KR0121550B1 - Tooth dentifrice composition - Google Patents

Abstract

The formulation that controls oral plaque is prepared by combining 0.005-5.0% w/w plant extract(s) of dandelion, lonicera japonica, scutellaria baicalensis Googi, denia jasminoides elles, pulsatilla koreana, and/or arrowroot with additives, such as a polishing agent, humectant, foaming agent, binder, flavor enhancer, etc.

Description

Oral Composition

The present invention relates to a composition for oral cavity, such as toothpaste, mouthwash, chewing gum, or gum massage cream for preventing the formation of plaque, and more specifically, in addition to pogongyoung extract or pore extract, gold silver extract, gold extract, tooth extract The present invention relates to oral compositions capable of inhibiting plaque formation and preventing and treating periodontal disease by combining a plant extract selected from a baekduong extract, a root extract or a mixture of two or more thereof.

In general, important diseases that occur in the teeth and surrounding tissues are caries and periodontal disease, the main cause of the plaque (or plaque) is known to be.

The plaque is a soft amorphous deposit formed on the surfaces of teeth and gingiva etc., the main component of which is bacteria and their metabolites. Major metabolites include organic acids produced by toxins and bacteria metabolizing sugars. These toxins cause damage to surrounding tissues adjacent to the tooth surface and cause periodontal disease, and organic acids decay tooth surfaces and cause tooth decay.

Therefore, in order to prevent and treat dental caries and periodontal disease, it is well known that it is required to prevent the formation of plaque by inhibiting and sterilizing the growth of Streptococcus mutans, a representative bacterium that forms plaque.

Antibiotics such as penicillin, erythromycin, tetracycline, and spiramycin are effective in in vivo and in vitro experiments, but they cause the emergence of resistant bacteria. It has a high side effect, and antibacterial agents such as chlorohexidine have the effect of inhibiting tooth decay, but it is known to have side effects such as destruction of the ecosystem in the oral cavity and tooth coloring. Also, enzymes that directly decompose plaque have been used but stored. It is a situation that stability problems, such as a decrease in enzyme activity, are not completely solved.

In recent years, in order to solve such a problem, a lot of researches have been conducted on substances extracted from various species of plants, and the present inventors have responded to the trends in the prior art and other related technical literatures. After years of research on the antimicrobial and plag formation inhibitory properties of published plant extracts and extracts from hundreds of plants that have not been published, the extracts from pogongyoung are unknown. By inhibiting and sterilizing the growth of Streptococcus mutans by itself, it has been found to effectively inhibit plaque formation and that synergistic effects are obtained when combined with other specific plant extracts. Results Complete the present invention to be.

Therefore, the present invention relates to a composition for oral cavity, which contains a pogongyoung extract as a plaque formation inhibiting component.

In addition, the present invention is an oral cavity, characterized in that it further comprises a plant extract selected from the sterling silver extract, golden extract, chaga extract, baekduong extract, brown root extract or a mixture of two or more thereof in addition to the pogongyoung extract described above as a plaque formation inhibiting component It relates to a composition for.

The plant extract used in the present invention is obtained from the following main plants.

⊙ Pogongyoung is an outpost of Dandelion (Taraxacum platycarpum H. Dahlstedt) and the same plant (Asteraceae). It has antibacterial and antifungal action.

⊙ Gold and silver buds are buds of Lonicera japonica Thunberg, which has antibacterial, antiviral, antifungal, and astringent effects, and has been used for bleeding, swelling, etc. Combined with, used as a general inflammatory drug.

⊙ Golden silver is the root of the skin of Scutellaria baicalensis Georgi (Lamiaceae). It has antibacterial, antiviral, antifungal and sedative effects. It is combined with gardenia in oriental medicine, which causes inflammation, toothache, oral pain, tooth decay, Used for periodontitis.

⊙ Gardenia jasminoides Ellis (Gardenia jasminoides Ellis) is the fruit of the tree and the same plant (Gapniaceae) has a hemostasis, antibacterial and sedative, so in the oriental medicine used for various inflammation and bleeding caused by inflammation.

⊙ Baekduong is the root of Pulsatilla koreana Nakai and the same plant (Manarea), which has antibacterial, antifungal and astringent effects.

⊙ Root is the root of 주 (Pueraria thunbergiana Bentham) (soybeans) removed and has analgesic and anti-inflammatory action. In oriental medicine, it is mixed with golden lamp and used for toothache and oral inflammation.

The extract of the medicinal herb can be prepared according to the conventional method, and preferably, about 10-fold addition of a polar solvent such as ethanol or methanol is carried out by shaking or refluxing the filtered and concentrated under reduced pressure to obtain a concentrate.

In the composition for oral cavity of the present invention, it is effective to use pogongyoung extract alone, but it is more preferable to use the above-mentioned other plant extract and poongongong in view of antibacterial activity and plaque formation inhibitory power.

The total compounding amount of the plant extract in the composition for oral cavity of the present invention is 0.001% to 10% by weight, more preferably 0.005% to 5% by weight based on the dry matter. If it is formulated at 0.001% by weight or less, the effect of preventing tooth decay and periodontal disease is weak, and when it is formulated at 10% by weight or more, it is not suitable for use as an oral composition due to the inherent color and bitter taste of the plant extract. .

The composition for oral cavity according to the present invention is prepared using the appropriate components according to the product type. For example, in the case of a toothpaste composition, it is usually prepared in combination with the ingredients contained in the toothpaste, such components include abrasives such as alumina, silica gel, precipitated silica, calcium carbonate, calcium dihydrogen phosphate, sodium bicarbonate and the like; Wetting agents such as sorbitol, glycerin, polyethylene glycol, and the like; Foaming agents such as sodium lauryl sulfate, sodium lauryl sarcosinate, dodecylbenzenesulfonate, and the like; Binders such as carboxymethyl cellulose, carrageenan, polyacrylates, and the like; Sweetening agents such as saccharin, aspartame, stevioside, and the like; Preservatives such as methyl paraoxy benzoate, propyl paraoxy benzoate and the like; Medicaments such as sodium fluoride, sodium fluoride phosphate, allantoin, zinc salts, vitamins, salts, tranexamic acid, strontium chloride, triclosan and the like; Spices; Pigments; pH adjusters and the like.

Other compositions for oral cavity of the present invention can also be prepared by a conventional method with the plant extract of the present invention by selecting the appropriate components according to the type and purpose.

Hereinafter, the present invention will be described in more detail with reference to non-limiting examples. In the following examples,% represents% by weight unless otherwise specified.

Example 1 Antibacterial Activity Test of Plant Extract According to the Present Invention

Pogongyoung, Gardenia, Baekduong, Geumgumhwa, Golden, Brown root dried and cut to 30g each, 300ml of distilled water, ethanol or methanol, respectively, and shaken or refluxed for 3 hours, and the supernatant obtained by filtration and centrifugation. It was concentrated under reduced pressure to obtain the dried product shown in Table 1 below.

The obtained extract alone or in combination was added to Brain Heart Infusion medium at an appropriate concentration, inoculated with Streptococcus mutans (ATCC 25175), incubated at 37 ° C for 24 hours, and the cultured bacteria were mixed with a mixer. After constant dispersion, the absorbance (A _R ) was measured using a Spectrophotometer (Beckman DU Series 60, wavelength 550 nm). In addition, the plant extract was not added at all as a control test, the absorbance (A _B ) was measured at this time, and the antimicrobial activity and bacterial growth inhibition ability were evaluated according to the following equation. The evaluation results are shown in Tables 2 and 3 below:

* The rate of increase (%) is obtained by subtracting the percentage of inhibition of total plant extract (total concentration: 500 ppm) from the percentage of total plant extract (total concentration: 500 ppm).

From Table 2, it was found that the antimicrobial activity of the pogongyoung extract was the best, and from Table 3, the combination of pogongyoung and other plant extracts was superior in antimicrobial activity as compared with the use alone. In other words, it was found that synergistic effect is given when using a combination of pogongyoung extract and gardenia, gold and silver, gold, baekduong or brown root extract.

Example 2 Plaque Formation Inhibition Test of Plant Extract

The plant extract obtained in Example 1 was mixed with Brain Hert Infusion medium containing 2% of sugar in a test tube so as to have an appropriate concentration, and inoculated with Streptococcus mutans bacteria (ATCC 25175) which had been incubated beforehand. This was incubated anaerobicly for 24 hours at 37 ℃ to form a plaque and uniformly dispersing the plaque and cells with a mixer and an ultrasonic grinder, and then measured the absorbance (A) using a spectrophotometer (wavelength 550nm). In addition, the plant extract was not added at all as a control test, the absorbance (A) was measured at this time to evaluate the antimicrobial activity and bacterial growth inhibition capacity according to the following equation. The evaluation results are shown in Table 4 below.

It can be seen from Table 4 that the composite plant extract has an excellent plaque formation inhibitory effect. In addition, it was found that there is an excellent plaque formation inhibitory effect even when the blending ratio is different.

[Examples 3 to 4] Preparation of Toothpaste

Toothpaste was prepared according to a conventional method using the following composition.

Example 3

Example 4

Example 5 Preparation of Oral Cleaning Agent

A mouthwash was prepared according to the conventional method using the following composition.

Example 6 Preparation of Chewing Gum

Chewing gum was prepared according to a conventional method using the following composition.

Example 7 Preparation of Gum Massage Cream

The gum massage cream was prepared according to a conventional method using the following composition.

Claims (5)

A composition for inhibiting oral plaque oral cavity, wherein the composition for oral cavity contains a pogongyoung extract as a component for inhibiting plaque formation. The oral cavity according to claim 1, further comprising a plant extract selected from sterling silver extract, golden extract, chaga extract, baekduong extract, brown root extract or a mixture of two or more thereof in addition to the pogongyoung extract as a plaque formation inhibiting component. Composition. The composition for oral cavity according to claim 1 or 2, wherein the total content of the plant extract is 0.001 to 10% by weight based on the dry matter. 4. The composition for oral cavity according to claim 3, wherein the total content of the plant extract is 0.005 to 5% by weight based on the dry matter. The oral composition according to claim 1 or 2, wherein the formulation of the oral composition is a toothpaste, a mouthwash, a chewing gum or a gum massage cream.