KR101664810B1 - Oral composition and manufacturing method thereof - Google Patents

Abstract

The present invention relates to an oral composition containing: a natural material including trichosanthes seeds, fennel seeds, plantago seeds, Smilax glabra, cornus fruit, and salt; and vegetable oil. The present invention also relates to a manufacturing method of the oral composition. The oral composition has excellent efficacy of improving and preventing gum diseases.

Description

ORAL COMPOSITION AND MANUFACTURING METHOD THEREOF BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

The present invention relates to an oral composition and a method for producing the same.

Oral bacteria form a plaque, which is produced throughout the tooth, and in particular, the plaque between the gum and the tooth is not well removed by conventional brushing, but it is calcified and transformed into tartar to cause tooth decay and gum disease It causes. These oral bacteria are surrounded by fatty membranes or lipid membranes.

Meanwhile, oil pooling is introduced in Ayurveda, a traditional medicine of India. It is a natural gaggle solution for eliminating oral bacteria. It is a principle that absorbs oral bacteria in oil and releases toxins in the body. The oil pooling is performed mainly by putting coconut oil or olive oil into a spoonful and then gagging for about 20 minutes.

However, as a side effect of oil pooling, there is a problem that when some of the oil passes over the back of the neck, it may cause pneumonia, and if there is a wound in the mouth, it may be infected by germs, and if there is amalgam or metal There is a problem that the use time of the cold-pressed olive oil must be shortened.

The present invention relates to a natural product including a gum, a sweet potato, a tea gum, a sweet potato, a corn oil and a salt; And oral compositions containing vegetable oils.

However, the technical problem to be solved by the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.

In one embodiment of the present invention, a natural product including a gum, a sweetener, a tea gum, a green gum, corn oil and salt; And a vegetable oil.

The natural product is 30 to 60% by weight of guluth; 10 to 40% by weight; 5-15% by weight of car electronics; 1 to 10% by weight of earth soil; 5 to 15% by weight of corn oil and 5 to 15% by weight of salt.

The natural product may be extracted, fermented or fermented.

Wherein the extraction is carried out by a solvent comprising at least one selected from the group consisting of water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, a lower ketone having 1 to 4 carbon atoms, a lower ester having 1 to 4 carbon atoms, chloroform, Lt; / RTI >

The vegetable oil may include castor oil and nematic oil.

The weight ratio of the castor oil and the nematic oil may be from 1: 1 to 5: 1.

70 to 90 parts by weight of the natural product and 10 to 30 parts by weight of the vegetable oil may be contained per 100 parts by weight of the oral composition.

The oral composition may be one for inhibiting one or more oral bacteria selected from the group consisting of Streptococcus mutans, Porphyromonas gingivalis and Streptococcus gordonii.

The oral composition may be formulated in the form of powders, granules, tablets, capsules, creams, transparent gels or translucent gels.

In another embodiment of the present invention, there is provided a method for producing an extract, a fermented extract or an extract fermented by extracting a natural product including (a) a gut, a carrot, a tea gut, And (b) adding a vegetable oil to the extract, the fermentation extract or the fermented extract, and mixing the mixture.

The extraction in step (a) may be performed at 80 to 90 for 60 to 70 minutes.

In the step (b), the vegetable oil may include castor oil and nematic oil.

The oral composition containing the natural product and the vegetable oil according to the present invention is excellent in the inhibitory effect on Streptococcus mutans, Porphyromonas gingivalis and Streptococcus gordonii, It is not only excellent in prevention of tooth decay and improvement and prevention of gum disease, but also can prevent oral bacteria from penetrating blood vessels and causing heart disease.

FIG. 1 is a photograph showing the comparison of the degree of gingival inflammation in vivo (a) before using the oral composition prepared in Example 1 and (b) using the toothbrush for three consecutive days for about 30 days.

The present inventors have made oral compositions containing specific natural products and vegetable oils to maximize the oil pooling effect and to minimize side effects, and have studied tooth decay prevention and gum disease prevention and prevention efficacy.

The present invention relates to a natural product including a gum, a sweet potato, a tea gum, a sweet potato, a corn oil and a salt; And a vegetable oil.

First, the oral composition according to the present invention contains a natural product and a vegetable oil. In order to maximize the oil pooling effect, a natural product having a negative energy form is added to the vegetable oil, Oral bacteria can be strongly adsorbed like a magnet to release toxins in the body.

Specifically, the oral composition according to the present invention contains a natural product including a gum, a gum, an algae, a gum, a mineral oil and a salt, wherein the natural product comprises 30 to 60% by weight of gum; 10 to 40% by weight; 5-15% by weight of car electronics; 1 to 10% by weight of earth soil; 5 to 15% by weight of corn oil and 5 to 15% by weight of salt.

The gulouin is a natural ingredient having antimicrobial, anticancer, analgesic, vincine and antipyretic properties as a main ingredient in the natural product. The guluth is preferably contained in the natural product in an amount of 30 to 60 wt%, more preferably 40 to 50 wt%, but is not limited thereto. At this time, when the gulouin is less than the above range, there is a problem that the toxin removal and the anti-inflammatory effect are deteriorated. When the gulouin exceeds the above range, the efficacy according to the other components is deteriorated.

 The above-mentioned confectionery is a natural product having smoothness of metabolism and pain-relieving effect, and it is preferable that the confectionery is contained in the natural product in an amount of 10 to 40% by weight, more preferably 20 to 30% by weight, but is not limited thereto. At this time, when the flavor of the tournament is less than the above range, there is a problem that the odor removal and antibacterial activity are deteriorated, and when the tournament flavor exceeds the above range, there is a problem that the efficacy according to other ingredients is deteriorated.

The secondary electrons are natural substances having toxin and waste elimination and immunity enhancing effect. The secondary electrons are preferably contained in the natural product in an amount of 5 to 15% by weight, more preferably 5 to 10% by weight, Do not. At this time, when the difference electrons are less than the above range, there is a problem that the toxin removal, antibacterial and regeneration promoting effects are deteriorated, and when the difference electrons exceed the above range, the efficacy according to the other components is deteriorated.

The above-mentioned soil treatment is a natural product having toxins, waste elimination, dermatitis alleviation and anti-aging effects. The soil treatment is preferably contained in the natural product in an amount of 1 to 10 wt%, more preferably 1 to 5 wt% But is not limited thereto. At this time, when the soil texture is less than the above range, there is a problem that the efficacy of heavy metals and waste materials is lowered, and when the soil texture is above the above range, there is a problem that the efficacy according to other ingredients is deteriorated.

The natural vegetable oil is a natural product having anticancer, blood circulation improvement, bacterial inhibition and liver function improving effect. The natural vegetable oil is preferably contained in the natural product in an amount of 5 to 15% by weight, more preferably 5 to 10% But is not limited thereto. At this time, when the acid value is less than the above range, there is a problem that the effect of enhancing antifungal, whitening, regeneration and immunity enhancement is deteriorated, and when the acid value of the acid value exceeds the above range,

The salt is used to remove poison, to remove toxins, to kill inflammation, to kill germs, to sterilize the body and to prevent rotting, to repair broken cells, The salt may be baked salt, more preferably 5 to 15% by weight, and more preferably 5 to 15% by weight in the natural product, but is not limited thereto. At this time, by using the salt within the above range, balance among the other components can be achieved.

The natural product may be extracted, fermented or fermented.

Wherein the extraction is carried out by a solvent comprising at least one selected from the group consisting of water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, a lower ketone having 1 to 4 carbon atoms, a lower ester having 1 to 4 carbon atoms, chloroform, And the content of the solid content after the extraction may be 10% to 90%, preferably 30 to 90%, more preferably 40% to 90%.

The extraction is carried out under optimal conditions of 80 to 90 for 60 to 70 minutes to optimize the active ingredient content in the natural product, so that it is excellent in prevention of tooth decay and improvement of gum disease and prevention efficacy, It is possible to prevent the infiltration of blood vessels and the occurrence of heart disease.

In addition, the oral composition according to the present invention contains vegetable oil for oil pooling, and the vegetable oil preferably includes, but is not limited to, castor oil and nematic oil.

In the present invention, vegetable oil includes castor oil, which is also referred to as castor oil and castor oil obtained by squeezing seeds of castor. In addition, the castor oil is characterized in that it contains purified components of ricin (toxic protein) and ricinine (alkaloid), which have a sterilizing action, and is characterized in that the skin (soft tissue) The synergistic effect can be obtained when they are discharged and decrypted and mixed at an appropriate ratio. It is particularly preferable in terms of detoxification to contain 0.1-2 wt% of leucine and 0.1-2 wt% of leucine, preferably 1 ± 0.1 wt% of leucine and 1 ± 0.1 wt% of leucine relative to the total weight of the castor oil , But is not limited thereto. However, it should be noted that the lethal dose of the drug is 7 mg and 160 mg as an adult. The castor oil has antiviral, antibacterial and waste disposal efficacy in the present invention.

In the present invention, the vegetable oil includes nem oil in addition to castor oil. The nem oil is an oil extracted from nymphal, and nympae is rich in fatty acids and contains vitamin E and essential amino acids In the present invention, the nymph oil has an antibacterial and immunity enhancing effect and is characterized by containing purified components of azadirachtin and nimbidin. It is preferred that the composition contains 5 to 15% by weight of azadirachtin, 5 to 15% by weight of nidivine, 10 ± 1% by weight of azadirachtin and 10 ± 1% by weight of nimidivine relative to the total weight of the nematic oil, But is not limited thereto. The nymph oil can be extracted from leaves, stems, flowers, roots, husks, fruits, seeds or a mixture thereof, and the nymph oil is most preferably extracted from the skin in terms of detoxification, but is not limited thereto.

The weight ratio of the castor oil and the nematic oil is preferably 1: 1 to 5: 1, more preferably 1: 1 to 3: 1, but is not limited thereto. At this time, when the weight ratio of castor oil and nematic oil is less than the above range, the effect of sterilizing action is deteriorated. When the weight ratio of castor oil and nematic oil exceeds the above range, the detoxifying action is deteriorated.

That is, when the vegetable oil contains both the castor oil and the nematic oil in a specific weight ratio, it can exert an excellent sterilizing and detoxifying action at the same time. Therefore, it is possible to prevent tooth decay, gum disease disease improvement and prevention efficacy, and in particular, oral bacteria to invade blood vessels to cause heart disease. It is preferable that the natural composition contains 70 to 90 parts by weight of the natural product and 10 to 30 parts by weight of the vegetable oil with respect to 100 parts by weight of the oral composition.

The oral composition may be one for inhibiting one or more oral bacteria selected from the group consisting of Streptococcus mutans, Porphyromonas gingivalis and Streptococcus gordonii.

The Streptococcus mutans is a major bacterium that causes tooth decay. It decomposes organic matter to release acid, causing the tooth to be demineralized by the acid, and the Streptococcus mutans, Porphyromonas gingivalis) is a typical bacterium that causes gingivitis, periodontal disease, and tooth decay among oral bacteria.

In addition, Streptococcus gordonii penetrates into the gut blood vessels and penetrates into the aorta. Since the Streptococcus gordonii is disguised as the blood coagulation factor fibrinogen, the immune system does not work, Can cause. In particular, people with chronic diseases such as arteriosclerosis or hypertension need to work to prevent heart disease through inhibition of Streptococcus gordonii.

Therefore, it is not only excellent in prevention of tooth decay and improvement and prevention of periodontal disease, but also can prevent oral bacteria from penetrating blood vessels and causing heart disease.

The oral composition may be formulated in the form of powders, granules, tablets, capsules, creams, transparent gels or translucent gels. That is, the oral composition is not formulated into a liquid form such as a solution, a suspension, or an emulsion, and has the advantage of minimizing side effects of conventional oil pooling. The pharmaceutical composition may further comprise at least one additive selected from the group consisting of a suitable abrasive, wetting agent, binder, foaming agent, sweetener, preservative, medicinal agent, flavoring agent, acidity regulator and brightener, have. At this time, the additive is preferably contained in an amount of 0.01 to 10 parts by weight based on 100 parts by weight of the oral composition, but is not limited thereto.

The abrasive may be at least one selected from the group consisting of calcium monohydrogenphosphate, precipitated silica, calcium carbonate, hydrated alumina, kaolin, and sodium hypophosphite, preferably calcium monohydrogenphosphate or precipitated silica.

The wetting agent may be at least one selected from the group consisting of glycerin, sorbitol, amorphous sorbitol solution, propylene glycol, polyethylene glycol and xylitol, preferably sorbitol.

Examples of the binder include sodium carboxymethylcellulose, carrageenan, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, guar gum, gellan gum, carbomer, pectin, polyvinylpyrrolidone, carboxyvinylpoly And may be at least one selected from the group consisting of sodium alginate and laponite, preferably sodium carboxymethyl cellulose.

Examples of the foaming agent include anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, and surfactants such as C12-20 alkyl glucoside, sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and polyoxyethylene-polyoxypropylene copolymer Or a group of nonionic surfactants such as cocoaimidopropyl betaine, and preferably C12-20 alkyl glucosides. At this time, C12-20 alkyl glucoside is a condensation reaction product of C12-20 alcohol and glucose, which adsorbs at the interface of components to decrease the surface tension, thereby helping to disperse and emulsify incompatible components.

The sweetening agent may be at least one selected from the group consisting of sodium saccharin, sucralose, maltitol, aspartame, erythritol and licorice acid, preferably sodium saccharin.

The preservative may be a natural preservative or an artificial preservative. Specifically, natural preservatives may be at least one selected from the group consisting of grapefruit seed extract (GSE), NAPRE, and lavender. In this case, the grapefruit seed extract is characterized by having sterilization, disinfection and preservative effect, and napre is a herbal medicine of Sancho, moss, and Baekgohong, and can have an additional preservative effect for about 3 months, . Lavender is a typical natural preservative and has a characteristic that it can have a somewhat stable shelf life even if it does not contain other preservatives separately. The artificial preservative may be at least one selected from the group consisting of p-oxybenzoic acid ester and sodium benzoate. It is more preferable to use grapefruit seed extract or NAPRE as the preservative, but it is not limited thereto.

Examples of the active agent include sodium fluoride, sodium fluorophosphate, calcium fluoride, fluoroamine, chlorhexidine, aminocaproic acid, dipotassium glycyrrhizinate, tranexamic acid, allantoin, caproic acids, polyphosphates, And may be at least one selected from the group consisting of sodium fluoride, and preferably sodium fluoride.

As the fragrance, an appropriate amount of synthetic flavoring agents such as peppermint oil, spearmint oil and the like and menthol flavor and carbohydrate are mixed and used. Preferably, an appropriate amount of anise oil can be mixed with the fragrance in which a certain proportion thereof is mixed.

The present invention also provides a method for producing an extract, a fermented extract or an extract fermented by extracting a natural product including (a) a gut, a carrot, a tea gut, a tobacco gut, a cornstarch oil and a salt; And (b) adding a vegetable oil to the extract, the fermentation extract or the fermented extract, and mixing the mixture.

The step (a) is a step of extracting a natural product including a bamboo, a bean curd, a tea bamboo, a soil bamboo, a corn oil and a salt to produce an extract, a fermented extract or an extracted fermented product, Of a lower alcohol, a lower ketone of 1 to 4 carbon atoms, a lower ester of 1 to 4 carbon atoms, chloroform, and a mixture thereof, and may be made of a solvent containing 80 to 90 to 60 Min to 70 minutes from the standpoint of optimizing the active ingredient content in the natural product, but is not limited thereto. Fermentation may be added before and after the extraction.

Also, considering the optimization of the active ingredient in the natural product and the content of the solid content after the extraction, the weight ratio of the natural product and the solvent is preferably 1:30 to 1:10, but is not limited thereto.

In the step (b), vegetable oil is added to and mixed with the extract, fermented extract or fermented extract. Preferably, the vegetable oil includes castor oil and nematic oil, but is not limited thereto. The above addition can be carried out according to a conventional method in the above-mentioned contents.

Accordingly, the oral composition containing the natural product and the vegetable oil according to the present invention is excellent in both of the inhibitory effect on Streptococcus mutans, Porphyromonas gingivalis and Streptococcus gordonii Bar, prevention of tooth decay, improvement of gum disease and prevention efficacy, as well as preventing oral bacteria from penetrating blood vessels and causing heart disease.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the following examples.

[ Example ]

Example  One

1 part by weight of carnauba wax, 0.5 part by weight of carnauba wax, 0.2 part by weight of carnauba wax, 0.1 part by weight of ground wax, 0.2 part by weight of marine oil and 0.2 part by weight of baked salt, and water at 85 ° C for 65 minutes To obtain an extract (containing 50% solids). To 85 parts by weight of the extract thus prepared, 10 parts by weight of castor oil and 5 parts by weight of nematic oil as vegetable oil were added and mixed to prepare an oral composition.

Comparative Example  One

As the vegetable oil, an oral composition was prepared in the same manner as in Example 1 except that addition and mixing of 10 parts by weight of castor oil and 5 parts by weight of nematic oil were omitted.

Comparative Example  2

As the vegetable oil, 10 parts by weight of castor oil and 5 parts by weight of nematic oil were mixed to prepare an oral composition.

Experimental Example  One

Streptococcus mutans, Porphyromonas gingivalis and Streptococcus gordonii inhibitory effect of the oral composition prepared in Example 1 compared to the oral compositions prepared in Comparative Examples 1 and 2 (September 1, 2015 to September 25, 2015) was conducted by the BioSpectrum Life Science Research Institute for comparison. At this time, 0.1% NaF was used as a control group, and the results are shown in Table 1 below.

Clear zone size (mm) Streptococcus mutans (Streptococcus mutans) Porphyromonas gingivalis (Porphyromonas gingivalis) Streptococcus gordonii Example 1 20 14 14 Comparative Example 1 15 11 0 Comparative Example 2 18 13 0 Control group 18 20 15

As shown in the above Table 1, the oral compositions prepared in Example 1 were superior to the oral compositions prepared in Comparative Examples 1 and 2 with respect to Streptococcus mutans, Porphyromonas gingivalis and Streptococcus It was confirmed that the inhibitory effect of Streptococcus gordonii was excellent. Therefore, it was confirmed that not only tooth decay prevention but also gum disease improvement and prevention efficacy were particularly excellent.

In addition, the oral composition prepared in Example 1 was superior to the oral compositions prepared in Comparative Examples 1 and 2 in the inhibitory effect of Streptococcus gordonii, and Streptococcus gordonii penetrated into blood vessels Thereby preventing the occurrence of heart disease.

Experimental Example  2

To evaluate the efficacy of the prepared oral composition according to Example 1 as a health supplement toothpaste, 50 adult men and women diagnosed with or diagnosed with symptoms such as tooth decay and gum disease were administered the health supplement toothpaste of the oral composition prepared in the Example 3 times a day for about 6 months, and the results were evaluated by a questionnaire. The results are shown in Table 2 below.

Disease name no effect In effect Have a significant effect Cavity prevention effect 3 people (6%) 15 (30%) 32 (64%) Improving and preventing gum disease 4 ~ 5 people (8 ~ 10%) 10 (20%) 37 (74%)

As shown in Table 2, it was confirmed that the health supplement toothpaste of the oral composition prepared in the Examples effectively relieved gingival inflammation and effectively inhibited oral bacteria, and was particularly excellent in prevention and prevention of gum disease as well as prevention of tooth decay.

FIG. 1 is a photograph comparing the degree of gingival inflammation in vivo (a) before use of the oral composition prepared in Example 1 and (b) using the toothbrush for three consecutive days for about 30 days.

As shown in FIG. 1, when a patient having a yellow gum inflammation around the implant cover (born in 1951, female) repeatedly used the health supplement toothpaste of the oral composition prepared in Example 1 three times a day for about 30 days, It was confirmed that the yellow gum inflammation disappeared around the implant cover.

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (12)

Natural products including ginseng, konjac, ginseng, goshi, corn oil and salt; And
Castor oil, and nematic oil,
The weight ratio of the castor oil and the nematic oil is 1: 1 to 3: 1,
In order to inhibit Streptococcus gordonii
Oral composition.
The method according to claim 1,
The natural product is 30 to 60% by weight of guluth; 10 to 40% by weight; 5-15% by weight of car electronics; 1 to 10% by weight of earth soil; From 5 to 15% by weight of corn oil and from 5 to 15% by weight of salt
Oral composition.
The method according to claim 1,
The natural product may be extracted, fermented, fermented
Oral composition.
The method of claim 3,
Wherein the extraction is carried out by a solvent comprising at least one selected from the group consisting of water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, a lower ketone having 1 to 4 carbon atoms, a lower ester having 1 to 4 carbon atoms, chloroform, Done
Oral composition.
delete delete The method according to claim 1,
Wherein 70 parts by weight to 90 parts by weight of the natural product and 10 to 30 parts by weight of the vegetable oil are contained per 100 parts by weight of the oral composition
Oral composition.
The method according to claim 1,
The oral composition is intended to further inhibit oral bacteria of Streptococcus mutans or Porphyromonas gingivalis
Oral composition.
The method according to claim 1,
The oral composition may be formulated in the form of powders, granules, tablets, capsules, creams, transparent gels or translucent gels
Oral composition.
(a) preparing an extract, a fermented extract or an extracted fermentation product of a natural product including a gut, a carrot, a tea, a green tea, a corn oil and a salt; And
(b) adding and mixing vegetable oil containing castor oil and nematic oil to the extract, fermented extract or fermented extract,
The weight ratio of the castor oil and the nematic oil is 1: 1 to 3: 1,
In order to inhibit Streptococcus gordonii
≪ / RTI >
11. The method of claim 10,
The extraction in the step (a) is carried out at 80 to 90 DEG C for 60 to 70 minutes
≪ / RTI >
delete

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