JPS5855409A - Medicinal composition for preventing and treating periodontoses - Google Patents

Abstract

PURPOSE:A medicinal composition for preventing and treating periodontoses that contains extracts of herb medicines with styptic activity such as leaves of Gvnura japonica Juel, thistle, milk thistle and others as active ingredients. CONSTITUTION:The objective composition for preventing and treating periodontoses contains extracts of herb medicines selected from leaves of Gvnura japonica Juel, thistle, milk thistle and others, which increase the resistace of blood capillary and prevent its hyperpermeability. At least one of extracts with an organic solvent or a mixture thereof with water may be used and the content of the active ingredients is preferably 0.01-5% based on the composition.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition for preventing and treating periodontal diseases that has an excellent hemostatic effect and is effective for preventing and treating periodontal diseases.

Many people suffer from periodontal diseases such as gingivitis and alveolar pyorrhea, and it is said that about half of tooth loss is caused by periodontal diseases. Symptoms of periodontal disease include gingival redness, swelling, bleeding, pus drainage, and alveolar bone resorption. Bleeding from the gingiva is especially common, and is one of the subjective and objective symptoms of periodontal disease. There is one thing in particular that I admire. - Bleeding from the gums in periodontal disease is caused by inflammation in the gums caused by plaque or other factors, which weakens the capillaries and increases the permeability of the capillaries. It is thought that capillaries can be easily damaged by some kind of puncture, leading to bleeding.Currently, many hemostatic agents have been developed, but this is due to their mechanism of action. Things that cause blood to coagulate due to protein coagulation, ■
They can be classified into Class 04s: those that promote blood coagulation, (1) those that constrict local OH tubes, and (2) those that increase capillary resistance and suppress leftward permeability. Among these, from the perspective of the pathology of periodontal disease, the hemostatic agent for periodontal disease is ① above.

It is not a symptomatic treatment like the mechanism of action of ■ and ■,
Most preferred is Amano, which has a causative and therapeutic mechanism of action that acts from within the periodontal tissue. However, most of the current hemostatic agents for periodontal diseases have the mechanism of action described in ■, ■, and ■ above, and only a few have the mechanism of action described in ■. However, there are few that exhibit sufficiently satisfactory effects.

In view of the above circumstances, the present inventors conducted intensive research on active ingredients that have an action mechanism of increasing capillary resistance and suppressing hyperpermeability. , discovered that extracts of Oriental daisy, Soso, Shusui, and Senkakuso have an excellent hemostatic effect with the above-mentioned mechanism of action,
The inventors have discovered that these extracts are effective in preventing and treating periodontal diseases, leading to the present invention.

The present invention will be explained in detail below.

The composition for preventing and treating periodontal diseases according to the present invention can be used in dentifrices such as toothpaste, powdered toothpaste, and liquid toothpaste, mouthwash, gingival pine surge cream, chewing gum, oral/mass tablets, troches, gargling tablets, etc. It is used as a tablet, etc., and the active ingredient is 18I of extracts of herbal medicines selected from Sanshichi, Kogai, Daijia, Sogai, Otogi, and Senkakuso.
Or it is a mixture of two or more kinds.

In this case, the raw materials used to obtain extracts of the herbal medicines include powders of the herbal medicines; residues obtained by extracting oil from these by steam distillation and other essential oil collection residues; , acetone, lower alcohols such as ethanol and methanol, oleoresin and its extraction residue obtained by extraction with polar solvents such as ethyl acetate, propylene glycol, glycerin, and water; , cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, benzene, etc., and the extraction residue thereof. . When obtaining extracts of the herbal medicines from these raw materials, 1'!
Ii or 21I or more in a polar solvent and/or a non-polar solvent (
Note that the above-mentioned solvents can be used), and the extract (the extract or the solvent distilled from the extract) is collected. In the present invention,
This extract can be used as it is, but the steam distillation residue obtained by steam distilling this extract, or the steam distillation residue obtained by treating this extract or the steam distillation residue with an adsorbent such as activated carbon, diatomaceous earth, or acid clay, may be used. Furthermore, the residue obtained by steam distillation after treating the extract with an adsorbent can also be suitably used as the crude drug extract. Note that a well-known method can be used as the extraction method, for example, a method such as digesting the dry powder of the crude drug in a solvent can be used. In this case, the solvent is preferably an organic solvent or a mixed solvent of an organic solvent and water, and the extracts obtained by extracting the herbal medicines with these solvents are highly effective.

In the present invention, 1 lll of these solvent extracts (single crude drug extract, mixed crude drug extract) may be used, or two or more kinds may be used in combination.

In addition, the amount of extracts of these herbal medicines added to the oral composition is 0.001-xo* (weight%, same hereinafter) of the total.
In particular, it is preferably 0.01 to 5 inches.

Other ingredients used in the composition for preventing and treating periodontal diseases according to the present invention include appropriate ingredients depending on the type of the composition.For example, in the case of toothpaste, dicalcium phosphate I2 hydrate and abrasives such as anhydrides, calcium carbonate, calcium pyrophosphate, calcium sulfate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum hydroxide, aluminum oxide, and resin (compounding amount usually 20 to 60%) ), Calgoxymethylcellulose, hydroxyethylcellulose, alginate, caradanan, gum arabic, I lipinyl alcohol and other binders (O, 3-5%), / IJ ethylene glycol, sorbitol, glycerin, propylene glycol, etc. Thickening agent (10-70%), sodium lauryl sulfate totecylbenzenesulfonate, sodium added coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-lauryl sarcosinate, N-acyl glutamate. Foaming agents (0 to 5 units) such as phosphate, lauryl jetanolamide, sucrose fat ester, and peppermint,
Essential oils such as spearmint, fragrance materials such as t-menthol, calden, eugenol, anethole, etc.
Karin sodium, stevioside, neohesiridyldihydrochalcone, glycyrrhizin, 4lilartin, p
- O components such as methoxycinnamic aldehyde, sweeteners such as thaumatyl y, preservatives, etc. are mixed with water and produced according to a conventional method. Oh, mouthwash.

In oral cleansers, tablets for internal use, and other products, ingredients and carriers are appropriately blended according to the properties of the product.

In the present invention, in addition to the above-mentioned herbal medicine extracts, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or its salt, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethyl Glycine salt, allantoin, I-aminocaproic acid, tranexamic acid, azulene, vitamin E1 sodium monofluorophosphate, sodium fluoride, primary anchor, water-soluble primary or secondary phosphate, quaternary ammonium ( t
The composition for preventing and treating periodontal diseases according to the present invention may contain active ingredients such as Sanshichi, Komusubi, Ojia, Sogai, Katsuragi, and Senkakuso. 18 ti21 extracts of herbal medicines selected from! By using I or more as an active ingredient, the action is mild, and when used continuously, it has an excellent effect on bleeding from the gums and periodontal disease, and is extremely useful for the prevention and treatment of periodontal disease. It is something.

In addition, the composition for preventing and treating periodontal diseases of the present invention contains extracts of highly safe herbal medicines as active ingredients,
In addition, the effect is high even when blended at a relatively low concentration, and therefore the amount blended can be reduced, resulting in high safety in use.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

After drying, add 300 g of an aqueous solution of 30% ethanol to the shredded 300 I and reflux for 1 hour on a water bath at 70-80°C with a cooling tube attached.Then, the ethanol fraction was separated from house to house, and the residue was mixed with fresh 30% ethanol. Aqueous solution 3001 was added, and the same reflux was repeated twice, and the extraction operation tube was carried out 13 times. The extracts were combined and concentrated under reduced pressure to obtain 2.49 ml of yellowish brown 4-store.

A similar extraction operation was carried out using ethanol as a solvent to obtain brownish-brown ester 44.3j't-. Then, using Senkakuso, 86.7N brown paste was extracted from 30% ethanol aqueous solution and 511# brown yeast tube was extracted from ethanol. Furthermore, a similar extraction operation was performed using methanol as a solvent. In addition, a 1:1 mixture of Komusubi, Daiji, Soso, Osui, Sanshichi and Sokai, a 2:1 mixture of Sanshichi and Senkakuso, and a 3 mixture of Komusubi and Senkakuso (both weight ratio)
Also, 30ts ethanol aqueous solution, ethanol,
Similar extraction operations were performed using three types of solvents, including methanol, to obtain extracts.Next, we investigated the hemostatic effects of extracts of these crude drugs. The strengthening effect on capillaries, which is considered to be particularly important, was measured and judged using a purpurameter as 1 or less.

Hair was removed from the abdomen of Wistar rats, and each herbal medicine extract gold 5
A pharmacopoeial hydrophilic ointment containing % of the drug was applied. The application period was 5 hours per day, during which time the arm was sealed with rough-in paper, and the application was continued for 3 consecutive days. In addition, for the control group, only the pharmacopoeial hydrophilic ointment was applied, and for comparison, a pharmaceutical hydrophilic ointment containing 5% rutin, which is said to have a blood vessel strengthening effect, was used and applied in the same manner. did.

After the application was completed, suction was applied at 350 gmHg for 30 seconds using a purpura meter, and the bleeding spots within a circle with a diameter of 10 m were counted. The results are shown in Table 1.

From the results shown in Table 1, it can be seen that extracts of these herbal medicines have excellent hemostatic effects.

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to the following Examples.

[Example 1] According to a conventional method, a toothpaste with the following formulation was prepared: Dibasic calcium phosphate dihydrate 50.0% glycerin
2060 Calgaxymethylcellulose 1.0 Sodium lauryl sulfate 1.0 Flavor 1.0 Saccharin 0.1 Sanshichi 30'% ethanol aqueous extract 2.0
Using the toothpaste with the above formulation, the hemostasis effect and gingivitis improving effect were tested in the following manner.

The test subjects were 18 adult males and 8 adult females who had inflammatory changes in their gums and whose gums bleed due to some kind of irritation.
The participants were divided into two groups of 13 people, each with approximately the same symptoms. The experimental group received 4 toothpastes with the above formulation, and the control group received toothpastes with the same formulation as above except that it did not contain Sanshichi extract. Each subject was given the same new toothbrush and asked to brush their teeth after every meal for one month. In addition, the participants were free to use the plastic and sing method.

The hemostatic effect and gingivitis-improving effect were tested using the above method, and the hemostatic effect was evaluated according to the following criteria, and the gingivitis-improving effect was evaluated using the PMA index. The observation site was the 12 anterior teeth of the upper and lower jaws. The results are shown in Tables 2 and 3.

Judgment criteria for hemostatic effect: No bleeding even when the gingival margin is strongly pressed with fingers.
・・・・・・・・・Ol Bleeding occurs when you touch it with your finger forcefully ・・・・・・・・・・・・・・・11 It does not bleed even when you apply gentle pressure with your fingers ・・・・・・・・・・・・・・・21 Just touching it gently with my finger makes me bleed...
・3 Table 2 Hemostatic effect Table 3 Gingivitis improvement effect According to the results in Tables 2 and 3, the toothpaste containing the extract of the present invention has an excellent hemostatic effect and is extremely effective in improving gingivitis. It has been found to be effective in

[Example 2] Toothpaste dicalcium phosphate dihydrate 5
00 tiglycerin 20.0 cal xymethyl cellulose 1.
0 Sodium lauryl sulfate 1. O fragrance
1.0 Satukarin 0.2
37 methanol extract 0.2f, sodium chloride 0.1100.09
6 [Example 3] Toothpaste dicalcium phosphate dihydrate 5
0.01 nr bit 10
．． 0 Glycerin 10.0 Cal?
oxymethylcellulose 1.0
Sodium lauryl sulfate 1 2
．． 0 fragrance
1.0 Satukarin
0.1 Sodium monofluorophosphate
0.3% ethanol
2.0 Mutanase 0.
1100.0 [Example 4] Toothpaste calcium carbonate 50.0 Superior glycerin 20.0 Color r Nan
0.5 Calgeximethyl cellulose 1.0 Rawalyl diethanolamide 1.0 Sucrose monolaurate 2.0 Flavor
1.0 Satukarin 01 Oji ethanol extract O1 Koshugi 30
Ethanol aqueous extract 0.1 Chlorhexinone o, oos dextranase 0.01100
．． 0 Excellent [Example 5] Toothpaste, dicalcium phosphate dihydrate
500% glycerin 20.0 Cal? oxymethylcellulose 2
．． 0 Sodium lauryl sulfate 2.0 Fragrance
1.0 Satukarin 01
Violet Ethanol Ethanol Extract 0.137 Methanol Extract 0.1 Chlorhexinone 0.01100.0 [Example 6] Toothpaste Silicic Anhydride 30.0% Glycerin 30.0 Sorbit
20. O Carboxymethyl cellulose 1.0 Sonium lauryl sulfate 2.0 Fragrance
1.0 Satukarin O1
Small side 30 timeethanol aqueous extract
01 ethanol 2.0
1000 pieces [Example 7] Powdered toothpaste dicalcium phosphate dihydrate 50
．． 01 Calcium carbonate 300 Glycerin 1α0α-olefin sulfunanate 1.0 Fragrance
1.0 Satukarin 0
．． 1. Dou-gu wood water extract 01. Ethanol extract of Violet annuus 01. Sodium monofluorophosphate 01. Dextran 0.5100.0% [Example 8] Liquid toothpaste? Sodium lyacrylate 5
0.01 Glycerin 300 Chi Flavoring
O19 Saccharin 0
1 Chlorhexinone 0.01 Senkakusa ethanol extract 0.05 Ethanol 30 Chlorhexidine 0.01 Linole #
0.05100.0% [Example 9] Mouthwash ethanol 200 tsp
fee
1.0 Satukarin 005
Sodium monofluorophosphate
0.1 Chlorhexinone
001 lauryl diethanolamide
03 Daiji 30-thiethanol aqueous solution extract
O1 water
Remaining 100.0% [Example 10] Gargle tablet sodium bicarbonate 54.0 Section 2
Sodium phosphate 100 Polyethylene glycol 30 Citric acid 17.0 Sodium sulfate (anhydrous) 13.6 Flavor
2.0 Oleic acid 0.1 Sodium monofluorophosphate 0.1 Chlorhexidine O05
37 ethanol extract
0.1100.0% [Example 11] Gingivitis, Sarno Cream White Vaseline 8.0% Propylene Glycol 4.0 Stearyl Alcohol 80 Polyethylene Glycol 400
0 25.0 Polyethylene glycol 400 37.0% Senkakuso ethanol extract 0.1 Sugar stearate 05 Dextranase
10100.0chi [Example 12] Chi-ingamugamupace 43.8% calcium carbonate 2.0 water
Candy
150 powder sugar
30. Oshi, sugar palmitate
1.0 fructose
40 Maltose 3.0 Masaki water extract 011000% [Example 13] Oral Pasta I Lyoxyethylene Monostearate 2.051 Sorbitan Monooleate 2.
0% cetyl alcohol 2.0 no? Lumityl Alcohol 3.0 Glopylene Glycol 15.0 Calgeximethyl Cellulose 5° Gelatin
1.0 Satukarin
02 Oji Methanol Extract
o1 Senkakuso ethanol extract
o1 Shioshiri Zozyme 5000 enshrinement/
Chlorhexinone hydrochloride 0.0
1fi fragrance
03100.0chi [Example 14] Oral tablet Tamashichi ethanol extract 25 daika
Fee 10
Dasatsukarin 1Wv Corn, Dengun 5ooWI9 or more ingredients are made into tablets according to a conventional method. This is 3 times a day 1
, Take 2 tablets at a time after each meal.

[Example 15] Lozenge Gum Arabic 6.0% Glucose 72.0 Gelatin 3.0 Flavor
02 Dextranase 01 Chlorhexidine gluconate 001 Ethanol extract of Purple Steak 01 Sanshichi and Senkakuso 1
: of two mixtures. 230-thiethanol aqueous extract applicant: Lion Co., Ltd. agent: patent attorney Takashi Kojima! Patent attorney Hanyo Takahata

Claims (1)

[Claims] A composition for the prevention and treatment of periodontal diseases, which contains as an active ingredient an extract of a herbal medicine selected from Sanshichi, Kowari, Osaibu, Shibajing, Honki, and Senkakuso.