CN106619193A - Antibacterial and whitening toothpaste and preparation method thereof - Google Patents
Antibacterial and whitening toothpaste and preparation method thereof Download PDFInfo
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- CN106619193A CN106619193A CN201710061243.XA CN201710061243A CN106619193A CN 106619193 A CN106619193 A CN 106619193A CN 201710061243 A CN201710061243 A CN 201710061243A CN 106619193 A CN106619193 A CN 106619193A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses antibacterial and whitening toothpaste and a preparation method thereof and belongs to the field of daily chemicals. The antibacterial and whitening toothpaste prepared by the method contains 0.05% to 5% of epsilon-polylysine or epsilon-polylysine hydrochloride, 0.05% to 15% of chitosan, 0.01% to 1% of nisin, 0.01% to 1% of dextranase and toothpaste body matrix component. According to the antibacterial and whitening toothpaste and the preparation method thereof, the adopted natural antibacterial agents are in mutual synergism, so that the prepared toothpaste is high in safety and good in antibacterial activity and can be used for effectively preventing and treating the occurrence of dental plaque and oral inflammation; the natural antibacterial agents and the dextranase exert a synergistic effect so as to effectively remove inherent dental plaque and achieve the actions of comprehensively nursing oral cavities, maintaining tooth health and whitening teeth.
Description
Technical field
The present invention relates to a kind of antibacterial whitening toothpaste and preparation method thereof, is related to household chemicals field.
Background technology
Confirm, in the middle of dental caries and chronic periodontitises (gum disease) both most common oral diseases, dental plaque
Antibacterial is main pathogenic factor.The past prevention of both diseases focuses primarily upon the cleaning of oral hygiene and safeguards, including
Tartar is removed with toothbrush mechanical, or with other methods (as removed with wax wire or toothpick), later, people are tended to using fluorination
Thing, and fluoride has no effect to tartar antibacterial, can only prevent tooth surface decalcification.Consider prevention the various of gum disease to arrange
Apply, machinery prevents the disease still to take advantage except tartar, and it is the most commonly used and most general to carry out oral cavity cleaning with toothpaste and toothbrush
And method.
With the addition of chemical bactericide triclosan etc., also known as triclosan in most of tooth paste products in the market.
American Studies personnel exist within 2012《State academy of sciences journal》On deliver report claim, carry out for mouse and fish muscle cell
Test result indicate that, triclosan disturbs the communication between two protein of an important ion channel, weakens muscle
Strength.The research worker of the New York State University and Arizona State University is once to the urine of 184 anemia of pregnant woman in New York Brooker forest zone
Liquid and umbilical-cord blood-sample are chemically examined.They find, triclosan is all contained in all urine samples, contain trichlorine in the urine sample more than 85%
Card class.More also contain triclosan it is a concern that exceeding in half umbilical-cord blood-sample, this shows that the chemical composition can be to tire
Youngster causes to directly affect.Food and drug administration will then issue a statement in the end of the year 2010, it is desirable to forbid containing triclosan and three
The antibacterial soap and bath gel of chlorine card class is sold in shop shelf.
To find a kind of natural, antibiotic substance for having no toxic side effect for replacing triclosan, research worker have done many tasting
Examination.Because the one-component antibacterial antiplaque agent spectrum having now been found that has his own strong points, it is impossible to play to the overall protected effect of tooth, because
This, one kind strengthens antibacterial effect, suppresses the broad spectrum antimicrobicide of the formation of dental plaque very big for the daily preventing and treating of dental caries has
Using value.
The content of the invention
For a series of above-mentioned deficiency that prior art is present, the invention provides a kind of antibacterial whitening toothpaste, the tooth
Cream contains epsilon-polylysine or epsilon-polylysine hydrochlorate, shitosan, nisin, dextranase and lotion of toothpaste base
Matter component.
In one embodiment of the invention, the epsilon-polylysine or epsilon-polylysine hydrochloride content are 0.05-
5%.
In one embodiment of the invention, the chitosan content is 0.05-15%.
In one embodiment of the invention, the streptococcus acidi lactici cellulose content is 0.01-1%.
In one embodiment of the invention, the dextranase content is 0.01-1%.
In one embodiment of the invention, the lotion of toothpaste matrix components include abrasive, wetting agent, foaming
Agent, binding agent, sweeting agent, acid-base modifier, essence and deionized water.
In one embodiment of the invention, described abrasive is silicon dioxide.
In one embodiment of the invention, described wetting agent be glycerol, Sorbitol, in Propylene Glycol or Polyethylene Glycol
One kind or its combination.
In one embodiment of the invention, described binding agent be Carboxymethyl cellulose sodium, carrageenan, guar gum,
One kind or its combination in xanthan gum.
In one embodiment of the invention, described foaming agent is sodium lauryl sulphate.
In one embodiment of the invention, described stabilizer is acid-base modifier, using citric acid, malic acid,
Sodium citrate, one or two combinations of natrium malicum.
In one embodiment of the invention, the sweeting agent be saccharin, trehalose, one or more of aspartame
Combination.
In one embodiment of the invention, epsilon-polylysine or epsilon-polylysine hydrochlorate are in the antibacterial whitening tooth
Mass percent in cream is 0.01-5%.
In one embodiment of the invention, epsilon-polylysine or epsilon-polylysine hydrochlorate are in the antibacterial whitening tooth
Mass percent in cream is 0.01-1%.
In one embodiment of the invention, epsilon-polylysine or epsilon-polylysine hydrochlorate are in the antibacterial whitening tooth
Mass percent in cream is 0.01-0.5%.
In one embodiment of the invention, mass percent of the shitosan in the antibacterial whitening toothpaste is
0.05-15%.
In one embodiment of the invention, mass percent of the shitosan in the antibacterial whitening toothpaste is 0.2-
5%.
In one embodiment of the invention, mass percent of the shitosan in the antibacterial whitening toothpaste is 0.5-
5%.
In one embodiment of the invention, mass percent of the nisin in the antibacterial whitening toothpaste
For 0.01-1%.
In one embodiment of the invention, mass percent of the nisin in the antibacterial whitening toothpaste
For 0.02-0.2%.
In one embodiment of the invention, mass percent of the dextranase in the antibacterial whitening toothpaste is
0.01-1%.
In one embodiment of the invention, mass percent of the dextranase in the antibacterial whitening toothpaste is
0.06-0.4%.
Second object of the present invention is to provide the manufacture method of antibacterial whitening toothpaste, is to be prepared in the steps below：
Prepare antibacterial component：By mass fraction 0.05-5% epsilon-polylysines or epsilon-polylysine hydrochlorate, the lactic acid chain of 0.01-1%
Coccus element, the shitosan of 0.05-15% is dissolved in 8～12g/L citric acid solutions, and 45～55 DEG C of 1～4h of insulation, stirring is equal
It is even；With binding agent, wetting agent, abrasive, foaming agent, essence mix homogeneously, regulation pH is 6-7, adds mass fraction 0.01-
1% dextranase, grinding, degassing.
In one embodiment of the invention, methods described is specifically：
(1) antibacterial component is prepared：Epsilon-polylysine or epsilon-polylysine hydrochlorate, nisin, shitosan are delayed
Slowly in being dissolved in 10g/L citric acid solutions, 50 DEG C of 1～2.5h of insulation stir；
(2) binding agent is added in wetting agent, dispersed with stirring forms suspension；
(3) by abrasive, foaming agent, essence, sweeting agent is added in purified water, dispersed with stirring dissolving；
(4) during the solution of above-mentioned steps (3) to be added the solution of step (2), it is uniformly mixing to obtain paste；
(5) during the solution of above-mentioned steps (1) to be added the paste of step (4), stir；Using acid-base modifier
(sodium hydroxide) adjusts pH to 6-7.
(6) dextranase is added in pure water, is added after dissolving into the paste of step (5).
(7) grind, degassing, evacuation obtains lotion of toothpaste.
The present invention also provides application of the antiseptic toothpaste in oral cavity cleaning, periodontal disease protection.
Beneficial effect：The present invention is safe using toothpaste prepared by natural antibacterial agent, has no toxic side effect, antibacterial activity
It is good, can effectively suppress the breeding of the microorganisms such as the antibacterial in oral cavity, funguses, the minimum to common are harmful microorganism in oral cavity
Mlc is less than 10ppm, and effectively prevents and treats the generation of dental plaque and oral inflammation；The toothpaste of the present invention is by antibacterial and the right side
The synergism of the sugared acid anhydride enzyme of rotation can effectively remove intrinsic dental plaque, according to CIE table colour standards, after the toothpaste using the present invention
Tooth L-value be higher by control 12.5%, can reach antibacterial, whitening, the total care oral cavity of teeth consolidating, keep dental health work
With.
Specific embodiment
The evaluation methodology that the present invention is adopted is as follows：
(1) minimal inhibitory concentration MIC evaluation methodology
By the Streptococcus mutans ATCC25135 of oral cavity common pathogen, actinobacillus actinomycetem comitanses ATCC29523, gingiva porphin
Quinoline Zymomonas mobiliss ATCC33277, actinomyces viscosus ATCC19246, staphylococcus aureuses are placed on broth bouillon cultivates 24h,
With inoculating loop picking representative configuration for examination bacterium colony, in being inoculated in 5mL LB fluid mediums, 37 DEG C, 200r/min, culture 2～
6h is to exponential phase.Appropriate bacterium solution is taken, bacteria concentration is adjusted to 10 with LB fluid mediums5CFU/mL.To minimal inhibitory concentration
MIC is measured.Under aseptic condition, 1 component the step of each embodiment is pressed than dilution successively.By dilution factor from low to high successively
It is added to the 1st of aseptic 96 orifice plate to arrange to the 11st row, per the μ L of hole 50, the 12nd is classified as positive control, plus equivalent sterilized water.It is subsequently every
Hole adds 50 μ L bacterium solutions, and sealing is mixed.Now, the 1st hole to the 11st hole toothpaste end mass concentration be respectively 3200,1600,
800th, 400,200,100,50,25,12.5,6.25,3.125 μ g/mL (pressing mastic quality).With microplate reader determine 0h when
OD630nm values, then 96 orifice plates are placed in 37 DEG C of incubators cultivate 24h, and OD630nm values are determined again.By contrast 0h with
The OD of bacterium solution during 24h630Nm values, it is determined that MIC of the different embodiments to each main oral pathogenic bacterium, with this fungistatic effect is weighed.
(2) plaque index
The present invention using the Dental Plaque index before and after each embodiment toothpaste to being counted.
144 adult men and women are divided into into 6 groups, are respectively brushed teeth once sooner or later daily using toothpaste, each toothpaste dosage is 2g.It is right
It is measured with continuous experimenter's dental plaque index using after toothpaste 3 months using before toothpaste, calculates the tooth before and after use
Plaque index.As a result it is as shown in table 3.
Concrete dental plaque index assay method is as follows：
Facing is dried up with air gun, direct visual perception is simultaneously observed by mouth mirror, and be used in combination the side of probe pinpoint and drawn
Facing is crossed, so that it is determined that facing and the bacterial plaque amount near gum edge.
Facings of the 0=at nearly gum edge is without bacterial plaque；
1=facings at nearly gum edge have thin bacterial plaque, but are invisible to the naked eye, and only streak facing just with the side of probe pinpoint
Can find；
2=has macroscopic moderate bacterial plaque in Yin Yuan areas or tooth proximal surface；
3=is in gingival sulcus and (or) Yin Yuan areas and neighbouring facing have a large amount of soft dirts.
Each tooth be divided into buccal surface it is near in, central authorities, 4 areas of remote neutralization lingual surface, score respectively.The summation of 4 score values is divided by 4
For the score value of the tooth, it is the individual score value that the score value of each tooth is added divided by receiving to examine tooth number.The present invention shows liquid using with bacterial plaque
(basic fuchsin) carries out plaque stain, and method is to be extruded between each two phase adjacent teeth with the cotton pellet containing plaque disclosing agent, is made
Plaque disclosing agent diffuses to facing, is coated with the cheek of dental pattern, lingual surface, then is gargled with clear water, is then observed, and colour attaching area is
There is area in bacterial plaque.
As a result criterion is as follows：
0=is without bacterial plaque；
There is the mottled bacterial plaque being dispersed on facing at the nearly gum edge of 1=；
Bacterial plaque thin on facing is in continuously banding at the nearly gum edge of 2=；
3=bacterial plaque colored band is wider than 1mm, but the area of coverage less than the 1/3 of facing；
4=bacterial plaques cover facing more than 1/3, but less than facing 2/3；
5=bacterial plaques cover facing more than 2/3.
(3) whitening effect evaluation
Using the Isolated Tooth for having tooth stain under 37 DEG C, 100% relative humidity first with artificial saliva infiltrate, then using 2g teeth
Cream, scrubbed using common soft bristle tooth brush, each brush 1 minute, after rinsed well, dried with water, repeat abovementioned steps,
Scrub 30 times altogether.All teeth respectively before scrub, by DIC collection images, whole gatherer process enters in darkroom within 2 weeks after scrubbing
OK.Every time machine system is debugged before operation, proofreaded 2 times with hawk, colored steel is proofreaded 1 time, to ensure to shoot bar every time
The concordance of part, then be placed in imaging center with standard color sample and calibrated, the state of machine is protected during ensureing to gather image every time
Hold consistent, colour code is removed after proof.In operating process, recalibration is answered to reduce error per hour.The digital picture that will be shot
In input computer, the L* of corona color, a*, b* value are determined using color analysis software GIANT, and calculate sending out before and after brushing teeth
Luminosity (L* values).
Embodiment 1
Prepare raw material (by mass) according to following proportioning：Silicon dioxide 25%, glycerol 10%, Polyethylene Glycol 3%, Pyrusussuriensiss
Alcohol 10%, Carboxymethyl cellulose sodium 1%, dodecyl sodium sulfate 2.0%, saccharin 0.2%, essence 1%, citric acid 1%, hydrogen-oxygen
Change sodium 0.5%, epsilon-polylysine 0.1%, shitosan 2%, nisin 0.05%, dextranase 0.1%, purified water
44.05%.
Toothpaste is prepared according to following steps,
(1) antibacterial component is prepared：By 0.1 part of epsilon-polylysine, 0.05 part of nisin, 2 parts of shitosans are slowly molten
Solution is in acid-base modifier (1 part of citric acid be dissolved in prepared in 20 parts of purified water acidolysis regulator), and 50 degree of insulations 2 are little
When, stir；
(2) 1 part of Carboxymethyl cellulose sodium is added to by 10 parts of glycerol, 3 parts of Polyethylene Glycol, what 10 parts of Sorbitol were constituted
In solution, dispersed with stirring forms suspension；
(3) by 25 parts of silicon dioxide, 2 parts of dodecyl sodium sulfates, 1 part of essence, 0.2 part of saccharin adds 20 parts of purified water
In, dispersed with stirring dissolving；
(4) during the solution of above-mentioned steps (3) to be added the solution of step (2), it is uniformly mixing to obtain paste；
(5) during the solution of above-mentioned steps (1) to be added the paste of step (4), stir；Using acid-base modifier
(0.5 part of sodium hydroxide) adjusts pH to 6-7.
(6) 0.1 part of dextranase is added in 4.05 parts of pure water, is added after dissolving into the paste of step (5).
(7) grind, degassing, evacuation obtains lotion of toothpaste.
Reference examples 1
With embodiment 1, difference is that step (1) is added without epsilon-polylysine or its hydrochlorate to specific embodiment, is not added
The epsilon-polylysine for entering or its hydrochlorate ratio are in step (1) by purified water polishing.
Reference examples 2
With embodiment 1, difference is to be added without nisin in step (1) to specific embodiment, the breast not added
Acid streptococci element ratio is in step (1) by purified water polishing.
Reference examples 3
With embodiment 1, difference is to be added without shitosan in step (1) to specific embodiment, the shitosan ratio not added
Example is in step (1) by purified water polishing.
Reference examples 4
With embodiment 1, difference is to be added without dextranase in step (6) to specific embodiment, the dextrorotation not added
Sugared acid anhydride enzyme ratio is in step (6) by purified water polishing.
Reference examples 5
With embodiment 1, difference is that epsilon-polylysine or its hydrochlorate are added without in step (1) to specific embodiment, breast
Acid streptococci element, shitosan adds 0.2 part of triclosan, and the said components ratio not added is by purified water polishing.
The formulation of tooth-paste ratio (by mass) of table 1
Minimal inhibitory concentration MIC ※ (ppm) experimental result of table 2
The weight of antibacterial is with the calculating of pressed powder weight in ※ minimal inhibitory concentrations.
The result of table 2 is clearly showed that, compared with reference examples 1-5, by natural component constitute containing nisin, ε-poly-
Lysine, the antibacterial whitening toothpaste of shitosan can significantly reduce minimal inhibitory concentration, with exclusive use or using wherein 2 kinds phases
Than, synergism can be played, its bactericidal effect is compared with commercially available conventional antimicrobial triclosan, and effect is more excellent,
The dental plaque index of table 3
Note：Dental plaque index rate of descent=(using front 3 months dental plaque index meansigma methodss-referred to using rear 3 months dental plaques
Number meansigma methodss)/using flat value ╳ 100% of front 3 months dental plaque indexs
Found out by table 3, after the toothpaste 3 months of embodiment 1, dental plaque index has and significantly dropped relative to reference examples
It is low.Confirm that embodiment toothpaste has more superior antibacterial effect compared to reference examples toothpaste.
The whitening effect evaluation of table 4
Found out by table 4, using the toothpaste 3 months of embodiment 1 after, tooth whitening effect evaluation number (luminosity) has phase
For significantly improving for reference examples.Confirm that embodiment toothpaste has more superior whitening effect compared to reference examples toothpaste.
The present invention is also to epsilon-polylysine or epsilon-polylysine hydrochlorate, shitosan, nisin and dextran
Other contents of enzyme are attempted, and are as a result shown, as the concentration ＜ 0.01% of epsilon-polylysine or its hydrochlorate, its antibacterial
Decreased effectiveness；When the concentration of epsilon-polylysine or its hydrochlorate is in ＞ 3%, its antibacterial ability no longer strengthens, and to toothpaste
Mouthfeel can cause certain impact；As shitosan ＜ 0.01%, antibacterial effect weakens；As chitosan content ＞ more than 5%, its
Compared with indissoluble solution, antibacterial ability no longer strengthens, and, such as viscosity can be caused big the physical behavior of toothpaste, it is uneven, easily stick
Deng negative effect；As nisin ＜ 0.01%, its antibacterial effect weakens；As nisin ＞ 1%, its compared with
Indissoluble solution, antibacterial ability no longer strengthens；When dextranase is in ＜ 0.06%, it decomposes dental plaque ability can weaken；Work as the right side
In ＞ 1%, it decomposes dental plaque ability no longer strengthens the sugared acid anhydride enzyme of rotation.
Although the present invention is disclosed as above with preferred embodiment, it is not limited to the present invention, any to be familiar with this skill
The people of art, without departing from the spirit and scope of the present invention, can do various changes and modification, therefore the protection model of the present invention
Enclosing should be by being defined that claims are defined.
Claims (10)
1. a kind of antibacterial whitening toothpaste, it is characterised in that the toothpaste contains epsilon-polylysine or epsilon-polylysine hydrochlorate, shell
Polysaccharide, nisin, dextranase and lotion of toothpaste substrate.
2. antibacterial whitening toothpaste according to claim 1, it is characterised in that the epsilon-polylysine or epsilon-polylysine salt
Phosphate content is 0.05-5%, and chitosan content is 0.05-15%, and streptococcus acidi lactici cellulose content is 0.01-1%, dextran
Enzyme content is 0.01-1%.
3. antibacterial whitening toothpaste according to claim 1, it is characterised in that the lotion of toothpaste substrate includes abrasive,
Wetting agent, foaming agent, binding agent, sweeting agent, acid-base modifier, at least one in essence and deionized water.
4. antibacterial whitening toothpaste according to claim 3, it is characterised in that described abrasive is silicon dioxide.
5. the antibacterial whitening toothpaste according to claim 3 or 4, it is characterised in that wetting agent is glycerol, Sorbitol, the third two
Alcohol, the one kind or its combination in Polyethylene Glycol.
6. antibacterial whitening toothpaste according to claim 5, it is characterised in that binding agent is Carboxymethyl cellulose sodium, OK a karaoke club
Glue, guar gum, the one kind or its combination in xanthan gum；Stabilizer is acid-base modifier, using citric acid, malic acid, citric acid
Sodium, one or two combinations of natrium malicum.
7. according to claim 3-4,6 arbitrary described antibacterial whitening toothpastes, it is characterised in that sweeting agent is saccharin, trehalose,
The combination of one or more in aspartame.
8. the method for preparing the antibacterial whitening toothpaste described in claim 1, it is characterised in that be prepared in the steps below：(1)
Prepare antibacterial component：To 0.05-5% epsilon-polylysines or epsilon-polylysine hydrochlorate by mass, the lactic acid chain of 0.01-1%
Coccus element, the shitosan of 0.05-15% is dissolved in 8～12g/L citric acid solutions, and 45～55 DEG C of 1～4h of insulation, stirring is equal
It is even；(2) with binding agent, wetting agent, abrasive, foaming agent, essence mix homogeneously, regulation pH is 6-7, is added by mass
The dextranase of 0.01-1%, grinding, degassing.
9. method according to claim 7, it is characterised in that methods described is specifically：
(1) antibacterial component is prepared：By epsilon-polylysine or epsilon-polylysine hydrochlorate, nisin, shitosan is slowly molten
In 10/L citric acid solutions, 50 DEG C of 1～2.5h's solution of insulation stir；(2) binding agent is added in wetting agent, is stirred
Dispersion forms suspension；(3) by abrasive, foaming agent, essence, sweeting agent is added in purified water, dispersed with stirring dissolving；(4) will
The solution of above-mentioned steps (3) is added in the solution of step (2), is uniformly mixing to obtain paste；(5) by the molten of above-mentioned steps (1)
Liquid is added in the paste of step (4), is stirred, adjust pH to 6-7；(6) dextranase is added in pure water, it is molten
Add after solution into the paste of step (5)；(7) grind, degassing, evacuation obtains lotion of toothpaste.
10. claim 1-4, application of the 6 arbitrary described antiseptic toothpastes in oral cavity cleaning.
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Cited By (8)
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| CN107373668A (en) * | 2017-08-02 | 2017-11-24 | 苟春虎 | Lycium ruthenicum decayed tooth lozenge |
| CN108498401A (en) * | 2018-05-25 | 2018-09-07 | 钱兴 | A kind of preparation method of mouthwash |
| CN109820748A (en) * | 2019-03-25 | 2019-05-31 | 昆明蓝橙口腔医院有限责任公司 | It is a kind of for the no moisture matrix of dental products and its application |
| CN110946778A (en) * | 2019-12-19 | 2020-04-03 | 华熙生物科技股份有限公司 | Toothpaste with anti-inflammation and bacteriostasis functions |
| CN112089670A (en) * | 2020-09-29 | 2020-12-18 | 陕西恒远生物科技有限公司 | Children's anti-caries toothpaste containing natural antibacterial ingredients and preparation process thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| US20230043687A1 (en) * | 2018-10-18 | 2023-02-09 | Oraldent Limited | Bioflavonoid Compositions and Their Use |
| US11980185B2 (en) | 2018-10-18 | 2024-05-14 | Citrox Biosciences Limited | Bioflavonoid compositions and their use for water purification and food preservation |
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| CN107373668A (en) * | 2017-08-02 | 2017-11-24 | 苟春虎 | Lycium ruthenicum decayed tooth lozenge |
| CN108498401A (en) * | 2018-05-25 | 2018-09-07 | 钱兴 | A kind of preparation method of mouthwash |
| US20230043687A1 (en) * | 2018-10-18 | 2023-02-09 | Oraldent Limited | Bioflavonoid Compositions and Their Use |
| US11980185B2 (en) | 2018-10-18 | 2024-05-14 | Citrox Biosciences Limited | Bioflavonoid compositions and their use for water purification and food preservation |
| CN109820748A (en) * | 2019-03-25 | 2019-05-31 | 昆明蓝橙口腔医院有限责任公司 | It is a kind of for the no moisture matrix of dental products and its application |
| CN109820748B (en) * | 2019-03-25 | 2021-10-22 | 昆明蓝橙口腔医院有限责任公司 | Moisture-free matrix for oral products and application thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110946778A (en) * | 2019-12-19 | 2020-04-03 | 华熙生物科技股份有限公司 | Toothpaste with anti-inflammation and bacteriostasis functions |
| CN112089670A (en) * | 2020-09-29 | 2020-12-18 | 陕西恒远生物科技有限公司 | Children's anti-caries toothpaste containing natural antibacterial ingredients and preparation process thereof |
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| CN106619193B (en) | 2018-01-16 |
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