KR0149483B1 - Antiplague compositions - Google Patents

Abstract

Oral hygiene composition comprising one or two or more herbal extracts selected from chodugu, munmundong, hyunggeul, neck skin and gardenia.

Description

Oral Hygiene Composition Containing Herbal Extracts

The present invention relates to a composition for preventing or treating periodontal disease and preventing oral hygiene and having excellent effects, and more particularly, applying the herbal ingredient extracted from a herbal medicine to an oral composition to prevent and treat periodontal disease, and to prevent tooth decay. It relates to a composition for enhancing oral hygiene.

Dental diseases could already be found in Egyptian mummies that formed ancient cultures, and in the 3,000 BC Babylon and Assyrians used records of medicinal herbs or dentifrices to prevent and treat tooth decay and periodontal disease. (Ramirex, JM et al, Periodont, Abst. 18: 139-142, 1970).

In the Orient, it is known that Chinese medicine was used to treat oral diseases by inflammation, periodontal disease and tooth decay by Hwang-Fi in 2,697 BC.

To date, studies on plaque as a cause of dental diseases have been actively conducted by antibiotics, enzymes, and other chemical agents as plaque inhibitors by various medicines. In particular, the use of herbal medicine for the treatment of dental diseases in the countries of the East, mainly in Korea, and is applied to various prescriptions.

Known herbal extracts extracted from herbal medicines and applied to periodontal disease include berberine extracts extracted from yellow and white and applied to oral compositions (JP-A-57-56, 415, et al. 57-85, 319), Compounds containing licorice extract or those containing herbal extracts such as bone stalks, leukostatitis, fat milk, lotus root and leaf loaves (Japanese Patent Laid-Open No. 55-120, 509) and the like are known.

The present inventors have anti-inflammatory action, hemostatic action, plaque formation inhibitory effect in the process of extracting and confirming effective ingredients for tooth decay disease and periodontal disease centering on the medicines used for periodontal disease and the medicinal herbs used in the private sector in the prior literature. Excellent, good bad breath removal effect, good taste to find an extract with excellent feeling and to complete the present invention.

The herbal extract of the present invention was prepared by steam distillation extraction, ethanol extraction and methanol extraction. Steam distillation extracts medicinal herbs in a fine or controlled state into an extractor and boils with water to extract the herbal ingredients and concentrate or dry them, or distill water so that steam is incorporated into the extractor. The extract was filtered to extract the extract, and the resultant was concentrated under reduced pressure and dried to obtain a granulated state. Ethanol and methanol extracts were prepared according to the percolation method, and concentrated under reduced pressure to make granules or as a tank. use.

More specifically, the present invention provides a composition for enhancing oral hygiene, containing one or two or more herbal extracts selected from cedar, munmundong, mold opening, neck peel, and gardenia.

Oral hygiene-promoting composition of the present invention preferably contains only 0.01 to 10% by weight of the total weight of the composition of the herbal extracts alone or mixed two or more kinds. When the component is used at 0.01 wt% or less, the effect of preventing, treating and preventing tooth decay is weakened. When used at 10 wt% or more, each component of the extract lowers the usability of the product due to its unique taste.

In the present invention, the herbal extract is in a granular state, and the content thereof is preferably 0.01 to 5% by weight. In addition, the herbal extract in the present invention is a tin agent and the content is preferably 0.05 to 10% by weight.

Oral hygiene-promoting composition of the present invention as a medicinal ingredient excellent in preventing or treating periodontal disease, treatment and tooth decay effects on conventional ingredients such as toothpaste, mouthwash, denture cleaner, chewing gum, oral products, such as chondura, pulmonary dong, mold opening, abdominal skin , Extracts of gardenia, etc. can be prepared by using single or two or more kinds.

The present invention is formulated using an appropriate amount of the component commonly used according to the type and purpose of the oral composition as a component. For example, the toothpaste components of the present invention may contain conventional abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, fragrances, PH adjusters, brighteners and the like.

Examples of the abrasive include potassium carbonate, calcium dihydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium metaphosphate, and zirconium silicate. These abrasives may be used alone or in combination of two or more thereof, preferably 20 to 60% by weight. 20 to 50% by weight is used.

As the humectant, 20 to 60% by weight, preferably 20 to 50% by weight, of glycerin, sorbitol solution, and amorphous sorbitol solution alone or in combination of two or more thereof is used.

As the binder, 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight of carrageenan, xanthan gum, sodium carboxymethyl cellulose, carboxy vinyl polymer (trade name: Carbopol), sodium alginate, or a mixture of two or more thereof is preferably used. .

As the foaming agent, anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, sorbitan fatty acid esters, polyoxyethylene-cured castor oil, polyoxyethylene polyoxypropylene-based condensed polymer materials, etc. may be used alone or in a mixture. To 5% by weight, preferably 0.5 to 2.5% by weight.

Examples of sweeteners include saccharan sodium, aspartame, stevioside, and licorice acid, and suitable amounts of 0.05 to 0.5 wt% are used alone or in mixture of two species.

As the preservative, paraoxybenzoic acid ester, benzoic acid, sodium benzoate is used alone or in mixture of two species.As a medicinal agent, sodium fluoride, chlorohexidine, tranexamic acid, allantoin, capronic acid, licorice extract, sanphenone extract Use narin extract, yellow white extract, berberine and glycyrrhizin. As a flavoring agent, a suitable amount of peppermint oil, spearmint oil, menthol, and carbon are mixed. As a pH adjuster, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid and sodium stannate are used. The range is 5 to 8% by weight. Titanium oxide is used as the brightener, and preferably 0.1 to 5% by weight.

Experimental Example 1

This test is a test of the bactericidal activity of herbal extracts against oral microorganisms.

[Medicinal Herb Extracts]

Gapuk, Licorice, Gyeji, Gold and Silver Coins, Rhubarb, Doin, Macmun-dong, Peel, Peel, Gilgyeong, Sesin, Yeongyo, Injinho, Cheongung, Chodugu, Hyeonggae, Golden, Yellow White, Gardenia

[Test strain]

Streptococcus mutans 10449, serotype C

Rothia dentocariosa

Streptococcus mitis

Actinomyces viscosus

[Test Methods]

0.1 g of each extract was added to 10 mm of BHI (Brain Heart Infusion), and then inoculated with the strain cultured for 1 to 2 days, and then cultured for 1 to 2 days.

[Experiment result]

The bactericidal test, chondura bulb, plantain, pulmonary dong, hyunggae, neck skin, Injinho, Hwangbaek, and Gardenia showed significant effects.

[Examples 1-3]

In order to prepare the toothpaste composition in the composition for promoting oral hygiene, a small amount of powder components such as sodium carboxymethyl cellulose, saccharin, and preservatives are dispersed in an amorphous sorbitol liquid as a wet component, diluted with purified water, and then mixed in a mixer firstly. Abrasives, such as calcium dihydrogen phosphate, were mixed.

And finally, the toothpaste composition was prepared by adding a foaming agent sodium sulfate, stabilizers, fragrance components, etc. and tertiary mixing under vacuum. The preparation of the other oral hygiene-promoting compositions was made according to conventional manufacturing procedures.

Comparison of the plaque production adverse effects and gingivitis relief effects of Examples 1 to 3 and Comparative Examples 1 to 4 toothpaste

Experimental Example 2

Tooth plaque formation inhibitory effect was tested using the toothpaste of Examples 1 to 3 and Comparative Examples 1 to 4 of Table 2.

Experimental Structure

Streptococcus mutans 10449, serotype C

Experimental Method

end. Experimental incubator is incubated in BHI medium (Brain-heart infusion agar) and inoculated in THB medium (Todd Hewit Broth) with the bacteria incubated at 37 ℃ for 15 to 16 hours.

I. For plaque formation inhibition test, prepare a glass rod with a diameter of 2mm and a length of 7cm, sterilize at 180 ℃ for 2 hours, and weigh.

All. The glass rod was placed in a test tube containing THB medium containing 1% sucrose (w / v), and a test solution of the toothpaste of Examples and Comparative Examples was added at a constant concentration, followed by adding 0.1 mm of streptococcal mutanz to 37 ° C. Incubate for 24 hours.

la. After incubation, carefully lift the glass rod and dry it at 37 ° C for one day, and then measure the final weight. The control group is the test group without the test solution.

* Preparation of test solution of toothpaste

Make a 50% by weight solution of each toothpaste, remove the insolubles by centrifugation, and use the filtrate as a test solution.

[Experiment result]

The experimental results are shown in Table 3 below.

The results of Table 3 showed that Examples 1 to 3 and Comparative Examples 2 to 3 are effective in inhibiting plaque formation.

Experimental Example 3

Table 2 was used to compare the gingival inflammation relief effect using the toothpaste of Examples 1-3 and Comparative Examples 1-4.

The toothpaste of the present invention and the comparative example toothpaste was brushed three times daily (for 3 minutes each) for 20 days and the color change of the gum was measured to compare and maintain the health condition and improvement effect of the gums. For color change, I80 color difference meter of all colors of Japan was used.

Normally, healthy gums have a higher brightness index, higher redness, and lower yellowness. That is, a bright red color will appear.

[Experiment result]

Examples 1 to 3 show a clear red color as compared to Comparative Example 1 and Comparative Example 4 shows excellent gingival inflammation alleviating effect, Comparative Examples 2 to 3 have excellent gingivitis alleviating effect but unique of the herbal extract contained in toothpaste The toothpaste feeling was poor because of the taste.

Example 4 Toothpaste

Calcium Hydrogen Monoxide 40.0%

Hydrous alumina 5.0%

Titanium Oxide 1.0%

Amorphous Sorbitol Liquid 30.0%

Alkyl sodium sulfate 1.5%

Zaccarin Sodium 0.1%

Paraoxybenzoic acid ester 0.1%

Carboxymethylcellulose Sodium 1.0%

Green bean extract 0.1%

Mold opening extract 0.1%

Licorice Extract 0.1%

Spices 1.0%

100.0% by adding purified water

Example 5 Oral Cleanser

Ethanol (90%) 20.0%

Glycerin (98%) 10.0%

Polyoxyethylene Polyoxy 1.0%

Propylene copolymer

Super Chill Extract 01.%

Gardenia extract 0.1%

Macmundong Extract 0.1%

Zaccarin Sodium 0.1%

Spices 1.0%

100.0% by adding purified water

Example 6 Denture Cleaner (Tablet)

Sodium bicarbonate 30.0%

Tartaric acid 27.0%

Sodium Cocoyl Sarcosate 5.0%

Sodium Lauryl Sulfate 5.0%

Benzalconium chloride 2.0%

EDTA Sodium 5.0%

Sodium tripolyphosphate 14.0%

Polyethylene Glycol 2.0%

Super bean extract 0.2%

Mold opening extract 0.1%

Spices

Example 7 Chewing Gum

Gum base 25.0%

Sorbitol 44.0%

Mannitol 12.0%

Glycerin 13.0%

Lexidine 0.5%

Sweetener 2.0%

Green bean extract 0.1%

Macmundong Extract 0.1%

Mold opening extract 0.1%

Spices

It can be seen that Examples 1 to 7 all have excellent effects on preventing, treating and preventing tooth decay.

Claims (6)

Oral hygiene composition with bactericidal effect, plaque formation inhibitory effect and gingival inflammation relieving effect, characterized in that it contains one or two or more herbal extracts selected from the pulse worm, mold opening, neck peel and gardenia together with the head extract. According to claim 1, wherein the extract is in a granular state, the content of the oral hygiene composition, characterized in that the content of 0.01 to 5% by weight. The composition of claim 1 or 2, wherein the composition for promoting oral hygiene is toothpaste. The composition according to claim 1 or 2, wherein the composition for promoting oral hygiene is an oral cleaning agent. The composition of claim 1 or 2, wherein the composition for promoting oral hygiene is a positional cleanser. The composition according to claim 1 or 2, wherein the composition for promoting oral hygiene is chewing gum.