CN106963662B - Color-changing toothpaste for children and preparation method and application thereof - Google Patents
Color-changing toothpaste for children and preparation method and application thereof Download PDFInfo
- Publication number
- CN106963662B CN106963662B CN201710153230.5A CN201710153230A CN106963662B CN 106963662 B CN106963662 B CN 106963662B CN 201710153230 A CN201710153230 A CN 201710153230A CN 106963662 B CN106963662 B CN 106963662B
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- children
- color
- toothpaste
- stirring
- changing
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 51
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000003094 microcapsule Substances 0.000 claims abstract description 50
- 239000000049 pigment Substances 0.000 claims abstract description 36
- 230000001680 brushing effect Effects 0.000 claims abstract description 35
- 210000000214 mouth Anatomy 0.000 claims abstract description 19
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 17
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- 235000010447 xylitol Nutrition 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
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- 159000000000 sodium salts Chemical class 0.000 claims abstract description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical group OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
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- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
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- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
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- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
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- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
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Abstract
The invention discloses color-changing children toothpaste and a preparation method and application thereof. The toothpaste comprises the following components: the color-changing children toothpaste contains microcapsules containing pigments, xylitol, fructo-oligosaccharide, pearl hydrolysate, humectant, an abrasive, a surfactant and sodium salt, and the capsules containing the pigments in the color-changing children toothpaste can be exploded in the tooth brushing process under proper friction force and friction time, so that the foam color is changed, an exciting visual effect is brought to the tooth brushing of children, the children love to brush the teeth, and the interest of tooth brushing is enjoyed. The product of the invention adopts a scientific using method, and can help children to remove the dirt in the oral cavity, massage the gum, reduce dental plaque and improve the disease resistance of gum tissue by repeated use in a period of multiple days.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to color-changing children toothpaste and a preparation method and application thereof.
Background
The prevalence rate of oral diseases of children in China is high, wherein caries and periodontal diseases are the most common oral diseases of children. The third national oral health epidemiological survey in 2005 shows that the prevalence of caries in deciduous teeth of 5 years old and permanent teeth of children of 12 years old in China is as high as 66% and 28.9% respectively. The factors causing the higher oral disease rate of children play an important role in tooth brushing except for improper tooth development and feeding modes of children.
The prevalence rate of tooth decay of children is high, but the attention is not paid, and many mothers think that the deciduous teeth of babies are changed sooner or later, and even if the children suffer from tooth decay, the worry is not too much. Early caries or loss of deciduous teeth can directly lead to disorganization of new teeth and prevent beauty. The chronic pain and inflammation of the mouth caused by tooth decay also causes pain to the patient.
In conclusion, the toothpaste suitable for the oral environment of the children is selected, the children are educated about the correct tooth brushing method, the correct tooth brushing mode of the children is developed, and the oral hygiene of the children is improved. The research on the oral environment of children is systematic and comprehensive, and various companies in the oral care industry have also successively introduced toothpaste for children, such as Yaodonle, Beijing, Shuke baby and the like. The interest of brushing teeth of children is cultivated, the interest of brushing teeth of children is increased, the boring task of brushing teeth of children is changed into interesting activity, and the brushing teeth of 3 minutes in the morning and at night is developed to be an effective way for solving the current situation of oral cavity of children.
In patent CN1077884A, a liquid color-changing toothpaste and its production method are disclosed. The adsorbent for the liquid color-changing toothpaste replaces the traditional abrasive, is added with substances such as elastin, special additives and the like, has the advantages of comfortable mouthfeel, good deformation and diffusivity, no abrasion to enamel, capability of forming a layer of protective film in the oral cavity and on the surface of a gum, capability of directly indicating the tooth brushing quality and the like, and is an ideal oral hygiene product.
The children's oral cavity morbidity is high in China, although the children's toothpaste with strong pertinence is developed under the study of a large number of characteristics of the children's oral cavity environment, the children's toothpaste of the type can better improve the children's oral cavity environment on the premise that the children insist on brushing the teeth for three minutes in the morning and at night by using a correct tooth brushing method. Therefore, the development of the toothpaste has practical significance for enabling children to enjoy tooth brushing and love tooth brushing and changing tooth brushing into interesting activities.
Disclosure of Invention
The invention aims to provide a color-changing toothpaste for children and a preparation method and application thereof. In the process of brushing teeth of children, the capsule is softened and exploded under the action of brushing teeth force and paste abrasive material friction, and the wrapped pigment is gradually dispersed and is expressed by foam color change. The capsule is exploded in the set brushing time of 3 minutes, the foam color is changed to bring an exciting visual effect to children, help the children to remove the dirt in the oral cavity, massage the gum, reduce dental plaque and improve the disease resistance of gum tissues.
The invention provides a children toothpaste containing capsules which are coated with pigment and are easy to burst under proper friction force and friction time. In the process of brushing teeth, the foam color changes along with the explosion of the capsule, thereby bringing exciting visual effect to children to brush teeth, enabling children to love to brush teeth and enjoying the fun of brushing teeth. The product of the invention adopts a scientific using method, and can help children to remove the dirt in the oral cavity, massage the gum, reduce dental plaque and improve the disease resistance of gum tissue by repeated use in a period of multiple days.
According to the invention, the children color-changing toothpaste is provided, and color change is realized by adding capsules containing pigment for blasting. The invention has the following advantages: firstly, microcapsules for coating pigments are added into the color-changing toothpaste. The microcapsule is a micro-granular capsule formed by continuously dispersing food-grade pigments in a matrix structure, and the capsule adopts a hydrogel matrix structure formed by a special technology and can firmly lock water-insoluble powder, grease and water-soluble active substances. Secondly, the added microcapsules are composed of water, glycerin, sorbitol, pigment, carrageenan, agar and other components according to a certain proportion, all the components are common raw materials of toothpaste, and the microcapsules have good compatibility and safety when added into the toothpaste. Thirdly, the microcapsules added into the children toothpaste endow the toothpaste with unique advantages and enrich the product forms. Fourthly, the microcapsules are designed to have toughness according to the tooth brushing strength of children and the characteristics of abrasives used by the toothpaste of the children, so that the capsules are exploded when most of the children brush the teeth for 3 minutes, and the color of foams changes to show that the tooth brushing time is up.
The purpose of the invention is realized by the following technical scheme.
A color-changing children toothpaste comprises the following components:
the amount of the pigment-containing microcapsule is preferably 1 to 5 parts, and more preferably 2 to 3 parts.
The dosage of the xylitol is preferably 0.1-5 parts, and more preferably 0.1-1 part.
The dosage of the fructo-oligosaccharide is preferably 0.1-2 parts, and more preferably 0.1-1 part.
The amount of the pearl hydrolysate is preferably 0.05-1 part, and more preferably 0.1-0.5 part.
The sodium salt is saccharin sodium, sodium benzoate and crystalline sodium pyrophosphate, and the dosage of the saccharin sodium is preferably 0.01-1 part, more preferably 0.1-0.5 part; the amount of the sodium benzoate is preferably 0.01-1 part, more preferably 0.1-0.5 part; the dosage of the crystalline sodium pyrophosphate is preferably 0.01-2 parts, and more preferably 0.3-0.8 part;
also included in the children's color-changing toothpaste of the present invention are antibacterial agents, antiplaque agents, anti-adhesion agents (to prevent plaque from adhering to the enamel surface), antioxidants (such as coenzyme Q10), anticaries agents, desensitizing agents (such as potassium nitrate, potassium tartrate, potassium citrate, and strontium chloride), whitening agents, tartar control agents, periodontal actives, chlorophyll compounds, abrasives, breath freshening control agents (such as zinc salts, e.g., zinc gluconate, zinc citrate, zinc chloride), and salivary stimulants (e.g., citric acid, lactic acid, malic acid), as well as any other ingredient known to those skilled in the art to be suitable for oral care.
The children's color-changing toothpaste of the present invention optionally includes other substances such as viscosity modifiers, diluents, surface active substances, emulsifiers and foam modulators, pH modifiers, abrasives, humectants, emollients, mouthfeel modifiers, sweeteners, flavoring agents, coloring agents, preservatives and combinations thereof. While the general nature of each of the above categories of materials may vary, there may be some common properties and any given material may belong to two or more of these categories of materials. Preferably according to the substances compatible with the xylitol, the fructo-oligosaccharide and the pearl hydrolysate.
In another aspect, the invention provides a preparation method of the color-changing children toothpaste, which comprises the following steps:
(1) adding xylitol, pearl hydrolysate, fructo-oligosaccharide and sodium salt into water, and stirring to obtain water phase;
(2) adding sorbitol and glycerin into the water phase, and stirring for 5-10 min to obtain a uniform liquid phase;
(3) uniformly stirring silicon dioxide and sodium carboxymethylcellulose into powder for later use;
(4) adding the liquid phase and the powder material into a paste making machine, controlling the vacuum degree to be more than-0.92 Mpa, and quickly stirring for 20-30 min under the condition that the temperature of a water bath kettle is controlled at 42 ℃;
(5) adding sodium lauryl sulfate and essence, controlling the vacuum degree to be more than-0.94 Mpa, quickly stirring for 15-20 min, opening a cover, adding the pigment-containing microcapsule, and stirring for 8-10 min under vacuum with the scraper speed controlled at 30-50 r/min; and (5) exhausting and filling.
The air pumping is to control the vacuum degree to be more than-0.96 Mpa and continuously pump the vacuum for 15 minutes.
After the toothpaste prepared by the process is aged for 3 months at the temperature of 40 ℃, the microcapsules in the paste are well preserved, the abnormalities such as explosion, color change and the like do not appear, and the paste is stable.
In the preparation method of the invention, the difficulty lies in how to prevent the pigment-containing microcapsule from cracking in the paste preparation process and the negative influence of strong stirring force on the particle toughness, and the inventor of the invention finds that the pigment-containing microcapsule is added in the later stage of the paste preparation process, and adopts a low-speed scraper stirring process: the stirring speed of the scraper is controlled to be 30 r/min-50 r/min; the stirring time is controlled to be 8-10 min, the damage to the microcapsule structure caused by homogeneous strong stirring can be avoided, the abnormal occurrence of the toughness of the microcapsule can be reduced, the microcapsule toothpaste containing pigment is ensured not to break in the storage period, and the microcapsule toothpaste can break after the tooth brushing time reaches 3min, thereby realizing the expected effect.
The components of the microcapsule containing the pigment are as follows: based on the parts by weight, the weight ratio,
the children color-changing toothpaste is added with microcapsules containing pigments. The addition of carrageenan and agar in the microcapsule provides a hydrogel matrix structure, and glycerin and sorbitol are used as preservative and fresh-keeping components. The microcapsule has good compatibility and safety. Microcapsules are a series of tiny granular (about 0.8 mm) capsules containing pigments continuously dispersed in a matrix structure. The microcapsule forms a hydrogel matrix structure, and can firmly net water-insoluble powder, grease and water-soluble active substances. The pigment contained in the microcapsule is food grade pigment (such as bright blue pigment, lemon yellow pigment, etc.), and can be released into colorless ointment to change the color of the ointment.
The pigment-containing microcapsule is prepared by the following steps:
(1) preparing a liquid phase: adding pigment into water, stirring, adding glycerol and sorbitol, and stirring to obtain liquid phase;
(2) preparing powder: uniformly stirring carrageenan, agar and butylated polyvinylpyrrolidone for later use;
(3) adding the powder into the liquid phase, stirring uniformly, and spray drying to obtain the microcapsule containing the pigment.
The microcapsule containing the pigment is stored in a dark place, the suitable storage temperature is 0-30 ℃, and the effective shelf life of the microcapsule under the storage condition is 12 months.
In another aspect, the invention provides the application of the color-changing children toothpaste in oral cavity cleaning, which is characterized in that the application method comprises the following steps: when children brush teeth, the toothpaste with the size of the soybean is squeezed on the toothbrush, the teeth are brushed, and when the foam of the paste body is discolored, the teeth brushing time is up, and the oral cavity is cleaned. When children brush teeth in the morning and evening, the toothpaste with the size of the soybean is squeezed on the toothbrush, the teeth are brushed according to the correct tooth brushing mode, when the foam of the paste body is discolored, the tooth brushing time is up (about 3min), and the oral cavity is cleaned.
The children color-changing toothpaste is designed according to the characteristics of the oral cavity of children. Aiming at higher caries of children, xylitol is added to prevent caries. The xylitol anticarious mechanism has the following ways: can not be fermented and utilized by cariogenic cells in the oral cavity, and can effectively inhibit the growth of streptococcus and the generation of acid; can stimulate oral cavity to secrete saliva, and saliva can wash bacteria in oral cavity, increase concentration of alkaline amino acids and ammonia at saliva and dental caries spots, slow down pH value decrease of oral cavity, inhibit bacteria adsorption on tooth surface, slow down dental erosion, prevent dental caries formation and reduce dental plaque production, and promote tooth health.
The children color-changing toothpaste is added with fructo-oligosaccharide and a plurality of amino acid compounds (pearl hydrolysate), so that the gums are nourished, the breeding of microorganisms is reduced, and the oral micro-ecological balance is maintained. The fructo-oligosaccharide is a low-polymerization-degree multifunctional carbohydrate, is a recognized typical prebiotic, is also a water-soluble dietary fiber, and can promote the absorption of minerals such as calcium, magnesium, zinc and the like. The pearl hydrolysate is effective component amino acid and various nutritional components extracted from pearl, is rich in protein, and has good nutrition and health promotion effects.
Compared with the prior art, the invention has the advantages and beneficial effects.
(1) The invention relates to a children color-changing toothpaste, which is added with microcapsules containing pigments, adopts unique microcapsule components and a unique preparation process, and when children brush teeth, the rupture time can be controlled to be about 3min under the friction of tooth brushing force and abrasive materials, the capsules explode foams and change colors, so that a unique signal prompt of tooth brushing time is formed, the foam colors change to bring exciting visual effect to the children to brush teeth, and the children can love to brush teeth.
(2) The children color-changing toothpaste with xylitol, fructo-oligosaccharide, pearl hydrolysate and other active substances added into the toothpaste has the functions of effectively preventing caries, nourishing gums and reducing the breeding of oral microorganisms, and can effectively help children to remove oral dirt, massage gums, prevent the generation of decayed teeth, reduce dental plaque and improve the disease resistance of gum tissues.
The children color-changing toothpaste containing the pigment capsule is added, the color change of foam can provide unique sensory experience for children in the tooth brushing process, the color signal prompt is striking, fun is brought to the children in tooth brushing, the tedious task of tooth brushing is changed into interesting activity, the children can love tooth brushing, the teeth brushing is insisted on in the morning and at night, the children are helped to remove oral dirt, massage the gums, inhibit the breeding of gingival bacteria, nourish and strengthen the gums, the disease resistance of gum tissues is improved, and a healthy oral environment is provided for the children.
Detailed Description
The present invention is further illustrated by examples.
The compositions of the microcapsules in the examples of the present invention are as follows:
the components of the microcapsule containing the pigment are as follows: based on the parts by weight, the weight ratio,
the preparation method comprises the following steps:
(1) preparing a liquid phase: adding pigment into water, stirring, adding glycerol and sorbitol, and stirring to obtain liquid phase;
(2) preparing powder: uniformly stirring carrageenan, agar and butylated polyvinylpyrrolidone for later use;
(3) adding the powder into the liquid phase, stirring uniformly, and spray drying to obtain the microcapsule containing the pigment.
The first embodiment is as follows: weighing 10g of xylitol, 2.5g of fructo-oligosaccharide and 0.01g of pearl hydrolysate, adding into the water phase, and stirring uniformly for later use; 0.1g of microcapsules was weighed out and stored at room temperature.
Example two: weighing 0.01g of xylitol, 0.01g of fructo-oligosaccharide and 2.5g of pearl hydrolysate, adding into the water phase, and stirring uniformly for later use; 10g of microcapsules are weighed and stored at room temperature.
Example three: weighing 5g of xylitol, 5g of fructo-oligosaccharide and 5g of pearl hydrolysate, adding into the water phase, and stirring uniformly for later use; 5g of microcapsules are weighed and stored at room temperature.
Preparation example of children color-changing toothpaste:
the first embodiment is as follows:
(1) adding xylitol, pearl hydrolysate, fructo-oligosaccharide and sodium salt into water, and stirring to obtain water phase;
(2) adding sorbitol and glycerin into the water phase, and stirring for 5-10 min to obtain a uniform liquid phase;
(3) uniformly stirring silicon dioxide and sodium carboxymethylcellulose into powder for later use;
(4) adding the liquid phase and the powder material into a paste making machine, controlling the vacuum degree to be more than-0.92 Mpa, and quickly stirring for 20-30 min under the condition that the temperature of a water bath kettle is controlled at 42 ℃;
(5) adding sodium lauryl sulfate and essence, controlling the vacuum degree to be more than-0.94 Mpa, quickly stirring for 15-20 min, opening a cover, adding the pigment-containing microcapsule, and stirring for 8-10 min under vacuum with the scraper speed controlled at 30-50 r/min; controlling the vacuum degree to be more than-0.96 Mpa, continuously vacuumizing for 15 minutes, and filling.
Example two:
the formula is as follows:
(1) adding xylitol, pearl hydrolysate, fructo-oligosaccharide and sodium salt into water, and stirring to obtain water phase;
(2) adding sorbitol and glycerin into the water phase, and stirring for 5-10 min to obtain a uniform liquid phase;
(3) uniformly stirring silicon dioxide and sodium carboxymethylcellulose into powder for later use;
(4) adding the liquid phase and the powder material into a paste making machine, controlling the vacuum degree to be more than-0.92 Mpa, and quickly stirring for 20-30 min under the condition that the temperature of a water bath kettle is controlled at 42 ℃;
(5) adding sodium lauryl sulfate and essence, controlling the vacuum degree to be more than-0.94 Mpa, quickly stirring for 15-20 min, opening a cover, adding the pigment-containing microcapsule, and stirring for 8-10 min under vacuum with the scraper speed controlled at 30-50 r/min; controlling the vacuum degree to be more than-0.96 Mpa, continuously vacuumizing for 15 minutes, and filling.
Example three:
| composition (I) | Final content (%) |
| Microcapsules | 5 |
| Xylitol, its preparation method and use | 5 |
| Fructo-oligosaccharide | 5 |
| Pearl hydrolysate | 5 |
| Sorbitol | 45 |
| Glycerol | 3 |
| Saccharin sodium salt | 0.22 |
| Sodium benzoate | 0.25 |
| Crystalline sodium pyrophosphate | 0.3 |
| Essence | 0.8 |
| Sodium carboxymethylcellulose | 0.8 |
| Silicon dioxide | 18 |
| Sodium lauryl sulfate | 1.8 |
| Water (W) | Is added to 100 |
(1) Adding xylitol, pearl hydrolysate, fructo-oligosaccharide and sodium salt into water, and stirring to obtain water phase;
(2) adding sorbitol and glycerin into the water phase, and stirring for 5-10 min to obtain a uniform liquid phase;
(3) uniformly stirring silicon dioxide and sodium carboxymethylcellulose into powder for later use;
(4) adding the liquid phase and the powder material into a paste making machine, controlling the vacuum degree to be more than-0.92 Mpa, and quickly stirring for 20-30 min under the condition that the temperature of a water bath kettle is controlled at 42 ℃;
(5) adding sodium lauryl sulfate and essence, controlling the vacuum degree to be more than-0.94 Mpa, quickly stirring for 15-20 min, opening a cover, adding the pigment-containing microcapsule, and stirring for 8-10 min under vacuum with the scraper speed controlled at 30-50 r/min; controlling the vacuum degree to be more than-0.96 Mpa, continuously vacuumizing for 15 minutes, and filling.
Comparison example 1
The formulation of example one was used. The toothpaste is prepared by the following steps:
(1) adding xylitol, pearl hydrolysate, fructo-oligosaccharide and sodium salt into water, and stirring to obtain water phase;
(2) adding sorbitol and glycerin into the water phase, and stirring for 5-10 min to obtain a uniform liquid phase;
(3) uniformly stirring silicon dioxide and sodium carboxymethylcellulose into powder for later use;
(4) adding the liquid phase and the powder material into a paste making machine, controlling the vacuum degree to be more than-0.92 Mpa, and quickly stirring for 20-30 min under the condition that the temperature of a water bath kettle is controlled at 42 ℃;
(5) adding sodium lauryl sulfate, essence and pigment-containing microcapsule, rapidly stirring for 15-20 min under vacuum degree of-0.94 MPa or more, continuously vacuumizing for 15min under vacuum degree of-0.96 MPa or more, and bottling.
The experimental results are as follows:
1. the product stability test of example one is shown in the following table:
from the investigation period of 3 months, the microcapsules in the paste of the embodiment of the preparation method are well preserved, the abnormalities such as explosion, color change and the like do not occur, and the paste is stable.
2. The product stability test of example two is shown in the following table:
from the investigation period of 3 months, the microcapsules in the second paste prepared by the preparation method of the invention are well preserved, the abnormalities such as explosion, color change and the like do not occur, and the paste is stable.
3. The product stability test of example three is shown in the following table:
from the investigation period of 3 months, the microcapsules in the paste obtained in the third embodiment of the preparation method are well preserved, the abnormalities such as explosion, color change and the like do not occur, and the paste is stable.
4. The product stability test of the first control example is shown in the following table:
from the investigation period of 3 months, the microcapsules in the paste body are exploded after being stirred with strong force, so that the paste body is abnormal in color change and unstable.
Variations and modifications to the above-described embodiments may occur to those skilled in the art, which fall within the scope and spirit of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.
Claims (9)
1. The color-changing children toothpaste is characterized by comprising the following components:
the microcapsule is a hydrogel matrix structure, the microcapsule is a micro-granular capsule formed by continuously dispersing food-grade pigments in the hydrogel matrix structure, and the hydrogel matrix structure is formed by carrageenan and agar; the pigment-containing microcapsule is added at the later stage of the paste preparation process by adopting a low-speed scraper stirring process: the stirring speed of the scraper is controlled to be 30 r/min-50 r/min; the stirring time is controlled to be 8 min-10 min.
2. The color-changing toothpaste for children as claimed in claim 1, wherein the amount of said pigment-containing microcapsules is 1-5 parts.
3. The color-changing toothpaste for children as claimed in claim 1, wherein the xylitol is used in an amount of 0.1-5 parts.
4. The color-changing toothpaste for children as claimed in claim 1, wherein the amount of fructo-oligosaccharide is 0.1-2 parts.
5. The color-changing toothpaste for children as claimed in claim 1, wherein the pearl hydrolysate is used in an amount of 0.05 to 1 part.
6. The color-changing children toothpaste according to claim 1, wherein the sodium salt is saccharin sodium, sodium benzoate, crystalline sodium pyrophosphate.
7. A method of preparing a color-changing children's toothpaste according to any one of claims 1 to 6, comprising the steps of:
(1) adding xylitol, pearl hydrolysate, fructo-oligosaccharide and sodium salt into water, and stirring to obtain water phase;
(2) adding sorbitol and glycerin into the water phase, and stirring for 5-10 min to obtain a uniform liquid phase;
(3) uniformly stirring silicon dioxide and sodium carboxymethylcellulose into powder for later use;
(4) adding the liquid phase and the powder material into a paste making machine, controlling the vacuum degree to be more than-0.92 Mpa, and quickly stirring for 20-30 min under the condition that the temperature of a water bath kettle is controlled at 42 ℃;
(5) adding sodium lauryl sulfate and essence, controlling the vacuum degree to be more than-0.94 Mpa, quickly stirring for 15-20 min, opening a cover, adding the pigment-containing microcapsule, and stirring for 8-10 min under vacuum with the scraper speed controlled at 30-50 r/min; and (5) exhausting and filling.
8. The preparation method according to claim 7, wherein the pigment-containing microcapsules are composed of: based on the parts by weight, the weight ratio,
9. use of a color-changing children's toothpaste according to any one of claims 1 to 6 for oral cavity cleaning, wherein children brush their teeth by squeezing a bean-sized toothpaste onto a toothbrush and start brushing their teeth, and when the foam of the paste is found to change color, it is indicated that the teeth are brushed for a long time and the oral cavity is cleaned.
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| CN113197794A (en) * | 2021-05-10 | 2021-08-03 | 广州市盛龙口腔清洁用品有限公司 | Children toothpaste for preventing decayed teeth and preparation method thereof |
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