kind of toothpaste and its manufacturing method for a variety of oral problems
And application.
Background technology
Our whole living standard is just in General Promotion, but with the change of eating habit, especially high sugar, exquisiteness
The oral health issue of the increase let us of food intake increasingly allows people to worry.China's third time oral health epidemiological
Investigation display：Up to 97% adult perplexs by different degrees of oral problem --- and 97% adult suffers from tooth knot
Stone, 88% have saprodontia, and 85% has gum problem, along with sensitivity of tooth, implication, tooth stain, plaque etc., constitute Chinese most
7 common big oral problems.
With the development of science and technology, people add drug and certain ingredients in toothpaste, many new work(are added to toothpaste
Can, for mouth diseases such as pre- anti-caries.And Chinese herbal toothpaste, have the mild property and drug that Chinese herbal medicine is possessed
Effect.In toothpaste a kind of trend is had become using various Chinese herbal medicines.But how preferably to apply these valuable ingredients of traditional Chinese medicine resources
The prior art also lacks some further investigations.
Invention content
In consideration of it, it is necessary to provide regarding to the issue above a kind of toothpaste for a variety of oral problems and its manufacturing method and
Using.
The present invention is achieved by the following technical solutions：
A kind of toothpaste for a variety of oral problems includes the Cortex Ilicis Rotundae extract of 0.4-2%.
Further, the Cortex Ilicis Rotundae extract is iron holly bark ethanol extract, iron holly bark supercritical extract, iron holly bark
Ultrasonic extraction object, iron holly bark medicinal extract extract.Such as the present invention is applied to the raw material of extracting solution, medicinal extract or other form of formulations
When in composition, addition should be converted to the addition of extract in the formula of the present invention.
The toothpaste of the present invention, including：The rubbing agent of 40-60%, the wetting agent of 20-50%, 1-5% surfactant,
The adhesive of 1-4%, the Cortex Ilicis Rotundae extract of 0.4-2%, 1-2% fragrance, 0.1-1% tetrasodium pyrophosphates, 0.1-1% sweet tastes
Agent, 0.1-0.5% preservatives, 0.1-0.5% vitamin Cs, the stannous chloride of 0.001-0.01%, 0.05-0.2% it is refrigerant
Agent, the edible light green pigment of 0.01-0.05% and the deionized water of surplus.
Further, the rubbing agent includes one or more of calcium carbonate, hydrated silica, calcium monohydrogen phosphate；
The wetting agent includes one or more of glycerine, PEG-400, D-sorbite, 1,2- hexylene glycols, propylene glycol；
The surfactant is sldium lauryl sulfate, lauric acid sodium sarcosinate, sodium lauroyl glutamate, methyl cocoyl
One or more of acyl taurines sodium；
Described adhesive includes that described adhesive is carragheen, xanthans, sanlose and its derivative, angle
Pitch one or more of dish, sodium alginate；
The fragrance is food flavor；The sweetener is the one or two of saccharin sodium and xylitol；
The preservative is one or more of methyl hydroxybenzoate, sodium benzoate；
The freshener is in menthol, methyl diisopropyl propionamide, terpane formyl ethamine, menthyl lactate etc.
It is one or more of.
Further, the toothpaste is by 46% calcium monohydrogen phosphate, 4% hydrated silica, 6% glycerine, 6% PEG-
400,30% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% tetrasodium pyrophosphate, 0.6% carragheen, 0.9%
Xanthans, 0.8% Cortex Ilicis Rotundae extract, 1% food flavor, 0.25% saccharin sodium, 0.5% xylitol,
0.15% methyl hydroxybenzoate, 0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine,
0.05% menthol, 0.028% edible light green pigment and the deionized water of surplus.
The preparation method of the toothpaste of the present invention, includes the following steps：
1) each raw material is weighed by formula ratio,
2) adhesive is added in wetting agent, stirs and forms finely dispersed suspension；
3) sweetener, tetrasodium pyrophosphate, stannous chloride, vitamin C are add to deionized water, are stirred to completely molten
Solution；
4) solution described in step 3) is added in step 2) in suspension, stirs into uniform rubber cement；
5) preservative, freshener are dissolved with essence；
6) by rubbing agent, surfactant, Cortex Ilicis Rotundae extract, the mixture of step 5), edible light green pigment are added to
In the rubber cement of step 4), 3000 turns of stirrings of mixing speed obtain lotion of toothpaste after lotion, then ground degassing being made within 15 minutes, wrap
Dress is completed.
, material mixing more moist using lotion made from the above method is evenly.
Advantageous effect of the present invention：
Chinese medicine iron holly bark, alias is silver bark, ninebark, white orchid perfume, bear gall wood etc..For Aquifoliaceae Holly iron
The bark (double-layer fur) of Chinese ilex, leaf, root can also be used as medicine.
The pharmacological action of iron holly bark
1. anastalsis：Iron holly bark B prime (Triterpene Glycosides) can in vitro make reduced clotting time, be cut to Canine femoral artery,
Dog, the excision of rabbit lobe segments, dog spleen cross recess, rabbit ear and the incision of rabbit mesenteric vein can shorten bleeding stopping period.
2. the influence of pair smooth muscle：Iron holly bark B prime is to Isolated rabbit ear vessls, it was demonstrated that has contraction to vascular smooth muscle
Effect.There are relexation, and enterospasm caused by energy antagonism acetylcholine in its glycosides displayed part to isolated ileum segments in guinea pigs.
3. antibacterial action：Decoction test tube interior energy inhibits staphylococcus aureus, hemolytic streptococcus and dysentery (Freund), wound
Cold, Pseudomonas aeruginosa.
The glycosides composition composition extracted from iron holly bark, has significant fungistatic effect, can prevent a variety of body surface bacteriums, fungi
Infectious diseases, and with antipruritic, anti-inflammatory, hemostasis and other effects, and have no toxic side effect, application is safe.
Present invention adds having the function of hemostasis, anti-inflammatory, analgesic iron holly bark toothpaste medicinal powder, increase in the function of preventing decayed tooth
Add and mitigates gum problem (bleeding gums, gum pain) with help, repairs mucosa injury, nutrition gum and improve periodontal health
Effect.
Vitamin C is added in toothpaste of the present invention and stannous chloride extends the shelf of toothpaste to delay lotion oxidation stain
Period.
The present invention provides a kind of with anti-inflammatory, it is antibacterial with dispel implication, it is anti-inflammatory, hemostasis, antibacterial, analgesic effect group
Object is closed, can be used for treating stomatitis, periodontitis, canker sore, prevent plaque from being formed, prevent decayed tooth, reduces that oral cavity is a variety of asks
Topic.
Specific implementation mode
In order to better illustrate technical solution of the present invention problem to be solved, the technical solution of use and reach beneficial
Effect is expanded on further in conjunction with specific implementation mode.It is worth noting that technical solution of the present invention is including but not limited to following
Embodiment.
Particular technique or condition are not specified in the embodiment of the present invention, according to technology described in document in the art or
Condition is carried out according to product description.Reagents or instruments used without specified manufacturer, being can be by purchased in market etc.
The conventional products that approach obtains.
The toothpaste for a variety of oral problems of 1 present invention of embodiment
Group becomes：0.8% Cortex Ilicis Rotundae extract, 46% calcium monohydrogen phosphate, 4% hydrated silica, 6% glycerine, 6%
PEG-400,30% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% tetrasodium pyrophosphate, 0.6% carragheen,
0.9% xanthans, 1% food flavor, 0.25% saccharin sodium, 0.5% xylitol, 0.15% methyl hydroxybenzoate,
0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine, 0.05% menthol, 0.028%
The deionized water for eating light green pigment and surplus.
The preparation method of toothpaste containing above-mentioned composition, includes the following steps：
1) each raw material is weighed by above-mentioned formula ratio,
2) adhesive (carragheen and xanthans) is added in wetting agent (glycerine, PEG-400 and D-sorbite), is stirred
And form finely dispersed suspension；
3) sweetener (saccharin sodium and xylitol), tetrasodium pyrophosphate, stannous chloride, vitamin C are added to deionized water
In, stirring is to being completely dissolved；
4) solution described in step 3) is added in step 2) in suspension, stirs into uniform rubber cement；
5) preservative (methyl hydroxybenzoate), freshener (terpane formyl ethamine and menthol) are dissolved with essence；
6) rubbing agent (calcium monohydrogen phosphate and hydrated silica), surfactant (laruyl alcohol sodium sulfovinate), iron holly bark are extracted
Object, the mixture of step 5), edible light green pigment are added in the rubber cement of step 4), and the stirring 15 minutes of 3000 turns of mixing speed is made
At lotion of toothpaste is obtained after lotion, then ground degassing, packaging is completed.
The toothpaste for a variety of oral problems of 2 present invention of embodiment
Group becomes：Cortex Ilicis Rotundae extract 2%, 46% calcium monohydrogen phosphate, 4% hydrated silica, 6% glycerine, 6%
PEG-400,20% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% tetrasodium pyrophosphate, 0.6% carragheen,
0.9% xanthans, 1% food flavor, 0.25% saccharin sodium, 0.5% xylitol, 0.15% methyl hydroxybenzoate,
0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine, 0.05% menthol, 0.028%
The deionized water for eating light green pigment and surplus.
The preparation method is the same as that of Example 1.
The toothpaste for a variety of oral problems of 3 present invention of embodiment
Group becomes：Cortex Ilicis Rotundae extract 1.6%, 46% calcium monohydrogen phosphate, 4% hydrated silica, 6% glycerine, 6%
PEG-400,20% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% tetrasodium pyrophosphate, 0.6% carragheen,
0.9% xanthans, 1% food flavor, 0.25% saccharin sodium, 0.5% xylitol, 0.15% methyl hydroxybenzoate,
0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine, 0.05% menthol, 0.028%
The deionized water for eating light green pigment and surplus.
The preparation method is the same as that of Example 1.
The toothpaste for a variety of oral problems of 4 present invention of embodiment
Group becomes：Cortex Ilicis Rotundae extract 0.8%, 46% calcium monohydrogen phosphate, 4% hydrated silica, 6% glycerine, 6%
PEG-400,20% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% tetrasodium pyrophosphate, 0.6% carragheen,
0.9% xanthans, 1% food flavor, 0.25% saccharin sodium, 0.5% xylitol, 0.15% methyl hydroxybenzoate,
0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine, 0.05% menthol, 0.028%
The deionized water for eating light green pigment and surplus.
The preparation method is the same as that of Example 1.
The toothpaste for a variety of oral problems of 5 present invention of embodiment
Group becomes：Cortex Ilicis Rotundae extract 0.4%, 46% calcium monohydrogen phosphate, 4% hydrated silica, 6% glycerine, 6%
PEG-400,20% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% tetrasodium pyrophosphate, 0.6% carragheen,
0.9% xanthans, 1% food flavor, 0.25% saccharin sodium, 0.5% xylitol, 0.15% methyl hydroxybenzoate,
0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine, 0.05% menthol, 0.028%
The deionized water for eating light green pigment and surplus.
The preparation method is the same as that of Example 1.
Comparative example 1：Formula and each component dosage are in being directly formulated difference lies in this comparative example with embodiment 1
The mixture that each dosage component is disposably directly mixed to get.
Above-described embodiment 1-5, the Cortex Ilicis Rotundae extract used in comparative example 1 are same batch.
Animal experiment
Experiment content and result
(1) experiment material
Test medicine：
Experimental group：The a variety of oral problem toothpaste of improvement of 1-5 of the embodiment of the present invention.
Control group 1：The mixture of comparative example 1.
Control group 2：Toothpaste bare substrate without Cortex Ilicis Rotundae extract.Group becomes：46% calcium monohydrogen phosphate, 4% water
Close silica, 6% glycerine, 6% PEG-400,30% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% burnt phosphorus
Sour four sodium, 0.6% carragheen, 0.9% xanthans, 1% food flavor, 0.25% saccharin sodium, 0.5% xylose
Alcohol, 0.15% methyl hydroxybenzoate, 0.15% vitamin C, 0.008% stannous chloride, 0.03% terpane formyl ethamine,
0.05% menthol, 0.028% edible light green pigment and the deionized water of surplus.
Control group 3：Cortex Ilicis Rotundae extract (with embodiment 1-5, the Cortex Ilicis Rotundae extract used in comparative example 1 be same
Batch).
Experimental animal：Rabbit, kunming mice.Quality of Experimental Animals quality certification number：2006A051；SPF grades of experimental animal rings
Border condition quality certification number：2006B023；SPF grades of experimental animal production licence numbers：The Guangdong SCXK 2011-0015；Animal is by south
Medical university's animal experimental center provides.
Formalin analyzes pure, lot number 20111007, Guangdong Guanghua Science and Technology Co., Ltd.；Absolute ethyl alcohol, analysis
Pure, lot number 20110416, Tianjin is into rich Chemical Co., Ltd.；Dimethylbenzene analyzes pure, lot number 20101224, Guangdong graduation
Learn Co., Ltd., Factory；Hematoxylin, biological stain element, lot number 20160408, Beijing Ding Guo biotechnologys Co., Ltd
Fluka imports dispense；Eosin Y, biological stain element, lot number 20160912, Chinese East China Normal University chemical plant；OLYMPUS
AU5421 type automatic clinical chemistry analyzers, Japanese OLYMPUS companies production；OLYMPUS BH-2 fluorescence microscopes, Japan
OLYMPUS companies produce；BECKMANTM30 type refrigerated centrifuges, the production of BACKMAN companies of the U.S.；LEICA RM2135 types are cut
Piece machine, German LEICA companies production；SARTORIUS electronic balances, German SARTORIUS companies production.
(2) experimental method and result
1. anastalsis
Extracting waste rabbit, weight 2.0-2.5kg, male and female dual-purpose.It is slow with 3% yellow Jackets 30mg/kg auricular veins
It injects, after family's rabbit anesthesia, lies on the back and be fixed on operating table, abdomen median incision is about 6-8cm, and exposure simultaneously fixes liver, uses hand
Art, which is cut, to be cut liver organization in left lobe of liver and is about 1cm, wide about 1cm, high about 1cm, and the surface of a wound is in injection sample bleeding.Wipe the blood of ejection
Afterwards, immediately in surface of a wound part spreading test agent sample lg, gauze is covered with, and counterweight is removed after oppressing 1min with 200g counterweights, is seen
Haemostatic effect is examined, is hemostasis with not bleeding, such as still bleeding, then plus spreading continues to pressurize after trying object sample, and one is observed every 30s
It is secondary, record bleeding stopping period.Such as more than 3min still bleeding, then it is denoted as and fails to stop blooding, bleeding stopping period is denoted as>3min.Each sample
After test, residual tested material is washed away with 37 DEG C of physiological saline, makes surface of a wound bleeding again, the lower tested material sample of re-test.Every
Rabbit carries out four liver local woanded surface damage hemostasis test experiments, and each tested material sample presses the Latin equation topical application of drug, to reduce
Liver local woanded surface damages the influence of notch difference and medication sequence.Each tested material sample, which amounts to, carries out 20 rabbit liver parts
The hemostasis of surface of a wound bleeding due to trauma is tested.Haemostatic effect presses point-score (10/T) reciprocal and is denoted as score value F, and 3min or more fails to stop blooding, F
No Yu's value is denoted as 0.Statistics t check analyses are recorded and carried out, the results are shown in Table 1.
Haemostatic effect (x ± SD) of 1 toothpaste sample of table to rabbit liver local woanded surface bleeding due to trauma
Toothpaste group of the present invention is compared with toothpaste bare substrate：P<0.01.
The above results show that：
(a) present invention for being added to Cortex Ilicis Rotundae extract improves a variety of oral problem toothpaste and control mixture test group pair
Rabbit liver local woanded surface bleeding due to trauma has apparent anastalsis, compared with toothpaste blank control group, significant difference (P<
O.Ol), statistically significant.Illustrate that the present invention improves a variety of oral problem toothpaste and has significant anastalsis.
(b) 1 group of embodiment is compared with 1 group of comparative example, it can be seen that：Similarly it is formulated preparation side using the present invention
After prepared by method, haemostatic effect is obviously improved.
(c) embodiment 2-5 groups, which compare, obtains：The poor nothing of haemostatic effect institute when Cortex Ilicis Rotundae extract usage amount is in 0.8-2%
It is several, but at 0.4%, haemostatic effect then wants slower, illustrates that Cortex Ilicis Rotundae extract usage amount effect at 0.8% can reach
Preferably, the dosage haemostatic effect promotion unobvious for subsequently increasing Cortex Ilicis Rotundae extract can be by 0.8% in conjunction with real cost of production
As most preferred quantities.
2. anti-inflammatory effect
Healthy male Kun Ming mice 90,18~22g of weight is taken, it is random to divide equally 9 groups, every group 10.When experiment, respectively
0.1ml caused by dimethylbenzene xylene inflammation is uniformly smeared on two sides inside and outside every animal auris dextra exterior feature of group, and left ear is untreated to make self-blank control.It applies
After smearing dimethylbenzene 30min, each group tested material sample 0.1g is uniformly smeared on two sides respectively inside and outside every animal auris dextra exterior feature of each group.Administration
After 1h, mouse cervical dislocation is put to death, and cuts two auricles, auris dextra exterior feature tested material sample is washed away with physiological saline, and dry cotton ball is cleaned, weight
Folded two auricles take two circle auricles in same position chisel with the card punch of internal diameter 8mm, weigh on electronic analytical balance respectively, right
It is swelling value that auricle weight, which subtracts left auricle weight,.It the results are shown in Table 2.
The influence (X ± SD) of 2 sample paraxylene induced mice auricle acute inflammation swelling of table
| Group | Dosage (g/ is only) | Auricle edema value (mg) |
| Blank control group | 0.1 | 18.03±8.68 |
| Toothpaste bare substrate group | 0.1 | 16.51±6.92 |
| 1 toothpaste group of embodiment | 0.1 | 10.53±8.69**## |
| Cortex Ilicis Rotundae extract group | 0.1 | 9.18±7.13**## |
| 2 toothpaste group of embodiment | 0.1 | 10.02±6.17**## |
| 3 toothpaste group of embodiment | 0.1 | 10.19±7.34**## |
| 4 toothpaste group of embodiment | 0.1 | 10.61±7.83**## |
| 5 toothpaste group of embodiment | 0.1 | 12.87±9.72*# |
| 1 group of comparative example | 0.1 | 11.24±9.15*# |
Toothpaste group of the present invention is compared with toothpaste bare substrate：P<0.01.
The above results show that：The present invention, which improves a variety of oral problem toothpaste, can make chmice acute inflammation swelling auricle weight aobvious
It writes and mitigates, can obviously inhibit dimethylbenzene induced mice auricle acute inflammation swelling.
3. analgesic activity
Weight 18~22g health Kun Ming mices are chosen, with hot plate pain threshold detector adjusting control temperature at 55 ± 0.5 DEG C,
Small white mouse is placed on to the pain threshold (small white mouse contacts hot plate to the time for licking metapedes) measured on hot plate per mouse, it is all to lick the metapedes time
It gives it up less than 5 seconds or more than 30 seconds and leaper, selects qualified small white mouse 90, it is random to divide equally 9 groups, every group 10, divide
It Yong Yu not blank control group, toothpaste bare substrate group, positive drug diclofenac diethylamine emulgel, toothpaste group of the present invention and comparison
1 group of embodiment.Each group small white mouse is repeated 2 times the normal pain threshold for measuring small white mouse by the same method, per minor tick 15min, takes twice
Normal pain threshold average value, the pain threshold before being administered as this group of small white mouse.Respectively at each group animal phase is given per 4 vola pedis paintings of mouse
Answer test medicine 0.2g/ only, blank control group painting gives physiological saline 0.2ml/ only, painting give drug 15,30,45min divides by the same method
Not Ce Ding the pain threshold of mouse small white mouse is taken out if small white mouse 60 seconds (S) is still reactionless, in order to avoid scald, pain threshold is with 60
Second (S) is calculated, and tested toothpaste sample carries out analgesic activity using woolfe-Macdonald method and records each group small white mouse pain threshold, data into
Row statistics t is examined.It the results are shown in Table 3
Analgesic activity (hot plate method) (X ± SD) of 3 sample of table to small white mouse
Toothpaste group of the present invention is compared with toothpaste bare substrate：P<0.01.
The result shows that the present invention, which improves a variety of oral problem toothpaste test groups, a degree of analgesic effect.
In summary, the present invention, which improves a variety of oral problem toothpaste, stronger hemostasis, anti-inflammatory, analgesic effect, successfully
Multiple efficacies have been concentrated in a kind of toothpaste, and by specific preparation process, has further enhanced these functions, avoids
Drug waste.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (7)
1. a kind of toothpaste for a variety of oral problems, which is characterized in that the Cortex Ilicis Rotundae extract including 0.4-2%.
2. toothpaste as described in claim 1, which is characterized in that including 0.8% Cortex Ilicis Rotundae extract.
3. toothpaste as described in claim 1, which is characterized in that the Cortex Ilicis Rotundae extract is iron holly bark ethanol extract, rescues
Supercritical extract, iron holly bark ultrasonic extraction object or iron holly bark medicinal extract extract must be answered.
4. the toothpaste as described in claim 1-3 any one, which is characterized in that including：Rubbing agent, the 20-50% of 40-60%
Wetting agent, the surfactant of 1-5%, the adhesive of 1-4%, the Cortex Ilicis Rotundae extract of 0.4-2%, 1-2% fragrance, 0.1-
The chlorine of 1% tetrasodium pyrophosphate, 0.1-1% sweeteners, 0.1-0.5% preservatives, 0.1-0.5% vitamin Cs, 0.001-0.01%
Change stannous, the deionized water for eating light green pigment and surplus of the freshener of 0.05-0.2%, 0.01-0.05%.
5. toothpaste as claimed in claim 4, which is characterized in that the rubbing agent includes calcium carbonate, hydrated silica, phosphoric acid hydrogen
One or more of calcium；
The wetting agent includes one or more of glycerine, PEG-400, D-sorbite, 1,2- hexylene glycols, propylene glycol；
The surfactant is sldium lauryl sulfate, lauric acid sodium sarcosinate, sodium lauroyl glutamate, methyl cocoyl
One or more of sodium taurocholate；Described adhesive includes that described adhesive is carragheen, xanthans, sodium carboxymethylcellulose
One or more of salt and its derivative, Irish moss, sodium alginate；
The fragrance is food flavor；The sweetener is the one or two of saccharin sodium and xylitol；
The preservative is one or both of methyl hydroxybenzoate, sodium benzoate；
The freshener be menthol, methyl diisopropyl propionamide, terpane formyl ethamine, one kind in menthyl lactate or
It is several.
6. toothpaste as claimed in claim 5, which is characterized in that the toothpaste is by 46% calcium monohydrogen phosphate, 4% hydration silicon
Stone, 6% glycerine, 6% PEG-400,30% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 0.5% pyrophosphoric acid four
Sodium, 0.6% carragheen, 0.9% xanthans, 0.8% Cortex Ilicis Rotundae extract, 1% food flavor, 0.25% saccharin
Sodium, 0.5% xylitol, 0.15% methyl hydroxybenzoate, 0.15% vitamin C, 0.008% stannous chloride, 0.03% it is thin
Lotus alkane formyl ethamine, 0.05% menthol, 0.028% deionized water for eating light green pigment and surplus.
7. a kind of preparation method of toothpaste for a variety of oral problems, which is characterized in that include the following steps：
1) each raw material is weighed by formula ratio,
2) adhesive is added in wetting agent, stirs and forms finely dispersed suspension；
3) sweetener, tetrasodium pyrophosphate, stannous chloride, vitamin C are add to deionized water, stirring is to being completely dissolved；
4) solution described in step 3) is added in step 2) in suspension, stirs into uniform rubber cement；
5) preservative, freshener are dissolved with essence；
6) by rubbing agent, surfactant, Cortex Ilicis Rotundae extract, the mixture of step 5), edible light green pigment are added to step
4) in rubber cement, 3000 turns of stirrings of mixing speed obtain lotion of toothpaste after lotion, then ground degassing being made within 15 minutes, and packaging is
It completes.
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| CN111632004A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Anti-inflammation antibacterial hemostasis toothpaste |
| CN111643415A (en) * | 2020-06-18 | 2020-09-11 | 广州市飞雪材料科技有限公司 | Double-layer silicon dioxide coated particle and preparation method and application thereof |
| CN111888315A (en) * | 2020-09-10 | 2020-11-06 | 山东钰财农业发展有限公司 | Preparation method of black garlic toothpaste |
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| CN111888315A (en) * | 2020-09-10 | 2020-11-06 | 山东钰财农业发展有限公司 | Preparation method of black garlic toothpaste |
| CN112137901A (en) * | 2020-10-16 | 2020-12-29 | 清远市华宝生物科技有限公司 | Anti-inflammation hemostasis whitening toothpaste and preparation method thereof |
| CN112057390A (en) * | 2020-10-21 | 2020-12-11 | 广东南方洁灵科技实业有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method and application thereof |
| CN113633586A (en) * | 2021-06-30 | 2021-11-12 | 广州名大实业有限公司 | Formula of efficient periodontal nursing toothpaste |
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