KR100750474B1 - Oral compositions against breath - Google Patents

Abstract

The present invention relates to oral compositions for inhibiting bad breath by inhibiting and eliminating odor causing substances that cause bad breath, and specifically, ephedra extract, earl extract and It relates to an oral composition for inhibiting bad breath containing one or two or more selected from the group of the sterling silver extract.

The present invention exhibits a sustained and strong effect of removing bad breath and suppressing bad breath by adding one or two or more types of herbal medicines ephedra extract, earl extract, and sterling silver extract to the conventional oral composition.

Oral composition, bad breath control, ephedra, earl, gold

Description

Oral compositions against breath

The present invention relates to oral compositions for inhibiting bad breath by inhibiting and removing malodor causing substances that cause bad breath, and specifically, ephedra extract and earl extract as a herbal ingredient effective for removing bad breath in conventional oral compositions. And it relates to an oral composition for suppressing bad breath containing one or two or more selected from the group of the sterling silver extract as an active ingredient.

In general, bad breath is caused by acquired systemic diseases, proteins in the saliva, food residues, etc., are broken down by microorganisms in the oral cavity, and amino acids are decomposed by dehydrating enzymes or amino enzymes to produce odor-causing substances. Is generated. In addition, when ingesting garlic or red pepper, bad breath is also caused by sulfides contained in these substances. The main components that cause bad breath are Volatile Sulfide Compounds (VSC). These volatile sulfides include Hydrogen sulfide (H ₂ S), Methyl mercaptan (CH ₃ SH) and Dimethyl mercaptan (Dimethyl). mercaptan, (CH ₃ ) ₂ S], and methylmercaptan, in particular, is known to be the main component of the disgusting smell during bad breath. In addition, in the case of fish, as the freshness drops, trimethyl amine ((CH ₃ ) ₃ N] or δ-aminovaleric acid, which is fish fish, is formed, and these volatile amine compounds, in particular, Trimethylamine is a major part of the malodor component. Other bad breathing agents include aldehydes, fatty acids, ammonia or pyridine.

Korean Unexamined Patent Publication No. 97-8154, Japanese Unexamined Patent Publication No. 60-75418 and the like also claim the right to suppress bad breath by removing such VSC.

As a result of continuous research on the removal of bad breath, the present inventors have found that adding ephedra, birch and gold and silver as a VSC remover to a conventional oral composition exhibits a strong and powerful bad breath removing effect.

The ephedra used in the present invention is an Ephedraceae plant whose scientific name is Ephedra sinica Stapf., Which is used by cutting off untrimmed stems in autumn. Ephedra has been used in Chinese medicine for colds, asthma and the like, and known chemical components include ephedrine, N-methylephedrine, norephedrine, benzylmethylamine and terpineol. The earl is a dried bark of the oleander flower of the scientific name Paeonia albiflora Pallas, and it has been used as an antispasmodic and analgesic in Chinese medicine. Known chemicals include phenol glycosides and peonyflorin, peonine, tannin and albiflorin. Gold and silver coins are named after the buds of the Lonera japonica Thunb., A caprifoliaceace bush. It has been used as an antipyretic and swelling disease in Korean medicine, and it has been used as a cancer treatment in the private sector. Known chemicals of gold and silver include luteolin, inositol, tannins and other fatty acids.

These ephedra, earl, gold and silver coins have been used in herbal medicine for a long time, the human safety is already secured by the body ingestion, and is an extremely safe plant with little irritation to the skin and mucous membranes.

The preparation method of ephedra, earl, gold and silver coin extract used in the present invention is as follows.

Select Ephedra, Baekjak and Geumhwa medicinal herbs alone or two or more and pulverize to 10 to 200 mesh size, add the extraction solvent to the pulverized ephedra, Baekjak and Geumhwa powder for 48 hours, and then filtered and filtered Concentrated to obtain ephedra, earl, gold and silver coin extract. The extraction solvent used at this time is extracted by mixing one or two or more solvents selected from the group consisting of purified water, methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, ethyl acetate, acetone Used for.

In the composition for oral cavity according to the present invention, it is preferable to use ephedra, baekjak, and sterling extract based on 0.01 to 2% by weight based on the total amount of the composition. Less than 0.01% by weight can not be expected to inhibit the bad breath, more than 2% by weight it is difficult to expect an increase in the bad breath inhibitory effect due to the increase in the content, the turbidity of the color is greatly increased, there is a difficulty in applying the product.                     

Oral compositions according to the present invention can be prepared in various formulations of oral hygiene enhancers such as toothpaste, dentifrice and spray, but in the present invention was tested as toothpaste.

The toothpaste composition of the present invention used ephedra extract as the main active ingredient, and may further contain oral fungicides, abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, pH adjusters, fragrances and the like.

Oral fungicides include triclosan or cetylpyridium chloride, and 0.01 to 1% by weight of these fungicides alone or in combination.

Abrasives include calcium carbonate, calcium monohydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium m- phosphate, zirconium silicate, and the like. 20 to 70% by weight, or 35 to 55% by weight, preferably two or more mixed.

The humectant is 20 to 60% by weight, preferably 20 to 50% by weight of glycerin, sorbitol liquid, amorphous sorbitol liquid, glycerin, polyethylene glycol, or the like, alone or in combination of two or more thereof.

As the binder, carrageenan, xanthan gum, carboxymethyl cellulose sodium, carboxy vinyl polymer, sodium alginate and the like are usually suitable. The amount of the binder used is appropriately 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight.

Examples of the foaming agent include anionic surfactants such as sodium lauryl sulfate and sodium lauroyl sarcosinate, and nonionic surfactants such as sorbitan fatty acid ester, polyoxyethylene hardened castor oil, and polyoxyethylene polyoxypropylene copolymer. The foaming agent is used in an amount of 0.5 to 5.0% by weight, preferably 0.5 to 2.5% by weight, either alone or in combination with an anionic surfactant and a nonionic surfactant.

Examples of the sweetening agent include sodium saccharin, aspartame, acesulfame, stevioside, and licorice acid, and these are preferably used alone or in a mixture of two or more of 0.05 to 0.5% by weight.

It is preferable to use 0.05-0.25 weight% of preservatives individually or in mixture of 2 or more types of paraoxybenzoic acid ester, benzoic acid, and sodium benzoate.

In addition, a fluorine compound may be used as a caries preventive agent, and metabisulfite sodium (Sodium m- bisulfite) may be used to prevent discoloration of the drug.

As a pH adjuster, it is preferable to use 0.02 to 1.5 weight% of phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartarate, etc. individually or in mixture of 2 or more types.

The fragrance substances include aromatic substances used in conventional toothpaste and substances used in food fragrance, such as peppermint oil, menthol, spearmint oil, carbon, anise oil, anitol, eucalyptus oil, and clove oil. Type, eugenol, winter green oil type, methyl salicylate, cinnamon oil type, cinnamic aldehyde and other fragrance ingredients are used, the material constituting the fragrance is 0.1 to 2.0 weight by mixing one or two or more of the above components %, Preferably 0.5 to 1.5% by weight.

Hereinafter, although this invention is demonstrated concretely based on an Example and an experimental example, the technical scope of this invention is not limited to these.

Example 1 Grinding and Extraction

100g each of dried ephedra, earl and gold and silver medicinal herbs were pulverized into 10 to 200 mesh sizes using a medicinal herb grinder. 500 ml of 80% (v / v) ethanol solution was added thereto, and the mixture was cooled at room temperature for 48 hours, and then Whatman # 2 filter paper. It was filtered using. Each of the filtered extracts was concentrated under reduced pressure at 45 ° C. to obtain a concentrated solution.

Experimental Example 1: Determination of the bad breath inhibitory effect of ephedra, earl, eunbi extract

In order to measure the bad breath inhibitory effect of the ephedra, earl, gold and silver coin extract obtained in Example 1, the degree of bad breath inhibition was measured using a Halimeter.

Dilute methylmercaptan standard solution (1µg / µl in benzene) in 0.2M Potassium Phosphate buffer (pH 7.5) until the Halimeter reading reaches 500-600ppb Used as original solution. Ephedra, Baekjak and Geumhwa extracts were dissolved in 0.2M potassium phosphate buffer (pH 7.5) to make 1% solution and used for the experiment. As a control, 500 μl of buffer solution and 500 μl of bad breath source solution were added to a test tube with a lid, and 500 μl of extract solution and 500 μl of bad breath source solution were added to the test group. Each test tube was allowed to stand in a 36.5 ° C. water bath for 5 minutes, and then measured the amount of sulfur compound in the head-space of the test tube using a Halimeter. Experiments in the control and test groups were repeated four times and three times, respectively, and averaged each Halimeter measurement.                     

The degree of inhibition of bad breath of the 1% solution of ephedra, baekryak, and sterling extract is shown in Table 1 below.

Bad breath inhibitory results (unit:%) Bad breath control degree Control 0 Ephedra extract 59 Earl extract 56 Gold Coin Extract 47

Example 2 Preparation of Toothpaste Composition

Toothpaste composition of the present invention (Examples 2-1 to 2-3) and a conventional toothpaste composition (Comparative Example 2-1) were prepared using the ingredients shown in Table 2 as main components.

Preparation of Toothpaste Composition (Unit: Weight%) division Ingredient Name Example Comparative example 2-1 2-2 2-3 2-1 abrasive Calcium carbonate 40.0 40.0 40.0 40.0 Humectant Sorbitol Liquid 25.0 25.0 25.0 25.0 Foam    Alkyl Sodium Sulfate 2.0 2.0 2.0 2.0 Binder     Carboxymethyl Cellulose 1.0 1.0 1.0 1.0 Sweetener    Zaccarin Sodium 0.2 0.2 0.2 0.2 antiseptic       Paraoxy Benzoate 0.1 0.1 0.1 0.1 Spices       Combination spices 1.0 1.0 1.0 1.0 Oral fungicides      Triclosan 0.01 0.01 0.01 0.01 Active ingredient      Ephedra extract 0.01 0.5 2 -       Purified water Remainder Remainder Remainder Remainder

Example 3: Clinical comparison experiment on the bad breath inhibitory effect of the present invention toothpaste (Examples 2-1 to 2-3) and comparative toothpaste (Comparative Example 2-1)

In this experiment, 20 men and women who did not have dental caries were selected and 5 subjects per toothpaste.

After the same meal, they brushed their teeth for a certain time, and after 1 hour, a bad breath measurement was performed with a Halimeter. After 3 hours, a second measurement was performed to confirm whether or not the bad breath was continued. How to use Halimeter is as follows. For 2 minutes before the measurement, the mouth was closed and breathed only through the nose. During the measurement, the straw was kept in the mouth for about 15 cm for about 15 seconds. At this time, the straw did not touch the tongue, the lips were kept about 3-4mm wide, and the breathing was only nose.

the results are as follow.

Bad breath reduction and duration (unit:% = measured value after brushing ÷ initial measured value before brushing) 1 hour after brushing 4 hours after brushing Example 2-1 79 106 2-2 56 70 2-3 38 45 Comparative example 2-1 86 121

As a result of using the Example toothpaste and Comparative Example toothpaste in the method described above by Halimeter, the bad breath generated after meal was reduced by 14% in Comparative Example, similarly to Example 2-1 when measured 1 hour after brushing Although there was a tendency, the reduction rate was not as large as in the other examples. In the example using ephedra extract, bad breath was reduced after brushing, and the degree of suppression of bad breath continued 4 hours after brushing, and in Example 2-3 containing 2.0% ephedra extract, the bad breath was decreased after 38% reduction. The degree lasted. On the other hand, in Comparative Example 2-1 without the active ingredient of the present invention, when measuring bad breath after 1 hour after brushing, 86% decreased to 14% from the beginning, but increased to 121% after 4 hours to prevent bad breath. Seemed to not last at all. Therefore, it was judged that toothpaste using ephedra extract had superior effect of removing bad breath and suppressing bad breath occurrence than other toothpastes.

The present invention relates to a composition for oral cavity which suppresses and removes odor causing substances that cause bad breath, and specifically, the ephedra extract, earl extract as a herbal ingredient effective in removing the bad breath in conventional oral compositions. And it relates to an oral composition for inhibiting bad breath containing one or two or more selected from the group of the sterling silver extract as an active ingredient.

The present invention exhibits a sustained and strong effect on removing bad breath and suppressing bad breath by adding one or two or more types of herbal ephedra extracts, earl extracts, and sterling silver extracts to conventional oral compositions.

Claims (3)

In the oral composition, oral composition for inhibiting bad breath, characterized in that it contains 0.01 to 2% by weight based on the total weight of the composition as one or two or more selected from ephedra extract, baekryeok extract and gold coin extract. delete The method of claim 1, wherein the ephedra extract, earl extract and gilding extract is dried or dried crushed ephedra, earl and gold gilde respectively purified water, methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol Oral composition for inhibiting bad breath, characterized in that extracted by using a mixture of one or two or more solvents selected from ethyl acetate and acetone.