CN110917065A - Color-changing toothpaste containing biological enzyme coated particles and preparation method thereof - Google Patents
Color-changing toothpaste containing biological enzyme coated particles and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses a color-changing toothpaste containing biological enzyme coated particles and a preparation method thereof, wherein the toothpaste comprises the components of a humectant, a rubbing agent, a thickening agent, a surfactant, essence, a sweetening agent, a pigment, an oral efficacy additive, menthol, sodium dihydrogen phosphate, the biological enzyme coated particles and water, the raw materials are weighed, mixed and stirred into paste, the biological enzyme coated particles are added, and the mixture is uniformly stirred through double planets to obtain the toothpaste. Through the mode, the biological enzyme effectively protects the activity of the biological enzyme through a packaging technology, prevents the influence of other raw materials on the biological enzyme, omits the step of preparing various pastes and then combining and filling, has high production efficiency and is easy to realize, the biological enzyme coated particles are broken in the using process of a consumer, the biological enzyme is released, and meanwhile, the color of the tooth brushing foam is changed through the pigment, so that the consumer can intuitively feel the release of the biological enzyme.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a color-changing toothpaste containing biological enzyme coated particles and a preparation method thereof.
Background
With the development of science and technology, human health problems become more and more of concerns of people, and with the wider and wider range of diet, the oral health problems become more and more serious. The diseases are introduced orally, people in modern society have more and more miscellaneous dietary types and more changeable dietary time, and teeth are the most important first-line of our dietary links, thus being faced with more and more serious challenges. In recent years, dentistry in various hospitals becomes a hot department, more or less epidemic diseases in teeth, such as dental caries, decayed teeth, hypersensitive dentin, gingivitis, periodontitis and the like of urban people deeply affect the daily life of people, and many people are suffering from the trouble and suffering from the trouble of eating and suffering from the trouble of not eating due to toothache.
The toothpaste can effectively keep the teeth clean and sanitary, and can effectively prevent gum diseases, such as gingivitis, gingival bleeding, gingival inflammation and the like. The functional toothpaste in the market at present mainly comprises two main types, one is used for preventing and assisting to treat oral diseases, such as periodontitis, gingivitis, oral ulcer, hemostasis and pain relief, tooth sensitivity and the like, and the other is used for helping to adjust and improve oral conditions, such as tooth whitening, oral odor removal, dental calculus removal, stain removal, dental plaque removal and the like. Some of the toothpaste is added with some effective ingredients of Chinese herbal medicines, such as pseudo-ginseng, paeonol, radix zanthoxyli, glabrous sarcandra herb and the like, some of the toothpaste is added with some western medicine ingredients, such as tranexamic acid or some chemical ingredients, such as strontium chloride, sodium fluoride and the like, some of the toothpaste is even added with some antibiotics, certain toxic and side effects are caused to a human body, and certain hidden dangers exist in safety performance. In recent years, functional toothpaste prepared by adding bioactive materials such as biological enzyme into toothpaste is more and more accepted and purchased by wide consumers. At present, a plurality of domestic brands are sold in the market, and the daily chemical treatment of Jiangsu ounces promotes the own biological enzyme toothpaste. The company of Longli Biotechnology GmbH has also introduced toothpaste of bio-enzyme series.
However, most of the existing bio-enzyme toothpastes on the market have poor effect and usually have the following defects: (1) the added biological enzymes have single species and incomplete functions, so that the oral cavity is difficult to be effectively protected in all aspects, and the problems related to teeth, gums and the like are solved. (2) The biological enzyme itself is unstable and is easily denatured by external factors (such as acid, alkali, perfume, metal ions in the formulation, etc.), thereby losing the enzyme activity. The required effect is difficult to achieve by a biological enzyme preparation with single component and single performance, so that the Jiangsu ounce daily chemical company performs secondary compounding on the optimized biological lysozyme, adds lysozyme and proteolytic enzyme, and prepares a high-purity high-efficiency compound preparation to be added into the toothpaste. Utilizing the color bar toothpaste technology, the Jiangsoluonli Biotechnology corporation, when preparing the enzyme-containing paste, adding one or more of the biological enzymes which are classified in advance into the color bar toothpaste with the same color, and selecting other toothpaste components and a biological enzyme stabilizer according to the characteristics of the biological enzymes so as to ensure the stable existence condition of various biological enzymes; when preparing the conditioning paste, chemical additives and biological enzyme activators are added. Then the color adjusting paste and the enzyme-containing paste of one or more colors are canned together to form the color bar toothpaste. When the biological enzyme toothpaste is used, the biological enzyme activator can improve the activity of the biological enzyme. However, in the actual storage process of the biological enzyme toothpaste, the biological enzyme is influenced by the action of other components in the toothpaste, the enzyme activity is still influenced to a certain extent, and meanwhile, the multicolor toothpaste causes a lot of troubles in the production of gel.
The bio-enzyme color strip toothpaste needs to prepare an adjusting paste body and color strip toothpaste respectively, and then the final color strip toothpaste form is realized through filling, so that certain challenges are provided for production and filling plans and productivity, colloid overstock is easily caused if the proportion matching is not good, and the efficiency of the whole production process is influenced. The biological enzyme activity is influenced by other components, and the enzyme activity is influenced to a certain extent in the storage process. During the use process of the consumer, no obvious indication phenomenon can make the consumer feel the release effect of the biological enzyme.
Disclosure of Invention
The invention mainly solves the technical problem of providing the color-changing toothpaste containing the biological enzyme coated particles and the preparation method thereof, and the color-changing toothpaste has the advantages of long storage time, simple production process and good consumer experience.
In order to solve the technical problems, the invention adopts a technical scheme that: the color-changing toothpaste containing the biological enzyme coated particles comprises the following components of a humectant, an abrasive, a thickening agent, a surfactant, essence, a sweetener, a pigment, an oral efficacy additive, menthol, sodium dihydrogen phosphate, the biological enzyme coated particles and water, wherein the content of each component of the color-changing toothpaste containing the biological enzyme coated particles is as follows: 20-73% of humectant, 15-50% of abrasive, 0.7-1.7% of thickening agent, 1.7-2.5% of surfactant, 0.8-1.2% of essence, 0.1-0.35% of sweetener, 0-0.5% of pigment, 0.03-5% of oral cavity efficacy additive, 0-0.1% of menthol, 0-0.5% of sodium dihydrogen phosphate, 0.1-1% of biological enzyme coated particles and the balance of water.
In a preferred embodiment of the invention, the humectant is one or a mixture of several of sorbitol, glycerol and propylene glycol with the mass fraction of 70%; the friction agent is one or a mixture of more of calcium carbonate, silicon dioxide, aluminum hydroxide and calcium hydrophosphate; the thickening agent is one or a mixture of more of sodium carboxymethylcellulose, carrageenan, hydroxyethyl cellulose, xanthan gum and carbomer; the sweetening agent is one or a mixture of saccharin sodium, sucralose and aspartame; the surfactant is one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl sarcosinate, imidazoline amphoteric surfactant, methyl cocoyl sodium taurate, cocamidopropyl betaine, polyoxyethylene alkyl ether phosphoric acid and salts thereof, and polyoxyethylene alkyl ether tripolyphosphoric acid; the pigment is one or a mixture of more of CI 42090, CI19140, CI 42051, CI 15985, CI 17200 and CI 77891; the oral cavity effect additive is one or a mixture of more of sodium monofluorophosphate, sodium fluoride, potassium nitrate, sodium pyrophosphate, potassium pyrophosphate, allantoin, sodium phytate, strontium chloride, sodium copper chlorophyllin, dipotassium glycyrrhizinate, zinc citrate, potassium citrate and calcium glycerophosphate.
In a preferred embodiment of the invention, the biological enzyme in the biological enzyme-coated particle is one or a mixture of more of dextranase, lysozyme, protease, glucose oxidase, amylase, superoxide dismutase, catalase, lipase, papain and bromelain.
In a preferred embodiment of the present invention, the bio-enzyme coated particles are obtained by coating a mixture of microcrystalline cellulose, mannitol and corn starch with biotin or a mixture of biotin and a pigment, and then coating the mixture with a polymer.
In a preferred embodiment of the invention, the polymer is polylactic acid, alginate jelly or gelatin.
In a preferred embodiment of the invention, the pigment is one or a mixture of titanium dioxide and amino cobalt phthalocyanine.
In a preferred embodiment of the present invention, the contents of the components of the biological enzyme-coated particle are as follows: 8-12 parts of biological enzyme, 0-70 parts of pigment, 20-30 parts of mannitol, 1-5 parts of corn starch, 1-5 parts of microcrystalline cellulose and 1-5 parts of polymer.
In a preferred embodiment of the present invention, the preparation method of the bio-enzyme coated particle comprises: uniformly mixing microcrystalline cellulose, corn starch and mannitol, and then floating up and down by biological enzyme under the action of airflow in a fluidized bed to enable the mixture of microcrystalline cellulose, corn starch and mannitol and the biological enzyme to generate interfacial polymerization so as to finish first-layer coating and obtain first coating particles; and then the first coating particles float up and down in the fluidized bed under the action of air flow, so that the polymer or the mixture of the polymer and the pigment completes second layer coating, and the biological enzyme coating particles are obtained.
Provides a preparation method of color-changing toothpaste containing biological enzyme coated particles, which comprises the following steps: mixing humectant, abrasive, thickener, surfactant, essence, sweetener, pigment, oral cavity effect additive, Mentholum, sodium dihydrogen phosphate and water, stirring to obtain paste, adding biological enzyme coated particles, and stirring with double planets.
In a preferred embodiment of the invention, the vacuum degree is kept between-0.096 and-0.098 MPa during the double-planetary stirring.
The invention has the beneficial effects that: according to the color-changing toothpaste containing the biological enzyme coated particles and the preparation method thereof, biological enzyme effectively protects the activity of the biological enzyme through a coating technology, the influence of other raw materials on the biological enzyme is prevented, the step of preparing various pastes and then combining and filling is omitted, the production efficiency is high, the realization is easy, the biological enzyme coated particles are broken in the using process of a consumer, the biological enzyme is released, meanwhile, the color of tooth brushing foam is changed through pigments, and the consumer can intuitively feel the release of the biological enzyme.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a schematic structural diagram of a preferred embodiment of the bio-enzyme coated particles in the color-changing toothpaste containing the bio-enzyme coated particles according to the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
the color-changing toothpaste containing the biological enzyme coated particles is provided, and consists of the following raw materials: 1.5kg of biological enzyme coated particles, 60kg of 70% sorbitol, 45kg of aluminum hydroxide, 1.5kg of carrageenan, 2.2kg of sodium dodecyl sulfate, 0.8kg of essence, 12kg of deionized water, 0.2kg of saccharin sodium, 0.3kg of sodium fluoride, 0.1kg of menthol and 0.1kg of sodium dihydrogen phosphate.
Wherein, the biological enzyme coated particle is composed of the following raw materials: 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine, 20kg of mannitol, 4kg of corn starch, 10kg of biological enzyme, 2kg of microcrystalline cellulose and 3kg of polylactic acid.
The preparation method of the color-changing toothpaste containing the biological enzyme coated particles comprises the following steps:
preparation of bio-enzyme coated particles: uniformly mixing 2kg of microcrystalline cellulose, 4kg of corn starch and 20kg of mannitol, and then floating up and down 10kg of biological enzyme in a fluidized bed under the action of airflow to enable the mixture of the microcrystalline cellulose, the corn starch and the mannitol and the biological enzyme to generate interfacial polymerization so as to finish first-layer coating and obtain first coating particles; and then the first coating particles float up and down in the fluidized bed under the action of air flow, so that the mixture of 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine and 3kg of polylactic acid is coated by a second layer, and the biological enzyme coated particles are obtained.
0.1kg of sodium dihydrogen phosphate, 0.2kg of saccharin sodium, 0.3kg of sodium fluoride and 12kg of deionized water are uniformly mixed, then 60kg of a mixture of 70 mass percent of sorbitol and 1.5kg of carrageenan, 45kg of aluminum hydroxide, 2.2kg of sodium dodecyl sulfate, 0.8kg of essence and 0.1kg of menthol are sequentially added, after the mixture is stirred to prepare an ointment, 1.5kg of biological enzyme coated particles are added, the mixture is uniformly stirred through double planets, the vacuum degree is kept between-0.096 and-0.098 MPa, the phenomenon that air is mixed in to affect the appearance is avoided, and the color-changing toothpaste containing the biological enzyme coated particles is obtained.
Example two:
the color-changing toothpaste containing the biological enzyme coated particles is provided, and consists of the following raw materials: 1.5kg of biological enzyme coated particles, 50kg of 70% sorbitol, 25kg of silicon dioxide, 1.5kg of hydroxyethyl cellulose, 2.2kg of sodium dodecyl sulfate, 0.8kg of essence, 12kg of deionized water, 0.2kg of aspartame, 1kg of zinc citrate, 0.1kg of menthol and 0.1kg of sodium dihydrogen phosphate.
Wherein, the biological enzyme coated particle is composed of the following raw materials: 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine, 20kg of mannitol, 4kg of corn starch, 10kg of biological enzyme, 2kg of microcrystalline cellulose and 3kg of polylactic acid.
The preparation method of the color-changing toothpaste containing the biological enzyme coated particles comprises the following steps:
preparation of bio-enzyme coated particles: uniformly mixing 2kg of microcrystalline cellulose, 4kg of corn starch and 20kg of mannitol, and then floating up and down 10kg of biological enzyme in a fluidized bed under the action of airflow to enable the mixture of the microcrystalline cellulose, the corn starch and the mannitol and the biological enzyme to generate interfacial polymerization so as to finish first-layer coating and obtain first coating particles; and then the first coating particles float up and down in the fluidized bed under the action of air flow, so that the mixture of 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine and 3kg of polylactic acid is coated by a second layer, and the biological enzyme coated particles are obtained.
0.1kg of sodium dihydrogen phosphate, 0.2kg of aspartame and 12kg of deionized water are uniformly mixed, then a mixture of 50kg of sorbitol with the mass fraction of 70% and 1.5kg of hydroxyethyl cellulose, 25kg of silicon dioxide, 2.2kg of sodium dodecyl sulfate, 0.8kg of essence and 0.1kg of menthol are sequentially added, after the mixture is stirred to prepare paste, 1.5kg of biological enzyme coated particles are added, the mixture is uniformly stirred by double planets, the vacuum degree is kept between-0.096 and-0.098 MPa, the influence on the appearance caused by the mixing of air is avoided, and the color-changing toothpaste containing the biological enzyme coated particles is obtained.
Example three:
the color-changing toothpaste containing the biological enzyme coated particles is provided, and consists of the following raw materials: 1.5kg of biological enzyme coated particles, 10kg of 70% sorbitol, 35kg of glycerol, 50kg of calcium carbonate, 3kg of silicon dioxide, 1.5kg of hydroxyethyl cellulose, 2.2kg of sodium dodecyl sulfate, 0.8kg of essence, 12kg of deionized water, 0.2kg of aspartame, 0.1kg of menthol and 0.1kg of sodium dihydrogen phosphate.
Wherein, the biological enzyme coated particle is composed of the following raw materials: 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine, 20kg of mannitol, 4kg of corn starch, 10kg of biological enzyme, 2kg of microcrystalline cellulose and 3kg of polylactic acid.
The preparation method of the color-changing toothpaste containing the biological enzyme coated particles comprises the following steps:
preparation of bio-enzyme coated particles: uniformly mixing 2kg of microcrystalline cellulose, 4kg of corn starch and 20kg of mannitol, and then floating up and down 10kg of biological enzyme in a fluidized bed under the action of airflow to enable the mixture of the microcrystalline cellulose, the corn starch and the mannitol and the biological enzyme to generate interfacial polymerization so as to finish first-layer coating and obtain first coating particles; and then the first coating particles float up and down in the fluidized bed under the action of air flow, so that the mixture of 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine and 3kg of polylactic acid is coated by a second layer, and the biological enzyme coated particles are obtained.
Preparation of bio-enzyme coated particles: uniformly mixing 2kg of microcrystalline cellulose, 4kg of corn starch and 20kg of mannitol, and then floating up and down 10kg of biological enzyme in a fluidized bed under the action of airflow to enable the mixture of the microcrystalline cellulose, the corn starch and the mannitol and the biological enzyme to generate interfacial polymerization so as to finish first-layer coating and obtain first coating particles; and then the first coating particles float up and down in the fluidized bed under the action of air flow, so that a mixture of 30kg of titanium dioxide, 28kg of amino cobalt phthalocyanine and 3kg of polylactic acid is coated on the second layer, and the biological enzyme coated particles are obtained.
0.1kg of sodium dihydrogen phosphate, 0.2kg of aspartame and 12kg of deionized water are uniformly mixed, then 10kg of sorbitol with the mass fraction of 70%, 30kg of a mixture of glycerol and 1.5kg of hydroxyethyl cellulose, 50kg of calcium carbonate, 3kg of silicon dioxide, 2.2kg of sodium dodecyl sulfate, 0.8kg of essence and 0.1kg of menthol are sequentially added, the mixture is stirred to prepare paste, 1.5kg of biological enzyme coated particles are added, the mixture is uniformly stirred through double planets, the vacuum degree is kept between-0.096 and-0.098 MPa, the phenomenon that air is mixed in to affect the appearance is avoided, and the color-changing toothpaste containing the biological enzyme coated particles is obtained.
The biological enzyme effectively protects the activity of the biological enzyme through a packaging technology, prevents other raw materials in a formula from influencing the biological enzyme, and meanwhile, the pigment is added into the packaged particles, so that the particles are broken in the tooth brushing process, the biological enzyme is released, and meanwhile, the color of the tooth brushing foam is changed by the pigment, so that a consumer can intuitively feel the release of the biological enzyme.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. The color-changing toothpaste containing the biological enzyme coated particles is characterized by comprising the following components: 20-73% of humectant, 15-50% of abrasive, 0.7-1.7% of thickening agent, 1.7-2.5% of surfactant, 0.8-1.2% of essence, 0.1-0.35% of sweetener, 0-0.5% of pigment, 0.03-5% of oral cavity efficacy additive, 0-0.1% of menthol, 0-0.5% of sodium dihydrogen phosphate, 0.1-1% of biological enzyme coated particles and the balance of water.
2. The color-changing toothpaste containing the bio-enzyme coated particles as claimed in claim 1, wherein the humectant is one or a mixture of sorbitol, glycerin and propylene glycol; the friction agent is one or a mixture of more of calcium carbonate, silicon dioxide, aluminum hydroxide and calcium hydrophosphate; the thickening agent is one or a mixture of more of sodium carboxymethylcellulose, carrageenan, hydroxyethyl cellulose, xanthan gum and carbomer; the sweetening agent is one or a mixture of saccharin sodium, sucralose and aspartame; the surfactant is one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl sarcosinate, imidazoline amphoteric surfactant, methyl cocoyl sodium taurate, cocamidopropyl betaine, polyoxyethylene alkyl ether phosphoric acid and salts thereof, and polyoxyethylene alkyl ether tripolyphosphoric acid; the pigment is one or a mixture of more of CI 42090, CI19140, CI 42051, CI 15985, CI 17200 and CI 77891; the oral cavity effect additive is one or a mixture of more of sodium monofluorophosphate, sodium fluoride, potassium nitrate, sodium pyrophosphate, potassium pyrophosphate, allantoin, sodium phytate, strontium chloride, sodium copper chlorophyllin, dipotassium glycyrrhizinate, zinc citrate, potassium citrate and calcium glycerophosphate.
3. The color-changing toothpaste containing the biological enzyme-coated particles as claimed in claim 1, wherein the biological enzyme in the biological enzyme-coated particles is one or a mixture of more of dextranase, lysozyme, protease, glucose oxidase, amylase, superoxide dismutase, catalase, lipase, papain and bromelain.
4. The color-changing toothpaste containing the bio-enzyme-coated particles as claimed in claim 1, wherein the bio-enzyme-coated particles are obtained by coating biotin or a mixture of biotin and a pigment with a mixture of microcrystalline cellulose, mannitol and corn starch and then coating with a polymer.
5. The color-changing toothpaste containing bio-enzyme coated particles according to claim 4, wherein the polymer is polylactic acid, alginate gel or gelatin.
6. The color-changing toothpaste containing bio-enzyme coated particles according to claim 4, wherein the pigment is one or a mixture of titanium dioxide and amino cobalt phthalocyanine.
7. The color-changing toothpaste containing the bio-enzyme coated particles as claimed in claim 4, wherein the contents of the bio-enzyme coated particles are as follows: 8-12 parts of biological enzyme, 0-70 parts of pigment, 20-30 parts of mannitol, 1-5 parts of corn starch, 1-5 parts of microcrystalline cellulose and 1-5 parts of polymer.
8. The color-changing toothpaste containing the bio-enzyme coated particles as claimed in claim 4, wherein the bio-enzyme coated particles are prepared by the following method: uniformly mixing microcrystalline cellulose, corn starch and mannitol, and then floating up and down by biological enzyme under the action of airflow in a fluidized bed to enable the mixture of microcrystalline cellulose, corn starch and mannitol and the biological enzyme to generate interfacial polymerization so as to finish first-layer coating and obtain first coating particles; and then the first coating particles float up and down in the fluidized bed under the action of air flow, so that the polymer or the mixture of the polymer and the pigment completes second layer coating, and the biological enzyme coating particles are obtained.
9. The method for preparing a color-changing toothpaste containing bio-enzyme coated particles according to claim 1, comprising the steps of: mixing humectant, abrasive, thickener, surfactant, essence, sweetener, pigment, oral cavity effect additive, Mentholum, sodium dihydrogen phosphate and water, stirring to obtain paste, adding biological enzyme coated particles, and stirring with double planets.
10. The method for preparing color-changing toothpaste containing bio-enzyme coated particles according to claim 9, wherein the degree of vacuum maintained during the double planetary stirring is-0.096 to-0.098 MPa.
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Cited By (4)
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| CN112137897A (en) * | 2020-09-20 | 2020-12-29 | 湖州蔻婷生物科技有限公司 | Active substance microcapsule with indication effect for oral cleaning product |
| CN113749970A (en) * | 2021-10-27 | 2021-12-07 | 上海圣岳生物科技有限公司 | Toothpaste containing superoxide dismutase SOD for promoting tooth whitening and preparation method thereof |
| CN114010569A (en) * | 2021-11-11 | 2022-02-08 | 江苏罗来雅实业股份有限公司 | Anhydrous whitening paste and preparation method thereof |
| WO2022261879A1 (en) * | 2021-06-17 | 2022-12-22 | The Procter & Gamble Company | Dentifrice compositions with striated appearance |
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| WO2022261879A1 (en) * | 2021-06-17 | 2022-12-22 | The Procter & Gamble Company | Dentifrice compositions with striated appearance |
| CN113749970A (en) * | 2021-10-27 | 2021-12-07 | 上海圣岳生物科技有限公司 | Toothpaste containing superoxide dismutase SOD for promoting tooth whitening and preparation method thereof |
| CN114010569A (en) * | 2021-11-11 | 2022-02-08 | 江苏罗来雅实业股份有限公司 | Anhydrous whitening paste and preparation method thereof |
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Address after: 215000 Xinzhuang section of 227 provincial road, Changshu City, Suzhou City, Jiangsu Province Applicant after: Crowley Cosmetics Co.,Ltd. Address before: 215000 Xinzhuang section of 227 provincial road, Changshu City, Suzhou City, Jiangsu Province Applicant before: Suzhou Crowley Cosmetics Co.,Ltd. |