WO2017086653A1 - Oral composition and method for preparing same - Google Patents

Abstract

The present invention relates to an oral composition containing: a natural substance comprising trichosanthes seeds, fennel seeds, plantago seeds, Smilax glabra, cornus fruit and a salt; and vegetable oil, and a method for preparing the same.

Description

Oral composition and preparation method thereof

This application claims the priority of Korean Patent Application No. 10-2015-0161974 filed on November 18, 2015, the entirety of which is a reference of the present application.

The present invention relates to a composition for oral cavity and a method for producing the same.

Oral bacteria form plaques, which are formed throughout the teeth, especially those between the gums and the teeth that are not easily removed by conventional brushing, but also calcified and turn into tartar causing dental caries and gum disease. Cause. These oral bacteria are surrounded by fat or lipid membranes.

Meanwhile, oil pooling was introduced in Ayurveda, a traditional Indian medicine book, and is a natural goggle solution for removing oral bacteria, and it is a principle of releasing toxins in the body by adsorbing oral bacteria in oil. Oil pooling is usually done by putting coconut oil or olive oil in a spoonful of mouth and gargle for about 20 minutes.

However, as a side effect of oil pooling, if some of the oil passes over the back of the neck, it may cause pneumonia. If there is a wound in the mouth, it may be rather infected with bacteria through the wound, and if there is amalgam or metal in the teeth, There is a problem in that the use of cold press olive oil should be shortened.

The present invention is a natural product, including the parenthesis, gyunyanghyang, chajeon, Tobokyeong, cornus and salt; And oral compositions containing vegetable oils.

In addition, the present invention is a natural product, including the parenthesis, gyunyanghyang, chajeon, Tobokyeong, cornus and salt; And to provide a method for preventing caries and gum disease improvement and prevention comprising administering an oral composition containing a vegetable oil.

Furthermore, the present invention is a natural product, including a balsamin, competition fragrances, chajeonja, bokbokyeong, cornus and salt for the prevention of tooth decay and gum disease improvement and production of a preventive agent; And oral compositions containing vegetable oils.

However, the technical problem to be achieved by the present invention is not limited to the above-mentioned problem, another task that is not mentioned will be clearly understood by those skilled in the art from the following description.

In one embodiment of the present invention, natural products, including gug luin, convention fragrance, chajeon, Tobokyeong, cornus and salt; And oral compositions containing vegetable oils.

The natural product is 30 to 60% by weight of the guru; 10 to 40% by weight of the fragrance; 5-15% by weight of electrons; Tobok age 1-10 wt%; It may include 5-15% by weight of cornus oil and 5-15% by weight of salt.

The natural product may be extracted, fermented or extracted and fermented.

The extraction is performed by a solvent comprising at least one selected from the group consisting of water, anhydrous or hydrous lower alcohols of 1-4 carbon atoms, lower ketones of 1-4 carbon atoms, lower esters of 1-4 carbon atoms, chloroform and mixtures thereof. Can be done.

The vegetable oil may include castor oil and nim oil.

The weight ratio of the castor oil and the nim oil may be 1: 1 to 5: 1.

With respect to 100 parts by weight of the oral composition, it may contain 70 parts by weight to 90 parts by weight of the natural product and 10 parts by weight to 30 parts by weight of the vegetable oil.

The oral composition may be for inhibiting one or more oral bacteria selected from the group consisting of Streptococcus mutans, Porphyromonas Gingivalis, and Streptococcus Gordonii.

The oral composition may be formulated in the form of a powder, granules, tablets, capsules, creams, transparent gels or translucent gels.

In another embodiment of the present invention, (a) extracting a natural product, including the parenthesis, gyunyanghyang, chajeonja, Tobokyeong, cornus and salt to prepare an extract, fermented extract or extract fermentation; And (b) provides a method for producing an oral composition comprising the step of adding and mixing the vegetable oil to the extract, fermented extract or extract fermentation.

Extraction in step (a) may be performed for 60 to 70 minutes at 80 ℃ to 90 ℃.

The vegetable oil in step (b) may include castor oil and nim oil.

Oral compositions containing natural and vegetable oils according to the present invention are excellent in inhibiting both Streptococcus mutans, Porphyromonas Gingivalis and Streptococcus Gordonii, In addition to excellent caries prevention and gum disease prevention and prevention efficacy, oral bacteria can penetrate blood vessels and prevent heart disease.

1 is a photograph comparing the degree of gum inflammation in vivo (b) in vivo after (a) and steadily using for about 30 days three times a day before using the health supplement toothpaste of the oral composition prepared in Example 1.

The present inventors prepared a composition for oral cavity containing specific natural products and vegetable oils in order to maximize the oil pooling effect while minimizing side effects, and studied caries prevention and gum disease improvement and prevention efficacy.

The present invention is a natural product, including the parenthesis, gyunyanghyang, chajeon, Tobokyeong, cornus and salt; And oral compositions containing vegetable oils.

First, the oral composition according to the present invention contains a natural product and a vegetable oil, in order to maximize the oil pooling effect, by adding a natural product having a negative energy form to the vegetable oil, having a positive energy form Oral bacteria can be strongly adsorbed like magnets to release toxins from the body.

Specifically, the oral composition according to the present invention contains a natural product including a parenthesis, gyunhyang fragrance, chacha, Tobokyeong, cornus and salt, wherein the natural product is 30 to 60% by weight of the parenthesis; 10 to 40% by weight of the fragrance; 5-15% by weight of electrons; Tobok age 1-10 wt%; It may include 5-15% by weight of cornus oil and 5-15% by weight of salt.

The guru luin is a main component in the natural product, and is a natural product having antibacterial, anticancer, analgesic, antitussive and antipyretic effects. The guru luin is preferably included in the natural product 30 to 60% by weight, more preferably 40 to 50% by weight, but is not limited thereto. At this time, when the guruin is less than the above range, there is a problem that the toxin removal and anti-inflammatory efficacy is lowered, and if the guruluin exceeds the above range, there is a problem that the efficacy according to other components is lowered.

 The convention fragrance is a natural product having a smooth and pain relief effect of metabolism, the convention fragrance is preferably included in the natural product 10 to 40% by weight, more preferably 20 to 30% by weight, but is not limited thereto. At this time, when the meeting fragrance is less than the above range, there is a problem that bad breath removal and antimicrobial efficacy is lowered, and when the meeting fragrance exceeds the above range, there is a problem that the efficacy according to the other components is reduced.

The charger is a natural product having toxins and waste removal and immunity enhancing effects, and the charger is preferably contained in an amount of 5 to 15% by weight, more preferably 5 to 10% by weight, but is not limited thereto. Do not. At this time, when the chager is less than the above range, there is a problem that the toxin removal, antibacterial and regeneration promoting efficacy is lowered, and when the chaeon exceeds the above range, there is a problem that the efficacy of other components is lowered.

The Tobokyeong is a natural product having toxins and waste removal, dermatitis alleviation and anti-aging efficacy, the Tobokyeong is preferably contained 1 to 10% by weight in the natural product, more preferably 1 to 5% by weight, It is not limited to this. At this time, when the abdomen age is less than the above range, there is a problem that the efficacy of discharging heavy metals and waste products is reduced, and when the abdomen age exceeds the above range, there is a problem that the efficacy according to other components is lowered.

The cornus milk is a natural product having anti-cancer, blood circulation improvement, bacterial inhibition and liver function-improving effect, the cornus milk is preferably contained in the natural product 5-15% by weight, more preferably 5-10% by weight, It is not limited to this. At this time, if the cornus milk is less than the above range, there is a problem that the antifungal, whitening, regeneration promoting and immune-enhancing efficacy is lowered, and if the cornus milk exceeds the above range, there is a problem that the efficacy according to other components is lowered.

The salt is a detoxifying action to remove the poison, anti-inflammatory action to remove inflammation, sterilization and antiseptic action to kill bacteria and prevent the body from rotting, and restore damaged cells. By doing so, the salt may be grilled salt, it is preferably included 5 to 15% by weight in the natural product, more preferably 5 to 10% by weight, but is not limited thereto. At this time, by using the salt within the above range, it is possible to balance the other components.

The natural product may be extracted, fermented or extracted and fermented.

The extraction is performed by a solvent comprising at least one selected from the group consisting of water, anhydrous or hydrous lower alcohols of 1-4 carbon atoms, lower ketones of 1-4 carbon atoms, lower esters of 1-4 carbon atoms, chloroform and mixtures thereof. The content of the solid content after the extraction may be 10% to 90%, preferably 30 to 90%, more preferably 40% to 90%.

The extraction is performed under the optimum conditions for 60 minutes to 70 minutes at 80 ℃ to 90 ℃, it is possible to optimize the active ingredient content in the natural product, as well as to prevent tooth decay and improve gum disease and prevent efficacy, oral It can prevent bacteria from penetrating blood vessels and causing heart disease.

In addition, the oral composition according to the present invention contains a vegetable oil for oil pulling, and the vegetable oil preferably includes castor oil and nim oil, but is not limited thereto.

Vegetable oil in the present invention includes castor oil, the castor oil (castor oil) is a fat oil obtained by pressing the seed of the castor, also called castor oil. In addition, the castor oil is characterized in that the tablet contains a component of lysine (toxic protein) and lyricin (alkaloid), which has a bactericidal action, lowers swelling of the skin (soft tissue) and pus. The synergistic effect can be obtained by detoxification and mixing at the proper ratio. It is particularly preferable in terms of detoxifying action to include 0.1-2% by weight of lysine and 0.1-2% by weight of lysine, preferably 1 ± 0.1% by weight of lysine and 1 ± 0.1% by weight of lysine, relative to the total weight of castor oil It is not limited to this. However, it should be noted that the lethal doses of the toxins are lysine 7mg and richin 160mg. The castor oil has antiviral, antibacterial and waste excretion effects in the present invention.

In the present invention, the vegetable oil includes, in addition to castor oil, the neem oil, and the neem oil is an oil extracted from the neem tree, which is rich in fatty acids, and contains vitamin E, essential amino acids, and the like. In addition, the neem oil has an antibacterial and immune enhancing effect in the present invention, and is characterized in that it contains azadirachtin and a component of nimbidin. Compared to the total weight of the Nim oil, it is 5 to 15% by weight of azadilactin, 5 to 15% by weight of animadidine, preferably 10 ± 1% by weight of azadilactin and 10 ± 1% by weight of nimvidin, in particular in terms of bactericidal action Preferred but not limited thereto. The neem oil may be extracted from the leaves, stems, flowers, roots, bark, fruit, seeds or mixtures thereof of the neem tree, and the extract from the bark is most preferred in terms of detoxification, but is not limited thereto.

The weight ratio of the castor oil and the nim oil is preferably 1: 1 to 5: 1, more preferably 1: 1 to 3: 1, but is not limited thereto. At this time, when the weight ratio of castor oil and nim oil is less than the above range, there is a problem that the effect of the sterilization action is lowered, and when the weight ratio of castor oil and nim oil exceeds the above range, there is a problem that the detoxification action is reduced.

That is, when the vegetable oil contains both castor oil and nim oil in a specific weight ratio, it can exert excellent sterilization and detoxification effects simultaneously. Due to this, it is possible to prevent tooth decay and gum disease improvement and prevention effect, in particular, oral bacteria can penetrate blood vessels and cause heart disease. It is preferable to contain 70 parts by weight to 90 parts by weight of the natural product and 10 parts by weight to 30 parts by weight of the vegetable oil with respect to 100 parts by weight of the oral composition, but is not limited thereto.

The oral composition may be for inhibiting one or more oral bacteria selected from the group consisting of Streptococcus mutans, Porphyromonas Gingivalis, and Streptococcus Gordonii.

The Streptococcus mutans is a major bacterium that causes tooth decay (tooth caries), and decomposes organic matter and releases acid and causes demineralization of teeth by these acids, and the porphyromonas gingivalis Porphyromonas Gingivalis) is a representative bacterium that causes gingivitis, periodontal disease, and tooth decay.

In addition, Streptococcus Gordonii penetrates the blood vessels of the gum and into the aorta. Streptococcus Gordonii penetrates the heart due to the inability of the immune system to act as a blood coagulation factor, fibrinogen. Can cause. In particular, chronic diseases such as arteriosclerosis and hypertension need to try to prevent heart disease by suppressing Streptococcus Gordonii.

Therefore, it is possible to prevent tooth decay and improve gum disease and prevent efficacy, and to prevent oral bacteria from penetrating blood vessels and causing heart disease.

The oral composition may be formulated in the form of a powder, granules, tablets, capsules, creams, transparent gels or translucent gels. That is, the oral composition is characterized in that it is not formulated in liquid form, such as in the form of a solution, suspension or emulsion, there is an advantage that can minimize the side effects of the existing oil pooling. For the formulation may further comprise one or more additives selected from the group consisting of suitable abrasives, wetting agents, binders, foaming agents, sweetening agents, preservatives, agonists, flavors, acidity regulators and brighteners commonly used in the manufacture of pharmaceutical compositions. have. In this case, the additive is preferably included in an amount of 0.01 to 10 parts by weight based on 100 parts by weight of the oral composition, but is not limited thereto.

The abrasive may be one or more selected from the group consisting of calcium monohydrogen phosphate, precipitated silica, calcium carbonate, hydrous alumina, kaolin and sodium bicarbonate, preferably calcium monohydrogen phosphate or precipitated silica.

The wetting agent may be at least one selected from the group consisting of glycerin, sorbitol, amorphous sorbitol liquid, propylene glycol, polyethylene glycol, and xylitol, and preferably sorbitol.

The binder is sodium carboxymethyl cellulose, carrageenan, xanthan gum, hydroxyethyl cellulose, hydroxypropylmethylcellulose, hydroxypropyl cellulose, guar gum, gellan gum, carbomer, pectin, polyvinylpyrrolidone, carboxyvinyl poly It may be one or more selected from the group consisting of sodium alginate and laponite, preferably sodium carboxymethyl cellulose.

Examples of the foaming agent include anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, C12-20 alkyl glucosides, sorbitan fatty acid esters, polyoxyethylene-cured castor oil, and polyoxyethylene-polyoxypropylene copolymers. It may be at least one selected from the group consisting of nonionic surfactants or amphoteric surfactants such as cocoidopropylbetaine, preferably C12-20 alkyl glucoside. In this case, C12-20 alkyl glucoside is a condensation reaction of C12-20 alcohol and glucose, and may help to disperse and emulsify the immiscible components by adsorbing at the interface of the components to reduce the surface tension.

The sweetener may be at least one selected from the group consisting of sodium saccharin, sucralose, maltitol, aspartame, erythritol, and licoriceic acid, preferably sodium saccharin.

As the preservative, natural preservatives or artificial preservatives may be used. Specifically, the natural preservative may be one or more selected from the group consisting of grapefruit seed extract (GSE), napri (NAPRE) and lavender. At this time, the grapefruit seed extract is characterized in that it has a bactericidal, disinfecting and antiseptic effect, napri is a herbal medicine of Sancho, moss, Baekduhong, can have an additional antiseptic effect of about 3 months, no problems due to troubles and other raw materials It is characterized by excellent compatibility with the field, lavender is a typical natural preservative is a feature that can have a stable storage date to some extent even if it does not contain other preservatives separately. It may be at least one selected from the group consisting of paraoxybenzoic acid ester and sodium benzoate as an artificial preservative. More preferably, grapefruit seed extract or napri (NAPRE) is used as the preservative, but is not limited thereto.

The medicament agents include sodium fluoride, sodium fluoride phosphate, monofluoride, fluorinated amine, chlorhexidine, aminocaproic acid, dipotassium glycyrizine, tranexamic acid, allotoin, capronic acid, polyphosphate, enzymes and herbal extract It may be at least one selected from the group consisting of, preferably sodium fluoride.

The fragrance is used by mixing an appropriate amount of natural flavors such as peppermint oil, spearmint oil and synthetic flavors such as menthol, carbon, and preferably, an appropriate amount of anise oil may be mixed with the fragrance mixed with a certain ratio.

In addition, the present invention comprises the steps of (a) extracting the natural product, including the parenthesis, gyunyanghyang, chajeon, Tobokyeong, cornus and salt to prepare an extract, fermented extract or extract fermentation; And (b) provides a method for producing an oral composition comprising the step of adding and mixing the vegetable oil to the extract, fermented extract or extract fermentation.

The step (a) is a step of preparing an extract, fermented extract or extractive fermentation product by extracting natural products including gwalyeoin, gyunyanghyang, chajeon, Tobokyeong, cornus and salt, the extraction is water, carbon number 1-4 Anhydrous or hydrous lower alcohols, lower ketones of 1-4 carbon atoms, lower esters of 1-4 carbon atoms, chloroform, and mixtures thereof. It is preferably performed for from minutes to 70 minutes in terms of optimizing the active ingredient content in the natural product, but is not limited thereto. Fermentation may be added before and after the extraction.

In addition, considering the optimization of the active ingredient in the natural product and the content of the solid content after the extraction, the weight ratio of the natural product and the solvent is preferably 1:30 to 1:10, but is not limited thereto.

The step (b) is a step of adding and mixing the vegetable oil to the extract, fermented extract or fermentation extract, the vegetable oil preferably includes castor oil and nim oil, but is not limited thereto. The addition may be carried out according to conventional methods in the above-mentioned content.

Therefore, the composition for oral cavity containing natural and vegetable oils according to the present invention is excellent in inhibiting both Streptococcus mutans, Porphyromonas Gingivalis and Streptococcus Gordonii. Bars, caries prevention and gum disease improvement and prevention efficacy is excellent, as well as oral bacteria can be prevented from penetrating blood vessels and causing heart disease.

Hereinafter, preferred examples are provided to aid in understanding the present invention. However, the following examples are merely provided to more easily understand the present invention, and the contents of the present invention are not limited by the following examples.

EXAMPLE

Example 1

Natural products and water, including 1 part by weight of kwaruin, 0.5 part by weight of crab, 0.2 part by weight of chacha, 0.1 part by weight of Tobok-ryong, 0.2 part by weight of cornus oil and 0.2 part by weight of grilled salt, were mixed at 85 ° C. in a 1:19 weight ratio for 65 minutes. Extraction to prepare an extract (containing 50% solids). To 85 parts by weight of the prepared extract as a vegetable oil, 10 parts by weight of castor oil and 5 parts by weight of nim oil were added and mixed to prepare an oral composition.

Comparative Example 1

As the vegetable oil, an oral composition was prepared in the same manner as in Example 1, except that 10 parts by weight of castor oil and 5 parts by weight of nim oil were omitted.

Comparative Example 2

As the vegetable oil, an oral composition was prepared by mixing 10 parts by weight of castor oil and 5 parts by weight of nim oil.

Experimental Example 1

Inhibitory Effect of the Oral Compositions Prepared in Example 1 Compared to the Oral Compositions Prepared in Comparative Examples 1 and 2, Streptococcus mutans, Porphyromonas Gingivalis and Streptococcus Gordonii To compare the results, an antimicrobial efficacy test (disk diffusion test) was performed by the Biospectrum Life Science Institute (September 1, 2015 to September 25, 2015). At this time, 0.1% NaF was used as a control, and the results are shown in Table 1 below.

	Clear zone size (mm)
	Streptococcus mutans	Porphyromonas Gingivalis	Streptococcus Gordonii
Example 1	20	14	14
Comparative Example 1	15	11	0
Comparative Example 2	18	13	0
Control	18	20	15

As shown in Table 1, the oral composition prepared in Example 1 is compared to the oral compositions prepared in Comparative Examples 1 and 2, Streptococcus mutans, Porphyromonas Gingivalis and Streptococcus It was confirmed that all of the inhibitory effects of Streptococcus Gordonii were excellent. Therefore, it was confirmed that not only caries prevention but also gum disease improvement and prevention efficacy were particularly excellent.

In addition, the oral composition prepared in Example 1 has a particularly excellent effect of inhibiting Streptococcus Gordonii, compared to the oral compositions prepared in Comparative Examples 1 and 2, and Streptococcus Gordonii penetrates into blood vessels. It was confirmed that it can also prevent the occurrence of heart disease.

Experimental Example 2

To evaluate the efficacy of the oral composition prepared in Example 1 as a health supplement toothpaste, the health supplemental toothpaste of the oral composition prepared in Example was administered to 50 adult men and women who complained or diagnosed symptoms such as tooth decay and gum disease. Three times a day was used continuously for about six months, the effect was evaluated by a survey, the results are shown in Table 2 below.

Disease name	no effect	In effect	Significant effect
Caries prevention effect	3 people (6%)	15 people (30%)	32 people (64%)
Improve and prevent gum disease	4 to 5 people (8 to 10%)	10 people (20%)	37 people (74%)

As shown in Table 2, the health supplement toothpaste of the oral composition prepared in the embodiment was found to be particularly excellent in reducing gum inflammation and effectively inhibiting oral bacteria, as well as preventing tooth decay and improving gum disease.

1 is a photograph comparing the degree of gum inflammation in vivo (a) and steadily using for about 30 days before (a) and three times a day before using the health supplement toothpaste of the oral composition prepared in Example 1.

As shown in Figure 1, a patient (born in 1951, female) in the state of yellow gum inflammation around the implant cover as a result of using the health supplement toothpaste of the oral composition prepared in Example 1 for about 30 days three times a day, Yellow gum inflammation disappeared around the implant cover.

The foregoing description of the present invention is intended for illustration, and it will be understood by those skilled in the art that the present invention may be easily modified in other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are exemplary in all respects and not restrictive.

Claims (12)

1. Natural products, including walnuts, scents, chajeon, Tobokyeong, cornus and salt; And

   Containing vegetable oils

   Oral composition.
2. The method of claim 1,

   The natural product is 30 to 60% by weight of the guru; 10 to 40% by weight of the fragrance; 5-15% by weight of electrons; Tobok age 1-10 wt%; Comprising 5-15% by weight of cornus oil and 5-15% by weight of salt

   Oral composition.
3. The method of claim 1,

   The natural product is extracted, fermented or extracted and fermented

   Oral composition.
4. The method of claim 3,

   The extraction is performed by a solvent comprising at least one selected from the group consisting of water, anhydrous or hydrous lower alcohols of 1-4 carbon atoms, lower ketones of 1-4 carbon atoms, lower esters of 1-4 carbon atoms, chloroform and mixtures thereof. Made up

   Oral composition.
5. The method of claim 1,

   The vegetable oil includes castor oil and nim oil

   Oral composition.
6. The method of claim 5,

   The weight ratio of the castor oil and the nim oil is 1: 1 to 5: 1

   Oral composition.
7. The method of claim 1,

   100 parts by weight of the oral composition, containing 70 parts by weight to 90 parts by weight of the natural product and 10 parts by weight to 30 parts by weight of the vegetable oil.

   Oral composition.
8. The method of claim 1,

   The oral composition is for inhibiting one or more oral bacteria selected from the group consisting of Streptococcus mutans, Porphyromonas Gingivalis and Streptococcus Gordonii.

   Oral composition.
9. The method of claim 1,

   The oral composition is formulated in the form of a powder, granules, tablets, capsules, creams, transparent gels or translucent gels

   Oral composition.
10. (a) extracting a natural product including a parenthesis, gyunhyang fragrance, cha-cha, bokbokyeong, cornus and salt to prepare an extract, fermented extract or extract fermentation; And

    (b) adding and mixing vegetable oils to the extract, fermented extract or fermented extract;

    Method for preparing the oral composition.
11. The method of claim 10,

    Extraction in the step (a) is carried out for 60 to 70 minutes at 80 ℃ to 90 ℃

    Method for preparing the oral composition.
12. The method of claim 10,

    In the step (b) the vegetable oil comprises castor oil and nim oil

    Method for preparing the oral composition.

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