CN105726402A - Application of bauhinia championii benth extract to preparing oral nursing product - Google Patents
Application of bauhinia championii benth extract to preparing oral nursing product Download PDFInfo
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- CN105726402A CN105726402A CN201610164940.3A CN201610164940A CN105726402A CN 105726402 A CN105726402 A CN 105726402A CN 201610164940 A CN201610164940 A CN 201610164940A CN 105726402 A CN105726402 A CN 105726402A
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- bauhiniae championii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses application of bauhinia championii benth extract to preparing an oral nursing product, and relates to the technical field of oral nursing. The method has the advantages that the bauhinia championii benth extract is added into the oral nursing healthcare product as a unique active component with effects of preventing and treating decayed teeth in processes for preparing the oral nursing healthcare product, and is safe in use when applied to oral nursing products such as toothpaste, mouthwash and tooth powder, and the obvious effects of preventing and treating the decayed teeth can be realized.
Description
Technical field
The present invention relates to oral care techniques field, especially a kind of have the oral cavity nursing health products preventing and treating dental caries.
Background technology
Dental caries is common clinical, frequently-occurring disease, belongs to bacterial disease, and Streptococcus mutans is the dominant bacteria in Dental plaque biofilm, being main cariogenic bacteria, its cariogenic potential is strong, can not only cause a gap fissure caries, can result in shiny surface dental caries, have substantial connection with dental caries.Streptococcus mutans is adhered to by bacterium surface bonding element and is settled in facing, forms dental plaque, and utilizes carbohydrate to produce acid, causes tooth local environment pH value and decline, enamel decalcification, and then produces dental caries.Therefore, research controls the quantity of Streptococcus mutans, reduces its acid producing ability and that shiny surface adhesive capacity is reduced its cariogenicity is significant, is the most frequently used prevent and treat dental caries method.People always strive to adopt medicine to control or pre-anticariogenic generation in recent years, and early stage, people adopted the antibiotics such as tetracycline, erythromycin, although have certain anti-caries effect, but life-time service can cause oral cavity and alteration of intestinal flora to cause the generation of Other diseases.Fluoride preventing decayed tooth is current most study and the method widely approved, but there is the problem of the aspects such as the stability of fluoride concentration, fluorosis and oral cavity F resistant Strain, makes the application of fluoride there is limitation.
Chinese herbal medicine, owing to toxicity is low, few side effects, the features such as convenience of drawing materials, is subject to common concern and the accreditation of people.Research finds, many Chinese herbal medicine extracts can suppress cariogenic bacteria, can be used for the preventing and treating of dental caries.Thus, screening Chinese herbal medicine carries out dental caries preventing and treating and is increasingly subject to the concern of people, and the oral care product adding natural preventing decayed tooth composition becomes the focus in market.Patent 200310111519.9 proposes a kind of technical scheme combined by three taste Chinese crude drugs such as Fructus Ligustri Lucidi, Flos Lonicerae, Radix Glycyrrhizaes as compound recipe, for the preventing and treating of dental decayed tooth；Patent 201310103450.9 proposes a kind of technical scheme containing sweet tea extract, can reach good pre-anti-caries and improve the effect of oral health；Patent 201210409317.1 proposes the technical scheme of a kind of Radix Gentianae extract, has significant anti-caries effect；Patent 201310374036.1 proposes a kind of technical scheme as preventing and treating anticaries active composition adding Fructus Momordicae extract, for pre-anti-caries and improve oral health；The open Fructus Canarii extract of patent 201310050652.1 has obvious bacteriostasis to bringing out the Streptococcus mutans of dental caries, Streptococcus sobrinus and lactobacillus, the adhesiveness of above-mentioned bacterium can be suppressed, the product acidity of above-mentioned bacterium there is is inhibitory action, is highly suitable for preventing and treating dental caries；Patent 201510238951.7 proposes the application in anti-caries oral care implement of the blade of grass Alga Sgrgassi Enerves extract.Technique scheme is Chinese medicine extract application in oral care product, and preventing and treating dental decayed tooth is had good effect.But the effective ingredient proportioning in some oral care product is also improper, and the actual effect played is extremely limited, can not really improve oral problem.
Summary of the invention
The problem that this invention address that is to provide Caulis Bauhiniae Championii extract application scheme in preparing oral care product, and this oral cavity nursing health products has significantly prevents and treats dental caries effect.
The Caulis Bauhiniae Championii extract of present invention application scheme in preparing oral care product is exactly added in oral cavity nursing health products as the sole active agent preventing and treating dental caries effect by Caulis Bauhiniae Championii extract in the technique prepare oral cavity nursing health products.
In technique scheme, described Caulis Bauhiniae Championii extract is as the sole active agent preventing and treating dental caries effect in preparing toothpaste technique, and described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.1%-10%.
Further: described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.2%-5%.
In such scheme, described Caulis Bauhiniae Championii extract is as the sole active agent preventing and treating dental caries effect in preparing collutory technique, and described Caulis Bauhiniae Championii extract mass percent in the raw material of collutory is 0.1%-10%.
Further: described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.2%-5%.
In such scheme, described Caulis Bauhiniae Championii extract is as the sole active agent preventing and treating dental caries effect in preparing dentifrice technique, and described Caulis Bauhiniae Championii extract mass percent in the raw material of dentifrice is 0.1%-10%.
Further: described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.2%-5%.
Caulis Bauhiniae Championii described in the present invention is the dry rattan of pulse family Caesalpinoidea bauhinia Caulis Bauhiniae Championii.Its sweet in the mouth, micro-hardship, temperature, return liver, large intestine channel, has expelling wind and removing dampness, effect of promoting flow of QI and blood.For rheumatic arthralgia, apoplectic hemiplegia, epigastric distending pain, traumatic injury, the diseases such as children's's skin ulcer is amassed, dysentery.Its contained chemical composition is mainly flavonoid, saccharide, volatile oil etc..Caulis Bauhiniae Championii has anti-inflammatory and analgesic effect, antibacterial action, scavenging activated oxygen effect and Cardiovascular etc..We find under study for action, and oral cavity typical case's cariogenic bacteria Streptococcus mutans is had high inhibition effect by Caulis Bauhiniae Championii extract, can reduce its acid producing ability and to shiny surface adhesive capacity.Make an addition in oral care product, can be used for pre-anti-caries, improve oral health.
The pure extract powder that in oral care product of the present invention, the concentration of Caulis Bauhiniae Championii is all 100% for active component, but it is not limited to extract powder, it is also possible to for extracting solution or extractum etc..In time being applied to oral care product such as extracting solution mode otherwise, the addition in formula should be converted to the amount of the pure form of extract that disclosed in this invention.
In the present invention, the extracting method of Caulis Bauhiniae Championii is: Caulis Bauhiniae Championii is ground into below 100 orders, and by 20 times of 70% soak with ethanol 24 hours, then at 65 DEG C, stirring was extracted 100 minutes, and elimination medicinal residues obtain filtrate, decompression recycling ethanol, obtain Caulis Bauhiniae Championii extract.
The extracting method of Caulis Bauhiniae Championii is not limited to said method, it is possible to adopt additive method to extract, such as supercritical extraction, ultrasonic extraction etc..
Such scheme is in preparing toothpaste technique, described Caulis Bauhiniae Championii extract is the sole active agent preventing and treating dental caries effect as toothpaste, and in the prior art such as friction fit agent, foaming agent, wetting agent, thickening agent, sweeting agent, preservative and spice, toothpaste made by the conventional raw material of toothpaste.Described Caulis Bauhiniae Championii extract mass percent in raw material of toothpaste can be 0.1%-10%, and this content is generally advisable with 0.2%-5%, and other various raw material dosage are by the formula of existing toothpaste manufacturing process.In existing toothpaste manufacturing process formula, other various raw material percentage compositions can be abrasivus 15%-50%, foaming agent 2%-3%, wetting agent 15%-30%, thickening agent 0.8%-1.3%, sweeting agent 0.1%-0.3%, preservative 0.1%-0.3%, the water of spice 0.8%-1.2% and surplus.
Abrasivus therein can be that calcite in powder, any one or silicon dioxide of silicon dioxide powder and calcium hydrogen phosphate are combined；Foaming agent therein can select sodium lauryl sulphate；Wetting agent therein can select sorbitol, it is also possible to selects the combination of sorbitol and propylene glycol, it is also possible to selects the combination of sorbitol and glycerol；Thickening agent therein can select the combination of the combination of sodium carboxymethyl cellulose or itself and guar gum or itself and carrageenan；Sweeting agent therein is generally saccharin sodium；Preservative therein is generally Nipagin complex esters；Spice therein can be Herba Menthae Rotundifoliae or minty note or various fruit essence as required.
In such scheme technique in preparing collutory, described Caulis Bauhiniae Championii extract is the sole active agent preventing and treating dental caries effect as collutory, coordinates other raw materials of collutory in prior art to make collutory.Wherein said Caulis Bauhiniae Championii extract mass percent in collutory raw material can be 0.1%-10%, and this content is generally advisable with 0.2%-5%, and other various raw material dosage are by the formula of existing collutory manufacturing process.In existing collutory manufacturing process formula, other various raw material percentage compositions can be sorbitol 15%-30%, edible ethanol 5%-15%, castor oil hydrogenated is 0.5%-1.0%, saccharin sodium 0.01%-0.1%, preservative 0.1%-0.3%, the water of spice 0.3%-0.5% and surplus.
Such scheme is in the technique preparing dentifrice, and described Caulis Bauhiniae Championii extract is the sole active agent preventing and treating dental caries effect as toothpaste, coordinates other raw materials of dentifrice in prior art to make dentifrice.Wherein said Caulis Bauhiniae Championii extract mass percent in dentifrice raw material can be 0.1%-10%, and this content is generally advisable with 0.2%-5%, and other various raw material dosage are by the formula of existing dentifrice manufacturing process.The compositions such as in existing dentifrice manufacturing process formula, other various raw material percentage compositions can be abrasivus 70%-80%, foaming agent 2%-3%, thickening agent 0.2%-0.4%, sweeting agent 0.1%-0.3%, preservative 0.1%-0.3%, spice 0.8%-1.2%.Abrasivus therein can be that calcite in powder, any one or silicon dioxide of silicon dioxide powder and calcium hydrogen phosphate are combined；Foaming agent therein can select sodium lauryl sulphate；Thickening agent therein can select the combination of the combination of sodium carboxymethyl cellulose or itself and guar gum or itself and carrageenan；Sweeting agent therein is generally saccharin sodium；Preservative therein is generally Nipagin complex esters；Spice therein can be Herba Menthae Rotundifoliae or minty note or various fruit essence as required.
The oral care product preparation process of the present invention adds the Caulis Bauhiniae Championii extract raw material as active component, not only uses safety, and have and prevent and treat dental caries effect significantly.
The present invention is to containing Caulis Bauhiniae Championii extract ora care product, more specifically, carrying out the toothpaste containing Caulis Bauhiniae Championii extract, to suppressing Streptococcus mutans experiment, doing blank and observing simultaneously.Test result indicate that, the toothpaste containing Caulis Bauhiniae Championii extract compares with blank group, can significantly inhibit the growth of Streptococcus mutans, can significantly lower its acid producing ability and to shiny surface adhesive capacity, have and significantly prevent and treat dental caries effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and in following examples, involved percentage ratio except as otherwise noted, is all calculate by percentage to the quality.
Embodiment 1～5: Caulis Bauhiniae Championii extract application in toothpaste
Toothpaste constitutive material in embodiment 1 to embodiment 5 and mass percentage content such as table 1:
。
In the present embodiment 1, lotion of toothpaste adopts the one-step method cream production technology of conventional medicine toothpaste to make: pre-dispersed still abrasivus, sweeting agent, thickening agent, foaming agent, preservative etc. are carried out pre-dispersed, mix.Manufacturing medicine extract machine sucks the liquid materials such as wetting agent, Caulis Bauhiniae Championii extract, water, then resorbs above-mentioned powder, cream processed, be eventually adding essence, can be prepared by lotion of toothpaste.
The lotion of toothpaste production technology of embodiment 2-5 is with reference to embodiment 1.
Embodiment 6～10: Caulis Bauhiniae Championii extract application in collutory
The collutory constitutive material of embodiment 6 to embodiment 10 and mass percentage content such as table 2:
。
In the present embodiment 6, first Caulis Bauhiniae Championii extract, preservative are added stirring and dissolving in edible ethanol.Sorbitol, saccharin sodium, water, castor oil hydrogenated are added stirred tank and stir 10 minutes, then aforementioned alcoholic solution is added, be stirred for 10 minutes, be eventually adding essence, can be prepared by collutory.
The collutory production technology of embodiment 7-10 is with reference to embodiment 6.
Embodiment 11～15: Caulis Bauhiniae Championii extract application in dentifrice
The dentifrice constitutive material of embodiment 11 to embodiment 15 and mass percentage content such as table 3:
。
In the present embodiment 11, first abrasivus, sodium carboxymethyl cellulose, saccharin sodium, sodium lauryl sulphate, Nipagin complex esters are mixed in proportion, be subsequently adding Caulis Bauhiniae Championii extract, be eventually adding essence, sorbitol mix homogeneously, can be prepared by dentifrice.
The dentifrice production technology of embodiment 12-15 is with reference to embodiment 11.
Test of pesticide effectiveness part
Suppress Streptococcus mutans test and result referring to table 4.
Table 4 suppresses Streptococcus mutans test and result (representing with inhibition zone radius mm)
。
In table, data show, the toothpaste group of the embodiment of the present invention 1～5 preparation compares suppression Streptococcus mutans effect aspect with blank group, statistical significance has significant difference (P<0.05), wherein embodiment 4 and embodiment 5 and 0.2% hibitane bacteriostasis are quite (P>0.05), it was shown that the toothpaste group containing Caulis Bauhiniae Championii extract has prevents and treats dental caries effect significantly.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention, although the present invention being described in detail with reference to previous embodiment, for a person skilled in the art, technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature carries out equivalent replacement.All within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.
Claims (7)
1. Caulis Bauhiniae Championii extract application in preparing oral care product, namely adds Caulis Bauhiniae Championii extract in oral cavity nursing health products as the sole active agent preventing and treating dental caries effect in the technique prepare oral cavity nursing health products.
2. the Caulis Bauhiniae Championii extract according to claim 1 application in preparing oral care product, it is characterized in that: described Caulis Bauhiniae Championii extract is as the sole active agent preventing and treating dental caries effect in preparing toothpaste technique, and described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.1%-10%.
3. the Caulis Bauhiniae Championii extract according to claim 2 application in preparing oral care product, it is characterised in that: described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.2%-5%.
4. the Caulis Bauhiniae Championii extract according to claim 1 application in preparing oral care product, it is characterized in that: described Caulis Bauhiniae Championii extract is as the sole active agent preventing and treating dental caries effect in preparing collutory technique, and described Caulis Bauhiniae Championii extract mass percent in the raw material of collutory is 0.1%-10%.
5. the Caulis Bauhiniae Championii extract according to claim 4 application in preparing oral care product, it is characterised in that: described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.2%-5%.
6. the Caulis Bauhiniae Championii extract according to claim 1 application in preparing oral care product, it is characterized in that: described Caulis Bauhiniae Championii extract is as the sole active agent preventing and treating dental caries effect in preparing dentifrice technique, and described Caulis Bauhiniae Championii extract mass percent in the raw material of dentifrice is 0.1%-10%.
7. the Caulis Bauhiniae Championii extract according to claim 6 application in preparing oral care product, it is characterised in that: described Caulis Bauhiniae Championii extract mass percent in total mastic of toothpaste is 0.2%-5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610164940.3A CN105726402B (en) | 2016-03-22 | 2016-03-22 | Dracaena boisiana extract is preparing the application in oral care product |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610164940.3A CN105726402B (en) | 2016-03-22 | 2016-03-22 | Dracaena boisiana extract is preparing the application in oral care product |
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| CN105726402A true CN105726402A (en) | 2016-07-06 |
| CN105726402B CN105726402B (en) | 2019-10-01 |
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| CN201610164940.3A Active CN105726402B (en) | 2016-03-22 | 2016-03-22 | Dracaena boisiana extract is preparing the application in oral care product |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511423A (en) * | 2016-12-15 | 2017-03-22 | 柳州两面针股份有限公司 | Application of annual fleabane herb extract in preparation of mouth care health product |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003011311A1 (en) * | 2001-07-27 | 2003-02-13 | Merck Patent Gmbh | Bauhinia extracts |
| CN102579559A (en) * | 2012-03-31 | 2012-07-18 | 福建中医药大学 | Bauhinia championii ethyl acetate extract, n-butyl alcohol extract, and preparation methods and applications thereof |
| CN103405369A (en) * | 2013-08-26 | 2013-11-27 | 贵州省健康茶科技有限公司 | Tooth-protecting toothpaste |
| CN104840391A (en) * | 2015-05-12 | 2015-08-19 | 上海海洋大学 | Application of sargassum.graminifolium.turn extracts in caries prevention oral care articles |
-
2016
- 2016-03-22 CN CN201610164940.3A patent/CN105726402B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003011311A1 (en) * | 2001-07-27 | 2003-02-13 | Merck Patent Gmbh | Bauhinia extracts |
| CN102579559A (en) * | 2012-03-31 | 2012-07-18 | 福建中医药大学 | Bauhinia championii ethyl acetate extract, n-butyl alcohol extract, and preparation methods and applications thereof |
| CN103405369A (en) * | 2013-08-26 | 2013-11-27 | 贵州省健康茶科技有限公司 | Tooth-protecting toothpaste |
| CN104840391A (en) * | 2015-05-12 | 2015-08-19 | 上海海洋大学 | Application of sargassum.graminifolium.turn extracts in caries prevention oral care articles |
Non-Patent Citations (2)
| Title |
|---|
| 孙幕天，等: "《实用方法辞典》", 30 November 1990, 黑龙江人民出版社 * |
| 孙志胜，等: ""龙须藤研究进展"", 《广东药学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511423A (en) * | 2016-12-15 | 2017-03-22 | 柳州两面针股份有限公司 | Application of annual fleabane herb extract in preparation of mouth care health product |
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