CN109806222A - A kind of toothpaste and preparation method thereof for inhibiting helicobacter pylori - Google Patents
A kind of toothpaste and preparation method thereof for inhibiting helicobacter pylori Download PDFInfo
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- CN109806222A CN109806222A CN201910220996.XA CN201910220996A CN109806222A CN 109806222 A CN109806222 A CN 109806222A CN 201910220996 A CN201910220996 A CN 201910220996A CN 109806222 A CN109806222 A CN 109806222A
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Abstract
The invention discloses a kind of toothpaste and preparation method thereof for inhibiting helicobacter pylori, the component of the toothpaste and the parts by weight of each component are as follows: 1-10 parts of sorb (sugar) alcohol, 50-100 parts of deionized water, 2-8 parts of glycerol, 2-15 parts of silica, 0.02-4 parts of laruyl alcohol sodium sulfovinate, 0.8-2 parts of essence, 5-10 parts of xanthan gum, 0.5-3 parts of sodium cellulose glycolate, 0.1-0.8 parts of tetrasodium pyrophosphate, 1-6 parts of saccharin sodium, 0.1-1.5 parts of methyl hydroxybenzoate, 3-10 parts of olibanum, 2-9 parts of Radix Glycyrrhizae, 3-9 parts of evodia rutaecarpa, 2-6 parts of Java brucea, 3-10 parts of ginseng, 1-2 parts of Moringa, 5-10 parts of Scutellaria baicalensis extract, probiotics 3-10 parts of oral cavity, 2-6 parts of lactoferrin, 0.05-2 parts of lysozyme.Beneficial effect is: being added with Chinese herbal medicine, with the oral cares class product such as herbal health care toothpaste it is similar eliminate bad breath, treating dental ulcer, anti-oral cavity common pathogen reach anti-inflammatory purpose, more there is killing helicobacter pylori, the effect for effectively helicobacter pylori being prevented orally to propagate.
Description
Technical field
The present invention relates to technical field of toothpaste, more particularly to a kind of toothpaste for inhibiting helicobacter pylori and its preparation
Method.
Background technique
Helicobacter pylori disease is a kind of spiral shape, micro- anaerobism, the bacterium very harsh to growth conditions requirement.Survive in people
Body stomach pylorus position, is one of most common bacterial pathogens, research shows that helicobacter pylori is to lead to halitosis, chronic gastritis
Root.Oral cavity is second aggregation ground of the helicobacter pylori in addition to stomach.Pylorus of the presence of oral helicobacter pylori for stomach
The infection of helicobacter and oral health have significant impact.
In the prior art, the method for adding Chinese herbal medicine in toothpaste is mostly used to inhibit bacterium in oral cavity, while right
Tooth carries out health care, can not inhibit to helicobacter pylori.
Summary of the invention
The object of the invention is that provide a kind of for inhibiting the toothpaste of helicobacter pylori to solve the above-mentioned problems
And preparation method thereof.
The present invention through the following technical solutions to achieve the above objectives:
It is a kind of for inhibiting the toothpaste of helicobacter pylori, the component of the toothpaste and the parts by weight of each component are as follows: sorb
1-10 parts of (sugar) alcohol, 50-100 parts of deionized water, 2-8 parts of glycerol, 2-15 parts of silica, laruyl alcohol sodium sulfovinate 0.02-4
Part, 0.8-2 parts of essence, 5-10 parts of xanthan gum, 0.5-3 parts of sodium cellulose glycolate, 0.1-0.8 parts of tetrasodium pyrophosphate, saccharin sodium
1-6 parts, 0.1-1.5 parts of methyl hydroxybenzoate, 3-10 parts of olibanum, 2-9 parts of Radix Glycyrrhizae, 3-9 parts of evodia rutaecarpa, 2-6 parts of Java brucea, ginseng 3-10
Part, 1-2 parts of Moringa, 5-10 parts of Scutellaria baicalensis extract, probiotics 3-10 parts of oral cavity, 2-6 parts of lactoferrin, 0.05-2 parts of lysozyme.
Further, the Scutellaria baicalensis extract is prepared using following methods: scutellaria crushed 40 meshes, be placed in super
In critical extraction kettle, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35MPa, through cycling extraction and keeps constant temperature and pressure
Separator outlet blowing after 1.5~3.5h, obtains Scutellaria baicalensis extract.
Further, the sodium cellulose glycolate uses following methods to be prepared: by weight concentration for 45-52%'s
Sodium hydrate aqueous solution and weight concentration are that the ethanol water of 88-96% mixes in a mixer and is cooled to 10-30 DEG C, then
It is added in kneader, the cellulose crushed in advance is then added in kneader and carries out priming reaction, the control of priming reaction
20-40 DEG C of temperature processed, the mixing time 0.5-2.5h of priming reaction, after priming reaction, it is slowly added into 65%-75% chloroacetic acid
Aqueous solution carries out etherification reaction, and after adding chloroacetic acid aqueous solution, it is anti-to continue etherificate for 30-50 DEG C of the control temperature of etherification reaction
0.4-1h is answered, then heats to 60-80 DEG C, then constant temperature maintains 0.4-1.5h, after etherification reaction, adjustment pH value to neutrality, then
Material is transferred in washing kettle, is cleaned with the ethyl alcohol that concentration is 50%-75%, settle and separate after cleaning, to acquired solution into
Row drying, after crushing to obtain the final product.
The preparation method for the toothpaste that the present invention also provides a kind of for inhibiting helicobacter pylori, this method include following step
It is rapid:
Step 1: glue, by 1-10 parts of sorb (sugar) alcohol, 2-8 parts of glycerol, 0.02-4 parts of laruyl alcohol sodium sulfovinate, xanthan
5-10 parts of glue, 0.5-3 parts of sodium cellulose glycolate, 0.1-0.8 parts of tetrasodium pyrophosphate, 1-6 parts of saccharin sodium, methyl hydroxybenzoate 0.1-
1.5 parts, 3-10 parts of olibanum, 2-9 parts of Radix Glycyrrhizae, 3-9 parts of evodia rutaecarpa, 2-6 parts of Java brucea, 3-10 parts of ginseng, 1-2 parts of Moringa, scutellaria
5-10 parts of extract, probiotics 3-10 parts of oral cavity, 2-6 parts of lactoferrin, 0.05-2 parts of lysozyme in being pre-dissolved pot with deionization
50-100 parts of water are dissolved to uniformly；
Step 2: mixing cream, and dissolved solution is put into cream pot processed, is added 2-15 parts of powder silica, powder adds
After adding, then 0.8-2 parts of essence are added, carries out scraper plate stirring, homogeneous stirring, grinding, obtain creme；
Step 3: vacuum outgas will be mixed the creme after cream and be put into vacuum tank and vacuumizes；
Step 4: examining, get a small amount of lotion and test, and the lotion after qualification carries out next step operation；
Step 5: the lotion after qualification is put into storage pot and is aged, so that material is naturally cooled to room temperature, together by ageing
When material is expanded sufficiently form homogeneous adherend, improve the elasticity of material；
Step 6: it is filling, will after ageing lotion be sent into automatic filling line on carry out it is filling, it is filling after the completion of be packed and stored.
Further, in the step 2, summer need to use collet cooling water control temperature≤45 DEG C.
Further, in the step 3, vacuum degree is -0.096MPa, and the pumpdown time is 50 minutes.
Further, in the step 5, digestion time is 120 minutes.
Further, in the step 6, toothpaste weight and sealing weight need to be inspected periodically.
The beneficial effects of the present invention are: it is added with Chinese herbal medicine, there is the oral cares class products such as herbal health care toothpaste
It is similar eliminate bad breath, treating dental ulcer, anti-oral cavity common pathogen reach anti-inflammatory purpose, more have killing helicobacter pylori, effectively
The effect for preventing helicobacter pylori from orally propagating.
Specific embodiment
Below by embodiment, the present invention is described in further detail, following embodiment be explanation of the invention and
The invention is not limited to following embodiments.
Embodiment one:
It is a kind of for inhibiting the toothpaste of helicobacter pylori, the component of the toothpaste and the parts by weight of each component are as follows: sorb
(sugar) alcohol 8,57 parts of deionized water, glycerol 5,2 parts of silica 1,2 parts of laruyl alcohol sodium sulfovinate, 1 part of essence, 6 parts of xanthan gum,
3 parts of sodium cellulose glycolate, 0.6 part of tetrasodium pyrophosphate, 5 parts of saccharin sodium, 1.4 parts of methyl hydroxybenzoate, 9 parts of olibanum, 8 parts of Radix Glycyrrhizae, Wu
It is 8 parts of the fruit of medicinal cornel, 5 parts of Java brucea, 4 parts of ginseng, 1 part of Moringa, 8 parts of Scutellaria baicalensis extract, 6 parts of oral cavity probiotics, 5 parts of lactoferrin, molten
2 parts of bacterium enzyme.
In the present embodiment, the Scutellaria baicalensis extract is prepared using following methods: scutellaria crushed 40 meshes, be placed in
In supercritical extraction reactor, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35MPa, through cycling extraction and keeps constant temperature permanent
Separator outlet blowing after 1.5~3.5h of pressure, obtains Scutellaria baicalensis extract.
In the present embodiment, the sodium cellulose glycolate uses following methods to be prepared: by weight concentration for 45-52%
Sodium hydrate aqueous solution and weight concentration be 88-96% ethanol water mix in a mixer and be cooled to 10-30 DEG C,
It is then added in kneader, the cellulose crushed in advance is then added in kneader and carries out priming reaction, priming reaction
20-40 DEG C of temperature, the mixing time 0.5-2.5h of priming reaction of control after priming reaction, is slowly added into mono- chloroethene of 65%-75%
Aqueous acid carries out etherification reaction, and 30-50 DEG C of the control temperature of etherification reaction after adding chloroacetic acid aqueous solution, continues to be etherified
0.4-1h is reacted, then heats to 60-80 DEG C, then constant temperature maintains 0.4-1.5h, after etherification reaction, adjustment pH value to neutrality, then
Material is transferred in washing kettle, is cleaned with the ethyl alcohol that concentration is 50%-75%, settle and separate after cleaning, to acquired solution
It is dried, after crushing to obtain the final product.
The preparation method for the toothpaste that the present invention also provides a kind of for inhibiting helicobacter pylori, this method include following step
It is rapid:
Step 1: glue, by 8 parts of alcohol of sorb (sugar), 5 parts of glycerol, 2 parts of laruyl alcohol sodium sulfovinate, 6 parts of xanthan gum, hydroxyl first
3 parts of base sodium cellulosate, 0.6 part of tetrasodium pyrophosphate, 5 parts of saccharin sodium, 1.4 parts of methyl hydroxybenzoate, 9 parts of olibanum, 8 parts of Radix Glycyrrhizae, evodia rutaecarpa 8
Part, 5 parts of Java brucea, 4 parts of ginseng, 1 part of Moringa, 8 parts of Scutellaria baicalensis extract, 6 parts of oral cavity probiotics, 5 parts of lactoferrin, lysozyme 2
Part is dissolved to uniformly in being pre-dissolved pot with 57 parts of deionized water；
Step 2: mixing cream, and dissolved solution is put into cream pot processed, is added 2 parts of powder silica 1, powder addition
After, then 1 part of essence is added, scraper plate stirring, homogeneous stirring, grinding are carried out, creme is obtained；
Step 3: vacuum outgas will be mixed the creme after cream and be put into vacuum tank and vacuumizes；
Step 4: examining, get a small amount of lotion and test, and the lotion after qualification carries out next step operation；
Step 5: the lotion after qualification is put into storage pot and is aged, so that material is naturally cooled to room temperature, together by ageing
When material is expanded sufficiently form homogeneous adherend, improve the elasticity of material；
Step 6: it is filling, will after ageing lotion be sent into automatic filling line on carry out it is filling, it is filling after the completion of be packed and stored.
In the present embodiment, in the step 2, summer need to use collet cooling water control temperature≤45 DEG C.
In the present embodiment, in the step 3, vacuum degree is -0.096MPa, and the pumpdown time is 50 minutes.
In the present embodiment, in the step 5, digestion time is 120 minutes.
In the present embodiment, in the step 6, toothpaste weight and sealing weight need to be inspected periodically.
Embodiment two:
It is a kind of for inhibiting the toothpaste of helicobacter pylori, the component of the toothpaste and the parts by weight of each component are as follows: sorb
3 parts of (sugar) alcohol, 88 parts of deionized water, 4 parts of glycerol, 8 parts of silica, 4 parts of laruyl alcohol sodium sulfovinate, 2 parts of essence, xanthan gum 5
Part, 0.5 part of sodium cellulose glycolate, 0.5 part of tetrasodium pyrophosphate, 2 parts of saccharin sodium, 1 part of methyl hydroxybenzoate, 4 parts of olibanum, 4 parts of Radix Glycyrrhizae,
6 parts of evodia rutaecarpa, 5 parts of Java brucea, 4 parts of ginseng, 4 parts of Moringa, 5 parts of Scutellaria baicalensis extract, 4 parts of oral cavity probiotics, 4 parts of lactoferrin,
2 parts of lysozyme.
In the present embodiment, the Scutellaria baicalensis extract is prepared using following methods: scutellaria crushed 40 meshes, be placed in
In supercritical extraction reactor, extraction temperature is 35~50 DEG C, and extracting pressure is 25~35MPa, through cycling extraction and keeps constant temperature permanent
Separator outlet blowing after 1.5~3.5h of pressure, obtains Scutellaria baicalensis extract.
In the present embodiment, the sodium cellulose glycolate uses following methods to be prepared: by weight concentration for 45-52%
Sodium hydrate aqueous solution and weight concentration be 88-96% ethanol water mix in a mixer and be cooled to 10-30 DEG C,
It is then added in kneader, the cellulose crushed in advance is then added in kneader and carries out priming reaction, priming reaction
20-40 DEG C of temperature, the mixing time 0.5-2.5h of priming reaction of control after priming reaction, is slowly added into mono- chloroethene of 65%-75%
Aqueous acid carries out etherification reaction, and 30-50 DEG C of the control temperature of etherification reaction after adding chloroacetic acid aqueous solution, continues to be etherified
0.4-1h is reacted, then heats to 60-80 DEG C, then constant temperature maintains 0.4-1.5h, after etherification reaction, adjustment pH value to neutrality, then
Material is transferred in washing kettle, is cleaned with the ethyl alcohol that concentration is 50%-75%, settle and separate after cleaning, to acquired solution
It is dried, after crushing to obtain the final product.
The preparation method for the toothpaste that the present invention also provides a kind of for inhibiting helicobacter pylori, this method include following step
It is rapid:
Step 1: glue, by 3 parts of alcohol of sorb (sugar), 4 parts of glycerol, 4 parts of laruyl alcohol sodium sulfovinate, 5 parts of xanthan gum, hydroxyl first
0.5 part of base sodium cellulosate, 0.5 part of tetrasodium pyrophosphate, 2 parts of saccharin sodium, 1 part of methyl hydroxybenzoate, 4 parts of olibanum, 4 parts of Radix Glycyrrhizae, evodia rutaecarpa 6
Part, 5 parts of Java brucea, 4 parts of ginseng, 4 parts of Moringa, 5 parts of Scutellaria baicalensis extract, 4 parts of oral cavity probiotics, 4 parts of lactoferrin, lysozyme 2
Part is dissolved to uniformly in being pre-dissolved pot with 88 parts of deionized water；
Step 2: mixing cream, and dissolved solution is put into cream pot processed, is added 8 parts of powder silica, powder has added
Bi Hou, then 2 parts of essence are added, scraper plate stirring, homogeneous stirring, grinding are carried out, creme is obtained；
Step 3: vacuum outgas will be mixed the creme after cream and be put into vacuum tank and vacuumizes；
Step 4: examining, get a small amount of lotion and test, and the lotion after qualification carries out next step operation；
Step 5: the lotion after qualification is put into storage pot and is aged, so that material is naturally cooled to room temperature, together by ageing
When material is expanded sufficiently form homogeneous adherend, improve the elasticity of material；
Step 6: it is filling, will after ageing lotion be sent into automatic filling line on carry out it is filling, it is filling after the completion of be packed and stored.
In the present embodiment, in the step 2, summer need to use collet cooling water control temperature≤45 DEG C.
In the present embodiment, in the step 3, vacuum degree is -0.096MPa, and the pumpdown time is 50 minutes.
In the present embodiment, in the step 5, digestion time is 120 minutes.
In the present embodiment, in the step 6, toothpaste weight and sealing weight need to be inspected periodically.
The clinical trial of the toothpaste:
Toothpaste 60g is prepared using embodiment one, the formula of embodiment two and method, and embodiment one, embodiment two are made
Standby toothpaste and control toothpaste (ordinary toothpaste without functional component) carries out the negative conversion rate clinical trial of oral cavity pylori.
600 experimenters are chosen first, informed consent form is signed, fills in pre-sifted table, divide three groups: embodiment one group 200
(toothpaste prepared using embodiment one), embodiment two groups 200 (toothpaste prepared using embodiment two) and control group 200
(using control toothpaste).With helicobacter pylori (HP) Test paper on-the-spot test, tester's essential information is filled in.To tester
It is sooner or later primary daily using the toothpaste 10 days, the toothpaste is used according to normal method for brushing teeth, test result is seen below again after 10 days
Table:
| Group | Number of cases | It is effective | It improves | In vain | It is efficient |
| Embodiment one | 200 | 184 | 10 | 6 | 97% |
| Embodiment two | 200 | 171 | 21 | 8 | 96% |
| Control group | 200 | 30 | 13 | 157 | 21.5% |
In conclusion the toothpaste prepared in the present invention, which can press down, kills intraoral helicobacter pylori, prevent harmful in oral cavity
The effect eliminated bad breath may be implemented in the growth of bacterial strain, adjustment Oral health behaviours balance, the toothpaste, is that a good oral cavity is protected
Toothpaste has a vast market.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the present invention is not limited to the above embodiments, and the above embodiments and description only describe originals of the invention
Reason, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements
It all fall within the protetion scope of the claimed invention.
Claims (8)
1. a kind of toothpaste and preparation method thereof for inhibiting helicobacter pylori, it is characterised in that: the component and each group of the toothpaste
The parts by weight of part are as follows: 1-10 parts of sorb (sugar) alcohol, 50-100 parts of deionized water, 2-8 parts of glycerol, 2-15 parts of silica, the moon
0.02-4 parts of cinnamic alcohol sodium sulfovinate, 0.8-2 parts of essence, 5-10 parts of xanthan gum, 0.5-3 parts of sodium cellulose glycolate, pyrophosphoric acid four
0.1-0.8 parts of sodium, 1-6 parts of saccharin sodium, 0.1-1.5 parts of methyl hydroxybenzoate, 3-10 parts of olibanum, 2-9 parts of Radix Glycyrrhizae, 3-9 parts of evodia rutaecarpa, crow
2-6 parts of courage, 3-10 parts of ginseng, 1-2 parts of Moringa, 5-10 parts of Scutellaria baicalensis extract, probiotics 3-10 parts of oral cavity, lactoferrin 2-6
Part, 0.05-2 parts of lysozyme.
2. according to claim 1 a kind of for inhibiting the toothpaste of helicobacter pylori, it is characterised in that: the scutellaria is extracted
Object is prepared using following methods: scutellaria crushed 40 meshes, be placed in supercritical extraction reactor, extraction temperature is 35~50
DEG C, extracting pressure is 25~35MPa, and separator outlet blowing after through cycling extraction and keeping 1.5~3.5h of constant temperature and pressure obtains
Scutellaria baicalensis extract.
3. according to claim 1 a kind of for inhibiting the toothpaste of helicobacter pylori, it is characterised in that: the methylol is fine
Tieing up plain sodium uses following methods to be prepared: for the sodium hydrate aqueous solution of 45-52% and weight concentration being 88- by weight concentration
96% ethanol water mixes in a mixer and is cooled to 10-30 DEG C, is then added in kneader, then in kneader
The cellulose that crushes in advance is added and carries out priming reaction, 20-40 DEG C of the control temperature of priming reaction, when the stirring of priming reaction
Between 0.5-2.5h, after priming reaction, be slowly added into 65%-75% chloroacetic acid aqueous solution and carry out etherification reaction, etherification reaction
30-50 DEG C of temperature of control after adding chloroacetic acid aqueous solution, continues etherification reaction 0.4-1h, then heats to 60-80 DEG C, then
Constant temperature maintains 0.4-1.5h, after etherification reaction, adjustment pH value to neutrality, then material is transferred in washing kettle, it is 50%- with concentration
75% ethyl alcohol is cleaned, and settle and separate after cleaning dries acquired solution, after crushing to obtain the final product.
4. according to claim 1 a kind of for inhibiting the toothpaste of helicobacter pylori, it is characterised in that: preparation method packet
Include the following steps:
Step 1: glue, by 1-10 parts of sorb (sugar) alcohol, 2-8 parts of glycerol, 0.02-4 parts of laruyl alcohol sodium sulfovinate, xanthan gum 5-
10 parts, 0.5-3 parts of sodium cellulose glycolate, 0.1-0.8 parts of tetrasodium pyrophosphate, 1-6 parts of saccharin sodium, 0.1-1.5 parts of methyl hydroxybenzoate,
3-10 parts of olibanum, 2-9 parts of Radix Glycyrrhizae, 3-9 parts of evodia rutaecarpa, 2-6 parts of Java brucea, 3-10 parts of ginseng, 1-2 parts of Moringa, Scutellaria baicalensis extract
5-10 parts, probiotics 3-10 parts of oral cavity, 2-6 parts of lactoferrin, 0.05-2 parts of lysozyme in being pre-dissolved pot with deionized water 50-
100 parts are dissolved to uniformly；
Step 2: mixing cream, and dissolved solution is put into cream pot processed, is added 2-15 parts of powder silica, powder has added
Bi Hou, then 0.8-2 parts of essence are added, scraper plate stirring, homogeneous stirring, grinding are carried out, creme is obtained；
Step 3: vacuum outgas will be mixed the creme after cream and be put into vacuum tank and vacuumizes；
Step 4: examining, get a small amount of lotion and test, and the lotion after qualification carries out next step operation；
Step 5: the lotion after qualification is put into storage pot and is aged, so that material is naturally cooled to room temperature, make simultaneously by ageing
Material, which sufficiently expands, forms homogeneous adherend, improves the elasticity of material；
Step 6: it is filling, will after ageing lotion be sent into automatic filling line on carry out it is filling, it is filling after the completion of be packed and stored.
5. a kind of preparation method of toothpaste for inhibiting helicobacter pylori according to claim 4, it is characterised in that: institute
It states in step 2, summer need to use collet cooling water control temperature≤45 DEG C.
6. a kind of preparation method of toothpaste for inhibiting helicobacter pylori according to claim 4, it is characterised in that: institute
It states in step 3, vacuum degree is -0.096MPa, and the pumpdown time is 50 minutes.
7. a kind of preparation method of toothpaste for inhibiting helicobacter pylori according to claim 4, it is characterised in that: institute
It states in step 5, digestion time is 120 minutes.
8. a kind of preparation method of toothpaste for inhibiting helicobacter pylori according to claim 4, it is characterised in that: institute
It states in step 6, toothpaste weight and sealing weight need to be inspected periodically.
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Cited By (5)
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| CN110538318A (en) * | 2019-09-27 | 2019-12-06 | 中合泰克(南京)生物科技有限公司 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
| CN111714625A (en) * | 2020-07-14 | 2020-09-29 | 湖南大海医药集团有限公司 | Antibacterial paste for killing or inhibiting helicobacter pylori in oral cavity and preparation method thereof |
| CN111888315A (en) * | 2020-09-10 | 2020-11-06 | 山东钰财农业发展有限公司 | Preparation method of black garlic toothpaste |
| CN112316123A (en) * | 2020-12-03 | 2021-02-05 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof |
| CN114831910A (en) * | 2022-04-06 | 2022-08-02 | 广州盛景家庭服务有限公司 | Oral bacteriostatic paste for helicobacter pylori |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110538318A (en) * | 2019-09-27 | 2019-12-06 | 中合泰克(南京)生物科技有限公司 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
| CN111714625A (en) * | 2020-07-14 | 2020-09-29 | 湖南大海医药集团有限公司 | Antibacterial paste for killing or inhibiting helicobacter pylori in oral cavity and preparation method thereof |
| CN111888315A (en) * | 2020-09-10 | 2020-11-06 | 山东钰财农业发展有限公司 | Preparation method of black garlic toothpaste |
| CN112316123A (en) * | 2020-12-03 | 2021-02-05 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof |
| CN114831910A (en) * | 2022-04-06 | 2022-08-02 | 广州盛景家庭服务有限公司 | Oral bacteriostatic paste for helicobacter pylori |
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Application publication date: 20190528 |