KR20010001476A - Oral anti-halitosis preparations - Google Patents

Abstract

PURPOSE: An oral composition for repressing halitosis is provided to remove oral bacteria including Streptococcus, Actinomyces, Porphyromonas, Actinobacillus and periodontal disease and halitosis inducing materials. CONSTITUTION: An oral composition for repressing halitosis is characterized by using: (i)at least one kind selected from the group of triclosan, cetylpyridium chloride, sanguinarine, thymol, eucalyptol as oral disinfectant; (ii)at least one kind selected from the group of UDCA(urosodesoxycholic acid), chenodesoxycholic acid, the derivative thereof, taurourosodesoxycholic acid as repressor for periodontitis; (iii)at least one kind selected from the group of Quercetin, Kaempferol, Myricetin, Morin, Luteolin as flavonoid. Wherein, the composition comprises 0.001-1 wt.% of oral disinfectant, 0.001-2 wt% of repressor for periodontitis and 0.001-5 wt.% of flavonoid.

Description

Oral composition for suppressing bad breath {Oral anti-halitosis preparations}

The present invention relates to an oral composition for inhibiting bad breath by inhibiting and eliminating oral bacteria, periodontal disease and malodor causing substances that cause bad breath. More specifically, the present invention relates to an oral composition for inhibiting bad breath containing oral fungicides, periodontal disease inhibitors and flavonoids.

In general, bad breath is caused by acquired systemic diseases, proteins in the saliva, food residues, etc., are broken down by microorganisms in the oral cavity, and amino acids are decomposed by dehydrating enzymes or amino enzymes to produce odor-causing substances. Is generated. In addition, when ingesting garlic or red pepper, bad breath is also caused by sulfides contained in these substances. The main components that cause bad breath are volatile sulfide compounds (VSC). These volatile sulfides include hydrogen sulfide (H ₂ S), methyl mercaptan (CH ₃ SH), and dimethyl mercaptan [(CH ₃ ) ₂ S]. In particular, methylmercaptan is known as the main component of disgusting smell during bad breath. In addition, in the case of fish, as the freshness drops, trimethylamine [(CH ₃ ) ₃ N] or δ-aminovaleric acid, which is fish fish, is formed, and these volatile amine compounds, in particular, trimethylamine It forms a major part of the odor component. Other bad breathing agents include aldehydes, fatty acids, ammonia or pyridine.

Oral microorganisms that cause bad breath include Streptococcus, Actinomyces, Porphyromonas, and Actinobacillus, in particular Popiromonas and Actino. Anaerobic microorganisms, such as Bacillus, are the main cause of periodontal disease caused by the toxic substances they secrete. That is, streptococcus and actiomysis form plaques on the surface of the skin that is formed by adsorption of proteins and the like on the dentin surface of teeth. Over time, plaques grow and also reproduce anaerobic Gram-negative bacteria, such as Popiromonas and Actinobacillus. Periodontal disease is destroyed by the bacteria, bacterial components and toxic substances that are bacterial metabolites, and periodontal disease progresses. Therefore, in order to suppress bad breath, as well as to remove the bad breath-causing substances VSC, the primary cause should be to prevent the growth of microorganisms in the oral cavity and to suppress periodontal disease.

However, existing patents related to suppression of bad breath have attempted to remove bad breath mainly by removing only VSC (Korean Patent Publication No. 97-8154, Japanese Laid-Open Patent Publication 60-75418, etc.). In all these cases, it is known that it is difficult to obtain a continuous bad breath removal effect.

The present inventors have conducted numerous studies and experiments to improve the above-mentioned disadvantages and have a continuous bad breath elimination effect, and as a result, oral fungicides and periodontal disease inhibitors, and volatile compounds (VSC) removing agents, such as quercetin, myricetin, and camp The addition of ferrol, moline or luteolin has been shown to produce a lasting and powerful bad breath removal effect.

The present invention is an oral composition containing an oral fungicide, periodontal disease inhibitor and flavonoids, oral fungicides selected from the group consisting of triclosan, cetylpyridium chloride, sangirin, and essential oils such as thymol and eucalyptol As the periodontal disease inhibitor, one or two or more selected from the group consisting of ursodesoxic acid, chenodes oxycholic acid and its derivatives, tauruthoresoxycholic acid, is used. Inducing substance removal relates to an oral composition for suppressing bad breath, characterized in that one or two or more selected from flavonoids such as quercetin, camphorol, myricetin, moline and luteolin are used.

The oral fungicide used in the oral composition of the present invention is selected from the group of essential oils such as triclosan, cetylpyridium chloride (cetylpyridium Chloride), Sanguinarine, and thymol and eucalyptol. It is preferable to use species or two or more kinds. Triclosan has the chemical name 2,4,4'-trichloro-2'-hydroxydiphenyl ether, has antimicrobial activity in bacterial cell membranes and has excellent tooth retention effect. Cetylpyridium chloride was also used in oral products such as toothpaste and dentifrice as a representative antibacterial agent. In addition, there are quaternary ammonium compounds and essential oils as natural antibacterial agents, and examples thereof include cinnabarine, thymol and eucalyptol.

Urosodesoxycholic acid, chenodesoxycholic acid and its derivatives, tauroursodesoxycholic acid, used as periodontal disease inhibitors, are cytokines and prostaglandins. (PGE ₂ ) It is an active ingredient of woodam and woodam that have an effect of effectively inhibiting production. Woodam and Woongdam are herbal medicines that are stable to the human body and are known for their effects on Idam, sedation, myrrh, chronic hepatitis, sore throat, life support, and anti-inflammatory.

Quercetin, Kaempferol, Myricetin, Morin, and Luteolin, used as odor-causing agents, are a kind of flavonoids, which are pale yellow pigments contained in the leaves of plants. . Flavonoids are generally known to have a strong deodorant effect, and have been found to have anti-inflammatory, antibacterial and anti-allergic effects. Quercetin and camphorol are found in onions, broccoli, etc. and are known to have strong antioxidant effects. Myricetin is found in the bark of myricacea plants and has several effects, including antioxidants, anti-inflammatory and antibacterial properties. Maureen is contained in mulberry trees and also has antioxidant and anticancer effects. Luteolin has also been reported to have several effects, including antioxidants and anticancer.

According to the present invention, by containing the oral fungicide, periodontal disease inhibitors and flavonoids in addition to improve the disadvantages of the existing bad breath inhibitors through the synergistic effect of each component and has an excellent bad breath removal effect.

The present invention is to remove oral bacteria such as volatile sulfides (VSC) that cause the bad breath and triclosan, oral fungicides in conventional components such as toothpaste, oral cleaning agent, which is a conventional composition for oral cavity in order to suppress periodontal disease, One or two or more selected from the group of essential oils such as cetylpyridium chloride, sangguinarin, and thymol and eucalyptol.As an inhibitor of periodontal disease, ursodesoxic acid, chinodesoxycholine acid and its One or two or more selected from the group of tauruthoradesoxycholine acid derivatives are used, and the odor-inducing substance is removed by one or two from the group of quercetin, camphorol, myricetin, moline and luteolin. It relates to a bad breath control oral composition characterized in that the selection of more than one species.

The oral fungicide in the composition for oral cavity according to the present invention is preferably used in a predetermined ratio within 0.001 to 1% by weight of the total composition, periodontal disease inhibitor is 0.001 to 2% by weight, preferably 0.01 To 1% by weight, and flavonoids for removing substances such as SVC is used by mixing 0.001 to 5% by weight, preferably 0.001 to 2% by weight. At concentrations of 0.001% by weight or less of periodontal disease inhibitors, the effect on gingival inflammation cannot be expected, and when it exceeds 2% by weight, no synergistic effect can be expected for the three types of medicinal agents. In addition, if the content of flavonoids is less than 0.001% by weight can not be expected to prevent bad breath, if it exceeds 5% by weight it is difficult to expect an increase in the bad breath suppression effect due to the increase in content, difficult to apply the product due to the severe discoloration There is this.

Oral composition according to the present invention can be prepared in various formulations of oral hygiene enhancers such as toothpaste, dentifrice and spray, in the present invention was tested as toothpaste.

The toothpaste composition of the present invention uses triclosan, UDCA, and quercetin as the main active ingredients, and may further contain an abrasive, a humectant, a binder, a foaming agent, a sweetening agent, a preservative, a pH adjuster, a perfume, and the like.

Abrasives include calcium carbonate, calcium dihydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium m-phosphate, zirconium silicate, and the like. 70% by weight, preferably 35 to 55% by weight is used.

The humectant is 20 to 60% by weight, preferably 20 to 50% by weight of glycerin, sorbitol liquid, amorphous sorbitol liquid, glycerin, polyethylene glycol, or the like, alone or in combination of two or more thereof.

As the binder, carrageenan, xanthan gum, carboxymethyl cellulose sodium, carboxyvinyl polymer, sodium alginate and the like are usually suitable. The amount of the binder used is 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight.

Examples of the foaming agent include anionic surfactants such as sodium lauryl sulfate and sodium lauroyl sarcosinate, and nonionic surfactants such as sorbitan fatty acid ester, polyoxyethylene hardened castor oil, and polyoxyethylene polyoxypropylene copolymer. The foaming agent is used in an amount of 0.5 to 5.0% by weight, preferably 0.5 to 2.5% by weight, either alone or in combination with an anionic surfactant and a nonionic surfactant.

Examples of sweeteners include sodium saccharin, aspartame, acesulfame, stevioside, and licorice acid, and these are preferably used alone or in combination of two or more of 0.05 to 0.5% by weight.

It is preferable to use 0.05-0.25 weight% of preservatives individually or in mixture of 2 or more types of paraoxybenzoic acid ester, benzoic acid, and sodium benzoate.

In addition, a fluoride compound may be used as a caries preventive agent, and metabisulfite sodium (Sodium m-bisulfite) may be used to prevent discoloration of the drug.

As the pH adjuster, it is preferable to use 0.02 to 1.5% by weight of phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium stannate alone or in combination of two or more thereof.

The fragrance substances include aromatic substances used in conventional toothpaste and substances used in food fragrance, such as peppermint oil, menthol, spearmint oil, carbon, anise oil, anitol, eucalyptus oil, and clove oil. Type, eugenol, winter green oil type, metal salicylate, cinnamon oil type, cinnamic aldehyde and other flavoring ingredients are used, the composition of the perfume is 0.1 to 2.0% by weight of one or two or more of the above ingredients %, Preferably 0.5 to 1.5% by weight.

Hereinafter, although this invention is demonstrated concretely based on an Example, the technical scope of this invention is not limited to these.

Example 1 Preparation of Toothpaste Composition

Toothpaste composition of the present invention (Examples 1 to 3) and a conventional toothpaste composition (Comparative Example 1) was prepared using the ingredients shown in Table 1 as main components.

Example 2 Clinical comparison experiment on the effect of inhibiting bad breath of the present invention toothpaste (Examples 1-3)

In the present invention, 20 men and women who do not have dental caries were selected and 5 subjects per toothpaste were tested. After the same meal, they brush their teeth for a certain period of time, and after 1 hour, a bad breath measurement was carried out with a Halimeter. How to use Halimeter is as follows. For 2 minutes before the measurement, the mouth was shut and breathed only through the nose. During the measurement, the straw was kept in the mouth for about 15 cm for about 15 seconds. At this time, the straw did not touch the tongue, the lips were kept open about 3-4㎜, breathing was only with the nose.

The results are as shown in Table 2 below.

Bad breath reduction and duration (unit:% = measured after brushing ÷ initial measured before brushing) Early before brushing 1 hour after brushing 4 hours after brushing Example One 100 76 70 2 100 60 61 3 100 44 44 Comparative example One 100 86 121

As a result of measuring by Halimeter after using Example toothpaste and Comparative Example toothpaste by the above method, the bad breath produced after meal was slightly decreased similarly to Example with 14% decrease in the comparative example when measured 1 hour after brushing. Although seen, the reduction rate was not as large as in the case of the examples. In addition, in the examples using triclosan, UDCA, and quercetin, the bad breath was reduced after brushing, and the degree of suppression of bad breath was continued after 4 hours after brushing, and in Example 3 containing 1.0% of each of the three active ingredients, bad breath was 56 It continued after that percentage decline. On the other hand, in the comparative example without the active ingredient of the present invention, when measuring bad breath 1 hour after brushing, it was 86%, which was 14% lower than the initial time, but after 4 hours, it was increased to 121% and the inhibition of bad breath was not maintained at all. Seemed to do. Therefore, the toothpaste used by mixing oral fungicides such as triclosan, periodontal disease inhibitors such as UDCA, and flavonoids such as quercetin, is believed to have superior effect of removing bad breath and suppressing bad breath from other toothpastes.

The oral composition according to the present invention exhibits a strong bad breath removing effect in the oral cavity and is also excellent in sustaining bad breath occurrence.

Claims (3)

An oral composition for suppressing bad breath containing an oral fungicide, periodontal disease inhibitor and flavonoids, oral oral fungicides selected from the group consisting of triclosan, cetylpyridium chloride, sangguirin, and essential oils such as thymol and eucalyptol 2) As a periodontal disease inhibitor, one or two or more selected from the group consisting of ursodesoxic acid (UDCA), chinodesoxycholic acid, and its derivatives, taurusodesoxycholic acid, 3) Flavonoids, oral composition for inhibiting bad breath, characterized in that using one or two or more selected from the group consisting of quercetin, camphorol, mycetin, morphine and luteolin. The oral composition according to claim 1, which contains 0.001 to 1% by weight of oral fungicides, 0.001 to 2% by weight of periodontal disease inhibitors, and 0.001 to 5% by weight of flavonoids. The oral composition of claim 1, wherein the composition is in the form of a toothpaste, spray or dentifrice.