CN111888315A - Preparation method of black garlic toothpaste - Google Patents
Preparation method of black garlic toothpaste Download PDFInfo
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- CN111888315A CN111888315A CN202010947567.5A CN202010947567A CN111888315A CN 111888315 A CN111888315 A CN 111888315A CN 202010947567 A CN202010947567 A CN 202010947567A CN 111888315 A CN111888315 A CN 111888315A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/02—Local antiseptics
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a preparation method of black garlic toothpaste, which comprises the following steps: dissolving water, sorbitol, polyethylene glycol-400, essence, Mentholum, black Bulbus Allii extract, sodium benzoate, and saccharin sodium with purified water in a pre-dissolving pot or a pre-mixing pot; adding into paste making pot, adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate; after the material is added, stirring by a scraper, homogenizing, stirring and grinding are carried out; then, a small amount of paste is taken out for inspection; after the paste is qualified, the paste is put into a paste storage pot for aging, and meanwhile, the materials are fully expanded to form a homogeneous adhesive body; and then filling the paste by an automatic filling machine. The invention has the advantage of killing various pathogenic microorganisms such as influenza virus, diplococcus pneumoniae, candida, tubercle bacillus, typhoid bacillus, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like.
Description
Technical Field
The invention relates to the technical field of toothpaste, in particular to a preparation method of black garlic toothpaste.
Background
The toothpaste is a cleaning article commonly used in daily life, is a dentifrice, is generally in a gel shape, can be usually smeared on a toothbrush for cleaning teeth, keeps the beauty and brightness of the teeth, has a long history, and with the continuous development of scientific technology, the continuous improvement and perfection of manufacturing technology and equipment, various types of toothpaste are appeared one after another, the quality and the grade of products are continuously improved, and as far as 2019, the variety of the toothpaste is changed from single cleaning type toothpaste, the toothpaste is developed into hundreds of multifunctional toothpastes with complete varieties and various functions, thereby meeting the requirements of different consumption levels. Most of toothpaste in the market at present can only remove films and dental plaques on the surfaces of teeth through friction, but cannot inhibit bacteria in oral cavities, so that halitosis cannot be removed even after a lot of people brush teeth, and most of toothpaste with a sterilization function in the market adopts a bactericide of chemical substances, which can generate strong stimulation to oral tissues and easily cause imbalance of oral flora environments, so that an ideal effect of preventing oral diseases cannot be achieved.
Disclosure of Invention
The invention aims to provide a preparation method of black garlic toothpaste, which has the advantage of killing various pathogenic microorganisms such as influenza virus, diplococcus pneumoniae, candida, tubercle bacillus, typhoid bacillus, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like, and solves the problems that most of toothpaste on the market can only remove films and bacterial plaques on the surfaces of teeth through friction and cannot inhibit bacteria in oral cavities, so that halitosis cannot be removed by many people after tooth brushing, and most of toothpaste with a sterilization function on the market adopts a bactericide of chemical substances, which can generate strong stimulation to oral tissues and easily cause imbalance of oral flora environment, so that an ideal effect of preventing oral diseases cannot be achieved.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of black garlic toothpaste comprises the following steps:
s1, dissolving water, sorbitol, polyethylene glycol-400, essence, Mentholum, black Bulbus Allii extract, sodium benzoate, and saccharin sodium with purified water in a pre-dissolving pot or a pre-mixing pot, and adding into a paste-making pot;
s2, respectively adding the liquid materials in the liquid material storage tank into a paste making pot, and adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, a peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate;
s3, after the material adding is finished, stirring by a scraper, homogenizing, stirring and grinding;
s4, kneading and grinding, and then beating out a small amount of paste for inspection;
s5, after the materials are qualified, the materials are put into a paste storage pot for aging, the materials are naturally cooled to normal temperature, and meanwhile, the materials are fully expanded to form homogeneous adhesive bodies, so that the elasticity of the materials is improved;
and S6, filling the paste by an automatic filling machine.
Preferably, the grinding in S3 is carried out in vacuum environment with vacuum degree greater than-0.096 Mpa and grinding time of 30-60 min.
Preferably, in S3, the temperature of jacket cooling water is controlled to be less than or equal to 45 ℃ in summer because heat is generated by friction in the kneading and grinding processes during the paste making process.
Preferably, the aging time in S5 is 90-150 min.
Preferably, the percentage of each component is as follows: water: 20-40%, sorbitol: 1-2%, polyethylene glycol-400: 0.5-1%, calcium hydrogen phosphate: 25-60%, hydrated silica: 1-2%, cellulose gum: 2-5% and essence: 0.5-1.5%, menthol: 1-1.5%, xanthan gum: 1-2%, peony root extract: 1-1.5%, black garlic extract: 2-5%, sodium lauroyl glutamate: 1.5-2.5%, tetrasodium pyrophosphate: 1-2%, sodium saccharin: 1-2.5%, sodium lauroyl sarcosinate: 1-1.5%, sodium benzoate: 1 to 2 percent.
Compared with the prior art, the invention has the beneficial effects that: calcium hydrogen phosphate is used as an abrasive which is used for enhancing the friction effect and the dirt-removing power of the toothpaste and polishing the tooth surface, and the abrasive has a certain friction effect, but can not damage the tooth surface and the periodontal tissues and can not react with the medicines in the toothpaste; the water, the sorbitol and the polyethylene glycol-400 are used as humectants, the humectants can keep moisture of the toothpaste body, when the toothpaste is exposed in the air, the evaporation of the moisture can be prevented, the toothpaste at the opening of a tube is not easy to dry and solidify and is easy to extrude, the rheological property of the toothpaste body is kept, the mechanical processing is convenient, the freezing point of the toothpaste is reduced, the azeotropic point of the toothpaste is improved, when the toothpaste is melted after being frozen, the moisture in the toothpaste body is not separated, the toothpaste body is still stable even at high temperature (generally 50 ℃), the sodium lauroyl sarcosinate is used as a surfactant, and the toothpaste has richer and softer foam when being used by the optimal proportion; the cellulose gel is a thickening agent, the thickening agent enables the toothpaste to have proper viscosity and consistency, no sense of stickiness is caused, good flowing performance is achieved, the toothpaste has a framework, the extruded toothpaste can stay on a toothbrush and cannot collapse, good strip forming performance is achieved, the toothpaste is easy to disperse during tooth brushing, good diffusion performance is achieved, self stability is good, biodegradation is not prone to occurring, the toothpaste is stable and does not delaminate during storage, water is not separated, the smell and color of the toothpaste are not affected, good stability is achieved, the toothpaste is fine and smooth, abrasive materials are uniformly dispersed, no adhesion is caused, the toothpaste is coarse, the compatibility with other components in the toothpaste is good, particularly active substances is good, and good compatibility is achieved; the saccharin sodium salt is a sweetening agent and is used for improving the mouthfeel of the toothpaste, such as covering the alkaline-earth taste of some abrasives, the bitter taste of some special medicaments and blending with the spice to form a harmonious compound taste, so that the toothpaste is endowed with sweet mouthfeel and style; the black garlic extract mainly contains amino acid, polyphenol, protein, enzymes, glycosides, vitamins, fat, trace elements, carbohydrate, sulfur-containing compounds and other components, the allicin contained in the black garlic extract has a broad-spectrum antibacterial effect and has a killing effect on various pathogenic microorganisms such as influenza virus, pneumococcus, candida, tubercle bacillus, typhoid fever, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like, the component with the sterilizing effect is mainly allicin, and white grease liquid propylene sulfide [ (CH2CH 2H 2)2S ] is also provided, the allicin can instantly kill the typhoid bacillus, the dysentery bacillus, influenza virus and the like even if diluted by 10 ten thousand times, and the volatile substances, leachate and allicin of the black garlic have obvious inhibiting or killing effects on various pathogenic bacteria in a test tube.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The technical scheme of the preparation method of the black garlic toothpaste provided by the invention
Example 1:
a preparation method of black garlic toothpaste comprises the following steps:
s1, dissolving water, sorbitol, polyethylene glycol-400, essence, menthol, black garlic extract, sodium benzoate and saccharin sodium in a pre-dissolving pot or a pre-mixing pot with purified water to be uniform, adding a paste making pot, wherein the black garlic extract mainly contains amino acids, polyphenols, proteins, enzymes, glycosides, vitamins, fat, trace elements, carbohydrates, sulfur-containing compounds and other components, the garlicin in the black garlic extract has broad-spectrum antibacterial effect and has killing effect on various pathogenic microorganisms such as influenza virus, pneumococcus, candida, tubercle bacillus, typhoid fever, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like, the component with the sterilizing effect is mainly garlicin, and a white oil-fat liquid 'propylene sulfide' [ (CH2CH 2H 2)2S ], even if the garlicin is diluted by 10 times, the garlicin can still kill the pathogenic microorganisms such as typhoid bacillus, streptococcus pneumoniae, streptococcus, the toothpaste has the advantages that the dysentery bacillus, influenza virus and the like, volatile substances of the black garlic, leachate and allicin have obvious inhibiting or killing effects on various pathogenic bacteria in a test tube, water, sorbitol and polyethylene glycol-400 are used as humectants, the humectants can keep moisture of the toothpaste, when the toothpaste is exposed in air, evaporation of the moisture can be prevented, the toothpaste at a tube opening is not easy to dry and solidify and is easy to extrude, the rheological property of the toothpaste is kept, the mechanical processing is convenient, the freezing point of the toothpaste is reduced, the azeotropic point of the toothpaste is improved, when the toothpaste is thawed after being frozen, moisture separation in the toothpaste is avoided, and the toothpaste is still stable even at high temperature (generally 50 ℃).
S2, respectively metering the liquid materials in the liquid material storage tank into a paste making pot, and then adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, a peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate, wherein the percentage of each component is as follows: water: 20%, sorbitol: 2%, polyethylene glycol-400: 0.5%, calcium hydrogen phosphate: 50%, hydrated silica: 2% of cellulose gum: 5% and essence: 1.5%, menthol: 1.5%, xanthan gum: 1%, peony root extract: 1.5%, black garlic extract: 5%, sodium lauroyl glutamate: 2%, tetrasodium pyrophosphate: 2%, sodium saccharin: 2.5%, sodium lauroyl sarcosinate: 1.5%, sodium benzoate: 2 percent of cellulose gum is a thickening agent which enables the toothpaste to have proper viscosity and consistency, does not feel sticky, has good flowing property, enables the toothpaste to have a framework, enables the extruded toothpaste to stay on a toothbrush and not to collapse, has good strip forming property, is easy to disperse during tooth brushing, has good diffusion property, good self stability and difficult biodegradation, enables the toothpaste to be stable and not to be layered during storage, does not separate water, does not influence the smell and color of the toothpaste, has good stability, enables the toothpaste to be fine and smooth, enables the grinding material to be uniformly dispersed, does not bond and return to coarse, has good compatibility with other components in the toothpaste, particularly active substances, and has good compatibility.
S3, after the material is added, stirring by a scraper, homogenizing, stirring and grinding are carried out, the grinding is carried out in a vacuum environment, the vacuum degree is more than-0.096 Mpa, the grinding time is 30min, and in the paste preparation process, the temperature is controlled to be less than or equal to 45 ℃ by jacket cooling water because heat is generated by friction in the kneading and grinding processes.
And S4, kneading and grinding, and then, beating a small amount of paste for testing.
And S5, after the materials are qualified, putting the materials into a paste storage pot for aging, naturally cooling the materials to normal temperature, fully expanding the materials to form a homogeneous adhesive body, and improving the elasticity of the materials, wherein the aging time is 90 min.
And S6, filling the paste by an automatic filling machine.
Example 2:
a preparation method of black garlic toothpaste comprises the following steps:
s1, dissolving water, sorbitol, polyethylene glycol-400, essence, menthol, black garlic extract, sodium benzoate and saccharin sodium in a pre-dissolving pot or a pre-mixing pot with purified water to be uniform, adding a paste making pot, wherein the black garlic extract mainly contains amino acids, polyphenols, proteins, enzymes, glycosides, vitamins, fat, trace elements, carbohydrates, sulfur-containing compounds and other components, the garlicin in the black garlic extract has broad-spectrum antibacterial effect and has killing effect on various pathogenic microorganisms such as influenza virus, pneumococcus, candida, tubercle bacillus, typhoid fever, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like, the component with the sterilizing effect is mainly garlicin, and a white oil-fat liquid 'propylene sulfide' [ (CH2CH 2H 2)2S ], even if the garlicin is diluted by 10 times, the garlicin can still kill the pathogenic microorganisms such as typhoid bacillus, streptococcus pneumoniae, streptococcus, the toothpaste has the advantages that the dysentery bacillus, influenza virus and the like, volatile substances of the black garlic, leachate and allicin have obvious inhibiting or killing effects on various pathogenic bacteria in a test tube, water, sorbitol and polyethylene glycol-400 are used as humectants, the humectants can keep moisture of the toothpaste, when the toothpaste is exposed in air, evaporation of the moisture can be prevented, the toothpaste at a tube opening is not easy to dry and solidify and is easy to extrude, the rheological property of the toothpaste is kept, the mechanical processing is convenient, the freezing point of the toothpaste is reduced, the azeotropic point of the toothpaste is improved, when the toothpaste is thawed after being frozen, moisture separation in the toothpaste is avoided, and the toothpaste is still stable even at high temperature (generally 50 ℃).
S2, respectively metering the liquid materials in the liquid material storage tank into a paste making pot, and then adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, a peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate, wherein the percentage of each component is as follows: water: 30%, sorbitol: 1%, polyethylene glycol-400: 1% and calcium hydrogen phosphate: 41%, hydrated silica: 2% of cellulose gum: 5% and essence: 1.5%, menthol: 1.5%, xanthan gum: 1%, peony root extract: 1% and black garlic extract: 5%, sodium lauroyl glutamate: 2.5%, tetrasodium pyrophosphate: 2%, sodium saccharin: 2%, sodium lauroyl sarcosinate: 1.5%, sodium benzoate: 2 percent of cellulose gum is a thickening agent which enables the toothpaste to have proper viscosity and consistency, does not feel sticky, has good flowing property, enables the toothpaste to have a framework, enables the extruded toothpaste to stay on a toothbrush and not to collapse, has good strip forming property, is easy to disperse during tooth brushing, has good diffusion property, good self stability and difficult biodegradation, enables the toothpaste to be stable and not to be layered during storage, does not separate water, does not influence the smell and color of the toothpaste, has good stability, enables the toothpaste to be fine and smooth, enables the grinding material to be uniformly dispersed, does not bond and return to coarse, has good compatibility with other components in the toothpaste, particularly active substances, and has good compatibility.
S3, after the material is added, stirring by a scraper, homogenizing, stirring and grinding are carried out, the grinding is carried out in a vacuum environment, the vacuum degree is more than-0.096 Mpa, the grinding time is 60min, and in the paste preparation process, the temperature is controlled to be less than or equal to 45 ℃ by jacket cooling water because heat is generated by friction in the kneading and grinding processes.
And S4, kneading and grinding, and then, beating a small amount of paste for testing.
And S5, after the materials are qualified, putting the materials into a paste storage pot for aging, naturally cooling the materials to normal temperature, fully expanding the materials to form a homogeneous adhesive body, and improving the elasticity of the materials, wherein the aging time is 120 min.
And S6, filling the paste by an automatic filling machine.
Example 3:
a preparation method of black garlic toothpaste comprises the following steps:
s1, dissolving water, sorbitol, polyethylene glycol-400, essence, menthol, black garlic extract, sodium benzoate and saccharin sodium in a pre-dissolving pot or a pre-mixing pot with purified water to be uniform, adding a paste making pot, wherein the black garlic extract mainly contains amino acids, polyphenols, proteins, enzymes, glycosides, vitamins, fat, trace elements, carbohydrates, sulfur-containing compounds and other components, the garlicin in the black garlic extract has broad-spectrum antibacterial effect and has killing effect on various pathogenic microorganisms such as influenza virus, pneumococcus, candida, tubercle bacillus, typhoid fever, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like, the component with the sterilizing effect is mainly garlicin, and a white oil-fat liquid 'propylene sulfide' [ (CH2CH 2H 2)2S ], even if the garlicin is diluted by 10 times, the garlicin can still kill the pathogenic microorganisms such as typhoid bacillus, streptococcus pneumoniae, streptococcus, the toothpaste has the advantages that the dysentery bacillus, influenza virus and the like, volatile substances of the black garlic, leachate and allicin have obvious inhibiting or killing effects on various pathogenic bacteria in a test tube, water, sorbitol and polyethylene glycol-400 are used as humectants, the humectants can keep moisture of the toothpaste, when the toothpaste is exposed in air, evaporation of the moisture can be prevented, the toothpaste at a tube opening is not easy to dry and solidify and is easy to extrude, the rheological property of the toothpaste is kept, the mechanical processing is convenient, the freezing point of the toothpaste is reduced, the azeotropic point of the toothpaste is improved, when the toothpaste is thawed after being frozen, moisture separation in the toothpaste is avoided, and the toothpaste is still stable even at high temperature (generally 50 ℃).
S2, respectively metering the liquid materials in the liquid material storage tank into a paste making pot, and then adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, a peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate, wherein the percentage of each component is as follows: water: 30%, sorbitol: 2%, polyethylene glycol-400: 0.5%, calcium hydrogen phosphate: 42%, hydrated silica: 2% of cellulose gum: 4% and essence: 1.5%, menthol: 1%, xanthan gum: 1%, peony root extract: 1.5%, black garlic extract: 5%, sodium lauroyl glutamate: 2%, tetrasodium pyrophosphate: 2%, sodium saccharin: 2.5%, sodium lauroyl sarcosinate: 1% and sodium benzoate: 2 percent of cellulose gum is a thickening agent which enables the toothpaste to have proper viscosity and consistency, does not feel sticky, has good flowing property, enables the toothpaste to have a framework, enables the extruded toothpaste to stay on a toothbrush and not to collapse, has good strip forming property, is easy to disperse during tooth brushing, has good diffusion property, good self stability and difficult biodegradation, enables the toothpaste to be stable and not to be layered during storage, does not separate water, does not influence the smell and color of the toothpaste, has good stability, enables the toothpaste to be fine and smooth, enables the grinding material to be uniformly dispersed, does not bond and return to coarse, has good compatibility with other components in the toothpaste, particularly active substances, and has good compatibility.
S3, after the material is added, stirring by a scraper, homogenizing, stirring and grinding are carried out, the grinding is carried out in a vacuum environment, the vacuum degree is more than-0.096 Mpa, the grinding time is 60min, and in the paste preparation process, the temperature is controlled to be less than or equal to 45 ℃ by jacket cooling water because heat is generated by friction in the kneading and grinding processes.
And S4, kneading and grinding, and then, beating a small amount of paste for testing.
And S5, after the materials are qualified, putting the materials into a paste storage pot for aging, naturally cooling the materials to normal temperature, fully expanding the materials to form a homogeneous adhesive body, and improving the elasticity of the materials, wherein the aging time is 150 min.
And S6, filling the paste by an automatic filling machine.
Example 4:
a preparation method of black garlic toothpaste comprises the following steps:
s1, dissolving water, sorbitol, polyethylene glycol-400, essence, menthol, black garlic extract, sodium benzoate and saccharin sodium in a pre-dissolving pot or a pre-mixing pot with purified water to be uniform, adding a paste making pot, wherein the black garlic extract mainly contains amino acids, polyphenols, proteins, enzymes, glycosides, vitamins, fat, trace elements, carbohydrates, sulfur-containing compounds and other components, the garlicin in the black garlic extract has broad-spectrum antibacterial effect and has killing effect on various pathogenic microorganisms such as influenza virus, pneumococcus, candida, tubercle bacillus, typhoid fever, paratyphoid bacillus, staphylococcus, dysentery bacillus, vibrio cholerae and the like, the component with the sterilizing effect is mainly garlicin, and a white oil-fat liquid 'propylene sulfide' [ (CH2CH 2H 2)2S ], even if the garlicin is diluted by 10 times, the garlicin can still kill the pathogenic microorganisms such as typhoid bacillus, streptococcus pneumoniae, streptococcus, the toothpaste has the advantages that the dysentery bacillus, influenza virus and the like, volatile substances of the black garlic, leachate and allicin have obvious inhibiting or killing effects on various pathogenic bacteria in a test tube, water, sorbitol and polyethylene glycol-400 are used as humectants, the humectants can keep moisture of the toothpaste, when the toothpaste is exposed in air, evaporation of the moisture can be prevented, the toothpaste at a tube opening is not easy to dry and solidify and is easy to extrude, the rheological property of the toothpaste is kept, the mechanical processing is convenient, the freezing point of the toothpaste is reduced, the azeotropic point of the toothpaste is improved, when the toothpaste is thawed after being frozen, moisture separation in the toothpaste is avoided, and the toothpaste is still stable even at high temperature (generally 50 ℃).
S2, respectively metering the liquid materials in the liquid material storage tank into a paste making pot, and then adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, a peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate, wherein the percentage of each component is as follows: water: 20%, sorbitol: 2%, polyethylene glycol-400: 0.5%, calcium hydrogen phosphate: 51%, hydrated silica: 2% of cellulose gum: 5% and essence: 1.5%, menthol: 1.5%, xanthan gum: 2%, peony root extract: 1.5%, black garlic extract: 5%, sodium lauroyl glutamate: 1.5%, tetrasodium pyrophosphate: 2%, sodium saccharin: 1%, sodium lauroyl sarcosinate: 1.5%, sodium benzoate: 2 percent of cellulose gum is a thickening agent which enables the toothpaste to have proper viscosity and consistency, does not feel sticky, has good flowing property, enables the toothpaste to have a framework, enables the extruded toothpaste to stay on a toothbrush and not to collapse, has good strip forming property, is easy to disperse during tooth brushing, has good diffusion property, good self stability and difficult biodegradation, enables the toothpaste to be stable and not to be layered during storage, does not separate water, does not influence the smell and color of the toothpaste, has good stability, enables the toothpaste to be fine and smooth, enables the grinding material to be uniformly dispersed, does not bond and return to coarse, has good compatibility with other components in the toothpaste, particularly active substances, and has good compatibility.
S3, after the material is added, stirring by a scraper, homogenizing, stirring and grinding are carried out, the grinding is carried out in a vacuum environment, the vacuum degree is more than-0.096 Mpa, the grinding time is 60min, and in the paste preparation process, the temperature is controlled to be less than or equal to 45 ℃ by jacket cooling water because heat is generated by friction in the kneading and grinding processes.
And S4, kneading and grinding, and then, beating a small amount of paste for testing.
And S5, after the materials are qualified, putting the materials into a paste storage pot for aging, naturally cooling the materials to normal temperature, fully expanding the materials to form a homogeneous adhesive body, and improving the elasticity of the materials, wherein the aging time is 150 min.
And S6, filling the paste by an automatic filling machine.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Claims (5)
1. The preparation method of the black garlic toothpaste is characterized by comprising the following steps:
s1, dissolving water, sorbitol, polyethylene glycol-400, essence, Mentholum, black Bulbus Allii extract, sodium benzoate, and saccharin sodium with purified water in a pre-dissolving pot or a pre-mixing pot, and adding into a paste-making pot;
s2, respectively adding the liquid materials in the liquid material storage tank into a paste making pot, and adding calcium hydrogen phosphate, cellulose gum, sodium lauroyl sarcosinate, hydrated silica, xanthan gum, a peony root extract, sodium lauroyl glutamate and tetrasodium pyrophosphate;
s3, after the material adding is finished, stirring by a scraper, homogenizing, stirring and grinding;
s4, kneading and grinding, and then beating out a small amount of paste for inspection;
s5, after the materials are qualified, the materials are put into a paste storage pot for aging, the materials are naturally cooled to normal temperature, and meanwhile, the materials are fully expanded to form homogeneous adhesive bodies, so that the elasticity of the materials is improved;
and S6, filling the paste by an automatic filling machine.
2. The preparation method of the black garlic toothpaste according to claim 1, wherein the preparation method comprises the following steps: and grinding in the S3 process under vacuum condition with the vacuum degree higher than-0.096 Mpa for 30-60 min.
3. The preparation method of the black garlic toothpaste according to claim 1, wherein the preparation method comprises the following steps: in the paste preparation process of S3, jacket cooling water is needed to control the temperature to be less than or equal to 45 ℃ in summer because heat is generated by friction in the kneading and grinding processes.
4. The preparation method of the black garlic toothpaste according to claim 1, wherein the preparation method comprises the following steps: the aging time in S5 is 90-150 min.
5. The preparation method of the black garlic toothpaste according to claim 1, wherein the preparation method comprises the following steps: the percentage of each component is as follows: water: 20-40%, sorbitol: 1-2%, polyethylene glycol-400: 0.5-1%, calcium hydrogen phosphate: 25-60%, hydrated silica: 1-2%, cellulose gum: 2-5% and essence: 0.5-1.5%, menthol: 1-1.5%, xanthan gum: 1-2%, peony root extract: 1-1.5%, black garlic extract: 2-5%, sodium lauroyl glutamate: 1.5-2.5%, tetrasodium pyrophosphate: 1-2%, sodium saccharin: 1-2.5%, sodium lauroyl sarcosinate: 1-1.5%, sodium benzoate: 1 to 2 percent.
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Application publication date: 20201106 |