WO2022261879A1

WO2022261879A1 - Dentifrice compositions with striated appearance

Info

Publication number: WO2022261879A1
Application number: PCT/CN2021/100469
Authority: WO
Inventors: Jinfang YUAN; Hanjiang ZHU; Ruizhi Pei
Original assignee: The Procter & Gamble Company
Priority date: 2021-06-17
Filing date: 2021-06-17
Publication date: 2022-12-22

Abstract

An oral care composition, particular a dentifrice composition, having a unique striated appearance.

Description

DENTIFRICE COMPOSITIONS WITH STRIATED APPEARANCE

FIELD OF THE INVENTION

The present invention relates to an oral care composition, particular a dentifrice composition, having a uniquely striated appearance.

BACKGROUND OF THE INVENTION

As brushing teeth is generally considered a mundane routine of everyday life, consumers desire more delightful visual stimuli during the brushing experience. Transparent toothpastes have been in the market for years, and colored particles have been added therein to provide more visual stimuli.

However, there is still a continuous need for toothpaste with improved visual attractiveness or appearance.

SUMMARY OF THE INVENTION

Besides changing toothpaste color or adding aesthetics into the toothpaste, the applicant recently surprisingly discovers a toothpaste exhibiting a uniquely striated appearance that can be very interesting and attractive to the consumers. Such straited appearance is characterized by a relatively smaller Gaussian fitting Dispersion (i.e. the standard deviation of the gaussian fitting for imaging orientation analysis) , and a relatively higher Gaussian Fitting Goodness (i.e. Gaussian fitting Goodness for imaging orientation analysis) . Further, the applicant surprisingly discovers a toothpaste exhibiting an appearance change, from a non-striated appearance to a striated appearance, when a certain shear stress is applied. Particularly, the toothpaste has a non-striated appearance when in the tube, but it exhibits a striated appearance when being dispensed (e.g. being squeezed) out of the tube to spread on the toothbrush. The change on appearance provides unique visual delight and attractive brushing experience for consumer.

An advantage of the present invention is to provide a dentifrice composition with a unique attractive appearance, especially striated appearance, so as to provide the consumer a better sensorial experience.

Another advantage of the present invention is to provide a toothpaste having color contrast between a transparent base phase and a luminous striated stripe phase dispersed in the base phase.

Further another advantage of the present invention is to provide a toothpaste have changeable appearance from a non-striated appearance to a striated appearance upon application of shear stress.

Still another advantage of the present invention is to provide a phase stable formulation.

One aspect of the invention provides for an oral care composition comprising a first phase and a second phase, wherein the second phase is immiscibly dispersed in the first phase to form a striated appearance, wherein the appearance is characterized by a Gaussian Fitting Dispersion of no more than 15, and a Gaussian Fitting Goodness of no less than 0.6.

Another aspect of the invention provides a method of use comprising the step of brushing teeth with a composition of the present invention.

These and other features, aspects, and advantages of the present invention will become evident to those skilled in the art from the detailed description which follows.

BRIEF DESCRIPTION OF THE DRAWINGS

While the specification concludes with claims that particularly point out and distinctly claim the invention, it is believed the present invention will be better understood from the following description of the accompanying figures.

FIG. 1A to FIG. 1C are microscope photos of Comparative Examples A to C, respectively.

FIG. 2 is microscope photo of Inventive Example 1.

FIG. 3 is microscope photo of Inventive Example 2.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

As used herein, the articles including “a” and “an” when used in a claim, are understood to mean one or more of what is claimed or described.

The term “comprising” as used herein means that steps and ingredients other than those specifically mentioned can be added. This term encompasses the terms “consisting of” and “consisting essentially of. ” The compositions of the present invention can comprise, consist of, and consist essentially of the essential elements and limitations of the invention described herein, as well as any of the additional or optional ingredients, components, steps, or limitations described herein.

As used herein, the words "preferred" , "preferably" and variants refer to embodiments of the invention that afford certain benefits, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention.

The term "substantially free" as used herein refers to no intentional amount of that material is added to the composition or an amount of a material that is less than 0.05%, 0.01%, or 0.001%of the composition. The term “essentially free” as used herein means that the indicated material is not deliberately added to the composition, or preferably not present at analytically detectable levels. It is meant to include compositions whereby the indicated material is present only as an impurity of one of the other materials deliberately added. The term "free" as used herein refers to no reasonably detectable amount of that material is present in the composition.

The term “dentifrice” as used herein means paste, gel, powder, tablets, or liquid formulations, unless otherwise specified, that are used to clean the surfaces of the oral cavity. Preferably the dentifrice compositions of the present invention are single phase compositions. One example of a dentifrice is toothpaste (for brushing teeth) . The term “teeth” as used herein refers to natural teeth as well as artificial teeth or dental prosthesis.

All percentages, parts and ratios are based upon the total weight of the compositions of the present invention, unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore do not include solvents or by-products that may be included in commercially available materials, unless otherwise specified.

All measurements referred to herein are made at 25℃ (i.e., room temperature) unless otherwise specified.

Oral Care Composition

An oral care composition comprising a first phase and a second phase, wherein the second phase is immiscibly dispersed in the first phase, wherein the oral care composition exhibits a striated appearance characterized by a relatively smaller Gaussian Fitting Dispersion, and a relatively higher Gaussian Fitting Goodness.

In order to measuring the striated appearance, imaging orientation analysis utilizing the Fourier transform is applied to calculate the orientation histogram. Then the histogram is fitted with Gaussian to calculate the standard deviation (STD) and Goodness of Gaussian fitting. Particularly, the standard deviation of the gaussian fit for orientation histogram is represented by Gaussian Fitting Dispersion, while the goodness of the Gaussian fit for imaging orientation histogram is represented by Gaussian Fitting Goodness. Preferably, the oral care composition of the present invention exhibits a striated appearance characterized by a Gaussian Fitting Dispersion of no more than 15, and a Gaussian Fitting Goodness of no less than 0.6.

In some examples, the oral care composition of the present invention forms the striated appearance described above upon a shear stress, e.g. squeezed out of a tube through a nozzle. Optionally, but preferably, the oral care composition may form the striated appearance upon a shear stress more than 20 Pa. The lower limitation of the shear stress supplied on the composition can be measured by an Oscillation Measurement using stress-controlled rheometer (HAAKE MARS & ACCESSORIES) ; G' (viscous module) and G” (loss modulus) which reflecting elastic property and viscous property over the tested shear stress range, are obtained following the program of HAAKE MARS & ACCESSORIES software. Toothpaste can be spread at shear stress with G” ≥G'.

Preferably, the oral care composition of the present invention may exhibit the straited appearance characterized by exhibiting a Gaussian Fitting Dispersion of no more than 14, preferably no more than 12; and exhibiting a Gaussian Fitting Goodness of no less than 0.7, preferably no less than 0.8. Preferably, the oral care composition can be a dentifrice, e.g. a toothpaste.

The oral care composition of the invention comprising a first phase and a second phase, wherein the second phase is immiscibly dispersed into the first phase. The first phase of the composition can comprise an oral acceptable carrier selected from the group consisting of water, alcohol, glycerin, sorbitol, and any combinations thereof.

The oral care composition of the present invention can be a dentifrice composition that is anhydrous, a low water formulation, or a high water formulation. In total, the amount of water presented in the composition can be from about 0.5%to about 75%, preferably from about 1.5%to about 55%.

In a high water dentifrice formulation, the dentifrice composition comprises from about 45%to about 75%, by weight of the composition, of water. The high water dentifrice composition can comprise from about 45%to about 65%, from about 45%to about 55%, or from about 46%to about 54%, by weight of the composition, of water. The water may be added to the high water dentifrice formulation and/or may come into the composition from the inclusion of other ingredients.

In a low water dentifrice formulation, the dentifrice composition comprises from about 10%to about 45%, by weight of the composition, of water. The low water dentifrice composition can comprise from about 10%to about 35%, from about 15%to about 25%, or from about 20%to about 25%, by weight of the composition, of water. The water may be added to the low water dentifrice formulation and/or may come into the composition from the inclusion of other ingredients.

In an anhydrous dentifrice formulation, the dentifrice composition comprises less than about 10%, by weight of the composition, of water. The anhydrous dentifrice composition comprises less than about 5%, less than about 1%, or 0%, by weight of the composition, of water. The water may be added to the anhydrous formulation and/or may come into the dentifrice composition from the inclusion of other ingredients.

The oral care composition can also be a mouth rinse formulation. A mouth rinse formulation can comprise from about 75%to about 99%, from about 75%to about 95%, or from about 80%to about 95%of water.

The dentifrice composition can also comprise other orally acceptable carrier materials, such as alcohol, humectants, polymers, surfactants, and acceptance improving agents, such as flavoring, sweetening, coloring and/or cooling agents.

Humectant

The oral care composition can comprise one or more humectants, have low levels of humectant, be free of humectant, be substantially free of humectant, and/or essentially free of humectant. Humectants serve to add body or “mouth texture” to an oral care composition or dentifrice as well as preventing the dentifrice from drying out. Suitable humectants include polyethylene glycol (at a variety of different molecular weights) , propylene glycol, glycerin (glycerol) , erythritol, xylitol, sorbitol, mannitol, butylene glycol, lactitol, hydrogenated starch hydrolysates, and/or mixtures thereof. The oral care composition can comprise one or more humectants each at a level of from 0 to about 70%, from about 5%to about 50%, from about 10%to about 60%, or from about 20%to about 80%, by weight of the oral care composition.

Particles

The oral care composition of the present invention comprises a second phase which immiscibly dispersed in a first phase where water soluble carrier exists. The second phase comprises particles, wherein the particles comprise water swellable polymer and colorant. Preferably, the particles are present in an amount of from about 0.001%to about 5%, by weight of the composition. For example, the particles can be present in the oral care composition in an amount of from about 0.01%to about 4%by weight of the composition, preferably from about 0.1%to about 3%, more preferably from about 0.2%to about 2.5%, by weight of the composition.

The particles present in the second phase of the oral care composition may have an average particle size of from about 5μm to about 5000μm, preferably from about 20μm to about 3000 μm. For example, the particle may have an average particle size from about 50μm to about 2000 μm, preferably from about 100μm to about 1000μm.

The particles present in the second phase of the oral care composition comprise water swellable polymer and colorant. The particle can comprise from about 0.5%to about 30%of water sellable polymer and from about 1%to 70%of colorant. The particle may further comprise other ingredients such as sensates, or humectant.

The particles can be produced by any suitable method for making particles, including but not limited to fluidized bed granulation, agglomeration, protrusion, etc.

Water Swellable Polymer

Water-swellable polymers are well known in the art for being capable of absorbing large amounts of aqueous solutions relative to their mass. The water swellable polymer suitable used in the present invention can be selected from the group consisting of starch, starch derivatives, gelatin, polyvinyl alcohol (PVA) , PVA copolymers such as PVA/polyvinyl pyrrolidone and PVA/polyvinyl amine; alkyl cellulosics such as methyl cellulose, ethyl cellulose and propyl cellulose, alkylhydroxy cellulosics such as methylcellulose, carboxymethylcellulose sodium, modified carboxy-methylcellulose, dextrin, ethylcellulose, propylcellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, and any combinations thereof, as long as the polymers are oral acceptable and are able to provide the water swellable characteristics. In some preferred examples, the water swellable polymer is selected from starch, starch derivative, gelatin, hydroxypropyl methylcellulose, and any combinations thereof. The water-swellable polymer can act as carrier and/or binder agent in the particle.

Starch

The particles present in the second phase of the oral care composition may comprise starch or starch derivatives, preferably in an amount of from about 0.5%to about 30%, preferably from about 1%to about 20%, by weight of the said particles. The starch can be a low amylose starch, in this context a low amylose starch is considered to be a starch comprising less than 25 wt%amylose. i.e. 0.001 to 25 wt%amylose. A non-limiting list of low amylose starches includes Tapioca (also referred to as Cassava) , Sweet potato, potato and Arrowroot. For example, the starch has an amylose content of 0.001 to 21 wt%. A preferred low amylose starch is Tapioca.

Starch derivatives, also known as modified starch, are prepared by physically, enzymatically, or chemically treating native starch to change its properties. The particles may comprise starch derivatives as long as it can provide the straited appearance characteristics.

Colorant

The particle present in the second phase of the oral care composition may comprise colorants which selected from pigments, pealing agents, filler powders, talc, mica, titanium dioxide, dye lakes, magnesium carbonate, calcium carbonate, bismuth oxychloride, zinc oxide, and combinations thereof. The colorant can be present in the particle in an amount of from about 1%to about 70%by weight, preferably from about 10%to about 50%of said particle. One preferred example is titanium dioxide (TiO ₂) . Titanium dioxide is a white powder which provides opacity (thus possible provide color comparison in a transparent/translucent paste) to the composition. The colorant present in the particle may be a mixture of at least two ingredients selected from the group consisting of pigments, pealing agents, filler powders, talc, mica, titanium dioxide, dye lakes, magnesium carbonate, calcium carbonate, bismuth oxychloride, zinc oxide, and combinations thereof.

The particles comprising water swellable polymer and colorant can help provide striated appearance, especially when there is an opacity/transparency difference between the first phase and the second phase. Without being bound by any theory, the water swellable polymer absorb water contained in the first phase of the composition and get swelled, wherein the colorant associated with the polymer in the particle will be dispersed into the first phase, and upon shear press or not, lines-like structure or striated structure appearances occur.

Flavorant

Optionally, but preferably, the composition comprises a flavorant. The compositions herein may comprise from 0.001%to 5%, alternatively from 0.01%to 4%, alternatively from 0.1%to 3%, alternatively from 0.5%to 2%, alternatively 1%to 1.5%, alternatively 0.5%to 1%, by weight of the composition, of a flavorant. Preferably, the composition comprises at least one of a flavorant having a ClogP value from-2 to 12, preferably from 0 to 8.

Examples of some flavorant and flavor components used in oral care compositions are mint oils, wintergreen, clove bud oil, cassia, sage, parsley oil, marjoram, lemon, orange, propenyl guaethol, heliotropine, 4-cis-heptenal, diacetyl, methyl-p-tert-butyl phenyl acetate, methyl salicylate, ethyl salicylate, 1-menthyl acetate, oxanone, a-irisone, methyl cinnamate, ethyl cinnamate, butyl cinnamate, ethyl butyrate, ethyl acetate, methyl anthranilate, iso-amyl acetate, iso-amyl butyrate, allyl caproate, eugenol, eucalyptol, thymol, cinnamic alcohol, octanol, octanal, decanol, decanal, phenylethyl alcohol, benzyl alcohol, a-terpineol, linalool, limonene, citral, neral, geranial, geraniol nerol, maltol, ethyl maltol, anethole, dihydroanethole, carvone, menthone, β-damascenone, ionone, γ-decalactone, γ-nonalactone, y-undecalactone, or combinations thereof. Generally suitable flavoring ingredients are chemicals with structural features and functional groups that are less prone to redox reactions. These include derivatives of flavor chemicals that are saturated or contain stable aromatic rings or ester groups. Of these flavors, examples of some which provide an unwanted taste include, for example, citral, geranial, eucalyptol, thymol and eugenol. The unwanted tastes often associated with these types of flavors are sourness, chemical, bitter, pungent, and/or astringent. Flavor can, in a broad way, include sensates or sensate agent.

Sensates

Optionally, the oral care composition herein may comprise sensates or sensate agent. Sensate agents such as cooling, warming, and tingling agents are useful to deliver signals to the consumer. Sensates are generally used in amounts of 0.001%to 0.8%of the oral care composition. The most well-known cooling sensate compound is menthol, particularly 1-menthol, which is found naturally in peppermint oil.

Sweetener

Optionally, the oral care compositions herein may comprise a sweetening agent. These sweetening agents may comprise saccharin, dextrose, sucrose, lactose, maltose, levulose, aspartame, sodium cyclamate, D-tryptophan, dihydrochalcones, acesulfame, sucralose, neotame, and mixtures thereof. Sweetening agents are generally used in oral compositions at levels of from about 0.005%to about 5%, by weight of the composition, alternatively from about 0.01%to about 1%, alternatively from about 0.1%to about 0.5%, alternatively combinations thereof.

Fluoride Ion Source

Optionally, but preferably, the dentifrice compositions may comprise an effective amount of a fluoride ion source. The fluoride ion may be present in an amount sufficient to give a fluoride ion concentration in the composition at 25℃, and/or in one embodiment can be used at levels of from about 0.0025%to about 5%by weight of the composition. Examples of fluoride ion sources include stannous fluoride, sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, and zinc fluoride.

The method for assessing soluble fluoride is described consistent with the China’s National Standard Method GB8372-2008. Briefly, an ion-selective electrode (ISE) is used to test soluble fluoride in dentifrice. An example of a fluoride ion meter is SARTORIUS PP-50, but an equivalent may be used.

Surfactants

The oral care composition can comprise one or more surfactants. The surfactants can be used to make the compositions more cosmetically and/or consumer acceptable. The surfactant can be a detersive material which imparts to the composition detersive and foaming properties. Suitable surfactants include anionic, cationic, nonionic, zwitterionic, amphoteric and/or betaine surfactants. Other suitable surfactants include sodium lauryl sulfate, sodium lauryl isethionate, sodium lauroyl methyl isethionate, sodium cocoyl glutamate, sodium dodecyl benzene sulfonate, alkali metal or ammonium salts of lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate, polyoxyethylene sorbitan monostearate, isostearate and laurate, sodium lauryl sulfoacetate, N-lauroyl sarcosine, the sodium, potassium, and ethanolamine salts of N-lauroyl, N-myristoyl, or N-palmitoyl sarcosine, polyethylene oxide condensates of alkyl phenols, cocoamidopropyl betaine, lauramidopropyl betaine, palmityl betaine, sodium cocoyl glutamate, and the like. Sodium lauryl sulfate is a preferred surfactant. The oral care composition can comprise one or more surfactants each at a level from about 0.01%to about 15%, from about 0.3%to about 10%, or from about 0.3%to about 2.5%, by weight of the oral care composition.

Thickening Agent

The oral care composition can comprise one or more thickening agents. Thickening agents can be useful in the oral care compositions to provide a gelatinous structure that stabilizes the toothpaste against phase separation. Suitable thickening agents include polysaccharides, polymers, and/or silica thickeners. Some non-limiting examples of polysaccharides include starch; glycerite of starch; gums such as gum karaya (sterculia gum) , gum tragacanth, gum arabic, gum ghatti, gum acacia, xanthan gum, guar gum and cellulose gum; magnesium aluminum silicate (Veegum) ; carrageenan; sodium alginate; agar-agar; pectin; gelatin; cellulose compounds such as cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, hydroxymethyl carboxypropyl cellulose, methyl cellulose, ethyl cellulose, and sulfated cellulose; natural and synthetic clays such as hectorite clays; and mixtures thereof.

The thickening agent can comprise polysaccharides. Polysaccharides that are suitable for use herein include carageenans, gellan gum, locust bean gum, xanthan gum, carbomers, poloxamers, modified cellulose, and mixtures thereof. Carageenan is a polysaccharide derived from seaweed. There are several types of carageenan that may be distinguished by their seaweed source and/or by their degree of and position of sulfation. The thickening agent can comprise kappa carageenans, modified kappa carageenans, iota carageenans, modified iota carageenans, lambda carrageenan, and mixtures thereof. Carageenans suitable for use herein include those commercially available from the FMC Company under the series designation “Viscarin, ” including but not limited to Viscarin TP 329, Viscarin TP 388, and Viscarin TP 389.

The thickening agent can comprise one or more polymers. The polymer can be a polyethylene glycol (PEG) , a polyvinylpyrrolidone (PVP) , polyacrylic acid, a polymer derived from at least one acrylic acid monomer, a copolymer of maleic anhydride and methyl vinyl ether, a crosslinked polyacrylic acid polymer, of various weight percentages of the oral care composition as well as various ranges of average molecular ranges. The polymer can comprise polyacrylate crosspolymer, such as polyacrylate crosspolymer-6. Suitable sources of polyacrylate crosspolymer-6 can include Sepimax Zen ^TM commercially available from Seppic.

The thickening agent can comprise inorganic thickening agents. Some non-limiting examples of suitable inorganic thickening agents include colloidal magnesium aluminum silicate, silica thickeners. Useful silica thickeners include, for example, include, as a non-limiting example, an amorphous precipitated silica such as

165 silica. Other non-limiting silica thickeners include

153, 163, and 167, and

177 and 265 silica products, all available from Evonik Corporation, and

fumed silicas.

The oral care composition can comprise from 0.01%to about 15%, from 0.1%to about 10%, from about 0.2%to about 5%, or from about 0.5%to about 2%of one or more thickening agents.

Abrasive

The oral care composition of the present invention can comprise abrasive. Abrasives can be added to oral care formulations to help remove surface stains from teeth. The abrasive can comprise calcium abrasive and/or silica abrasive.

The calcium abrasive can be any suitable abrasive compound that can provide calcium ions in an oral care composition and/or deliver calcium ions to the oral cavity when the oral care composition is applied to the oral cavity. The oral care composition can comprise from about 5% to about 70%, from about 10%to about 60%, from about 20%to about 50%, from about 25%to about 40%, or from about 1%to about 50%of a calcium abrasive. The calcium abrasive can comprise one or more calcium abrasive compounds, such as calcium carbonate, precipitated calcium carbonate (PCC) , ground calcium carbonate (GCC) , chalk, dicalcium phosphate, calcium pyrophosphate, and/or mixtures thereof.

The oral care composition can also comprise silica abrasive, such as silica gel (by itself, and of any structure) , precipitated silica, amorphous precipitated silica (by itself, and of any structure as well) , hydrated silica, and/or combinations thereof. The oral care composition can comprise from about 5%to about 70%, from about 10%to about 60%, from about 10%to about 50%, from about 20%to about 50%, from about 25%to about 40%, or from about 1%to about 50%of a silica abrasive.

The abrasive can also comprise bentonite, perlite, titanium dioxide, alumina, hydrated alumina, calcined alumina, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, insoluble magnesium carbonate, zirconium silicate, particulate thermosetting resins and/or other suitable abrasive materials. The oral care composition can comprise from about 5%to about 70%, from about 10%to about 60%, from about 10%to about 50%, from about 20%to about 50%, from about 25%to about 40%, or from about 1%to about 50%of another abrasive.

Other Active Agents

The dentifrice compositions of the present invention may optionally also include other anti-bacterial agents, preferably present in an amount of from 0.035%or more, from 0.05%to 2%, from 0.1%to 1%, by weight of the composition. Examples of these other anti-bacterial agents may include non-cationic anti-bacterial agents such as, for example, halogenated diphenyl ethers, phenolic compounds including phenol and its homologs, mono and poly-alkyl and aromatic halophenols, resorcinol and its derivatives, xylitol, bisphenolic compounds and halogenated salicylanilides, benzoic esters, and halogenated carbanilidies. Other useful anti-bacterial agents are enzymes, including endoglycosidase, papain, dextranase, mutanase, and combinations thereof.

pH

The pH of the oral care compositions as described herein can be from about 4 to about 10, from about 6 to about 8, alternatively from 4.5 to 7.5. The pH of the oral care compositions, as described herein, can also be at least about 6, at least about 6.5, or at least about 7. The pH of a mouthrinse solution can be determined as the pH of the neat solution. The pH of a dentifrice composition can be determined as a slurry pH, which is the pH of a mixture of the dentifrice composition and water, such as a 1: 4, 1: 3, or 1: 2 mixture of the dentifrice composition and water. The pH of the oral care compositions as described herein have a preferred pH of from about 4 to about 10, from about 5 to about 9, from about 6 to 8, or about 7.

METHOD OF USE

The present invention also relates to methods for treating the oral cavity comprising administering to the oral care cavity an oral care composition according to the present invention. In an embodiment, the term "treating" refers to cleaning and polishing teeth. The method of use herein comprises contacting a subject’s dental enamel surfaces and oral mucosa with the oral care compositions according to the present invention. The method of treatment may be by brushing with a dentifrice or rinsing with a dentifrice slurry or mouth rinse. Other methods include contacting the topical oral gel, mouthspray, toothpaste, dentifrice, tooth gel, tooth powders, tablets, subgingival gel, foam, mouse, chewing gum, lipstick, sponge, floss, petrolatum gel, or denture product or other form with the subject’s teeth and oral mucosa. Depending on the embodiment, the oral care composition may be used as frequently as toothpaste, or may be used less often, for example, weekly, or used by a professional in the form of a prophy paste or other intensive treatment.

EXAMPLES

The following examples and descriptions further clarify embodiments within the scope of the present invention. These examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention as many variations thereof are possible without departing from the spirit and scope.

Test Method

1. Sample Preparation

A toothpaste sample is squeezed by manual out of a tube onto a rigid plate to form a straight toothpaste line with a minimum length of 60 mm, free of bubbles. The plate should have an appropriate color contrast against the article to inspect the toothpaste appearance clearly.

2. Image Acquisition

The sample on the rigid plastic plate is placed on a non-reflective black background plate with the toothpaste’s longitudinal axis perpendicular to the two bar lights used. Two bar lights (Smart Vision Lights LHF 300 or equivalent) are placed 650mm away from the sample in the transverse direction, 300mm away from the sample in the vertical direction. The perpendicular direction of the bar lights surface should be adjusted within an angle of around 45±6 degree against the horizontal direction. A Canon camera (CanonEO2 6D Mark 2) with lens (EF 24-105mm f/4L IS2 USM) or equivalent is placed directly vertically above the sample in a length of 105cm. The focal length of the camera is set to 105mm. The image acquisition settings are; ISO: 100, F: 8.0, exposure time: 1/6seconds, and a camera resolution of 6240*4160 so that the acquired image has physical resolution of around 18 pixel/mm.

3. Image Analysis for Orientation Standard Deviation and Orientation Distribution Gaussian Fit Goodness

a) The above acquired images are imported into ImageJ software (version 1.52h, National Institute of Health, USA) or equivalent, and converted into 8 bit.

b) The analyzing region image is cropped from the original images. The analyzing region spans in the longitudinal direction of the toothpaste with a length of 50mm. The transverse direction should cover 80%of the toothpaste width.

c) An ImageJ built-in plugin “Directionality” (version V2.2.0) is applied to the images obtained in step b) . The analysis parameters used are: Method: “Fourier components” , Nbins: 90, histogram start: 0. At this step, the article’s Orientation Standard Deviation are described by the parameter “Dispersion” which is the standard deviation of the Gaussian fit for the orientation distribution. The article’s Orientation Distribution Fitting Goodness are described by the parameter “Goodness” , which describe how well the orientation distribution is fitted by Gaussian function.

4. Microscope Photo

The same samples on the rigid plate are further photo-taken under microscope (ZEISS SteREO Discovery. V12 Modular Stereo Microscope, from Carl Zeiss Microscopy, LLC) .

Example: Comparative Example A to C and Inventive Examples 1 & 2

Comparative Example A is a commercially available toothpaste from Crest Thirty ENAMEL (202403N-10680386FB) , which is an opaque paste. Comparative Example B is a commercially available toothpaste from Oral-B Gum Care Siena Heavenly Mint (202207E-02081864BA) , containing colored particles but showing no striated appearance or appearance change. Comparative Example C is a commercially available toothpaste from Crest Pearl salt white (202203S-00730386GA) , exhibiting a white-blue dual phase paste. Figures 1A to 1C illustrate the EM Photos of the Comparative Examples A to C, which are out of the scope of the present invention.

Inventive Examples 1 to 2 according to the present disclosure are shown in Table 1 below with amounts of components in wt%. They are prepared by admixture of the components in below Tables, in the proportions indicated.

Table 1

1. Flavor A is Benzyl alcohol with ClogP of 1.10

2. Flavor B is Isopropyl myristate with ClogP of 7.17

3. Particle A is beads product from CPS (Huzhou) Biotechnology Co., Ltd., under tradename COSCOLOR Blue 30CS, containing 1-5%of corn starch and 30-40%of titanium dioxide.

The imaging analysis of the Inventive Examples 1 to 2 and Comparative Examples A to C are measured according to the above mentioned method (step 1 to 3) . Results are shown in Table 2 below.

Table 2

It can be seen from Table 2 that the Inventive Examples exhibit both optimal Gaussian Fitting Dispersion (below 15) and Gaussian Fitting Goodness (above 0.7) , which provide a visual variation. In the contrary, the Comparative Examples exhibit neither one nor both of desired Gaussian Fitting Dispersion and Gaussian Fitting Goodness of the present invention.

Example D: Exemplary Toothpaste formulations

The following are examples of toothpaste compositions of the present invention. The Examples are prepared similarly as in Example 1.

*Particle C is beads product commercially available from CPS (Huzhou) Biotechnology Co., Ltd., under tradename COSCOLOR Red 30LK, containing 1-5%of corn starch, 30-40%of titanium dioxide, and mannitol 20-30%.

**Particle D is commercially available from Chongqing Pellets Biotech Co., Ltd. Under tradename AC-AZR50-305, containing 1-5%of hydroxypropyl methyl cellulose, 1-5%of PVA, and 20-30%titanium dioxide.

The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as “40 mm” is intended to mean “about 40 mm. ”

Every document cited herein, including any cross referenced or related patent or application and any patent application or patent to which this application claims priority or benefit thereof, is hereby incorporated herein by reference in its entirety unless expressly excluded or otherwise limited. The citation of any document is not an admission that it is prior art with respect to any invention disclosed or claimed herein or that it alone, or in any combination with any other reference or references, teaches, suggests or discloses any such invention. Further, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.

While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims

An oral care composition comprising a first phase and a second phase, wherein the second phase is immiscibly dispersed in the first phase, wherein the oral care composition exhibits a striated appearance characterized by a Gaussian Fitting Dispersion of no more than 15, and a Gaussian Fitting Goodness of no less than 0.6.
The composition according to claim 1, wherein the appearance of the composition is characterized by exhibiting a Gaussian Fitting Dispersion of no more than 14, preferably no more than 12; and exhibiting a Gaussian Fitting Goodness of no less than 0.7, preferably no less than 0.8.
The composition according to any of the preceding claims, wherein the first phase comprises from 1.5%to 75%, preferably from 5%to 55%of oral acceptable carrier selected from the group consisting of water, glycerin, sorbitol, and any combinations thereof, by weight of the composition.
The composition according to any of the preceding claims, wherein the second phase comprises from 0.001%to 5%, by weight of the composition, of particles, wherein the particles comprise water swellable polymer and colorant.
The composition according to claim 4, wherein the particles have an average particle size from 5μm to 5000μm, preferably from 20μm to 3000μm, more preferably from 50μm to 1500μm.
The composition according to claim 4, wherein the water swellable polymer is selected from the group consisting of starch, starch derivatives, gelatin, hydroxypropyl methylcellulose, and any derivatives and combinations thereof.
The composition according to claim 4, wherein the colorant is selected from pigments, pearling agents, filler powders, talc, mica, titanium dioxide, dye lakes, magnesium carbonate, calcium carbonate, bismuth oxychloride, zinc oxide, and combinations thereof.
The composition according to any of the preceding claims, wherein the first phase of the composition comprises a flavorant, wherein the flavorant has a ClogP value from-2 to 12, preferably a ClogP value from 0 to 10.
The composition according to any of the preceding claims, wherein the first phase comprises one or more ingredients selected from the group consisting of active ingredients, abrasives, binders, humectant, sensates, sweetener, surfactant, and any combinations thereof.
The composition according to any of the preceding claims, wherein the first phase and the second phase has one or more visual difference from each other on characteristics selected from the group consisting of i) opacity, ii) color, iii) luminescence, iv) brightness, and v) reflective index.
An oral care composition, comprising:

a) from 1%to 75%by weight of oral acceptable carrier selected from the group consisting of water, glycerin, sorbitol, and any combinations thereof;

b) from 0.001%to 5%by weight of a particle, wherein the particle comprises:

i) a water swellable polymer selected from the group consisting of starch, starch derivatives, gelatin, hydroxypropyl methylcellulose, and any combinations thereof; and

ii) a colorant selected from the group consisting of titanium dioxide, mica, and any combinations thereof; and

c) optionally, from 0.001%to 5%by weight of flavorant having a ClogP value from 0 to 8;

wherein the oral care composition exhibits a striated appearance characterized by a Gaussian Fitting Dispersion of no more than 15, and a Gaussian Fitting Goodness of no less than 0.6.
An oral care composition, comprising a particle which comprises a water swellable polymer and a colorant, wherein the oral care composition are capable to exhibit a striated appearance upon a shear stress more than 20 Pa, wherein preferably the striated appearance characterized by a Gaussian Fitting Dispersion of no more than 15, and a Gaussian Fitting Goodness of no less than 0.6.