KR0138248B1 - The oral cavity hygienic compositions - Google Patents

Abstract

The present invention relates to a composition for enhancing oral hygiene, containing one or two of Yarrow, Horse chestnut (Horse chestnut) plant extract.

Description

Oral Hygiene Composition Containing Plant Extracts

The present invention relates to an oral hygiene-promoting composition excellent in preventing, treating and preventing tooth decay, and more particularly, by applying a plant extract extracted from a medicinal plant to an oral composition, to prevent and treat periodontal disease. It relates to a composition for enhancing oral hygiene.

Brushing teeth using toothbrushes and toothpaste is the most common way to maintain oral hygiene. The reason for using toothpaste is to brush teeth with abrasives and detergents, making mechanical plaque easier, lubricating the tooth surface, and making your mouth cleaner and more refreshing. However, it is not easy to obtain sufficient maintenance of oral hygiene and prevention of dental caries and periodontal disease by this method of removing plaque, so many people have gingival inflammation and the incidence of periodontal disease and the resulting tooth loss increase with age. It is the situation. Thus, many studies have been conducted on substances having bactericidal effects against the causative bacteria of Streptococcus mutans and periodontal diseases (Actinomyces Viscosus, Bacteroides gingivalis, Rothia dentocariosa, Streptococcus mitis, etc.). , Enzymes, metal salts and the like are known a lot.

It has been widely used in the private sector for thousands of years, and is effective in causative agents of caries and periodontal disease, such as chamomile, myrrh, ratany, sage, echinacea, etc. (S. de Rysky; Journal of Clinical Dentistry Vol.I, Supplement A. A22-24, 1988), Sanguinaria Extract (US Pat. No. 4,689,216), Hops Extract (Japanese Laid Open Patent) Japanese Patent Application Laid-Open No. 62-138,420), extracts such as Sage and Rosemary (Japanese Laid-Open Patent Publication No. 58-134,013) and the like are known.

In the present invention, while extracting 30 kinds of plant extracts excellent in the effect of inhibiting plaque formation, anti-inflammatory, hemostatic, and bad breath caused by caries, the extract of Yarrow and Horse Chestnut, etc. The present invention has been found to be excellent in the effect of inhibiting plaque formation, reducing inflammation, and the like.

It has been widely used as a popular folk medicine since the Greek hero Achilles during the Trojan war Ca. 1200 BC was used to stop blood flowing from the injuries of his men, especially cancer, tumors and inflammation. , Cramps, viral, toothache, wounds, etc. (JADuke: Handbook of Medicinal Herbs, Herbs, CRC press, 9-10, 1985).

The plant extract of the present invention is prepared using steam distillation, polar and nonpolar organic solvents. Steam distillation extracts short-cut medicinal plants into an extractor, distills water into the extractor, and when the steam is incorporated into the extractor, the active ingredient of the herbal medicine is extracted (the internal temperature of the extractor is adjusted to about 90 ℃). ). At this time, the extracted extract is collected, filtered and concentrated under reduced pressure to make a granular state. Polar and nonpolar organic solvent extraction is prepared according to the percolation method and concentrated under reduced pressure. As the organic solvent, ethanol, methanol, acetone, nucleic acid, benzene, water-ethanol and the like are used.

More specifically, the present invention provides a composition for promoting oral hygiene containing one or two kinds of vinegar or horse chestnut plant extract.

Oral hygiene-promoting composition of the present invention is to contain a plant extract alone or two kinds are mixed 0.02 to 4.5% by weight, preferably 0.05 to 3% by weight of the total weight of the composition.

When the plant extract components are used at less than 0.02% by weight, the periodontal disease prevention, treatment and caries prevention effect is weak, and when used at more than 4.5% by weight, the unique taste of each component of the extract lowers the feeling of use of the product.

Oral hygiene-promoting composition according to the present invention is an oral product toothpaste, mouthwash, denture cleaning, chewing gum and other common ingredients as excellent medicinal ingredients excellent in preventing periodontal disease prevention, treatment and tooth decay (Yarrow), Maronier (Horse) chestnut) Plant extract can be prepared by mixing alone or two kinds.

The other component of the present invention was formulated using an appropriate amount of the component normally used according to the kind and purpose of the oral composition. For example, the toothpaste composition of the present invention may contain abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, medicinal agents, flavoring agents, pH adjusters, brighteners and the like as conventional toothpaste components.

Examples of the abrasive include calcium carbonate, calcium dihydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium metaphosphate, zirconium silicate, and these abrasives alone or in combination of two or more thereof, 20 to 60% by weight, preferably 20 To 50% by weight.

As the humectant, 20 to 60% by weight, preferably 20 to 50% by weight of glycerin, sorbitol solution, and amorphous sorbitol solution alone or in mixture of two or more thereof are used.

As the binder, 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight of carrageenan, xanthan gum, sodium carboxymethyl cellulose, carboxy vinyl polymer (trade name Carbopol), sodium alginate, or the like may be used alone or in combination of two or more thereof. .

As the foaming agent, anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, sorbitan fatty acid esters, polyoxyethylene-cured castor oil, polyoxyethylene polyoxypropylene-based condensed polymer materials, etc. may be used alone or in combination of two or more thereof. 0.5 to 5% by weight, preferably 0.5 to 2.5% by weight is used.

As a sweetener, saccharin sodium, aspartame, stevioside, licorice acid, etc. may be used alone or in combination of two or more, and 0.05 to 0.5% by weight is used.

As a preservative, paraoxy benzoic acid ester, benzoic acid, and sodium benzoate are used individually or in mixture of 2 or more types. Pharmacologic agents include sodium fluoride, chlorohexidine, tranexamic acid, allantoin, capronic acid, licorice extract, sanphenone, raw guinea extract, sulfur white extract, chamomile extract, ratani extract, myrrh extract, sage extract Use incense extracts, hop extracts, and Echinacea extracts. As a fragrance, a suitable amount of peppermint oil, spearmint oil, menthol, and carbon are mixed and used as a pH adjuster. Phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid and sodium stannate are used. The range is 5 to 8, and titanium oxide is preferably 0.5 to 5% by weight as the brightener.

Hereinafter, the present invention will be described in detail based on the experimental examples and examples.

Example 1 Test of Sterilization of Plant Extracts against Oral Microorganisms

Plant Extract Types

Arnica, Birch, Chamomile,

Ginseng, Hay Flower, Henna neutral,

Rosemary, Sage,

Yarrow, House chestnut, etc.

Test strain

Streptococcus mutans 10449, serotype C

Rothia dentocariosa

Streptococcus mitis

Actinomyces Viscocus

Experiment method

0.1 g of each extract was added to 10 milliliters of Brain Heart Infusion (BHI), and then inoculated with strains cultured for 1 to 2 days, followed by 1 to 2 days of culture, and the number of viable cells was measured.

Experiment result

As a result of bactericidal activity, plant extracts such as marigold and horse chestnut showed significant effects.

Note) Sterilization power criteria

◎: Viable cell count 1.0 × 10 ⁵ or less

○: Number of viable cells 1.0 × 10 ⁶ or less to 1.0 × 10 ⁵ or more

X: Number of viable cells 1.0 × 10 ⁷ or more

Control bacteria: Number of live bacteria 1.0 × 10 ⁸ or less

Examples 1-2

Toothpaste composition of the composition for oral hygiene is prepared by dispersing a small amount of carboxy methyl cellulose sodium, saccharin, preservatives and the like in a wet crystalline sorbitol liquid, diluted with purified water, and then mixed first in a mixer, and then Abrasives, such as monocalcium phosphate, were mixed with it. And finally, the toothpaste composition was prepared by adding a foaming agent sodium sodium sulfate, stabilizers, flavoring ingredients and tertiary mixing under vacuum. The preparation of other oral hygiene neutralizing compositions was made according to a conventional manufacturing procedure.

Example 1 to 2 and Comparative Examples 1 to 3 toothpaste inhibitory effect, gingival inflammation alleviating effect comparison experiment

Example 2

Inhibition of plaque formation was tested using the toothpastes of Examples 1 to 2 and Comparative Examples 1 to 3 of Table 2.

Experimental strain

Streptococcus mutans (S. mutans 104449, serotype C)

Experiment method

end. The experimental strains were incubated in Brain Heart Infusion agar (BHI), and the bacteria were inoculated in THB (Todd Hewit Broth) with platinum and incubated at 37 ° C. for 15-16 hours.

I. For the plaque formation inhibition test, a glass rod having a diameter of 2 mm and a length of 7 cm is prepared, sterilized in a dryer at 180 ° C. for 2 hours, and weighed.

All. The glass rod was placed in a test tube containing THB containing 1% sucrose (w / v), and a test solution of the toothpaste of Examples and Comparative Examples was added at a constant concentration. Then, 0.1 mm of Strep Coca's Mutans was added thereto at 37 ° C. Incubate for 24 hours.

la. After incubation, carefully lift the glass rod and dry it at 37 ° C for one day, and then measure the final weight. The control group is the test group without the test solution.

* Preparation of Toothpaste Test Solution: Make a 50% by weight solution of each toothpaste, remove insolubles by centrifugation, and use the blank as a test solution.

Experiment result

The results in Table 3 show that Examples 1 and 2 and Comparative Example 2 have the effect of inhibiting plaque formation.

Experimental Example 3

Example 1 to 2 of Table 2 and the toothpaste of Comparative Examples 1 to 3 were used to compare the gingival inflammation relieving effect.

The toothpaste of the present invention and the comparative example toothpaste was brushed three times daily (for 3 minutes each) for 20 days and the color change of the gum was measured to compare and maintain the health condition and improvement effect of the gums. For color change, I80 color difference meter was used.

Normally, healthy gums have a higher brightness index, higher redness, and lower yellowness. That is, a bright red color will appear.

Experiment result

Examples 1 to 2 and Comparative Example 2 shows a clear red color compared to Comparative Examples 1 and 3 shows excellent gingival inflammation alleviating effect, Comparative Example 2 has excellent gingival inflammation alleviating effect but unique to plant extracts contained in toothpaste The toothpaste feeling was poor because of the taste.

Example 3: Mouthwash

Ethanol (90%) 20.0%

Glycerin (98%) 10.0%

Polyoxyethylene

Polyoxypropylene Copolymer 1.0%

Yarrow Extract 0.1%

Zaccarin Sodium0.1%

Fragrance1.0%

Purified water add 100.0%

Example 4 Denture Cleaner (Tablet)

Sodium bicarbonate 30.0%

Tartaric acid27.0%

Sodium Cocoyl Sarcosate 5.0%

Sodium Lauryl Sulfate5.0%

Benzalkonium Chloride2.0%

EDTA Sodium5.0%

Sodium tripolyphosphate14.0%

Polyethylene Glycol2.0%

Yarrow Extract 0.2%

Horse Chestnut Extract 0.2%

Perfumery

Example 5

Gum base 25.0%

Sorbitol44.0%

Mannitol 12.0%

Glycerin13.0%

Lexidine0.5%

Sweetener 2.0%

Yarrow Extract 0.1%

Fragrance

Examples 1 to 5 all had excellent effects on preventing, treating and preventing tooth decay.

Claims (7)

Oral hygiene-promoting composition containing one or two of Yarrow, Horse chestnut (Horse chestnut) plant extract. The oral hygiene composition according to claim 1, which contains 0.02 to 4.5% by weight of one or two plant extracts. The composition for enhancing oral hygiene according to claim 1, which contains 0.05 to 3.0% by weight of one or two plant extracts. The composition according to claim 1, 2 or 3, wherein the composition for promoting oral hygiene is a toothpaste. The composition according to claim 1, 2 or 3, wherein the composition for promoting oral hygiene is a mouthwash. The composition according to claim 1, 2 or 3, wherein the composition for promoting oral hygiene is a denture cleaner. The composition according to claim 1, 2 or 3, wherein the composition for promoting hygiene is chewing gum.