CN114831910A - Oral bacteriostatic paste for helicobacter pylori - Google Patents
Oral bacteriostatic paste for helicobacter pylori Download PDFInfo
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- CN114831910A CN114831910A CN202210359493.2A CN202210359493A CN114831910A CN 114831910 A CN114831910 A CN 114831910A CN 202210359493 A CN202210359493 A CN 202210359493A CN 114831910 A CN114831910 A CN 114831910A
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- 241000590002 Helicobacter pylori Species 0.000 title claims abstract description 20
- 229940037467 helicobacter pylori Drugs 0.000 title claims abstract description 20
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 78
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 39
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 26
- 102000016943 Muramidase Human genes 0.000 claims abstract description 17
- 108010014251 Muramidase Proteins 0.000 claims abstract description 17
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 17
- 239000004325 lysozyme Substances 0.000 claims abstract description 17
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 17
- 229960000274 lysozyme Drugs 0.000 claims abstract description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 13
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 13
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 13
- 239000010231 banlangen Substances 0.000 claims abstract description 13
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 13
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 13
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 13
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 13
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims abstract description 13
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 13
- 229960004029 silicic acid Drugs 0.000 claims abstract description 13
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 13
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 13
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 13
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 13
- 239000000600 sorbitol Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000230 xanthan gum Substances 0.000 claims abstract description 13
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 13
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 13
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 13
- 241000894006 Bacteria Species 0.000 claims abstract description 12
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 7
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 7
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 7
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 7
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 7
- 239000004310 lactic acid Substances 0.000 claims abstract description 7
- 235000011477 liquorice Nutrition 0.000 claims abstract description 7
- 229940105902 mint extract Drugs 0.000 claims abstract description 7
- 239000002023 wood Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 30
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 239000009513 Coptidis rhizoma extract Substances 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 6
- 241000186660 Lactobacillus Species 0.000 claims description 6
- 244000269722 Thea sinensis Species 0.000 claims description 6
- 238000007689 inspection Methods 0.000 claims description 6
- 229940039696 lactobacillus Drugs 0.000 claims description 6
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 4
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 3
- 244000247747 Coptis groenlandica Species 0.000 claims description 3
- 239000006071 cream Substances 0.000 abstract description 4
- 231100000344 non-irritating Toxicity 0.000 abstract description 4
- 239000000419 plant extract Substances 0.000 abstract description 4
- 241000589989 Helicobacter Species 0.000 description 3
- 208000007882 Gastritis Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 201000011549 stomach cancer Diseases 0.000 description 2
- 241000282465 Canis Species 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000016644 chronic atrophic gastritis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000011587 gastric lymphoma Diseases 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000001589 lymphoproliferative effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses oral bacteriostatic paste for helicobacter pylori, which comprises the following components in percentage by mass: 20-50 parts of calcium carbonate hydrated silica, 30-50 parts of sorbitol, 10-15 parts of propylene glycol, 20-35 parts of water, 8-12 parts of sodium lauryl sulfate, 3-8 parts of essence, 5-10 parts of xanthan gum, 5-10 parts of cellulose gum, 3-7 parts of sodium benzoate, 1-3 parts of saccharin sodium, 0.5-1.2 parts of mint extract, 0.5-1.2 parts of rhizoma coptidis extract, 0.5-1.2 parts of liquorice extract, 0.5-1.2 parts of radix scutellariae extract, 0.5-1.2 parts of bear gall wood extract, 0.5-1.2 parts of radix isatidis extract, 0.5-1.2 parts of honeysuckle extract, 0.1-1 part of lysozyme, 0.5-1 part of lactic acid bacteria and 0.8-2.5 parts of chlorhexidine acetate. The oral bacteriostatic cream for helicobacter pylori, which adopts the components, contains various natural plant extracts, is mild and non-irritating, and is particularly added with various active components such as lysozyme and the like, so that the oral flora balance is effectively adjusted, bacteria are inhibited, and breath is refreshed.
Description
Technical Field
The invention relates to the technical field of oral bacteriostatic paste, in particular to oral bacteriostatic paste for helicobacter pylori.
Background
Helicobacter pylori includes helicobacter pylori of canine, helicobacter pylori of gastric, helicobacter hei, helicobacter lapenii, and helicobacter sori, and is a gram-negative bacterium, and is a spiroid, microaerophilic, and very demanding in terms of growth conditions. Helicobacter pylori colonizes and infects after reaching gastric mucosa orally, and chronic and superficial gastritis is induced for weeks or months and develops into duodenal ulcer, gastric ulcer, lymphoproliferative gastric lymphoma, chronic atrophic gastritis and the like years or decades later, which is the most dangerous factor for gastric cancer. Gastric cancer is one of the most common malignant tumors worldwide, and ranks second among the causes of cancer death. Therefore, it is important to inhibit helicobacter pylori in the oral cavity.
Disclosure of Invention
The invention aims to provide oral bacteriostatic cream for helicobacter pylori, which contains various natural plant extracts, is mild and non-irritating, is particularly added with various active ingredients such as lysozyme and the like, effectively regulates the balance of oral flora, inhibits bacteria and freshes breath.
In order to achieve the aim, the invention provides an oral bacteriostatic paste for helicobacter pylori, which comprises the following components in percentage by mass: 20-50 parts of calcium carbonate hydrated silica, 30-50 parts of sorbitol, 10-15 parts of propylene glycol, 20-35 parts of water, 8-12 parts of sodium lauryl sulfate, 3-8 parts of essence, 5-10 parts of xanthan gum, 5-10 parts of cellulose gum, 3-7 parts of sodium benzoate, 1-3 parts of saccharin sodium, 0.5-1.2 parts of mint extract, 0.5-1.2 parts of rhizoma coptidis extract, 0.5-1.2 parts of liquorice extract, 0.5-1.2 parts of radix scutellariae extract, 0.5-1.2 parts of bear gall wood extract, 0.5-1.2 parts of radix isatidis extract, 0.5-1.2 parts of honeysuckle extract, 0.1-1 part of lysozyme, 0.5-1 part of lactic acid bacteria and 0.8-2.5 parts of chlorhexidine acetate.
Preferably, the mass fraction of each component is as follows: 40 parts of calcium carbonate hydrated silica, 30 parts of sorbitol, 10 parts of propylene glycol, 20 parts of water, 10 parts of sodium lauryl sulfate, 5 parts of essence, 9 parts of xanthan gum, 9 parts of cellulose gum, 7 parts of sodium benzoate, 3 parts of saccharin sodium, 0.7 part of mint extract, 0.7 part of coptis extract, 0.7 part of liquorice extract, 0.7 part of radix scutellariae extract, 0.7 part of bear gall wood extract, 0.7 part of radix isatidis extract, 0.7 part of honeysuckle extract, 1 part of lysozyme, 1 part of lactic acid bacteria and 2 parts of chlorhexidine acetate.
Preferably, the preparation method of the oral bacteriostatic paste for the helicobacter pylori is characterized by comprising the following steps of:
s1, preparation of mixture a: mixing 30 parts of sorbitol, 10 parts of propylene glycol, 5 parts of essence, 7 parts of sodium benzoate, 3 parts of saccharin sodium and 20 parts of water, and uniformly stirring;
s2, preparation of mixture B: mixing herba Menthae extract 0.7 parts, Coptidis rhizoma extract 0.7 parts, Glycyrrhrizae radix extract 0.7 parts, Scutellariae radix extract 0.7 parts, fel Ursi extract 0.7 parts, radix Isatidis extract 0.7 parts, flos Lonicerae extract 0.7 parts, lysozyme 0.8 parts, lactobacillus 1 parts, and chlorhexidine acetate 2 parts;
s3, premixing: placing the mixture A, the mixture B and 40 parts of calcium carbonate hydrated silica into a premixing pot for premixing for 15 min;
S4, preparing paste: putting the uniformly mixed mixture into a paste making machine, adding 9 parts of xanthan gum, 9 parts of cellulose gum and 10 parts of sodium lauryl sulfate, and then vacuumizing and stirring;
s5, submission: the vacuum is relieved, and then the inspection is carried out, and the tea is aged after being qualified;
s6, filling: and (5) filling the aged and lustered paste.
Therefore, the oral bacteriostatic cream for the helicobacter pylori, which adopts the components, contains various natural plant extracts, is mild and non-irritating, and is particularly added with various active components such as lysozyme and the like, so that the oral flora balance is effectively adjusted, bacteria are inhibited, and breath is refreshed.
Detailed Description
The technical solution of the present invention is further illustrated by the following examples.
Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The use of "first," "second," and similar terms in the present application do not denote any order, quantity, or importance, but rather the terms are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element or item listed before the word covers the element or item listed after the word and its equivalents, but does not exclude other elements or items. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
An oral bacteriostatic paste for helicobacter pylori comprises the following components in percentage by mass: 20-50 parts of calcium carbonate hydrated silica, 30-50 parts of sorbitol, 10-15 parts of propylene glycol, 20-35 parts of water, 8-12 parts of sodium lauryl sulfate, 3-8 parts of essence, 5-10 parts of xanthan gum, 5-10 parts of cellulose gum, 3-7 parts of sodium benzoate, 1-3 parts of saccharin sodium, 0.5-1.2 parts of mint extract, 0.5-1.2 parts of rhizoma coptidis extract, 0.5-1.2 parts of liquorice extract, 0.5-1.2 parts of radix scutellariae extract, 0.5-1.2 parts of bear gall wood extract, 0.5-1.2 parts of radix isatidis extract, 0.5-1.2 parts of honeysuckle extract, 0.1-1 part of lysozyme, 0.5-1 part of lactic acid bacteria and 0.8-2.5 parts of chlorhexidine acetate.
The mass fraction of each component is as follows: 40 parts of calcium carbonate hydrated silica, 30 parts of sorbitol, 10 parts of propylene glycol, 20 parts of water, 10 parts of sodium lauryl sulfate, 5 parts of essence, 9 parts of xanthan gum, 9 parts of cellulose gum, 7 parts of sodium benzoate, 3 parts of saccharin sodium, 0.7 part of mint extract, 0.7 part of coptis extract, 0.7 part of liquorice extract, 0.7 part of radix scutellariae extract, 0.7 part of bear gall wood extract, 0.7 part of radix isatidis extract, 0.7 part of honeysuckle extract, 1 part of lysozyme, 1 part of lactic acid bacteria and 2 parts of chlorhexidine acetate.
A preparation method of oral bacteriostatic paste for helicobacter pylori is characterized by comprising the following steps:
s1, preparation of mixture a: mixing 30 parts of sorbitol, 10 parts of propylene glycol, 5 parts of essence, 7 parts of sodium benzoate, 3 parts of saccharin sodium and 20 parts of water, and uniformly stirring;
s2, preparation of mixture B: mixing herba Menthae extract 0.7 parts, Coptidis rhizoma extract 0.7 parts, Glycyrrhrizae radix extract 0.7 parts, Scutellariae radix extract 0.7 parts, fel Ursi extract 0.7 parts, radix Isatidis extract 0.7 parts, flos Lonicerae extract 0.7 parts, lysozyme 0.8 parts, lactobacillus 1 parts, and chlorhexidine acetate 2 parts;
s3, premixing: placing the mixture A, the mixture B and 40 parts of calcium carbonate hydrated silica into a premixing pot for premixing for 15 min;
s4, preparing paste: putting the uniformly mixed mixture into a paste making machine, adding 9 parts of xanthan gum, 9 parts of cellulose gum and 10 parts of sodium lauryl sulfate, and vacuumizing and stirring;
s5, submission: the vacuum is relieved, and then the inspection is carried out, and the tea is aged after being qualified;
s6, filling: and (5) filling the aged and lustered paste.
Example 1
S1, preparation of mixture a: mixing 30 parts of sorbitol, 10 parts of propylene glycol, 5 parts of essence, 7 parts of sodium benzoate, 3 parts of saccharin sodium and 20 parts of water, and uniformly stirring;
S2, preparation of mixture B: mixing herba Menthae extract 0.7 parts, Coptidis rhizoma extract 0.7 parts, Glycyrrhrizae radix extract 0.7 parts, Scutellariae radix extract 0.7 parts, radix Urticae Cannabinae extract 0.7 parts, radix Isatidis extract 0.7 parts, flos Lonicerae extract 0.7 parts, lysozyme 0.8 parts, lactobacillus 1 parts, and chlorhexidine acetate 1 parts;
s3, premixing: placing the mixture A, the mixture B and 40 parts of calcium carbonate hydrated silica into a premixing pot for premixing for 15 min;
s4, preparing paste: putting the uniformly mixed mixture into a paste making machine, adding 9 parts of xanthan gum, 9 parts of cellulose gum and 10 parts of sodium lauryl sulfate, and then vacuumizing and stirring;
s5, submission: the vacuum is relieved, and then the inspection is carried out, and the tea is aged after being qualified;
s6, filling: and (5) filling the aged and lustered paste.
Example 2
S1, preparation of mixture a: mixing 30 parts of sorbitol, 10 parts of propylene glycol, 5 parts of essence, 7 parts of sodium benzoate, 3 parts of saccharin sodium and 20 parts of water, and uniformly stirring;
s2, preparation of mixture B: mixing herba Menthae extract 0.7 parts, Coptidis rhizoma extract 0.7 parts, Glycyrrhrizae radix extract 0.7 parts, Scutellariae radix extract 0.7 parts, fel Ursi extract 0.7 parts, radix Isatidis extract 0.7 parts, flos Lonicerae extract 0.7 parts, lysozyme 0.8 parts, lactobacillus 1 parts, and chlorhexidine acetate 2 parts;
S3, premixing: placing the mixture A, the mixture B and 40 parts of calcium carbonate hydrated silica into a premixing pot for premixing for 15 min;
s4, preparing paste: putting the uniformly mixed mixture into a paste making machine, adding 9 parts of xanthan gum, 9 parts of cellulose gum and 10 parts of sodium lauryl sulfate, and then vacuumizing and stirring;
s5, submission: the vacuum is relieved, and then the inspection is carried out, and the tea is aged after being qualified;
s6, filling: and (5) filling the aged and lustered paste.
Example 3
S1, preparation of mixture a: mixing 30 parts of sorbitol, 10 parts of propylene glycol, 5 parts of essence, 7 parts of sodium benzoate, 3 parts of saccharin sodium and 20 parts of water, and uniformly stirring;
s2, preparation of mixture B: mixing herba Menthae extract 0.7 parts, Coptidis rhizoma extract 0.7 parts, Glycyrrhrizae radix extract 0.7 parts, Scutellariae radix extract 0.7 parts, radix Urticae Cannabinae extract 0.7 parts, radix Isatidis extract 0.7 parts, flos Lonicerae extract 0.7 parts, lysozyme 0.8 parts, lactobacillus 1 parts, and chlorhexidine acetate 2.5 parts;
s3, premixing: placing the mixture A, the mixture B and 40 parts of calcium carbonate hydrated silica into a premixing pot for premixing for 15 min;
s4, preparing paste: putting the uniformly mixed mixture into a paste making machine, adding 9 parts of xanthan gum, 9 parts of cellulose gum and 10 parts of sodium lauryl sulfate, and then vacuumizing and stirring;
S5, submission: the vacuum is relieved, and then the inspection is carried out, and the tea is aged after being qualified;
s6, filling: and (5) filling the aged and lustered paste.
Therefore, the oral bacteriostatic cream for the helicobacter pylori, which adopts the components, contains various natural plant extracts, is mild and non-irritating, and is particularly added with various active components such as lysozyme and the like, so that the oral flora balance is effectively adjusted, bacteria are inhibited, and breath is refreshed.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the invention without departing from the spirit and scope of the invention.
Claims (3)
1. An oral bacteriostatic paste for helicobacter pylori, which is characterized in that:
the mass fraction of each component is as follows: 20-50 parts of calcium carbonate hydrated silica, 30-50 parts of sorbitol, 10-15 parts of propylene glycol, 20-35 parts of water, 8-12 parts of sodium lauryl sulfate, 3-8 parts of essence, 5-10 parts of xanthan gum, 5-10 parts of cellulose gum, 3-7 parts of sodium benzoate, 1-3 parts of saccharin sodium, 0.5-1.2 parts of mint extract, 0.5-1.2 parts of rhizoma coptidis extract, 0.5-1.2 parts of liquorice extract, 0.5-1.2 parts of radix scutellariae extract, 0.5-1.2 parts of bear gall wood extract, 0.5-1.2 parts of radix isatidis extract, 0.5-1.2 parts of honeysuckle extract, 0.1-1 part of lysozyme, 0.5-1 part of lactic acid bacteria and 0.8-2.5 parts of chlorhexidine acetate.
2. The oral bacteriostatic paste for helicobacter pylori according to claim 1, which is characterized in that: the mass fraction of each component is as follows: 40 parts of calcium carbonate hydrated silica, 30 parts of sorbitol, 10 parts of propylene glycol, 20 parts of water, 10 parts of sodium lauryl sulfate, 5 parts of essence, 9 parts of xanthan gum, 9 parts of cellulose gum, 7 parts of sodium benzoate, 3 parts of saccharin sodium, 0.7 part of mint extract, 0.7 part of coptis extract, 0.7 part of liquorice extract, 0.7 part of radix scutellariae extract, 0.7 part of bear gall wood extract, 0.7 part of radix isatidis extract, 0.7 part of honeysuckle extract, 1 part of lysozyme, 1 part of lactic acid bacteria and 2 parts of chlorhexidine acetate.
3. The preparation method of the oral bacteriostatic paste for helicobacter pylori according to claim 1, characterized in that:
s1, preparation of mixture a: mixing 30 parts of sorbitol, 10 parts of propylene glycol, 5 parts of essence, 7 parts of sodium benzoate, 3 parts of saccharin sodium and 20 parts of water, and uniformly stirring;
s2, preparation of mixture B: mixing herba Menthae extract 0.7 parts, Coptidis rhizoma extract 0.7 parts, Glycyrrhrizae radix extract 0.7 parts, Scutellariae radix extract 0.7 parts, fel Ursi extract 0.7 parts, radix Isatidis extract 0.7 parts, flos Lonicerae extract 0.7 parts, lysozyme 0.8 parts, lactobacillus 1 parts, and chlorhexidine acetate 2 parts;
S3, premixing: placing 40 parts of the mixture A, the mixture B and calcium carbonate hydrated silica into a premixing pot for premixing for 15 min;
s4, preparing paste: putting the uniformly mixed mixture into a paste making machine, adding 9 parts of xanthan gum, 9 parts of cellulose gum and 10 parts of sodium lauryl sulfate, and then vacuumizing and stirring;
s5, submission: the vacuum is relieved, and then the inspection is carried out, and the tea is aged after being qualified;
s6, filling: and (5) filling the aged and lustered paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210359493.2A CN114831910A (en) | 2022-04-06 | 2022-04-06 | Oral bacteriostatic paste for helicobacter pylori |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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| CN111000752A (en) * | 2020-01-06 | 2020-04-14 | 陕西润和堂医药有限公司 | Traditional Chinese medicine toothpaste for resisting helicobacter pylori |
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| CN109806222A (en) * | 2019-03-22 | 2019-05-28 | 姜集大 | A kind of toothpaste and preparation method thereof for inhibiting helicobacter pylori |
| CN111000752A (en) * | 2020-01-06 | 2020-04-14 | 陕西润和堂医药有限公司 | Traditional Chinese medicine toothpaste for resisting helicobacter pylori |
| CN111820407A (en) * | 2020-08-31 | 2020-10-27 | 北京同禧科技有限公司 | Helicobacter pylori-resistant composition and application thereof |
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| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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Application publication date: 20220802 |