CN106729656A - A kind of oral care composition for treating dry and its application in toothpaste - Google Patents
A kind of oral care composition for treating dry and its application in toothpaste Download PDFInfo
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- CN106729656A CN106729656A CN201611113599.5A CN201611113599A CN106729656A CN 106729656 A CN106729656 A CN 106729656A CN 201611113599 A CN201611113599 A CN 201611113599A CN 106729656 A CN106729656 A CN 106729656A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of oral care composition for treating dry and its application in toothpaste.A kind of oral care composition for treating dry includes Chinese herbal medicine extract and biology enzyme, and the Chinese herbal medicine extract is one or more of Herba Dendrobii extract, Rhizoma Polygonati Odorati extract, ophiopogon japonicus extract；The biology enzyme is one or more of lysozyme, lactoperoxidase, amylase, amyloglucosidase, glucose oxidase.Oral care composition of the present invention has the effect for mitigating dry, oral care composition one side energy exciting salivary secretion, on the other hand the component similar to the albumen or enzyme in saliva is included, artificial saliva can be played a part of, and with bactericidal effect, the sense of discomfort of xerostomia can be alleviated after use.
Description
Technical field
The present invention relates to oral care implement technical field, and in particular to a kind of oral care composition for treating dry and
Its application in toothpaste.
Background technology
Saliva is in lubrication digestion food, cleaning oral cavity and protects oral cavity not by chemistry, machinery and infective agent destructive process
In play an important role.Contain antibody, enzyme and buffer solution in normal saliva.It is by keeping the normal pH of oral environment
Value, makes it be in neutral, and limitation produces acid due to the degraded of sugar, so as to prevent the progress of dental caries.Ptyalin acts on food digestion
Incipient stage.Saliva also plays an important role to the sense of taste and language.
Salivary secretion is not enough, can cause xerostomia.Xerostomia is clinically much, and especially the elderly's incidence of disease is more
It is high.Some other factors such as radiation treatment, antidepressants, also anticholinergic drug, antiallergic, antihistamine, anti-spasm
Medicine, decongestant and diuretics are more often using can all cause xerostomia.Existing article report narcotic analgesic agent, chemotherapeutics
As adriamycin can cause xerosis.
When xerostomia, food and bacterial adhesion promote the formation of bacterial plaque in dental surface.Oral pH is also reduced,
Therefore increased the danger for suffering from dental caries.Oral cavity flora can change, the pathogenic bacteria relevant with dental caries generation, such as streptococcus mutans
It is significantly raised when more normal with ratio shared by actinomyces.By the carious tooth needs that radiotherapy is suffered from are pulled out, health status compared with
Difference and focus of infection can cause the generation of xerostomia syndrome.Chronic gingival infection can cause marginal periodontitis.Food particle
It is that the growth of bacterium creates conditions into gum and interdental gap, halitosis can be developed into.
Dry problem can influence the quantity of patients diet and the selection to food, and the insufficiency of intake that has additional nutrients danger
Property.Loesche etc. sends the food such as vegetables, dryness of creak squish when reporting that these patients more likely can avoid eating chewing
The foods such as food such as bread, viscous foodstuff such as peanut oil.Therefore, developing a kind of oral care composition for treating dry has very big
Social effect and market prospects.
Patent application publication CN105311404A relate to a kind of formula for controlling xerostomia in the elderly, recipe ingredient and each
Weight is：15 grams of the stem of noble dendrobium, 15 grams of radix polygonati officinalis, 18 grams of Chinese yam, 12 grams of sealwort.Can effective saliva stimulating gland secreting function, rise
To the effect for promoting salivary glands secrete saliva.
License notification number CN101678217B relate to a kind of comprising olive oil, trimethylglycine and xylitol
Composition for treating xerostomia and relative illness, it is increasing non-being excited property saliva stream or is mitigating dry mouth
The quality of life aspect of disease symptom and improvement patient has extraordinary effect.
Patent application publication CN103561719A be related to it is a kind of include from Araliaceae, Zingiber, Labiatae, pulse family, Solanaceae,
Extract or the oral cavity composition of its mixture that Punicaceae, composite family obtain, with the effect for mitigating dry.
Present technology often uses the method for exciting salivary secretion to increase oral cavity during xerostomia is treated
The amount of middle saliva, so as to alleviate dry.Because oral care composition action time in the oral cavity is short, active matter is in oral cavity
Residual quantity is low, causes the therapeutic effect of this method not notable, particularly to the hypokinetic crowd of some salivary gland secretions, effect
It is really less obvious.The oral care composition of prior art action time in the oral cavity is short, and active matter residual quantity is low；Only rise
To exciting salivary secretion, for the crowd that salivary gland function goes down, DeGrain.
The content of the invention
Present invention aim at a kind of oral care composition for treating dry of offer and its application in toothpaste.Have
Mitigate dry effect, said composition one side energy exciting salivary secretion, on the other hand comprising similar to the albumen or enzyme in saliva
Component, artificial saliva can be played a part of, and with bactericidal effect, after use, alleviate xerostomia sense of discomfort.
The object of the invention is achieved through the following technical solutions.
A kind of oral care composition for treating dry, comprising Chinese herbal medicine extract and biology enzyme, the Chinese herbal medicine is extracted
Thing is one or more of Herba Dendrobii extract, Rhizoma Polygonati Odorati extract, ophiopogon japonicus extract；
The biology enzyme is in lysozyme, lactoperoxidase, amylase, amyloglucosidase, glucose oxidase
More than one.
The extraction process of the ophiopogon japonicus extract is, by tuber of dwarf lilyturf pulverizing medicinal materials into 5~20 mesh coarse granules, to add 1~2 times of matter
The ethanol of the 80%wt of amount extracts 2~5h, is dried after flinging to ethanol, weighs said extracted thing, adds 4~8 times of water of quality, carries
Take 3 times, every time 1~2h；Aqueous extracts filtering is collected, the ethanol of 95%wt is added, stood overnight, collect lower sediment, in 50~
Dried to constant weight in 60 DEG C of baking ovens, pulverize and sieve and obtain final product ophiopogon japonicus extract；
It by stem of noble dendrobium coarse crushing is 1~3cm stem of noble dendrobium meal that the extraction process of the Herba Dendrobii extract is, plus 2~5 times of quality
Pure water is extracted 3 times, and 40~80 minutes every time, extraction temperature was 90~100 DEG C, collected aqueous extract, was concentrated into medicinal extract；Add
3~6 times of ethanol of quality of medicinal extract, stir 20 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, in 60~65 DEG C of temperature,
Sieving is dry, pulverize under conditions of 0.04~0.06Mp of vacuum obtain final product Herba Dendrobii extract；
It by radix polygonati officinalis coarse crushing is 1~3cm meal that the extraction process of the Rhizoma Polygonati Odorati extract is, plus 10~15 times of quality it is pure
1~3h of flooding, extraction temperature is 90~100 DEG C, collects aqueous extract, and filtering and concentrating to medicinal extract adds 4~6 times of medicinal extract
The ethanol of quality, stirs 30 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, drying under reduced pressure pulverizes and sieves and obtains final product radix polygonati officinalis
Take thing thing.
Further, the shadow of other compositions in temperature, formula being highly susceptible in oral care implement due to biology enzyme
Ring and lose activity, the ionic surface active agent commonly used particularly in oral care implement, such as laruyl alcohol sodium sulfovinate；Chelating
Agent, such as polyphosphate；The composition such as preservative and essence, can all cause the enzyme in formula to inactivate, and reduce the work(of product
Effect.
The present invention uses a kind of special technique for packing, and the biology enzyme in formula is wrapped up, and is then then added to oral cavity
In nursing materials, the stabilization of enzymatic activity is preferably kept.
A kind of oral care composition for treating dry, comprising Chinese herbal medicine extract and biology enzyme microballoon, the Chinese herbal medicine
Extract is one or more of Herba Dendrobii extract, Rhizoma Polygonati Odorati extract, ophiopogon japonicus extract；
The biology enzyme microballoon is the microballoon for being enclosed with biology enzyme, and the biology enzyme is lysozyme, lactoperoxidase, shallow lake
One or more of powder enzyme, amyloglucosidase, glucose oxidase；
The parts by weight of each composition of the biology enzyme microballoon are：
The preparation method of the biology enzyme microballoon, comprises the following steps：
(1) under stirring condition, adhesive is added in boiling water, is stirred for 20~40min, be cooled to less than 40 DEG C, homogeneous
And add biology enzyme, homogeneous to stir 10~20min；
(2) fluid unit is used, is 1100~1150m in air quantity3/ H, 45~75 DEG C of EAT, spray gun pressure
Under conditions of 0.24~0.3MPa, material prepared by step (1) is sprayed in core, dries to temperature of charge and reach 30~50
DEG C, obtain microballoon；
(3) diaphragm is added to 10 times of quality, in the alcohol that temperature is 40~50 DEG C, stirred to being completely dissolved, obtained
The alcoholic solution of diaphragm, is 1000~1150m in air quantity using fluid unit3/ H, 35~55 DEG C of EAT, spray gun
Under conditions of 0.16~0.20MPa of pressure, diaphragm alcoholic solution is sprayed on microballoon；In 35~60 DEG C of dryings, life is obtained final product
Thing enzyme microballoon.
Step (2) described drying is, in 45~75 DEG C of 10~20min of drying, 30~50 DEG C to be reached to temperature of charge, is stopped
Dry, obtain microballoon；
The preferred 20min of step (3) drying.
One or more of the preferred corn starch adhesive agent of described adhesive, microcrystalline cellulose, cellulose, cyclodextrin；
One or more of the preferred mannitol of core, sorbierite, antierythrite, silica, lactose；
One or more of the preferred HPMC of diaphragm, ethyl cellulose, PLA；
The extraction process of the ophiopogon japonicus extract：Tuber of dwarf lilyturf pulverizing medicinal materials add 1~2 times of quality into 5~20 mesh coarse granules
The ethanol of 80%wt extracts 2~5h, is dried after flinging to ethanol, weighs said extracted thing, adds 4~8 times of water of quality, extracts 3
It is secondary, 1~2h every time；Aqueous extracts filtering is collected, the ethanol of 95%wt is added, stood overnight, lower sediment is collected, in 50~60 DEG C
Dried to constant weight in baking oven, pulverize and sieve and obtain final product ophiopogon japonicus extract.
The content of ophiopogonpolysaccharide is 1%~20%wt, the preferably extract of 8%~15%wt in the ophiopogon japonicus extract；
The extraction process of the Herba Dendrobii extract：It is 1~3cm stem of noble dendrobium meal by stem of noble dendrobium coarse crushing, plus 2~5 times of quality
Pure water is extracted 3 times, and 40~80 minutes every time, extraction temperature was 90~100 DEG C, collected aqueous extract, was concentrated into medicinal extract, added
3~6 times of ethanol of quality of medicinal extract, stir 20 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, in 60~65 DEG C of temperature,
Sieving is dry, pulverize under conditions of 0.04~0.06Mp of vacuum obtain final product Herba Dendrobii extract.
The content of dendrobium polysaccharide is 3%~20%wt, the preferably extract of 5~15%wt in the Herba Dendrobii extract.
The extraction process of the Rhizoma Polygonati Odorati extract：Be 1~3cm meal by radix polygonati officinalis coarse crushing, plus 10~15 times of quality it is pure
1~3h of flooding, extraction temperature is 90~100 DEG C, collects aqueous extract, and filtering and concentrating to medicinal extract adds 4~6 times of medicinal extract
The ethanol of quality, stirs 30 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, drying under reduced pressure pulverizes and sieves and obtains final product radix polygonati officinalis
Take thing thing.
The content of dendrobium polysaccharide is 3%~30%, preferably 10~25% extract in the Rhizoma Polygonati Odorati extract.
Said composition can be applied to toothpaste, tooth powder, mouthwash, mouth spray, mouthwass, oral spray, chewing gum, mouth
In chamber syrup, liquid dentifrice, chewing gum, candy or lozenge product, the effect with exciting salivary secretion, alleviation dry.
On the other hand, the application the invention provides a kind of oral care composition for treating dry in toothpaste, with weight
Amount number meter, each component content of the toothpaste is as follows, in terms of parts by weight：
The percentage by weight that the lysozyme accounts for toothpaste gross weight is 0.075% to 3.0%；It is preferred that 0.1% to 1.5%,
Particularly preferred 0.3% to 1.0%.
The percentage by weight that the lactoperoxidase accounts for toothpaste gross weight is 0.05% to 2.0%；It is preferred that 0.1% to
1%；Particularly preferred 0.1% to 0.3%；
The percentage by weight that the amylase accounts for toothpaste gross weight is 0.05% to 2.0%；It is preferred that 0.1% to 1%, especially
It is preferred that 0.1% to 0.3%；
The percentage by weight that the amyloglucosidase accounts for toothpaste gross weight is 0.05% to 2.0%；It is preferred that 0.1% to
1%, particularly preferred 0.1% to 0.3%；
The percentage by weight that the glucose oxidase accounts for toothpaste gross weight is 0.075% to 3.0%.It is preferred that 0.1% to
1.5%, particularly preferred 0.3% to 1.0%；
The percentage by weight for accounting for toothpaste gross weight of the Rhizoma Polygonati Odorati extract is 0.075% to 1.00%；It is preferred that 0.08%
To 0.75%, particularly preferred 0.1% to 0.25%.
The percentage by weight for accounting for toothpaste gross weight of the Herba Dendrobii extract is less than 0.75%；It is preferred that 0.01% to
0.10%, particularly preferred 0.03% to 0.08%.
The percentage by weight for accounting for toothpaste gross weight of the ophiopogon japonicus extract is 0.075% to 1.00%.It is preferred that 0.1% to
0.75%, particularly preferred 0.1% to 0.5%.
On the other hand, present invention also offers the preparation method of the toothpaste, comprise the following steps：
(1) oral care composition described in sodium fluoride, xylitol, saccharin sodium and claim 1 or 3 is added to the water,
20~30min of stirring, obtains the aqueous solution；
(2) sorbierite, glycerine, polyethylene glycol are well mixed, are added in the aqueous solution, stir 10~15min, obtain water
Mixed liquor, by Carbomer, cellulose gum, silica, the well mixed prepared powder of lauryl sodium sulfate；
(3) water mixed liquid is drawn into Manufacturing medicine extract machine, opens stirring, add powder；Control vacuum for 0.04~
0.06MPa, stirs 15~20min, adds essence, glycine betaine, stirs 3~5min, and vacuumizing makes vacuum to maximum, takes out and stirs 20
~30min, stops stirring.
Oral care composition can take any formulation given for oral cavity.The illustrative example bag of these compositions
Include：Dentifrice such as toothpaste, dental gel, toothpaste or tooth powder；Mouthwash, mouthwass or oral spray；Oral cavity sugar
Slurry agent or liquid dentifrice；Chewing gum or other candies；Lozenge；Dental floss or dental tape；Function film or gel flakelet or work(
Can property millimeter, micron or nano particle；Film-forming composition comprising pregel or prepolymer, such as film forming tooth powder, dentistry japanning；
Tooth hardener.
Oral care composition of the invention, further includes, for ptyalizing, to mitigate the sense of dry or dry
The reagent of feel, the reagent is not described biology enzyme and Chinese herbal medicine extract or its mixture.The example of such reagent
Include, but are not limited in xylitol, glycine betaine, FOS, antierythrite, mannitol, citric acid, lactic acid, malic acid
More than kind.
Oral care composition of the invention, further includes other big points uncomfortable for substituting saliva, dry of releiving
Sub- polymer, including but not limited to Carbomer, poloxamer, xanthans, sodium carboxymethylcellulose, polyvinylpyrrolidone etc.
More than one.
Oral care composition of the invention, further includes fluoride sources, including but not limited to stannous fluoride, fluorination
One or more of sodium, amine fluoride, ammonium fluoride, monofluoro-phosphate, sodium monofluorophosphate.
If desired, can be to adding abrasive material in dentifrice formulation.Any suitable MC abrasive material or polishing can be used
Agent.Abrasive material such as silica, calcined alumina, sodium acid carbonate, calcium carbonate, dicalcium phosphate and calcium pyrophosphate can be included in use
In the matrix oral care implement composition of present invention practice.
If desired, can be to adding NMF in dentifrice formulation.Any suitable MC NMF can be used.Protect
Humectant such as sorbierite, glycerine, propane diols, PEG etc. can be included in the oral care implement composition for present invention practice.
If desired for when, due to for example preparing, stability, aesthetics, therapeutic action, the original of consumer appeal (consumer appeal) etc.
Cause, can include any other additive in Dentrifice composition.Exemplary additive includes that all other routine is clean
Tooth agent addition agent, viscosity modifier, diluent, foam modifier, desensitizer, brightening agent, pH adjusting agent, taste agent, sweetener,
Colouring agent, opacifier and flavorants.
The present invention has the advantage that and beneficial effect relative to prior art：
(1) effect of Chinese herbal medicine is mainly and promotes the production of body fluid, that is to say, that the generation of saliva stimulating.Enzyme be saliva important composition into
Point, on the one hand addition enzyme plays the effect of artificial saliva, is on the other hand also conducive to oral health to reducing oral bacteria.
(2) several Chinese herbal medicines and several enzymes of present invention selection have synergy, while adding the effect of Chinese herbal medicine and enzyme
Fruit is much better than the effect that Chinese herbal medicine and enzyme are used alone.
(3) in formula, enzyme individually adds the problem for having unstable inactivation, and the present invention uses a kind of special parcel skill
Art, the biology enzyme in formula is wrapped up, and is then then added in oral care implement, preferably keeps the steady of enzymatic activity
It is fixed.
(4) individually addition has the bad place such as color and smell to Chinese herbal medicine, and the present invention is extracted Chinese herbal medicine, gram
These drawbacks are taken.
Specific embodiment
The extraction process of ophiopogon japonicus extract described in the present embodiment：Tuber of dwarf lilyturf pulverizing medicinal materials add 2 times of quality into 20 mesh coarse granules
The ethanol of 80%wt extract 2h, fling to and dry after ethanol, weigh said extracted thing, add 4 times of water of quality, extract 3 times, often
Secondary 1h；Collect Aqueous extracts filtering, add 95%wt ethanol, stand overnight, collect lower sediment, in 50 DEG C of baking ovens dry extremely
Constant weight, pulverizes and sieves and obtains final product ophiopogon japonicus extract.
The extraction process of the Herba Dendrobii extract：Be 1cm stem of noble dendrobium meal by stem of noble dendrobium coarse crushing, plus 5 times of quality pure water leaching
Carry 3 times, 80 minutes every time, extraction temperature was 100 DEG C, collected aqueous extract, was concentrated into medicinal extract.Add 6 times of weight of medicinal extract
Ethanol, stirs 20 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, in 65 DEG C of temperature, under conditions of vacuum 0.06Mp
Dry, pulverize sieving and obtain final product Herba Dendrobii extract.
The extraction process of the Rhizoma Polygonati Odorati extract：Be 3cm meal by radix polygonati officinalis coarse crushing, plus 15 times of quality pure water extraction
3h, extraction temperature is 100 DEG C, collects aqueous extract, and filtering and concentrating to medicinal extract adds 6 times of ethanol of quality of medicinal extract, stirring 30
Minute, precipitation stands 24 hours；Ethanol pellet is collected, drying under reduced pressure pulverizes and sieves and obtains final product radix polygonati officinalis and take thing thing.
Embodiment 1-5
The application for the treatment of dry composition involved in the present invention in toothpaste.By formula as below and production technology, prepare
Toothpaste with treatment dry effect.
The process for producing of above example 1-5 is as follows：
By biology enzyme preparation technology, the biology enzyme in formula is mixed, be prepared into biology enzyme microballoon；The system of biology enzyme microballoon
Preparation Method：
(1) water for weighing formula ratio is heated to boiling, and 30min is stirred after adding amylum adhesive under stirring condition；
(2) amylum adhesive mixed liquor is cooled to 30 DEG C, homogeneous simultaneously adds biology enzyme, homogeneous 10min；
(3) fluid unit, arrange parameter air quantity 1150m are used3/ H, 65 DEG C of EAT, spray gun pressure 0.24MPa's
Under the conditions of, logistics prepared by step (2) is sprayed in mannitol core.
(4) after sprinkling terminates, spray gun is closed, 65 DEG C dry 10min, 30 DEG C is reached to temperature of charge, stop drying；
(5) HPMC of formula ratio is weighed, is added in 10 times of quality, hot alcohols that temperature is 40 DEG C, stirred
To being completely dissolved；
(6) fluid unit, parameter setting are continuing with：Air quantity 1000m3/ H, 35 DEG C of EAT, spray gun pressure
Under conditions of 0.160MPa, HPMC alcoholic solution prepared by step (5) is sprayed to the micro- of step (4) preparation
On ball.
(7) after material spray terminates, spray gun is closed, 60 DEG C dry 20min, obtain final product biology enzyme microballoon.
The preparation method of oral care composition：Obtained biology enzyme microballoon (embodiment 1 and 3) or biology enzyme (are implemented
Example 2) it is well mixed with Chinese herbal medicine extract, obtain final product oral care composition.
Application of the oral care composition in toothpaste, preparation method is as follows：
(1) sodium fluoride, xylitol, saccharin sodium and obtained oral care composition are added to the water, stir 20min, obtained
To the aqueous solution；
(2) sorbierite, glycerine, PEG are well mixed, are added in the aqueous solution, stir 10min, obtain water mixed liquid, will
The well mixed prepared powder of Carbomer, CMC, silica, lauryl sodium sulfate；
(3) water mixed liquid is drawn into Manufacturing medicine extract machine, opens stirring, add powder；Control vacuum for 0.04MPa, stir
15min is mixed, essence, glycine betaine is added, 3min is stirred, vacuumizing makes vacuum to maximum (- 0.1MPa), takes out and stirs 20min, stopped
Stirring.
Embodiment 6-9
The application for the treatment of dry composition involved in the present invention in gargle.By formula as below and production technology, system
It is standby that there is the gargle for treating dry effect.
The preparation method of oral care composition：Biology enzyme is well mixed with Chinese herbal medicine extract, MC is obtained final product
Composition.
The liquid preparing process of gargling of above example 6-9 is as follows：
(1) poloxamer, glycine betaine is soluble in water, stirring 15min adds essence to fully dissolving, stirs 5min；According to
In oral care composition, sorbierite, saccharin sodium, xylitol, sodium fluoride to the above-mentioned aqueous solution that secondary addition is obtained, stirring
30min, standing obtains the aqueous solution；
(2) by CMC, carbomer dispersion to glycerine, 5min is stirred, is uniformly dispersed；
(3) by step (2) the glycerine mixed liquor, it is added in the aqueous solution that step (1) is obtained, stirring 30min is obtained final product.
【Embodiment biology enzyme study on the stability】
Toothpaste prepared by embodiment 1, embodiment 2 (biology enzyme not wrapped up), embodiment 3, embodiment 6-8, is put into 40
DEG C, in the insulating box of 75 humidity, stability is investigated in accelerated ageing.Produced in starting, 1 month, 2 months, sampling detection in 3 months respectively
The conservation degree of enzyme activity in product.
Testing result is as follows：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 6 | Embodiment 7 | Embodiment 8 | |
| Starting | 100% | 100% | 100% | 100% | 100% | 100% |
| 1 month | 94% | 80% | 95% | 70% | 72% | 79% |
| 2 months | 89% | 65% | 90% | 60% | 62% | 65% |
| 3 months | 85% | 47% | 88% | 42% | 43% | 46% |
It can be seen from the results above that stability of the biology enzyme after parcel in formula is significantly improved, high temperature accelerates old
After changing 3 months, the activity of enzyme still can reach more than 85% in formula.
【The compliance test result of embodiment】
Effect of the composition of the invention to the Adult Groups with hyposalivation and the symptom of xerostomia.
Test object：60 subjects of total are convened and registered in population from the age between 50-67 Sui.Institute
Some objects all meet following condition：
Self assessment has xerostomia；
Non- stimulated property saliva stream is equal to or less than 0.2ml/ minutes
The product that object is voluntarily specified in each stage of research using only coordinator.
Object voluntarily assists all follow-ups needed for completing this research.
Method of testing：
By the way of xerostomia questionnaire, interview is carried out to each subject by coordinator, understand subject
Dry mouth symptom.Questionnaire is as follows：
Object is randomly divided into four groups.Every group is made up of 20 individualities, respectively using implement 1, embodiment 3, embodiment 4,
The product of embodiment 5.By normal teeth brushing way, brush teeth sooner or later, brush teeth within one day 2 times.
Subject first presses questionnaire before using test toothpaste by expeditor, and the dry situation to subject is remembered
Record, does base line measurement.
When subject was using test product the 8th day, all subjects are returned to research center.By expeditor is by investigation
Questionnaire, the dry situation to subject is recorded, and records possible side reaction.
By contrasting using before and after test product, the dry situation of subject evaluates the effect that product treats dry.
Test result：
80 subjects of this experiment, totally 78 complete all tests.Other 2 do not close the reason for exiting with product
System.Without discovery adverse reaction in experimentation.Test result is as shown in the table.
From test result as can be seen that in the contrast of embodiment 1 (enzyme+Chinese herbal medicine) and embodiment 3 (only addition biology enzyme)
It can be found that the effect of both additions simultaneously is much better than only to add the effect of biology enzyme, in addition, at embodiment 1 (enzyme+Chinese herbal medicine)
Contrast with embodiment 4 (only Chinese herbal medicine) is it can be found that both effects of addition simultaneously are much better than a kind of effect of Chinese herbal medicine.
The product of biology enzyme and Chinese herbal medicine extract is with the addition of, the effect of its treatment dry is significantly better than and only with the addition of Chinese herbal medicine merely
The product of extract or biology enzyme.And without biology enzyme and the product of Chinese herbal medicine extract, almost without therapeutic effect.
Therefore, the composition of the treatment dry of the involved biology enzyme of this explanation and Chinese herbal medicine extract, there is significant effect
Really, the dry situation of xerostomia colony can be alleviated.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in specific embodiment disclosed and described above, to of the invention
Some modifications and changes should also be as falling into scope of the claims of the invention.Although additionally, being used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any limitation to the present invention.
Claims (10)
1. a kind of oral care composition for treating dry, it is characterised in that comprising Chinese herbal medicine extract and biology enzyme, it is described in
Herb extracts are one or more of Herba Dendrobii extract, Rhizoma Polygonati Odorati extract, ophiopogon japonicus extract；
The biology enzyme is the one kind in lysozyme, lactoperoxidase, amylase, amyloglucosidase, glucose oxidase
More than.
2. oral care composition according to claim 1, it is characterised in that the extraction process of the ophiopogon japonicus extract is
By tuber of dwarf lilyturf pulverizing medicinal materials into 5~20 mesh coarse granules, add 1~2 times of ethanol of the 80%wt of quality to extract 2~5h, fling to ethanol
After dry, weigh said extracted thing, add 4~8 times of water of quality, extract 3 times, every time 1~2h；Aqueous extracts filtering is collected, plus
Enter the ethanol of 95%wt, stand overnight, collect lower sediment, in being dried to constant weight in 50~60 DEG C of baking ovens, pulverize and sieve and obtain final product
Ophiopogon japonicus extract；
It by stem of noble dendrobium coarse crushing is 1~3cm stem of noble dendrobium meal that the extraction process of the Herba Dendrobii extract is, plus 2~pure water of 5 times of quality
Extraction 3 times, 40~80 minutes every time, extraction temperature was 90~100 DEG C, collected aqueous extract, was concentrated into medicinal extract；Add medicinal extract
3~6 times of ethanol of quality, stir 20 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, in 60~65 DEG C of temperature, vacuum
Sieving is dry, pulverize under conditions of 0.04~0.06Mp of degree obtain final product Herba Dendrobii extract；
It by radix polygonati officinalis coarse crushing is 1~3cm meal that the extraction process of the Rhizoma Polygonati Odorati extract is, plus 10~the pure water leaching of 15 times of quality
1~3h is carried, extraction temperature is 90~100 DEG C, collect aqueous extract, filtering and concentrating to medicinal extract adds 4~6 times of quality of medicinal extract
Ethanol, stir 30 minutes, precipitation stand 24 hours；Ethanol pellet is collected, drying under reduced pressure pulverizes and sieves and obtains final product radix polygonati officinalis and take thing
Thing.
3. a kind of oral care composition for treating dry, it is characterised in that comprising Chinese herbal medicine extract and biology enzyme microballoon, institute
It is one or more of Herba Dendrobii extract, Rhizoma Polygonati Odorati extract, ophiopogon japonicus extract to state Chinese herbal medicine extract；
The biology enzyme microballoon is the microballoon for being enclosed with biology enzyme, and the biology enzyme is lysozyme, lactoperoxidase, starch
One or more of enzyme, amyloglucosidase, glucose oxidase；
The parts by weight of each composition of the biology enzyme microballoon are：
4. oral care composition according to claim 3, it is characterised in that the preparation method of the biology enzyme microballoon,
Comprise the following steps：
(1) under stirring condition, adhesive is added in boiling water, is stirred for 20~40min, be cooled to less than 40 DEG C, homogeneous simultaneously adds
Enter biology enzyme, homogeneous stirs 10~20min；
(2) fluid unit is used, is 1100~1150m in air quantity3/ H, 45~75 DEG C of EAT, spray gun pressure 0.24~
Under conditions of 0.3MPa, material prepared by step (1) is sprayed in core, drying reaches 30~50 DEG C to temperature of charge, obtains
To microballoon；
(3) diaphragm is added to 10 times of quality, in the alcohol that temperature is 40~50 DEG C, stirred to being completely dissolved, protected
The alcoholic solution of film, is 1000~1150m in air quantity using fluid unit3/ H, 35~55 DEG C of EAT, spray gun pressure
Under conditions of 0.16~0.20MPa, diaphragm alcoholic solution is sprayed on microballoon；In 35~60 DEG C of dryings, biology enzyme is obtained final product
Microballoon.
5. oral care composition according to claim 3, it is characterised in that the extraction process of the ophiopogon japonicus extract is
By tuber of dwarf lilyturf pulverizing medicinal materials into 5~20 mesh coarse granules, add 1~2 times of ethanol of the 80%wt of quality to extract 2~5h, fling to ethanol
After dry, weigh said extracted thing, add 4~8 times of water of quality, extract 3 times, every time 1~2h；Aqueous extracts filtering is collected, plus
Enter the ethanol of 95%wt, stand overnight, collect lower sediment, in being dried to constant weight in 50~60 DEG C of baking ovens, pulverize and sieve and obtain final product
Ophiopogon japonicus extract；
It by stem of noble dendrobium coarse crushing is 1~3cm stem of noble dendrobium meal that the extraction process of the Herba Dendrobii extract is, plus 2~pure water of 5 times of quality
Extraction 3 times, 40~80 minutes every time, extraction temperature was 90~100 DEG C, collected aqueous extract, was concentrated into medicinal extract；Add medicinal extract
3~6 times of ethanol of quality, stir 20 minutes, and precipitation stands 24 hours；Ethanol pellet is collected, in 60~65 DEG C of temperature, vacuum
Sieving is dry, pulverize under conditions of 0.04~0.06Mp of degree obtain final product Herba Dendrobii extract；
It by radix polygonati officinalis coarse crushing is 1~3cm meal that the extraction process of the Rhizoma Polygonati Odorati extract is, plus 10~the pure water leaching of 15 times of quality
1~3h is carried, extraction temperature is 90~100 DEG C, collect aqueous extract, filtering and concentrating to medicinal extract adds 4~6 times of quality of medicinal extract
Ethanol, stir 30 minutes, precipitation stand 24 hours；Ethanol pellet is collected, drying under reduced pressure pulverizes and sieves and obtains final product radix polygonati officinalis and take thing
Thing.
6. the oral care composition described in claim 1 or 3 is in toothpaste, tooth powder, mouthwash, mouth spray, mouthwass, oral cavity
Application in spray, chewing gum, oral cavity syrup, liquid dentifrice, chewing gum, candy or lozenge.
7. apply according to claim 6, it is characterised in that in terms of parts by weight, each component content of the toothpaste is as follows,
In terms of parts by weight：
8. application according to claim 7, it is characterised in that the percentage by weight that the lysozyme accounts for toothpaste gross weight is
0.075% to 3.0%；
The percentage by weight that the lactoperoxidase accounts for toothpaste gross weight is 0.05% to 2.0%；
The percentage by weight that the amylase accounts for toothpaste gross weight is 0.05% to 2.0%；
The percentage by weight that the amyloglucosidase accounts for toothpaste gross weight is 0.05% to 2.0%；
The percentage by weight that the glucose oxidase accounts for toothpaste gross weight is 0.075% to 3.0%.
9. application according to claim 7, it is characterised in that the weight hundred for accounting for toothpaste gross weight of the Rhizoma Polygonati Odorati extract
Divide than being 0.075% to 1.00%；
The percentage by weight for accounting for toothpaste gross weight of the Herba Dendrobii extract is less than 0.75%；
The percentage by weight for accounting for toothpaste gross weight of the ophiopogon japonicus extract is 0.075% to 1.00%.
10. apply according to claim 7, it is characterised in that the preparation method of the toothpaste, comprise the following steps：
(1) oral care composition described in sodium fluoride, xylitol, saccharin sodium and claim 1 or 3 is added to the water, is stirred
20~30min, obtains the aqueous solution；
(2) sorbierite, glycerine, polyethylene glycol are well mixed, are added in the aqueous solution, stir 10~15min, obtain water mixing
Liquid, by Carbomer, cellulose gum, silica, the well mixed prepared powder of lauryl sodium sulfate；
(3) water mixed liquid is drawn into Manufacturing medicine extract machine, opens stirring, add powder；Vacuum is controlled for 0.04~0.06MPa,
15~20min of stirring, adds essence, glycine betaine, stirs 3~5min, and vacuumizing makes vacuum to maximum, takes out and stirs 20~30min,
Stop stirring.
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| CN110547977B (en) * | 2019-08-30 | 2022-07-15 | 广州悦创实业有限公司 | Oral care composition containing baking soda as well as preparation method and application thereof |
| CN110547977A (en) * | 2019-08-30 | 2019-12-10 | 广州悦创实业有限公司 | oral care composition containing baking soda as well as preparation method and application thereof |
| CN110917065A (en) * | 2019-12-26 | 2020-03-27 | 苏州克劳丽化妆品有限公司 | Color-changing toothpaste containing biological enzyme coated particles and preparation method thereof |
| CN113521262A (en) * | 2021-07-30 | 2021-10-22 | 浙江莱康生物工程有限公司 | Lysozyme preparation with anti-inflammatory effect |
| CN113521262B (en) * | 2021-07-30 | 2023-10-13 | 浙江莱康生物工程有限公司 | Lysozyme preparation with anti-inflammatory effect |
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