KR100203733B1 - Bamboosalt-containing compositions for enhancing oral hygine - Google Patents

Abstract

The present invention is a bamboo salt which is a processed salt prepared by firing together bamboo and salt, the main components of which are 85% to 98% sodium chloride, 1.5% to 10.0% potassium, 0.2% to 1.0% phosphate (PO ₄ ), sulfate (SO ₄ ) 0.0005% to 0.3%, and as a sub-component it contains at least 5 types of magnesium, chromium, iron, silicon, aluminum, zinc, fluorine, copper, barium, manganese and nickel, and magnesium oxide (MgO) in water insoluble And 0.5 to 15% by weight of bamboo salt, which is configured to contain magnesium silicate.

Description

Oral hygiene composition containing bamboo salt

The present invention relates to a composition for promoting oral hygiene excellent in preventing and treating periodontal disease and preventing tooth decay. More specifically, it is an object of the present invention to provide a composition for promoting oral hygiene effectively preventing periodontal disease prevention and treatment of tooth decay by incorporating bamboo salt as a medicinal ingredient in a conventional composition for spheroidal hygiene.

In the art, oral hygiene compositions using sodium chloride, antiplasmin agents, allantoin derivatives, amines or the like alone or in combination are widely used to prevent and treat periodontal disease and to prevent tooth decay. However, the composition for promoting oral hygiene was found to have a weak preventive and therapeutic effect. In addition, since sodium chloride, which is known to have an effect of preventing and treating periodontal disease, should be used in an amount of 10 to 15% by weight or more based on the entire composition, its inherent salty taste and the foaming power of the foaming agent used for reinforcing cleaning ability when brushing teeth are remarkably increased. There was a disadvantage of being reduced.

In order to improve the efficacy and feeling, there have been attempts to increase the effect of preventing and treating periodontal disease and preventing tooth decay by using bamboo salt prepared by fire method using bamboo and salt. .

For example, in Korean Patent Publication No. 90-4318, sun-dried salt is filled in a bamboo barrel and the ocher is opened to seal the entrance of the bamboo barrel, and then fired twice in a firing furnace for 1 hour with charcoal. The calcined salt produced in this calcining process is made into powder, and then filled into a bamboo barrel, sealed with an inlet of ocher kneaded with water, put into a firing furnace, and heated to 1,000 ° C. with a fire fueled by rosin to melt and solidify the method. Makes bamboo salt with The bamboo salt was mixed with the extract extracted from the bark of elm at a ratio of 5: 7 to obtain an ointment to obtain caries prevention effect.

In Korean Patent Publication No. 94-64, a three-year-old king tree is cut to one side and blocked to one side, and then the natural salt is squeezed tightly into a bamboo barrel, the entrance is sealed with a clay dough made of water, and then pine is placed in a porcelain kiln made of ocher. Spread and spread the rosin, and then fire with firing at room temperature above 1,000 ℃. Allow it to cool naturally and collect only saltballs. The salt mass is finely crushed again, chopped into a new bamboo barrel in the same manner as the first time, and fired repeatedly for 8 times. In the ninth, a special stainless steel furnace made to produce high heat of 1,500 ℃ or more is used to make bamboo salt by melting it with only rosin. This bamboo salt contained sodium chloride, iron, calcium, potassium, magnesium, manganese, phosphorus, zinc, sulfur and the like. Thus, by using the bamboo salt made by firing 9 times alone or by containing 1 to 15% by weight of sodium chloride to provide a composition for promoting oral hygiene excellent in preventing and treating periodontal disease and preventing caries.

However, the bamboo salt-containing toothpaste provided by Korean Patent Application Publication No. 90-4318 uses bamboo salt made by firing three times, so that its efficacy is weak and mixed with elm extract at a ratio of 5: 7. Because it creates an image, it hardens within 2 hours and does not disperse easily in the oral cavity, so it could not function as a toothpaste.

In addition, Korean Patent Publication No. 94-64 fires eight times at about 1,000 hours or more at 1,000 ° C from the first firing process during the bamboo salt manufacturing process using bamboo and salt, and nine times burns and melts only with rosin. The content of the main mineral components became insufficient, and also the contents of the components were not constant. In addition, the toothpaste containing the bamboo salt also had problems such as lack in efficacy and use.

Therefore, the present inventors while continuing to research to improve the above-mentioned problems of the prior art, the bamboo salt made by a special method different from the conventional method is more effective and effective for improving oral hygiene using the bamboo salt at an optimum concentration The composition was found to be excellent in oral hygiene enhancement effect was completed the present invention.

The present invention is described in more detail as follows.

That is, the present invention is a bamboo salt which is a processed salt produced by baking together with bamboo, salt, as the main component of sodium chloride 85% to 98%, potassium 1.5% to 10.0%, phosphate (PO ₄ ) 0.2% to 1.0%, sulfate ( SO ₄ ) 0.0005% to 0.3%, and as a minor component thereof, contains 5 or more of magnesium, chromium, iron, silicon, aluminum, zinc, fluorine, copper, barium, manganese and nickel, and oxidizes in water insolubles It relates to a composition for promoting oral hygiene, characterized in that it contains 0.5 to 15% by weight of bamboo salt configured to contain magnesium (MgO) and magnesium silicate.

Bamboo salt in the composition for promoting oral hygiene of the present invention is preferably contained in 0.5 to 15% by weight in the composition. If bamboo salt is used at less than 0.5% by weight, the effect of preventing and treating periodontal disease and tooth decay is insignificant, and when it is used in excess of 15% by weight, there is a feeling of its own peculiar sulfide odor and the appearance and use of toothpaste.

The content of bamboo salt in the composition of the present invention is more preferably 1.0 to 5.0% by weight in the total composition. Particularly, the bamboo salt content for oral hygiene-promoting composition having the most excellent prevention and treatment of dental disease and caries prevention effect is most preferably 2.0 to 5.0% by weight in the total composition.

Bamboo salt used in the present invention is the weight ratio of bamboo and salt 1: 1: 2 to 5: 5 to fill the undried royal bamboo of 3 to 5 years old and sealed the entrance to the ocher, then the furnace (furnace) After stacking to 3 to 15 layers in a step of baking for 1 hour to 5 hours at 150 ℃ to 550 ℃ and baking for 2 hours to 10 hours at 600 ℃ to 800 ℃ After the calcined salt is made, the calcined salt is pulverized, filled with new bamboo, and then repeated seven times in the same manner as the calcining method, and then calcined by raising the temperature to 1,000 to 1,800 ° C during the last 9 calcining. It is prepared by melting salt.

Bamboo salt used in the present invention is also heated in the first step of firing and maintained for 2 hours to 3 hours at a temperature of 200 ℃ to 450 ℃, heated in a second stage 5 to 7 hours at a temperature of 700 ℃ to 800 ℃ During the last 9 firings were prepared by heating the temperature to 1,300 ° C. to 1,600 ° C.

Bamboo salt used in the present invention also allows bamboo salt to be fired by the fire of bamboo fired by the heat of pine wood fire and its flame without burning bamboo directly with the fire of pine wood until 1 to 8 times firing. Heat and smoke are produced by direct passage through the kiln.

The fuel for producing bamboo salt used in the present invention is preferably selected from pine wood fire, rosin, electricity and gas.

The composition according to the present invention may further contain abrasives, wetting agents, agonists, binders, foaming agents, preservatives, sweeteners, flavoring agents, pH adjusters, brighteners and the like, depending on the formulation and purpose of use.

Examples of the abrasive include monohydrate calcium phosphate, precipitated silica, calcium carbonate, hydrous alumina, kaolin, sodium bicarbonate (NaHCO ₃ ), and the like. Among these, monohydrogen phosphate, precipitated silica, calcium carbonate and sodium bicarbonate are preferable. These abrasives are used alone or in combination of two or more, 20 to 60%, preferably 20 to 50%.

As the humectant, 20 to 60% by weight of glycerin sorbitol, amorphous sorbitol solution, propylene glycol, polyethylene glycol, xylitol, or the like may be used alone or in combination of two or more thereof. Preferably, glycerin or amorphous sorbitol liquid and propylene glycol or polyethylene glycol are preferably used in a weight ratio of 20 to 50% by weight in a ratio of 10: 1 to 1: 1.

As the binder, carrageenan, xanthan gum, carboxymethylcellulose sodium, carboxyvinyl polymer, sodium alginate, begum, laponite, etc. may be used alone or in combination of two or more thereof, more preferably carrageenan and carboxymethylcellulose sodium. Use individually or 2 types or more. These binders use 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight.

As the foaming agent, anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, sorbitan fatty acid esters, polyoxyethylene-cured castor oil, polyoxyethylene-polyoxypropylene-based condensed polymer materials, etc. may be used alone or in combination. Preferably, sodium lauryl sulfate and polyoxyethylene-polyoxypropylene-based condensation polymer materials are used alone or in combination of two or more. When it contains 2 or more types, it uses in the ratio of 5: 1-1: 5. These foaming agents use 0.5 to 5.0% by weight, preferably 0.5 to 3.5% by weight.

As a sweetener, saccharin sodium, aspartame, licorice acid, etc. may be used alone or in combination of two or more, and 0.05 to 0.5% by weight is used.

As a preservative, paraoxy benzoic acid ester and sodium benzoate are used individually or in mixture of 2 or more types. Examples of the medicament include sodium fluoride, sodium phosphate, chlorhexidine, triclosan, tricaminesan, allantoin, capronic acid, and the like.

As a fragrance, peppermint oil, spearmint oil, menthol, carbon and the like are mixed and used in an appropriate amount. Preferably, an anise oil is preferably mixed with an aromatic oil mixed with a predetermined ratio.

The pH range is 5 to 8, preferably 6 to 6, using phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartarate and the like, preferably phosphoric acid, sodium phosphate, citric acid, sodium citrate. Adjust to 8.

Titanium oxide is used as the brightener, and its content is preferably 0.1 to 2% by weight, preferably 0.1 to 1.0% by weight.

Oral hygiene-promoting composition according to the present invention can be used in the formulation of toothpaste, globular cleaning agent, chewing gum, gum massage cream and the like. The daily usage amount is a commonly used dose, and may be usually used about 1 to 6 times a day.

Hereinafter, although an Example and a comparative example demonstrate this invention concretely, these Examples do not limit the technical scope of this invention.

Experimental Example 1

Bamboo salts (A and B) of the present invention and bamboo salts (C, D and saline) of the prior art were prepared as follows to analyze the components.

(1) Manufacturing method of bamboo salt

① Preparation of bamboo salt (A and B) of the present invention

Fill the bamboo barrel with three-year-old salt with weight ratio of 1: 2 to 1: 5 tightly, seal the entrance with kneaded ocher, and then fire with pine firewood in the kiln, and the internal temperature of the kiln is 150-550 ℃ in the first stage. Heat is applied for 2 hours to 5 hours, followed by firing at 600 to 800 ° C. for 2 to 10 hours. Then leave to cool naturally. The calcined salt column produced in this process is pulverized and filled in a new bamboo barrel in the same way, and the process is repeated 7 times. In the last 9 times, the salt was fired 8 times in the same way in a bamboo barrel, and the fired salt was melted and melted by producing pine wood and pine in a firing furnace to prepare bamboo salt.

② Production of well-known bamboo salt (C) (by Korean Patent Publication No. 90-4318)

Fill the bamboo barrel with sun salt, seal the entrance with ocher, and then fire twice with charcoal. The calcined salt is made into powder and filled into a bamboo barrel again, the inlet is sealed with an ocher and placed in a calcining furnace.

③ Preparation of well-known bamboo salt (D) (according to Korean Patent Publication No. 94-64)

Put salt into the barrel of three-year-old kingwood and seal the entrance with kneaded ocher. Then, pine in a kiln made of ocher, sprinkle pine resin, and fire it to the room temperature above 1,000 ℃. Then leave to cool naturally. The salt column made in this way is crushed and filled in a new bamboo barrel in the same way, and repeated firing seven times. In the last 9 times, it is prepared by filling the bamboo barrel with salt that has been fired 8 times in the same way and burning it with only rosin to melt and melt at temperatures above 1,500 ℃.

④ Preparation of Salt

Saline is prepared using an ion exchange membrane.

(2) Component Analysis

The components of the bamboo salts A, B, C, D and salts prepared above are known methods for measuring inorganic metal ions, namely, ion chromatography (IC), inductively coupled plasma (ICP), Analysis was performed using an electron diffraction X-ray (EDX) and an ion analyzer (IA), and the results are shown in Table 1.

-: No content measurement experiment was conducted.

Experimental Example 2

The bactericidal power against bamboo salt A. B. C. D and salt prepared in Experimental Example 1 was compared. By the method of comparing the minimum inhibitory concentration of anaerobic bacteria and aerobic bacteria against conventional microorganisms, Rothia dentocariosa (ATCC 19426), Actinomyces viscosus (KTCT 9146), which cause oral diseases, Streptococcus mutans (MDR 6715), Escherichia coli (ATCC 8739), a common microorganism, was added to each sample. After inoculating the bacteria at a concentration of CFU / ml and incubating for 1 day at 37 ℃ was determined the minimum concentration (MIC) to inhibit the growth of bacteria.

Experimental results (Table 2) shows that bamboo salts A and B produced by the production method of the present invention have a much superior microbial growth inhibitory effect than salts, which are raw materials used for bamboo salts C and D and general salt toothpaste prepared by known methods. Shows.

[Examples 1-8 and Comparative Examples 1-4 (Toothpaste Composition) (Table 3)]

Disperse powder components such as sodium carboxymethylcellulose, saccharin, and preservatives in the amorphous sorbitol liquid as a wet component, dilute with purified water, and then mix in a mixer first, and then use an abrasive and a pharmaceutical agent such as calcium monohydrogen phosphate. Into the mixture, and finally, the foaming agent sodium sodium sulfate, stabilizers, flavoring ingredients were added and mixed in a vacuum to prepare a toothpaste composition.

Experimental Example 3

The plaque formation inhibitory effect and the gum inflammation relieving effect using the toothpaste of Examples 1 to 8 and Comparative Examples 1 to 4 of Table 3 were compared.

(1) Test toothpaste group

Examples 1-8 and Comparative Examples 1-4

(2) Experimental method

① After selecting the test subjects, explain the oral examination.

② Ten randomized randomized subjects were trained in each experimental group, the correct brushing method was trained, and the oral examination was performed to measure the Quigley-Hein Index modified by Turesky and the Gingival Bleeding Index.

③ Scaling was performed on the entire teeth of the experimental group.

④ After the control toothpaste was used for 2 weeks, oral examination was performed. At this time, the plaque index and the gingivitis index were initial values.

⑤ Example Toothpaste and Comparative Example Toothpaste was distributed to each subject and tooth brushing was performed three times a day for 4 weeks in the same manner as usual, and oral examination was performed after 2 weeks and 4 weeks to score the plaque index and gingivitis index.

⑥ The experimental results were compared with the initial scores of the experimental group and the score after 4 weeks, and the statistical significance was tested by t-test, respectively.

(3) Experiment result

① Plaque Index Results (Table 4)

② Gingivitis index results (Table 5)

(4) Conclusion

a. As a result of statistically significant difference test by measuring the plaque index and gingivitis index after using Examples 1 to 8 and Comparative Examples 1 to 4 for 4 weeks, the results were significant after 4 weeks in Examples 1 to 8 and Comparative Examples 2 and 4 It was confirmed that one decrease. Therefore, Examples 1 to 8 using the bamboo salt of the present invention and Comparative Examples 2 and 4 using the known bamboo salt and salt were found to have a significant effect on the plaque and gingivitis alleviating effect.

b. In the significant difference test between the toothpaste containing bamboo salt of the present invention (Example 3) and the toothpaste containing known bamboo salt (Comparative Example 2), it was confirmed that there was a significant difference in the alleviation effect of plaque and gingivitis between the two toothpastes ( p <0.05). Therefore, it was found that the toothpaste containing bamboo salt prepared according to the production method of the present invention is superior to the toothpaste containing bamboo salt prepared by the known bamboo salt manufacturing method.

c. In the significant difference test between Example 2 and Example 3, it was confirmed that there is a significant difference between the two toothpaste.

d. Significant differences were not found between the toothpastes in the significant difference test between Example 3 and Example 8 (p0.05), but the effect was increased as the concentration was increased.

Experimental Example 4

A questionnaire for evaluating the feeling for the toothpaste of Examples 1 to 8 and Comparative Examples 1 to 4 of Table 3 was conducted and compared.

(1) Test toothpaste group

Examples 1 to 8 and Comparative Examples 1 to 4

(2) subject

20 agents participating in professional surveys between 20 and 40 years old

(3) Test method

① The questionnaire was given one toothpaste for each group, and one toothbrush was used every hour as a normal brushing method.

② The evaluation was performed using a double-pointed five-point comparison method.

5-point comparison evaluation table

③ Evaluation item

a. How good is it?

b. How good is the refreshment?

(4) Experimental Results (Table 6)

(5) Conclusion

a. The good degree of taste was shown to be moderate to good in Examples 1 to 6 and Comparative Examples 1 to 3, and in Example 7 and 8 and Comparative Example 4 was found to feel a slight rejection. Therefore, it was found that in toothpaste containing bamboo salt and salt, it was most appropriate to prescribe the amount used at 5% by weight or less based on the whole composition.

b. As for the good degree of freshness, Examples 2-6 and Comparative Examples 1-3 were good.

[Examples 9 to 16 and Comparative Examples 5 to 8 (Table 7)]

Examples 9-16 and Comparative Examples 5-8 are examples of mouthwash compositions.

After completely dissolving the solubilizer in ethanol, which is a solvent, the fragrance is added, and the mixture is sufficiently stirred. Then, it is added to the purified part (a solution in which the humectant and other components are dissolved in purified water) while stirring and completely solubilized. By filtration to prepare a mouthwash composition.

2) Experiment Method

Comparative tests of the plaque formation inhibitory effect and gingivitis mitigating effect on the oral cleanser composition of Examples 9 to 16 and Comparative Examples 5 to 8 were compared, and the results are shown in Tables 8 and 9 below.

(1) Test method

① 20 adult men and women in each group of Examples 9 to 16 and Comparative Examples 5 to 8 were tested to compare the inhibitory effect of plaque formation and the gingivitis relieving effect of the mouthwash composition of the present invention.

② Brush the same toothpaste three times a day for 4 weeks in the same way as usual, and gargle for about 20 seconds using 10ml each time 4 times a day as an oral cleanser of Examples and Comparative Examples for about 20 seconds after brushing and before bedtime. The pre- and post-use plaque index (Quigley-Hein Index modified by Turesky) and gingivitis index (Gingival Bleeding Index) were measured.

③ The experimental results were compared with the initial value of the test group and the score after 4 weeks, and the statistical significance was tested by T-test (t-test), respectively.

(2) Experiment result

① Plaque Index Results (Table 8)

② Gingivitis index results (Table 9)

(3) conclusion

a. After using Examples 9 to 16 and Comparative Examples 5 to 8 for 4 weeks, statistically significant test was performed by measuring plaque index and gingivitis index, and the significant decrease after 4 weeks in Examples 9 to 16 and Comparative Examples 62 and 8 It confirmed that it represents.

b. The plaque formation inhibitory effect and the gingivitis mitigation effect between the test group containing the bamboo salt of the present invention (Example 11) and the test group containing the same amount of known bamboo salt (Comparative Example 6) were measured by the plaque index and the gingivitis index. As a result of the comparative evaluation, it was confirmed that the oral cleanser containing bamboo salt of the present invention had a significant (P <0.05) effect than the oral cleanser containing known bamboo salt.

Example 17

Chewing gum

Gum Base: 25.0%

Sorbitol: 44.0%

Mannitol: 12.0%

Glycerin: 13.0%

Lexidine: 0.5%

Sweetener: 2.0%

Bamboo salt: 2.0%

Spices: 1.5%

Example 18

Gum massage cream

Glycerin Monolauryl: 3.0%

Oleic Alcoil: 5.0%

Polyethylene Glycol: 15.0%

White Waserine: 3.0%

N-palmitric monosodium glutamate: 0.5%

Hydroxyethyl Cellulose: 5.0%

Topherol Acetate: 0.1%

Bamboo salt: 3.0%

Allantoin Chlorohydroxy Aluminum: 1.0%

Sweetener: 0.2%

Fragrance: 0.3%

Purified water was added: 100.0%

Examples 17 and 18 were effective in preventing and treating periodontal disease and preventing tooth decay.

Claims (4)

Bamboo salt, which is a processed salt prepared by sintering bamboo and salt together, includes 85 to 98% of sodium chloride, 1.5% to 10.0% of potassium, 0.2% to 1.0% of phosphate (PO ₄ ), and 0.0005% to of sulfate (SO ₄ ). 0.3%; and as a minor component thereof, magnesium, chromium, iron, silicon, aluminum, zinc, fluorine, copper, barium, manganese, nickel and at least five kinds; magnesium oxide (MgO) and magnesium in water insoluble Oral hygiene-promoting composition, characterized in that it contains 0.5 to 15% by weight of bamboo salt configured to contain the silicate The method of claim 1, wherein the bamboo salt to the weight ratio of bamboo and salt of 1: 2 to 1: 5 is filled with salt to the undried royal bamboo of 3 to 5 years old and sealed the entrance to the ocher, then the furnace (furnace) ) Stacked in three to 15 layers, and then heating at 150 ° C. to 550 ° C. for 1 hour to 5 hours and firing at 600 ° C. to 800 ° C. for 2 hours to 10 hours. Calcined salt, and then the calcined salt was pulverized and filled with new bamboo again, and then repeated 7 more times in the same manner as the above calcining method, and the temperature was raised to 1,000 to 1,800 ° C during the last 9 calcinings. Composition prepared by melting the calcined salt The composition of claim 1, wherein the bamboo salt is present in an amount of 1.0% to 5.0% by weight throughout the composition. The composition of claim 1, wherein the composition for promoting oral hygiene is a toothpaste, mouthwash, chewing gum, or gum massage cream.