KR102562835B1 - Composition for prevention or treatment of oral disease comprising ROSAE LAEVIGATAE Extract - Google Patents

Abstract

The present invention relates to a composition for the prevention, improvement or treatment of oral diseases containing an extract of Golden Angelica, and relates to a composition for preventing, improving or treating oral diseases having excellent effects while being safe for the human body.

Description

Composition for prevention or treatment of oral disease comprising ROSAE LAEVIGATAE Extract}

The present invention relates to a composition for oral care, and relates to a composition that is safe for the human body and is effective in preventing, improving, or treating oral diseases such as dental caries, periodontal disease, halitosis, and cold ears.

Among oral diseases, dental caries and periodontal disease are known to cause various clinical symptoms such as pain, masticatory dysfunction, destruction of periodontal tissue, bad breath and cold teeth, and are the main factors that cause tooth loss. The causative factors are increasing.

It is a method of suppressing the growth of oral pathogens that live in the bacterial film of the tooth surface and cause dental caries, periodontal disease, bad breath, and cold teeth. , has been developed as an inhibitor and therapeutic agent for pulp and apical infections.

However, antibiotics have a disadvantage in that they can be used only as a treatment because it is difficult to use them for a long time because they can cause the appearance of resistant bacteria in the oral cavity and mycosis, along with systemic side effects on our body. In addition, antibacterial agents used in mouthwashes include raw guinarine, listerine, pyroxide, chlorhexidine, etc., but the effect of sangquinarine on bacteria in the oral cavity is unclear, and the treatment effect for periodontal disease is even more unclear. In addition, Listerine has the disadvantage of being expensive, and although alcohol is the main component, it actually has a temporary effect in the oral cavity, but has a slight bacteriostatic effect, but has the disadvantage that it may cause harm to tissues when used for a long time. Peroxide, which is added for a whitening effect, has a toxic effect on bacteria, but at the same time, it also exhibits a toxic effect on human tissues, resulting in safety problems and sometimes bacteria resistant to pyroxide appear. In addition, Chlorhexidine is known to be the best among known agents for preventing and treating periodontal disease as well as inhibiting plaque formation. In addition to the problems indicated, there are disadvantages that can not be used for a long period of time for the purpose of treatment or prevention, such as that it can also cause mycosis, and is carcinogenic, limiting its use in the case of pregnant women.

On the other hand, the symptom of tooth sensitivity or tooth hypersensitivity refers to a symptom of tooth sensitivity when eating sour fruits or drinking cold drinks. This causes the dentinal tubules that were protected by the gums to become exposed. Toothpaste for preventing dentin is being developed to improve these ache symptoms, and treatment is performed to fill the dentinal tubules exposed in dentistry with resin or the like. However, in the case of a toothpaste specializing in toothpaste that utilizes the conventional dentinal tubule sealing effect, it contains fine powder of active ingredients to seal the dentinal tubules. There was a problem that the customs could not be sealed and exposed again.

Accordingly, the present inventors conducted research to derive a component that is effective in preventing and improving oral diseases such as dental caries, periodontal disease, halitosis, and ache symptoms, while being harmless to the human body and having no concerns about side effects.

Therefore, the present invention is to solve the above problems, and to provide a new active ingredient that can inhibit the growth of bacteria in the oral cavity while being safe to the human body with fewer side effects, that is, such a useful use of the active ingredient.

In other words, the problem to be solved by the present invention is to provide a composition containing the active ingredient with excellent efficacy as an active ingredient, in particular, a composition for oral care for preventing or improving dental caries, periodontal disease, and bad breath.

The present invention is to provide a composition for treating or improving oral diseases using natural ingredients that are safe and can be safely used in the body.

An object of the present invention is to provide an oral composition capable of alleviating the symptoms of ache by forming a coating film on the surface of a damaged tooth using natural materials.

In order to solve the above problems, the present invention provides an oral composition derived from natural substances. Specifically, in one embodiment of the present invention provides a composition for oral cavity containing ( ROSAE LAEVIGATAE ) as an active ingredient.

That is, the present invention provides a new use of an oral composition for preventing, improving or treating a variety of oral diseases, especially oral compositions containing gold hyacinth.

Researchers of the present invention conducted research for the development of an oral composition that is harmless to the human body and can exhibit effects such as treatment, prevention, and improvement of diseases in the oral cavity. The present invention was completed after confirming that it can have a tooth surface coating effect and a tooth surface coating effect. Through the continuous research process of the inventors of the present invention, it was possible to identify for the first time the oral disease treatment or prevention effect of the golden cherry extract of the present invention.

The golden aengja refers to the fruit of the golden aengja (Rosa laevigata Michaux.) of the Rosaceae family. It is also called Zaiza(刺梨子), Freeja(刺楡子), Sanseokryu(山石榴), Sangyeduja(山鷄頭子).

The method of using the gold aengja is not particularly limited, and may be included in the oral composition as a pulverized powder after drying, preferably included in the oral composition as an extract.

As used herein, the term "extract" refers to an extract obtained by the extraction treatment of gold cherry blossoms, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a crude or purified product of the extract, or a mixture thereof, It includes the extract itself and extracts of all formulations that can be formed using the extract.

In the golden angel extract of the present invention, the method of extracting the golden angel is not particularly limited, and can be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include a hot water extraction method, an ultrasonic extraction method, a filtration method, a reflux extraction method, and the like, which may be performed alone or in combination of two or more methods, preferably using a hot water extraction method. can be done by

In the present invention, the type of extraction solvent used to extract the gold cherry blossom is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, acetic acid, formic acid, diethyl ether And one or more solvents selected from the group consisting of cyclohexane, and the like. When alcohol is used as a solvent, C ₁ to C ₄ alcohols (methanol, ethanol, propanol, butanol) may be preferably used. In the present invention, more preferably water, ethanol or a mixture thereof may be used as the extraction solvent of the gold flower.

In the present invention, the composition may be used for preventing, improving or treating oral diseases.

In the present invention, the oral disease includes, but is not limited to, halitosis, dental caries, periodontal disease including gingivitis and periodontitis, and mucosal ulcers in the oral cavity, which may be caused by microorganisms in the oral cavity. It is a concept.

In addition, the oral diseases may include various diseases in the oral cavity that may be caused by external physical stimuli as well as the effects of microorganisms in the oral cavity, for example, dentinal tubules are exposed due to tooth surface abrasion and exhibit hypersensitivity reactions. Achilles can also include symptoms.

As used herein, the term 'treatment' in the present invention refers to an approach for obtaining beneficial or desirable clinical results, regardless of whether beneficial or desirable clinical results are detectable or not possible for the purposes of the present invention, and also Alleviation of symptoms, reduction of severity of disease, stabilization (i.e., not getting worse) state of disease, delay or slowing of disease progression, amelioration or palliation and remission of disease state, whether partial or total; It is not limited to this. Thus, treatment refers to both therapeutic treatment and prophylactic treatment, and those requiring treatment include conditions in which a disease is to be prevented as well as conditions in which a disease is already present. In addition, it may mean any action that improves or benefits oral disease symptoms by administering the pharmaceutical composition of the present invention to a subject.

"Prevention" may refer to any activity that suppresses or delays a disease by using the composition for oral cavity. The oral composition may be used in the form of a pharmaceutical composition, a food composition, or an oral hygiene composition, but is not necessarily limited thereto.

In addition, the term "improvement" as used herein means that the symptoms of syrinx are reduced or mitigated, and can be understood as a broad concept including alleviation, prevention, treatment, and the like.

As used herein, the term "halitosis" may refer to a symptom of an unpleasant odor from the mouth, but is not limited thereto, and is typically caused by volatile sulfur compounds generated when microorganisms in the oral cavity decompose proteins. It may cause an unpleasant odor from the mouth.

As used herein, the term "dental caries" refers to tooth decay caused by damage to tooth enamel caused by acids generated when sugars and starches are decomposed by bacteria living in the mouth. The caries can be caused by various causes, for example, plaque, which is a bacterial film formed on the surface of a tooth. When food is ingested, food remnants remain in the mouth. When sugar or starch remaining in the mouth is decomposed by bacteria constituting plaque, acids generated attack and damage the enamel of the tooth surface, dental caries may occur.

As used herein, the term "periodontal disease" is an oral disease including gingivitis and periodontitis depending on the degree, but is not limited thereto, but bacteria attack the part below the gum line of the sulcus and damage the periodontal ligament and May result from damage to adjacent tissues.

As used herein, the term "oral mucosal ulcer" is also referred to as stomatitis, but is not limited thereto, due to infection by bacteria, viruses, fungi, etc. in the oral cavity (tongue, gums, lips, inside of the cheek) etc.) may include inflammatory diseases.

The oral disease may be caused by bacteria, and the bacteria may be bacteria such as the genus Streptococcus and the genus Porphyromonas.

The oral composition of the present invention is Streptococcus genus or Porphyromonas genus, more specifically, Streptococcus mutans, Streptococcus sanguis, Streptococcus sanguinis (Streptococcus sanguinis), Streptococcus salivarius subsp. thermophils, and Porphyromonas gingivalis have an excellent antibacterial effect on one or more bacteria selected from the group consisting of, preventing, improving or preventing oral diseases It can have an excellent effect on treatment.

More preferably, the oral composition of the present invention may exhibit an antibacterial effect against Streptococcus mutans or Porphyromonas gingivalis bacteria.

According to another embodiment of the present invention, the golden cherry extract of the present invention is contained in a composition for preventing, improving or treating symptoms of syringi.

As used herein, the term "cold ear" refers to any phenomenon in which sharp, temporary or continuous pain is manifested in response to external stimuli, apart from tooth decay or other pathological causes, but is not limited thereto. The external stimulus usually means a temperature stimulus, and usually complains of symptoms in a cold temperature stimulus, but pain may appear in a hot temperature. In addition to these temperature stimuli, pain may also be caused by stimuli such as tooth drying, contact with external substances, and osmotic pressure through sweet or sour food. It may appear throughout the entire tooth, may be limited to a specific area such as the upper or lower jaw, or the right or left side, or may be accompanied by dentine hyperesthesia, caries, or pulp inflammation.

Exposure of the entrance of the dentinal tubules can be considered as the cause of these symptoms.

When the enamel or cementum is destroyed and the entrance of the dentinal tubule is exposed to the outside, stimulation is transmitted to the dental pulp by the cell protrusions, nerves, and dentin fluid of the dentinal tubule, so that pain can be felt.

The inventors of the present invention found that the gold cherry extract can react with calcium ions contained in saliva to form a coating film on the tooth surface, and the formed coating film prevents exposure of dentinal tubules to prevent, improve, or treat symptoms of syringitis. Confirmed. The composition for preventing or treating oral diseases of the present invention may be directly applied to animals including humans. The animal refers to a group of organisms corresponding to plants, mainly ingesting organic matter as nutrients, and having differentiated digestion, excretion, and respiratory organs, preferably vertebrates, and more preferably mammals. Specifically, the mammal may be a human, pig, cow or goat. The composition for preventing or treating oral diseases may include the gold flower extract alone as an active ingredient, and other additional ingredients depending on the formulation, method of use, and purpose of use, that is, a pharmaceutically acceptable or nutritionally acceptable carrier, It may further contain excipients, diluents or minor ingredients.

More specifically, the composition for preventing or treating oral diseases includes nutrients, vitamins, electrolytes, flavors, colorants, enhancers, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners in addition to the active ingredients. , pH regulators, stabilizers, preservatives, glycerin, alcohol, carbonation agents used in carbonated beverages, and the like may be further contained. In addition, the carrier, excipient or diluent is lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, aquicia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline In the group consisting of cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, liquid paraffin, and physiological saline It may be one or more selected, but is not limited thereto, and all conventional carriers, excipients, or diluents may be used.

When the composition for preventing or treating oral diseases is medicated, it may further include conventional fillers, extenders, binders, disintegrants, surfactants, anticoagulants, lubricants, wetting agents, flavoring agents, emulsifiers or preservatives, and oral Or it can be used both parenterally.

Specifically, solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and these solid preparations contain at least one excipient, for example, starch, calcium carbonate It is prepared by mixing sucrose or lactose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral administration include suspensions, solutions for oral use, emulsions, syrups, etc., and various excipients such as wetting agents, sweeteners, aromatics, preservatives, etc. may be included in addition to water and liquid paraffin, which are commonly used simple diluents. .

Forms for parenteral administration include toothpaste, mouthwash, topical administration agents (creams, ointments, dressing solutions, sprays, other coating agents, etc.). An example of the formulation of the topical administration may be one in which a carrier such as gauze made of natural or synthetic fibers is impregnated with a composition for preventing or treating oral diseases containing the active ingredient, A. gauze extract.

In the case of the cream or ointment, it may be suitable for direct application to periodontal disease, gingival disease affected area or carious area or its surroundings. In the case of the spray agent, it can be prepared by a conventional spray agent manufacturing method, except for containing the golden cherry extract as an active ingredient. can be prevented or treated. In the case of the dressing solution, it can be prepared by a conventional dressing solution manufacturing method, except that it contains a golden cherry extract as an active ingredient, and can be used for oral disease dressings or other bacterial infection dressings for oral infection diseases can be prevented or treated.

In addition, the dosage form of the composition for preventing or treating oral diseases of the present invention may be in a preferred form depending on the method of use, and in particular, it is known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal. It can be formulated by adopting the method described above. Examples of specific formulations include warning agents, granules, lotions, liniment agents, limonade agents, powders, syrups, liquids, aerosols, EXTRACTS, elixirs, ointments, fluid extracts, emulsions, suspensions, There are preservatives, infusions, tablets, capsules, creams, pills, soft or hard gelatin capsules, and the like.

Furthermore, the composition for preventing or treating oral diseases of the present invention can be prepared using an appropriate method known in the art or a method disclosed in Remington's Pharmaceutical Science (recent edition), Mack Publishing Company, Easton PA). It can be formulated preferably using.

The dosage of the composition for preventing or treating oral diseases according to the present invention may be appropriately selected by those skilled in the art in consideration of the administration method, the age, sex and weight of the user, and the severity of the disease. For example, the composition for preventing or treating oral diseases of the present invention may be administered at 0.0001 mg/kg to 1000 mg/kg, and more effectively at 0.01 mg/kg to 100 mg/kg. Administration may be administered once a day, or may be administered in several divided doses. The dosage is not intended to limit the scope of the present invention in any way.

In addition, the composition for preventing or treating oral diseases of the present invention may further include a compound or plant extract having a known oral disease inhibiting activity in addition to the gold cherry blossom extract, and the content may be determined differently depending on the manufacturing method and purpose of use .

In one embodiment of the present invention also provides a food composition for preventing or improving oral diseases containing the golden angel extract as an active ingredient. Examples of the food composition of the present invention include food, food additives, beverages or beverage additives.

The food composition containing the Golden Angel extract as an active ingredient may further include suitable carriers, excipients and diluents commonly used in the preparation thereof.

In this specification, food means a natural product or processed product containing one or more nutrients, and preferably means a state that can be eaten directly through a certain degree of processing process, and in a conventional sense, It is intended to include all foods, food additives, health functional foods and beverages.

Foods to which the gold cherry blossom extract of the present invention can be added include, for example, various foods, beverages, gum, candy, tea, vitamin complexes, and functional foods. In addition, in the present invention, the food includes special nutritious food (eg, formula milk, infant/young child food, etc.), processed meat product, fish meat product, tofu, jelly, noodles (eg, ramen, noodles, etc.), health supplement food, seasoning food ( For example, soy sauce, soybean paste, gochujang, mixed paste, etc.), sauces, confectionery (eg, snacks), dairy products (eg, fermented milk, cheese, etc.), other processed foods, kimchi, pickled foods (various types of kimchi, pickles, etc.), drinks ( Examples include, but are not limited to, fruit and vegetable beverages, soymilk, fermented beverages, ice cream, etc.), natural seasonings (eg, ramen soup, etc.), vitamin complexes, alcoholic beverages, alcoholic beverages, and other health supplements. The food, beverage or food additive may be prepared by a conventional manufacturing method.

Functional food in the present invention is a food group or food composition that has added value so that the function of the food acts for a specific purpose by using physical, biochemical, or bioengineering methods, etc. Means a food designed and processed to sufficiently express the body control function related to the back to the living body, and preferably, the functional food of the present invention is capable of sufficiently expressing the body control function related to the prevention or improvement of oral diseases to the living body. means food. The functional food may include food additives that are acceptable in food science, and may further include appropriate carriers, excipients, and diluents commonly used in the manufacture of functional foods.

In the present invention, a beverage means a generic term for drinking to quench thirst or enjoy taste, and is intended to include functional beverages. The beverage has no particular restrictions on other ingredients other than including the golden cherry extract as an active ingredient as an essential ingredient in the indicated ratio, and may contain various flavors or natural carbohydrates as additional ingredients like conventional beverages. . Examples of the above natural carbohydrates include monosaccharides such as glucose, fructose, etc. disaccharides such as maltose, sucrose, etc. and polysaccharides such as dextrin, cyclodextrin, etc., common sugars, and It is a sugar alcohol, such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (thaumatin, stevia extract (e.g. rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can advantageously be used. The ratio of the natural carbohydrates is generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention In addition, the composition of the present invention is a natural fruit juice, fruit juice beverage, fruit pulp for the production of vegetable beverages may additionally contain.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants and enhancers (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its It may contain salts, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, carbonation agents used in carbonated beverages, and the like. These components may be used independently or in combination.

In the present invention, the functional beverage refers to a beverage group or beverage composition that has added value so that the beverage functions for a specific purpose by using physical, biochemical, or bioengineering methods, etc. It refers to a beverage designed and processed to fully express body control functions related to recovery.

The functional beverage is not particularly limited in other components except for containing the gold cherry extract of the present invention as an essential component in the indicated ratio, and may contain various flavors or natural carbohydrates as additional components like conventional beverages. . Examples of the natural carbohydrates include monosaccharides such as glucose, fructose, etc. disaccharides such as maltose, sucrose, etc. and polysaccharides such as dextrins, cyclodextrins, etc., common sugars, and xylitol , sorbitol, erythritol, and the like. As flavoring agents other than those mentioned above, natural flavoring agents (thaumatin, stevia extract (e.g. rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can advantageously be used. .

The present invention provides an oral hygiene composition for preventing or improving oral diseases comprising an extract of Golden Angelica as an active ingredient. The oral hygiene composition of the present invention includes all types and formulations that can be used for oral hygiene. Non-limiting examples of the oral hygiene composition include toothpaste, mouthwash, oral spray, oral ointment, gum, and the like.

When the oral hygiene composition of the present invention is toothpaste, it may further contain an abrasive, a binder, a moisturizer, a foaming agent, a sweetener, a whitening agent, or a flavoring agent in addition to containing the extract of Golden Angelica as an active ingredient. The abrasive includes aluminum hydroxide, silicic anhydride, aluminum silicate, dibasic calcium phosphate dihydroxide and anhydride, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, Polymethyl methacrylate and the like can be used alone or in combination. The content of the abrasive may be 20% to 90% by weight based on the total composition, but is not limited by the content.

When the oral hygiene composition is a paste-like composition, the binder is garagenin, various cellulose derivatives for thickening, xanthan gum, gums such as tragacanth gum, polyvinyl alcohol, sodium polyacrylate, polyacrylic acid/ Organic binders such as synthetic polymer derivatives such as maleic acid copolymers and carboxyvinyl polymers, and inorganic binders such as silica and laponite may be used alone or in combination. The content of the binder may be 0.3% to 5% by weight based on the total composition, but is not limited by the content.

In addition, the oral hygiene composition may further include sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol, polypropylene glycol, etc. as a moisturizing agent during its preparation.

In addition, the oral hygiene composition may further include a flavoring agent or a sweetener. The sweetening agent may be sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, glycerin, sodium saccharin, stevioside, aspartame, etc., and the flavoring agent may be peppermint, menthol, anethol, eugenol, It may be limonene, citronenol, alpha terpineol, salicylmethyl, cineol, linalol, ethyllinalol, vanillin, thymol, spearmint oil, seji oil, rosemary oil, cinnamon oil, etc., and the sweetener or flavoring agent is alone can be used singly or in combination.

In addition, the oral hygiene composition of the present invention may include a surfactant used as a foaming component or an additional active ingredient alone or in combination. The surfactant used as the foaming component may be any one selected from the group consisting of anionic surfactants, nonionic surfactants, and cationic surfactants.

When the oral hygiene composition of the present invention is a toothpaste, it can be prepared by a conventional toothpaste manufacturing method, except that it contains a golden cherry extract as an active ingredient, and when the oral hygiene composition of the present invention is a mouthwash solution, It can be prepared by mixing the gold flower extract with a solution and formulating it into a mouthwash solution, and oral diseases can be prevented or treated by washing the mouth 2 to 10 times a day.

In addition, when the oral hygiene composition of the present invention is a toothpaste cream, it may further include a liquid containing water and a moisturizing agent, a gelling agent or a water-insoluble brightener, a sweetener, a flavoring agent, and the like.

In addition, when the oral hygiene composition of the present invention is a mouthwash (cleaner), it may further include a toothpaste carrier, more specifically, a non-toxic alcohol.

The method for preparing the composition for treating or preventing oral diseases of the present invention may be prepared according to a method conventionally prepared in the art.

In the present invention, the golden cherry extract may be 0.001 to 10% by weight based on the total weight of the composition, preferably 0.005 to 5% by weight based on the total weight of the composition, more preferably 0.008 to 1% by weight based on the total weight of the composition % by weight. If the gold cherry extract is less than 0.001% by weight relative to the total weight of the composition, the effect on oral diseases may be insufficient, and if it is greater than 10% by weight, it may not be preferable because the feeling of use such as taste is not good when brushing teeth.

The oral composition of the present invention, in addition to the gold flower extract, may further include a wetting agent, an abrasive, a medicinal agent, a sweetening agent, a pH adjusting agent, a preservative, a binder, a flavoring agent, a foaming agent, etc. there is.

The humectant is used alone or in combination in the group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycol and propylene glycol, and the amount thereof is included in an amount of 1 to 70% by weight based on the total weight of the oral composition.

The abrasive is one selected from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, anhydrous calcium monohydrogen phosphate, hydrous alumina, light calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate. etc. can be used. The amount of the abrasive used is generally 1 to 60% by weight based on the total weight of the oral composition. In addition, additives used in small amounts may include sweeteners, pH adjusters, preservatives, colorants, and binders as commonly used components.

Sodium fluoride, sodium monofluorophosphate, sodium fluoride, tin fluoride, chlorhexidine, allantoin chlorohydroxyaluminate, aminocaproic acid, zinc chloride, pyridoxine hydrochloride, tocopherol acetate, enzymes, etc. alone or in combination It can be used by mixing more than one.

As the sweetener, saccharin, xylitol, erythritol, aspartame, etc. may be used, and the amount of the sweetener is generally 0.05 to 2% by weight based on the total weight of the oral composition.

As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, triethanolamine, and the like can be used.

Benzoic acid, methyl paraben, propyl paraben, sodium benzoate and the like can be used as preservatives. Peppermint oil, spearmint oil, menthol, etc. may be mixed and used as flavoring agents, and enzymes such as dextranase may be used as other additives.

As a binder, carrageenan, xanthan gum, sodium carboxymethyl cellulose, carboxy vinyl polymer, sodium alginate, laponite, etc. may be used alone or in combination of two or more.

As the foaming agent, sodium lauryl sulfate as an anionic surfactant, polyoxyethylene polyoxypropylene copolymer (poloxamer) as a nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, etc. may be used. .

In addition, a residual amount of water may be included.

According to another embodiment of the present invention, an oral hygiene product comprising the composition is provided. The oral hygiene composition according to the present invention, which contains the extract of A. japonica japonica as an active ingredient, is a composition for oral hygiene that can be included in all commercially available products generally manufactured for oral health, and there is no limitation on the applied oral hygiene products. . For example, the oral hygiene product includes, but is not limited to, toothpaste, oral spray, oral ointment, oral patch, mouthwash, and the like. The oral hygiene product of the present invention may be in the form of a liquid, solid, suspension, gel, or aerosol, but is not limited thereto.

Compositions containing the golden cherry extract of the present invention provide oral disease prevention, improvement or treatment effects.

The present invention provides a composition for preventing, improving or treating oral diseases derived from natural materials, which has few side effects, is safe for the human body, and can inhibit the growth of bacteria in the oral cavity.

It is possible to provide a composition that is non-toxic and has excellent stability while showing excellent dental caries, periodontal disease, and bad breath prevention or improvement.

It can show excellent effects in the prevention and treatment of dental caries.

Hereinafter, the following examples and the like will be described in order to explain the present invention in more detail. However, embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided by way of example to help a detailed understanding of the present invention.

<Preparation of gold cherry blossom extract>

The Golden Angel extract of the present invention was prepared in the following way.

The Golden Angel extract was obtained by immersing it in a 95% ethanol solution and extracting it at room temperature for 48 hours.

<Experiment 1. Antibacterial effect test>

An antibacterial activity test was conducted using the paper disk test method to see if there was an effect of inhibiting strains using Gram-positive bacteria Streptococcus mutans and Gram-negative bacteria Porphyromonas gingivalis, which are representative bacteria causing dental caries and periodontal disease. Each of the above bacteria was activated under the optimal culture conditions in Table 1 below, and then cultured in the optimal medium for each bacteria for about 4 to 6 hours to determine the turbidity of the culture medium by Macfarland turbidity No. After adjusting to be 0.5 (1.5x10 ⁸ ), 0.1 ml was spread evenly. A sterilized paper disk (Whatman no.5 paper, 8 mm diameter) was inoculated with gold cherry blossom extract at a concentration of 10 mg/disc and dried for 1 hour before use. After culturing for 24-48 hours at the optimal temperature for each of the above bacteria, the size (diameter mm) of the growth arrest ring was measured.

strain optimum condition Gram staining strain name temperature badge characteristics Gram (+) Streptococcus mutans 37℃ BHI Facultative anaerobic Gram (-) Porphyromonas gingivalis 37℃ TSA Hemin Menadione medium Anaerobic

The results are shown in the table below.

Results of measurement of antibacterial activity of oral pathogens of gold cherry blossom extract

Growth arrest ring diameter (mm) S. mutans P. gingivalis untreated - (No inhibition) - (No inhibition) Golden Angel Extract Treatment 10.8 10.6

<Experiment 2. Gingival inflammation inhibition effect>

In order to compare the degree of inhibition of gingival inflammation formation, first, sodium carboxymethylcellulose, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silica, and sodium cocoyl isethionate, which can be commonly used to prepare toothpaste , Dodicin, a sweetener, a fragrance, a colorant, etc. were used to prepare a control group toothpaste, and an experimental group toothpaste containing 0.01% by weight of the extract of Golden Angel was prepared.

The subjects of the experiment were gingivitis patients with even teeth and no missing teeth, and a detailed oral examination was conducted on 30 subjects by gender at 10-year intervals from 30 to 50 years of age. After selecting 120 subjects, they were divided into 60 subjects. A clinical trial was conducted on the treatment effect of gingival inflammation.

The experimental group was divided into an experimental group and a control group, and they were instructed to use it 3 times a day after 2 hours after eating and before going to bed. After 6 months and 6 months, an oral examination was conducted to examine the gingivitis index. The method of measuring the gingivitis index is to insert a periodontal probe into the gingival sulcus, burn around each tooth without applying force, and measure the state of bleeding after 30 seconds, and score the score in the following way. record and obtain the result.

score detail 0 points no bleeding 1 point normal bleeding 2 points glandular hemorrhage 3 points Interdental triangular bleeding condition 4 points Total gingival bleeding

Inhibition of gingival inflammation

army
hour control group test group 0 weeks 1.03 1.04 1 week 1.59 1.06 1 month 2.16 1.11 3 months 2.51 1.16 6 months 2.63 1.16

<Experiment 3. Comparison of degree of suppression of cold ear phenomenon>

In order to compare the degree of inhibition of syrin, first, sodium carboxymethylcellulose, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silica, sodium cocoyl isethionate, A control toothpaste was prepared using dodicin, a sweetener, a fragrance, a colorant, and the like, and an experimental group toothpaste containing 0.01% by weight of the extract of A. chinensis was prepared.

The degree of suppression of the syrinx phenomenon of the compositions prepared above was compared and measured. That is, 40 volunteers with hypersensitive teeth who agreed to participate in this experiment were studied, and the total number of teeth for the study was 80. In addition, among the applicants, there were 20 males and 20 females, and their ages ranged from 20 to 50 years. The subjects of the study were unaware of the contents of the toothpaste, and the total test period was 2 weeks.

The test was conducted by measuring the patient's response after applying the temperature stimulus. Before the test, the hypersensitive area of each volunteer's hypersensitive teeth was checked in advance, and cold water of about 5 ° C was dropped on the cold part of the tooth with a dropper, and then each composition was used 3 times a day for 2 weeks. After 2 weeks, cold water at about 5 ° C. was dropped with a dropper and evaluated. After stimulation, the patient's response rating criteria were set as follows (0 points: no discomfort, 1 point: slightly uncomfortable or cold, 3 points: painful). For statistical processing, stimulation scores before and 2 weeks after the laboratory test were tested by paired student-t test.

The response scores for the temperature stimulation after 2 weeks are shown in Table 5 below.

degree of suppression of syrin

army
hour control group experimental group 0 weeks 2.15±0.21 2.15±0.16 2 weeks 2.15±0.22 1.63±0.05 p>0.05 *p<0.05

As can be seen in Table 5, the reaction to the temperature stimulus was much less in the experimental group administered with the gold cherry blossom extract. This shows that the silin inhibitory effect was excellent in the group administered with the gold cherry blossom extract, and the ingredients contained in the gold cherry blossom extract of the present invention met with the calcium component contained in saliva to form a coating film on the tooth surface, thereby stimulating teeth. Hypersensitivity symptoms could be alleviated.

<Experiment 4. Bad breath removal effect test>

Sodium carboxymethylcellulose, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silicas, sodium cocoyl isethionate, dodicin and sweeteners that can be commonly used to prepare toothpaste for comparing the degree of bad breath removal A control group toothpaste was prepared using a fragrance, a coloring agent, etc., and an experimental group toothpaste containing 0.01% by weight of the golden cherry extract was prepared.

Fifty men and women without dental caries were selected and a cross-over test was conducted on the target beverage. Commercially available garlic powder was dispersed in water, allowed to stand for 24 hours, and then diluted so that the Halimeter measurement value was 700 ppb or more, and the diluted solution was used as a source of bad breath. After gargling with 15ml of diluted garlic powder for 30 seconds, after 1 minute, the level of bad breath was measured with a halimeter, and then brushed teeth for 30 seconds to 1 minute using toothpaste from the control group and the experimental group. After 1 minute, 5 minutes, and 30 minutes of brushing the teeth, the degree of bad breath was measured with a halimeter to determine whether or not the bad breath suppression continued. The results are shown in the table below.

bad breath removal effect

army
hour control group experimental group 1 min 54.8% 94.6% 5 minutes 42.5% 85.5% 30 minutes 37.9% 77.9%

[meaning]

It was confirmed that the extract of japonica japonica exhibits the effect of preventing or improving dental caries, gum disease, and removing bad breath. In addition, it improved the degree of hypersensitivity to temperature stimuli and gave a relaxing effect.

It is believed that the Golden Angel extract of the present invention will give a clear effect as a natural material that is included in an oral composition to effectively maintain and improve oral health.

Claims (16)

An oral hygiene composition for preventing or improving one or more oral diseases selected from the group consisting of halitosis, cold teeth, and dental caries, comprising an extract of A. The method of claim 1, wherein the gold cherry blossom extract is water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, acetic acid, formic acid, di An oral care composition characterized in that it is extracted using at least one solvent selected from the group consisting of ethyl ether and cyclohexane. The oral care composition according to claim 1, wherein the gold cherry blossom extract is extracted with water, ethanol, or a mixture thereof. The oral care composition of claim 1, wherein the golden cherry extract is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition. The oral care composition according to claim 1, wherein the oral disease is a symptom of ache. An antibacterial composition for the genus Streptococcus or Porphyromonas , containing a golden cherry extract as an active ingredient,
The Streptococcus genus is Streptococcus mutans ,
The Porphyromonas ( Porphyromonas ) The genus is Porphyromonas gingivalis ( Porphyromonas gingivalis ) Antimicrobial composition, characterized in that. delete delete delete delete [Claim 6] The oral care composition according to claim 5, wherein the extract of Golden Angelica is characterized in that it forms a coating film on the surface of teeth to alleviate or improve symptoms of ache. The oral hygiene composition according to claim 1, wherein the oral hygiene composition has one or more formulations selected from the group consisting of toothpaste, mouthwash, oral spray, oral ointment, oral patch, and gum. A food composition for preventing or improving one or more oral diseases selected from the group consisting of halitosis, cold teeth, and dental caries, comprising an extract of Azalea japonica as an active ingredient. delete A pharmaceutical composition for preventing, improving, or treating one or more oral diseases selected from the group consisting of halitosis, ache, and dental caries, comprising an extract of Azalea japonica as an active ingredient. delete