CN115836978A - Gel type cleaning agent for dental appliance and preparation and application thereof - Google Patents
Gel type cleaning agent for dental appliance and preparation and application thereof Download PDFInfo
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- CN115836978A CN115836978A CN202211486379.2A CN202211486379A CN115836978A CN 115836978 A CN115836978 A CN 115836978A CN 202211486379 A CN202211486379 A CN 202211486379A CN 115836978 A CN115836978 A CN 115836978A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of appliance cleaning, and provides a gel type cleaning agent for a tooth appliance, and preparation and application thereof, wherein the gel type cleaning agent comprises a gel, a bactericide, a biological enzyme and water; the gelling agent is more than one of cellulose gum, guar gum, xanthan gum, sodium alginate, chitosan, polyvinyl alcohol and carbomer; the bactericide is guanidine bactericide and/or plant bactericide; the biological enzyme is more than one of glucose oxidase, dextranase, proteolytic enzyme, amylase, lysozyme and superoxide dismutase; wherein, the mass ratio of the gel to the bactericide is 1-10. The preparation method is characterized in that the raw materials are uniformly mixed according to a certain sequence, the prepared gel type cleaning agent is smeared when the appliance is worn, and the gel type cleaning agent can keep stable and excellent bactericidal performance for a long time and has a wide application range.
Description
Technical Field
The invention relates to the technical field of appliance cleaning, in particular to a gel type cleaning agent for a tooth appliance, and preparation and application thereof.
Background
Orthodontic correction is mainly to adjust malocclusion, namely to treat the irregular arrangement of teeth, malposition of upper and lower dental arches, abnormal position or size of upper and lower jaws, the uncoordinated relationship between the jaws and the face and skull, etc. caused by various reasons in the growth and development process of people. Orthodontic treatment is the most widely applied high-efficiency treatment technology clinically at present, and can improve the chewing efficiency while improving the tooth aesthetic degree.
The invisible appliance is a thermoplastic removable transparent appliance appearing at the end of the 90 s in the 20 th century, and an arch wire and a bracket are not used in the correction process, so that the invisible appliance can be removed without affecting the appearance. In order to realize continuous tooth movement, each appliance needs to be worn in the mouth of a patient for 1-2 weeks, and the wearing time is more than 20h each day. Research shows that even if a patient strictly follows the medical advice to maintain the sanitation of the oral cavity and the appliance in the orthodontic treatment process, oral microorganisms are adsorbed on the surface of the appliance, and dental plaque biomembranes are formed on the surface of the material.
Dental plaque biofilm is a biofilm that gradually deposits on the tooth surface and is composed of food debris, exfoliated oral cells, saliva, and bacteria. When the patient wears the appliance for 1h, precipitates can appear on the surface of appliance materials; within 6-12 h, bacteria start to be planted, flora mainly adheres to the protruded edge and the rough surface of the appliance at the beginning, and after the appliance is worn for a period of time, microcracks, abrasion, layering areas, local calcification biomembrane deposition and transparency reduction can occur on the appliance, wherein the roughness of the surface of the appliance is increased, and the adhesion of the bacteria to the surface of the appliance is improved to a certain extent. Within 2 weeks, the surface of the appliance is staggered and accumulated with different types of bacteria to form mature dental plaque biomembranes, and the part of the appliance close to teeth or the part connected with accessories is hidden to contain more dental plaque biomembranes.
The growth of plaque biofilm not only affects the aesthetics of the appliance, but is also a potential risk factor for the development of bacterial related diseases. After 6 months of orthodontic treatment, the total number of bacteria of streptococcus mutans, lactobacillus and candida albicans in the mouth is greatly increased, and periodontal disease, halitosis and dental caries are easily caused. The cleanness of correcting the ware can not only reduce the bacterium and get into the oral cavity, but also can keep correcting the pleasing to the eye of ware, transparent and free from extraneous odour, also has certain influence to the performance of correcting the ware simultaneously, and then probably influences the final effect of correcting to a certain extent.
At present, the cleaning method of the appliance mainly comprises two methods, one is a physical method, and the other is chemical cleaning. The physical cleaning is mainly achieved by brushing with a toothbrush, but the brushing with the toothbrush can only remove part of dental plaque, the appliance is difficult to clean at the part close to the tip of the tooth and the concave part of the accessory, and the light transmittance of the appliance is greatly reduced due to the frictional wear of the toothbrush, so that the mechanical property of the appliance is reduced. The chemical cleaning is mainly various types of cleaning agents, such as hydrogen peroxide cleaning agent, mouthwash, chlorhexidine solution, biomembrane cleaning agent and the like, and the orthodontic appliance is soaked or scrubbed, then is thoroughly washed by running water and then is worn. The chemical cleaning method can effectively reduce the accumulation of dental plaque, but the operation is more complicated, the effect is short, and the mechanical property attenuation of correction equipment materials is easily caused by the use of the strong oxidation type bactericide, so that the correction accuracy is influenced; it also results in increased surface roughness of the appliance, easier plaque attachment, decreased light transmittance, and a reduced aesthetic impact. In the prior art, peroxide cleaning agent is adopted, for example, the invention patent CN102552054B discloses a denture effervescent tablet, a preparation method and application thereof, and sodium percarbonate and sodium persulfate are adopted as oxidizing agents. However, in the study of the use of the orthosis, the orthosis is frequently cleaned with a chemical cleaning agent, the operation is complicated, and the orthosis is damaged.
In view of the defects of the existing appliance cleaning mode, the inventor provides a novel gel type cleaning agent for a dental appliance with quick sterilization and dental care functions, and preparation and application thereof based on an oral care product.
Disclosure of Invention
The invention mainly aims to overcome the defects of the existing appliance cleaning agent product and provide a gel type cleaning agent with quick sterilization and tooth care functions, and preparation and application thereof. The gel type cleaning agent can be smeared inside the appliance, has the characteristics of high sterilization speed, high sterilization rate, tooth nursing and lasting effect, and can also improve the wearing convenience of the appliance.
The gel type cleaning agent for the dental appliance is provided for the first time, a brand-new cleaning mode of the invisible dental appliance is provided, and is completely different from the traditional soaking and brushing modes, the gel type cleaning agent is colorless and transparent, and can be placed on the inner surface of the dental appliance in a smearing mode and other modes when the dental appliance is worn, and can well penetrate into the part close to the tip of teeth and the concave part of an accessory due to the gel state, and the gel type cleaning agent can continuously maintain stable and excellent sterilization performance in long-time wearing, so that the phenomenon that the transparency and other indexes of the dental appliance are reduced due to the prolonged wearing time, and the sterilization effect and the attractiveness are influenced is avoided; further, after the dental appliance is removed, the removed gel type appliance cleanser may also be washed out by conventional water. By using the gel type cleaning agent disclosed by the invention during the use period of the dental appliance, not only is the generation of dental plaque biofilm avoided, but also the residual cleaning agent can be removed by taking out and washing with water, the surface of the dental appliance cannot be damaged, and the mechanical property of the dental appliance cannot be damaged. In addition, other components in the gel type cleaning agent, such as a tooth whitening agent and biological enzyme, can act on the surface of teeth for a long time in long-term wearing, and has the effects of whitening teeth, inhibiting the breeding of oral bacteria and protecting gums; in addition, the gel type cleanser can lubricate the surface of the appliance and also can play a role in facilitating the wearing of the appliance.
In the research process, the long-acting bactericidal performance of the gel cleanser is directly related to the stability of bactericidal components of the gel cleanser in a system, and the gel cleanser for the dental appliance has excellent initial bactericidal rate and long-acting bactericidal rate by controlling the types and the contents of the bactericide and the biological enzyme, can kill streptococcus mutans, lactobacillus and candida albicans within 1min, has a bacterial killing rate as high as 99.999 percent, and has a good bactericidal effect; after 90 days, the gel type cleaning agent has the bacteria killing rate of 99.999 percent and has long-acting sterilization effect.
Specifically, the invention provides a gel type cleaning agent for a dental appliance, which comprises a gel, a bactericide, a biological enzyme and water;
the gel is more than one of cellulose gum, guar gum, xanthan gum, sodium alginate, chitosan, polyvinyl alcohol and carbomer; the bactericide is a guanidine bactericide and/or a plant bactericide; the biological enzyme is more than one of glucose oxidase, dextranase, proteolytic enzyme, amylase, lysozyme and superoxide dismutase;
in the gel type cleanser, the mass ratio of the gel to the bactericide is 1-10.
Preferably, the mass ratio of the gelling agent to the bactericide is 1-10;
preferably, the gelling agent is xanthan gum.
According to the gel type cleaning agent for the dental appliance provided by the invention, the guanidine bactericide is at least one of chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene biguanide, polyhexamethylene guanidine and polyhexamethylene guanidine salt; the plant bactericide is at least one of ginger root extract, ginger essential oil, paeonol, thymol, eucalyptol, honeysuckle extract, magnolia bark extract, catechin and grapefruit extract.
The invention discovers that when the guanidine bactericide and the plant bactericide are used in a matching way, the bactericidal range is wider, the bactericidal effect is better, the toxicity to human bodies is low, and the irritation is low.
The gel type cleaning agent for the dental appliance further comprises a tooth whitening agent and/or fluoride;
the tooth whitening agent is more than one of sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate and sodium ethylene diamine tetracetate;
the fluoride is more than one of sodium monofluorophosphate, sodium fluoride and strontium fluoride.
Preferably, the mass ratio of the gel to the tooth whitening agent is 1-10, 0.1-10.0, preferably 1-10;
preferably, the mass ratio of the gelling agent to the fluoride is 1 to 10, 0.1 to 10.0, preferably 1 to 10.
The tooth whitening agent selected by the invention, such as sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, sodium ethylene diamine tetracetate and the like, has strong complexation force, can react with colored stains such as smoke stains, tea stains and the like deposited on the tooth surface to generate organic compound salt capable of being dissolved in water, promotes the desorption of protein and pigment on the tooth enamel surface, reduces the formation of the smoke stains, the tea stains and the like on the tooth surface, inhibits the mineralization of dental plaque, and rejects the appearance of new stains.
The present invention has found that when the fluoride compound of the present invention is added to the gel type cleanser, the fluoride compound can act on the surface of teeth for a long period of time, promote remineralization of teeth, and has an effect of caring teeth.
The gel-type cleaning agent for dental appliances provided by the present invention further comprises a flavoring agent; the flavoring agent is more than one of breath freshener, freshener and essence;
preferably, the breath freshener is one or more of zinc citrate, 0-cymene-5-ol, tea extract, licorice extract and radix zanthoxyli extract.
Preferably, the cooling agent is menthol and/or borneol.
Preferably, the essence is at least one of flower fragrance, fruit fragrance, tea fragrance, mint fragrance and marine fragrance.
More preferably, the mass ratio of the breath freshener is less than or equal to 0.5 percent;
more preferably, the mass ratio of the cooling agent is less than or equal to 0.5 percent;
more preferably, the mass ratio of the essence is less than or equal to 0.5%.
The gel type cleanser provided by the invention contains the breath freshener, the freshener and the essence, and has the effects of refreshing breath, refreshing and restoring consciousness and enabling people to feel happy.
The weight of the gel type cleanser product with the functions of quickly sterilizing and caring teeth can be the known weight unit of mu g, mg, g, kg and the like, and can also be multiples thereof, such as 1/10, 1/100, 10 times, 100 times and the like.
The invention also provides a preparation method of the gel type cleaning agent for the dental appliance, which comprises the following steps:
mixing the gel agent with the water to swell the gel agent to obtain gel A;
adding the bactericide into the gel A and uniformly mixing to obtain a gel B;
adding the biological enzyme into the gel B and mixing uniformly.
The preparation method of the gel type cleaning agent for the dental appliance further comprises the step of adding the tooth whitening agent and/or the fluoride into the gel B when the biological enzyme is added and uniformly mixing.
The preparation method of the gel type cleaning agent for the dental appliance further comprises the step of adding a flavoring agent into the gel type cleaning agent for the dental appliance.
The invention also provides application of the gel type cleaning agent for the dental appliance, which comprises the steps of smearing the gel type cleaning agent in the dental appliance and then wearing the gel type cleaning agent on teeth; preferably, the dental appliance is made of one or more of Thermoplastic Polyurethane (TPU), polycarbonate (PC), polyethylene terephthalate-1, 4-cyclohexadienedimethylene terephthalate (PETG) and ethylene-vinyl acetate copolymer (EVA). The gel type cleaning agent is particularly suitable for a tooth correcting appliance made of Thermoplastic Polyurethane (TPU) or polyethylene terephthalate-1, 4-cyclohexadienedimethylene terephthalate (PETG), and the correcting appliance has excellent stability and mechanical property.
According to the application of the gel type cleaning agent for the dental appliance, the gel type cleaning agent is coated on the dental appliance in an amount of 1-20 g.
According to the application of the gel type cleaning agent for the dental appliance, the gel type cleaning agent on the dental appliance is directly washed and removed by water.
The gel type cleaning agent for the dental appliance can well penetrate into the part close to the tooth tip and the concave part of the accessory due to the gel state, can continuously maintain stable and excellent sterilization performance in long-time wearing, and avoids the influence on sterilization effect and attractiveness due to the reduction of indexes such as transparency of the dental appliance caused by the prolonged wearing time; after being taken out, the residual cleaning agent can be removed by water washing, the surface of the tooth appliance can not be damaged, and the mechanical property of the tooth appliance can not be damaged. In addition, other components in the gel type cleaning agent, such as a tooth whitening agent and biological enzyme, can act on the surface of teeth for a long time in long-term wearing, and has the effects of whitening teeth, inhibiting oral bacteria breeding and protecting gums.
The gel type cleaning agent for the dental appliance provided by the invention has short sterilization time, can kill streptococcus mutans, lactobacillus and candida albicans within 1min, has a bacteria killing rate as high as 99.999 percent, and has a good sterilization effect; but also can promote the remineralization of teeth and care the teeth; can inhibit dental plaque mineralization and reject new stains; has effects of refreshing breath, and refreshing brain.
The gel type cleaning agent for the dental appliance provided by the invention is simple in preparation method, easy in process control and stable in effect.
The application of the gel type cleaning agent for the dental appliance is completely different from the traditional soaking and brushing, the gel type cleaning agent is colorless and transparent, can be placed on the inner surface of the dental appliance in a smearing mode and the like when the dental appliance is worn, and is beneficial to wearing of the dental appliance.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described clearly and completely below, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
Examples 1 to 10
(1) Weighing the raw materials according to the formula of the examples 1-10 in the table 1;
(2) Adding the gel into water, and stirring to swell the gel to obtain gel A;
(3) Adding the bactericide into the gel A, and uniformly stirring to obtain a gel B;
(4) Sequentially adding the tooth whitening agent, fluoride and biological enzyme into the gel B, and uniformly stirring to obtain gel C;
(5) And (3) sequentially adding the breath freshener, the freshener and the essence into the gel C, and uniformly stirring to obtain the gel type cleanser.
TABLE 1
Comparative example 1
A cleaning formulation and preparation substantially the same as in example 1 except that: the gelator in example 1 was replaced with povidone K30 (PVP).
Comparative example 2
A cleaning formulation and preparation substantially the same as in example 1 except that: the biological enzyme in example 1 was replaced with water.
Comparative example 3
A cleaning formulation and preparation substantially the same as in example 1 except that: the germicide in example 1 was replaced with hydrogen peroxide (H) 2 O 2 )。
Test example 1
The gel-type detergents of examples 1 to 10 were tested for their bactericidal effect, and the selected strains were Streptococcus mutans, lactobacillus, and Candida albicans.
Preparing a bacterial suspension: the streptococcus mutans, the lactobacillus and the candida albicans cultured for 24 hours are respectively diluted into bacterial suspensions by 0.03mol of phosphate buffer solution by using 5ml of sterile distilled water.
Quantitative sterilization test of bacterial suspension: 5.0ml of the aqueous gel-type detergent solutions of examples 1 to 10 (gel to water ratio 1. Acting for 1min, adding 1ml of the mixture into a sterile test tube containing 5ml of neutralizer, and mixing. Neutralizing for 10min, inoculating 1.0ml of the solution to sterile plate, pouring into common nutrient agar culture medium, culturing at 37 deg.C under inverted incubator for 24h (Streptococcus mutans and Lactobacillus), 48h (Candida albicans), counting plate colony number, averaging three times, averaging, and calculating sterilization rate. The test results are shown in table 2.
TABLE 2 germicidal Effect of gel-type cleaners
As can be seen from Table 2, the gel-type cleanser of the present invention killed Streptococcus mutans, lactobacillus, and Candida albicans within 1 min. The sterilization rate is high, the sterilization is quick, and the bacteria can be killed quickly and thoroughly. Compared with the comparative example 1, the povidone K30 is adopted as the gel, and the povidone K30 has strong complexation with the functional substances of the plant bactericide, such as gingerol, paeonol and the like, so that the sterilization function of the plant bactericide is reduced, and the sterilization rate of the cleaning agent is reduced. Comparative example 2 no bio-enzyme was used and the bactericidal efficiency of the detergent was reduced. Comparative example 3 using hydrogen peroxide as a bactericide resulted in a gel type detergent with strong oxidizing property, which collided with bio-enzyme, and the sterilization rate of the system was reduced.
Test example 2
The pH of the gel type detergents of examples 1 to 10 was measured.
The test method comprises the following steps: the pH of the gel-type cleaners in examples 1 to 10 of the present invention were tested according to the pH test method specified in the Sterilization specification (2002 edition). 50ml of each of the gel-type detergents of examples 1 to 10 was placed in a beaker, and the pH thereof was measured, and the test results are shown in Table 3.
TABLE 3 pH of gel type cleaners
Test example 3
The stability of the gel type cleaners in examples 1 to 10 was measured.
The test method comprises the following steps: the stability of the gel type cleaners in examples 1 to 10 of the present invention was tested according to the test method in "Sterilization Specification". The gel type detergents in examples 1 to 10 were stored in an incubator at 37 ℃ for 90 days and then taken out, and the appearance of the gel type detergents in examples 1 to 10 was observed, and the gel type detergents in examples 1 to 10 were stable and free from delamination.
Measuring the content of effective bactericidal components of the gel type cleaning agent before and after 90 days of storage; measuring the content of chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene biguanide, polyhexamethylene guanidine and polyhexamethylene guanidine salt according to GB/T26367-2020 hygienic requirements on guanidine disinfectants; testing the contents of gingerol and gingerol, and the contents of paeonol, thymol, catechin and hydrogen peroxide in the extract of ginger root according to 'Chinese pharmacopoeia' 2020 edition; testing the content of the hydrogen peroxide according to a potassium permanganate method; and calculating the reduction rate of the effective bactericidal components through the change of the content of the effective bactericide.
Calculating the formula: the reduction rate of the effective bactericidal ingredient = (the content of the effective bactericidal ingredient before storage-the content of the effective bactericidal ingredient after storage)/the content of the effective bactericidal ingredient before storage x 100%.
The test results are shown in table 4.
TABLE 4 reduction rate of effective germicidal ingredient content in gel type detergent
As can be seen from Table 4, the gel-type cleanser of the present invention is relatively stable, and the content of the effective germicidal ingredients does not change much after long-term storage, and thus, the gel-type cleanser can maintain a good germicidal effect for a long time. Comparative example 3 adopts hydrogen peroxide as the bactericide, the stability is poor, and the reduction rate of the effective bactericidal component reaches 27.8 percent after the bactericide is stored for 90 days at 37 ℃.
Test example 4
The long-lasting bactericidal properties of the gel type detergents of examples 1 to 10 were measured.
The gel-type detergents of examples 1 to 10 were stored in an incubator at 37 ℃ for 90 days and then taken out, and the bactericidal effects of the gel-type detergents of examples 1 to 10 were tested by the method of test example 1, and the selected strains were Streptococcus mutans, lactobacillus, and Candida albicans.
The test results are shown in table 5.
TABLE 5 germicidal efficacy of gel-type cleaners after 90 days of storage
As can be seen from Table 5, the gel-type detergent of the present invention can rapidly kill Streptococcus mutans, lactobacillus and Candida albicans within 1min after being left for 90 days, and has long-lasting and stable bactericidal properties. In the comparative example 1, the povidone K30 is adopted as the gel, and the povidone K30 and the polyphenol compound have strong complexation, so that the sterilization rate of the cleaning agent is reduced to 99.9 percent. After the cleaning agent of comparative example 2 is left for 90 days, the sterilizing rate of the cleaning agent is still 99.99 percent. Comparative example 3 adopts hydrogen peroxide as the bactericide, and after standing for 90 days, the hydrogen peroxide content is reduced, and the sterilization rate of the system is reduced to 99%.
Test example 5
The effect of the gel type cleaners on the performance of the appliances over long-term use in examples 1 to 10 was measured.
Thermoplastic Polyurethane (TPU) dental appliance material was processed into 100 specimens measuring 50.8 mm by 12.7mm by 1.0mm, randomly divided into ten groups of 10 specimens each. For all group samples, both sides were smeared with a total of 10g of the gels of examples 1 to 10 twice a week (once a week and four weeks), and soaked in saliva after smearing; before each application, the appliance samples were rinsed with running water, and fresh saliva was replaced for a total of 6 months. The dental appliance material was tested for light transmittance, surface roughness and tensile elastic modulus. Methods for testing light transmittance of dental appliance materials reference spin L S, rungruangganout P, megremis S, kelly JR. Company of an absolute and a sulfate measure of relative flux in density Mat.2013; 29, measuring by using a spectrophotometer; measuring the surface roughness of the appliance material by using a surface profiler; the tensile elastic modulus of the appliance material is measured by adopting a universal mechanical testing machine;
the test results are shown in table 6;
TABLE 6 appliance Material Performance
As can be seen from Table 6, the gel-type cleaning agent of the present invention is used for smearing and soaking a thermoplastic polyurethane dental appliance material for up to 6 months, and the light transmittance, surface roughness and tensile elastic modulus of the material are not significantly changed, so that the gel-type cleaning agent of the present invention has no adverse effect on the performance of the appliance after long-term use. While comparative example 3, which uses hydrogen peroxide as a bactericide, has strong oxidizing property, resulting in an increase in the surface roughness of the thermoplastic polyurethane dental appliance material to 0.21 μm, a decrease in transparency to 82%, and a decrease in tensile elastic modulus to 803.2MPa.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A gel-type cleaning agent for dental appliances is characterized by comprising a gel, a bactericide, a biological enzyme and water;
the gel is more than one of cellulose gum, guar gum, xanthan gum, sodium alginate, chitosan, polyvinyl alcohol and carbomer; the bactericide is a guanidine bactericide and/or a plant bactericide; the biological enzyme is more than one of glucose oxidase, glucanase, proteolytic enzyme, amylase, lysozyme and superoxide dismutase;
in the gel type cleanser, the mass ratio of the gel to the bactericide is 1-10.
2. The gel-type cleaning agent for dental appliances according to claim 1, wherein the guanidine bactericide is at least one of chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene biguanide, polyhexamethylene guanidine, and polyhexamethylene guanidine salt; the plant bactericide is at least one of ginger root extract, ginger essential oil, paeonol, thymol, eucalyptol, honeysuckle extract, magnolia bark extract, catechin and grapefruit extract.
3. The gel type cleanser for dental appliances according to claim 1 or 2, further comprising a tooth whitening agent and/or a fluoride;
the tooth whitening agent is more than one of sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate and sodium ethylene diamine tetracetate;
the fluoride is more than one of sodium monofluorophosphate, sodium fluoride and strontium fluoride.
Preferably, the mass ratio of the gel to the tooth whitening agent is 1-10, 0.1-10.0, preferably 1-10;
preferably, the mass ratio of the gelling agent to the fluoride is 1 to 10, 0.1 to 10.0, preferably 1 to 10.
4. The gel-type cleaning agent for dental appliances according to any one of claims 1 to 3, further comprising a flavor; the flavoring agent is more than one of breath freshener, freshener and essence;
preferably, the breath freshener is one or more of zinc citrate, 0-cymene-5-ol, tea extract, licorice extract and radix zanthoxyli extract.
Preferably, the cooling agent is menthol and/or borneol.
Preferably, the essence is at least one of flower fragrance, fruit fragrance, tea fragrance, mint fragrance and marine fragrance.
More preferably, the mass ratio of the breath freshener is less than or equal to 0.5 percent;
more preferably, the mass ratio of the cooling agent is less than or equal to 0.5 percent;
more preferably, the mass ratio of the essence is less than or equal to 0.5%.
5. The method of preparing a gel type cleanser for dental appliances according to any one of claims 1 to 4, comprising:
mixing the gel agent with the water to swell the gel agent to obtain gel A;
adding the bactericide into the gel A and uniformly mixing to obtain a gel B;
adding the biological enzyme into the gel B and mixing uniformly.
6. The method of claim 5, further comprising the step of adding a tooth whitening agent and/or fluoride to the gel B and mixing them uniformly while adding the bio-enzyme.
7. The method of preparing a gel type cleanser for dental appliances according to claim 5 or 6, further comprising the step of adding a flavoring agent to the gel type cleanser for dental appliances.
8. The use of the gel type cleanser for dental appliances according to any one of claims 1 to 4, comprising applying the gel type cleanser to the inside of the dental appliance and then wearing the gel type cleanser on teeth; preferably, the dental appliance is made of one or more of Thermoplastic Polyurethane (TPU), polycarbonate (PC), polyethylene terephthalate-1, 4-cyclohexadienedimethylene terephthalate (PETG) and ethylene-vinyl acetate copolymer (EVA).
9. The use of the gel type cleanser for dental appliances according to claim 8, wherein the gel type cleanser is applied to the dental appliances in an amount of 1 to 20g.
10. Use of a gel-type cleaning agent for dental appliances according to claim 8 or 9, characterized in that the gel-type cleaning agent on the dental appliance is removed by direct rinsing with water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211486379.2A CN115836978A (en) | 2022-11-24 | 2022-11-24 | Gel type cleaning agent for dental appliance and preparation and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211486379.2A CN115836978A (en) | 2022-11-24 | 2022-11-24 | Gel type cleaning agent for dental appliance and preparation and application thereof |
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| CN115836978A true CN115836978A (en) | 2023-03-24 |
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| CN202211486379.2A Pending CN115836978A (en) | 2022-11-24 | 2022-11-24 | Gel type cleaning agent for dental appliance and preparation and application thereof |
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- 2022-11-24 CN CN202211486379.2A patent/CN115836978A/en active Pending
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