CN105748344A - Edible toothpaste and preparation method thereof - Google Patents

Edible toothpaste and preparation method thereof Download PDF

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Publication number
CN105748344A
CN105748344A CN201610108556.1A CN201610108556A CN105748344A CN 105748344 A CN105748344 A CN 105748344A CN 201610108556 A CN201610108556 A CN 201610108556A CN 105748344 A CN105748344 A CN 105748344A
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Prior art keywords
powder
toothpaste
fruit juice
vitamin
juice
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CN105748344B (en
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徐双华
郑少辉
易斌
易怀东
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Beijing Scrianen Pharmaceutical Co Ltd
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Beijing Scrianen Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/737Galactomannans, e.g. guar; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses edible toothpaste. The toothpaste is prepared from the following components by 100 parts of total weight: 5-50 parts of one or more of fruit powder, vegetable powder and grain powder which having the grain size of 60-500 meshes and the content of soluble fibers of less than 20 percent, 0.001-0.1 part of folic acid, 0.1-2 parts of enzyme, 10-50 parts of one or more of sorbitol, glycerinum, propylene glycol and polyethylene glycol polyol, 0.05-2 parts of one or more of pectin, carrageenan, locust bean gum, chondrus ocellatus, xanthan gum, agar and guar gum, 0.1-10 parts of alkyl glycoside and the balance of deionized water. The toothpaste can be used for alleviating periodontitis and preventing decsyed teeth, and can be swallowed to supply nutrition and benefit health without toxic or side effect. The toothpaste is suitable for children, pregnant women, patients incapable of rinsing mouth and disabled people, is simple in formula and simple to implement, and is suitable for daily use of people.

Description

A kind of edible toothpaste and preparation method thereof
Technical field
The invention belongs to household chemicals field.More particularly, to a kind of edible toothpaste and preparation thereof Method.
Background technology
At present, Primary Caries tooth situation is quite serious, and illness rate is up to 70%, one of them major reason It is that infant does not note oral hygiene period and the sequelae that stays.Dental professional is advised, oral health care of children Should start as early as possible, carry out stage by stage, can prevent trouble before it happens, stop carious tooth.Concrete proposals: cleaning oral cavity From neonatal period, and should brush teeth and be preferably also from the beginning of first tooth of eruption.
Baby before 2 years old needs father and mother to help to clear up oral cavity and tooth, and period tempers baby oneself and brushes teeth, and 3 After Sui, baby just independently can brush teeth with oneself.But, baby the most also will not spue toothpaste foam, Aliquots of toothpaste may be swallowed in abdomen, if using fluorine-containing or common children's toothpaste, unfavorable to health, and After six months, baby just has started to add diatery supplement, if not using toothpaste to brush teeth, depends merely on the mechanical external force of toothbrush The more difficult tooth stain cleaning out dental surface and bacterial plaque, if now forming carious tooth, affect the absorption of food from And affect growing of children.
The common baby child in market can swallow toothpaste, can design according to appearance color smell, and major part is transparent Fruit flavouring, uses the color of pigment furnishing correspondence fruit flavouring, and formula composition is with adult's toothpaste component substantially Unanimously.The composition of toothpaste is extremely complex, and major part is chemical composition, and rubbing agent selects silica, has Containing foaming agent and reactive blowing agent two types, all contain preservative.If such toothpaste component is swallowed The health of infants and children can be brought bad impact by part.
Such as: it is " free-floride, non-pigment, micro-without saccharin sodium that Chinese patent 201510508373.4 discloses one Alveolitoid edible toothpaste for children and preparation method ", the weight proportion of raw material is: rubbing agent 15~20%, protect Humectant 60~70%, thickener 0.6~1.2%, foaming agent 0.5~2%, sweetener 0.08~0.15%, Auxiliary agent 0.5~3%, bacteriostatic agent 0.1~0.2%, flavoring essence 0.2~0.5%, deionized water surplus.Should Although the health of children still can be brought bad by the rubbing agents such as formula can reach food sanitation standard, silica Impact.
Therefore, this is further improved by prior art.Such as: Chinese patent 201310589393.X Disclose infant's toothpaste of a kind of total eclipse grade composition of raw materials, according to the percentages of described toothpaste gross mass Calculate, including the component of following percentage composition: NMF 25-45wt%, adhesive 1-2wt%, stabilizer 0.1-0.6wt%, rubbing agent 21-40wt%, sweetener 2-8wt%, nutrition fortifier 0.002-0.2wt%, Flavouring agent 0.2-0.6wt%, pigment 0.0005-0.0015wt%, surplus is water;Wherein, described rubbing agent is extremely Include the cellulose accounting for the 15%-72% of described rubbing agent gross weight less.This kind of toothpaste utilizes cellulose as rubbing Liniment, does not use silica, contributes to improving the adverse effect that silica brings.But add after all Cellulose human body is not had direct benefit.And raw material still with the addition of many chemical assistants.
In sum, current tooth paste product also lacks one not only edible, moreover it is possible to human body is had directly The tooth paste product of benefit.
Summary of the invention
First purpose of the present invention is to provide a kind of edible toothpaste, this toothpaste can pre-anti-caries and Periodontitis can be alleviated, swallow lotion and not only have no side effect, can supplement the nutrients on the contrary, good for health. This toothpaste is applicable to baby child, pregnant woman, can not carry out the patient and the disabled person that gargle.
Second object of the present invention is to provide the preparation method of a kind of above-mentioned edible toothpaste.
For reaching above-mentioned first purpose, the present invention uses following technical proposals:
A kind of edible toothpaste, in terms of gross weight 100 parts, including:
One or more in 5-50 fruits powder, Vegetable powder, grain dust, described Fruit powder, Vegetable powder, The particle diameter of grain dust is 60-500 mesh, and soluble fibre contents is less than 20%;
0.001-0.1 part folic acid;
0.1-2 part ferment;
One or more in 10-50 part D-sorbite, glycerine, propane diols, polyethylene glycol, polyalcohol;
0.05-2 part pectin, carragheen, locust bean gum, ripple carrageenan, xanthans, agar, guar gum In one or more;
0.1-10 part APG;
Deionized water surplus.
Further, one or more during described Fruit powder is oranges and tangerines powder, banaina, apple powder;Vegetables Powder is one or more in celery powder, carrot meal, peameal;Grain dust be oatmeal, wheat flour, One or more in soy meal, mung bean flour, millet powder, rice meal.Described Fruit powder, Vegetable powder, paddy Thing powder is not only nutrients in this formula, it is often more important that have effect and the function of rubbing agent, with toothbrush Coordinate, by rubbing action, remove tooth mycoderm.
Further, described ferment is amylase, protease, lysozyme, lactoperoxidase, glucose oxygen One or more change enzyme, exceeding in superoxide dismutase, oxidoreducing enzyme.
On the one hand described ferment plays in this formula and assists to decompose the residual on mucous membrane of mouth, tooth and gum Food, on the other hand plays the effect of antisepsis and sterilization.
Described D-sorbite, glycerine, propane diols, polyethylene glycol, polyalcohol play wetting agent at inventive formulation Effect.
Described pectin, carragheen, locust bean gum, ripple carrageenan, xanthans, agar are at inventive formulation Play the effect of thickener and binding agent.
Described APG Main Function in inventive formulation is to ensure that powder disperses not at friction process Conglomeration, in unlikely bonding oral cavity and dental surface;Also there is the function of foaming, bactericidal simultaneously.
Further, in order to make baby child's mouthfeel sweeter, described edible toothpaste can also include 0.1-20 The sweetener of part, described sweetener includes xylitol, Sucralose, glucose, fructose, sucrose, Fructus Hordei Germinatus One or more in sugar, lactose, lactitol, mannitol, mannose, compound sugar.Preferably, institute State compound sugar and include FOS, xylo-oligosaccharide, oligomeric maltose, isomaltose, galactooligosaccharide, big Beans compound sugar, trehalose therein one or more.Described sweetener can increase sugariness and mouthfeel, covers tooth The bitter taste of other raw materials of cream.
Further, in order to make baby child's sense organ and sense of smell joyful, described edible toothpaste can also include The dried fruit juice of 0.1-20 part, described dried fruit juice include strawberry fruit juice powder, apple juice powder, grape juice powder, Juice of Fructus vaccini vitis-idaeae powder, cherry dried fruit juice, pineapple fruit juice powder, lemon juice powder, sweet orange dried fruit juice, kiwi fruit Juice powder, watermelon dried fruit juice, banana dried fruit juice, orange dried fruit juice, pear juice powder, peach dried fruit juice, "Hami" melon Dried fruit juice, pawpaw dried fruit juice, mango juice powder, black currant juice powder, Litchi Juice powder, Cranberry fruit juice One or more in powder, blackberry fruit juice powder, carambola dried fruit juice, red bayberry juice powder.Described dried fruit juice can be composed Give lotion color and fragrance, add the virgin interest to toothpaste of baby.
Further, described edible toothpaste can also include amino acid or the vitamin of 0.02-5 part, Described amino acid includes lysine, threonine, leucine, isoleucine, valine, methionine, look ammonia Acid, phenylalanine, cystine, proline, glutamic acid, methionine, serine, arginine, histidine In one or more;Described vitamin includes vitamin A, vitamin B1, vitamin B2, vitamin PP, adenine phosphate, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, dimension One or more in raw element E, vitamin K.These functional components act not only as nutritional supplementation, Additionally can promote oral health.
Further, can also include the probio of 0.01-2 part in described edible toothpaste, this component has It is beneficial to help the growth of oral cavity probio, effectively reduces the impact of harmful bacteria, balance oral cavity flora, improve mouth Chamber microenvironment, the strengthening oral cavity pure and fresh power of oneself, make breath freshening more lasting.
For reaching above-mentioned second purpose, the invention provides the preparation method of a kind of above-mentioned edible toothpaste, Comprise the steps:
(1) above-mentioned folic acid, ferment, APG, amino acid, vitamin are added in wetting agent, high Speed dispersed with stirring is uniform, is prepared as solution or suspension;
(2) being added by thickener in above-mentioned solution or suspension, dispersed with stirring is uniform, obtains mixture A;
(3) water intaking is appropriate, adds dried fruit juice, is uniformly dispersed, adds sweetener, and dispersed with stirring is uniform, Obtain mixture B;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add rubbing agent, stirring It is uniformly dispersed;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product;
Described thickener refers in pectin, carragheen, locust bean gum, ripple carrageenan, xanthans, agar One or more.
Described rubbing agent refers to one or more in Fruit powder, Vegetable powder, grain dust.
Beneficial effects of the present invention is as follows:
Toothpaste of the present invention can alleviate periodontitis the pre-anti-caries of energy, swallows lotion and not only has no side effect, Can supplement the nutrients on the contrary, good for health.This toothpaste is applicable to baby child, pregnant woman, can not gargle Patient and disabled person.Formula safety, implements simple, is suitable for people's routine use.
Detailed description of the invention
In order to be illustrated more clearly that the present invention, below in conjunction with preferred embodiment, the present invention is done further Bright.It will be appreciated by those skilled in the art that following specifically described content is illustrative rather than restricted , should not limit the scope of the invention with this.
The various raw materials used in the embodiment of the present invention are commercially available prod.
Such as Fruit powder, Vegetable powder, grain dust use Shanghai Tong Yuan food technology Co., Ltd and Shaanxi Ao Yuan Bioisystech Co., Ltd product sold.
Embodiment 1
A kind of edible toothpaste, formula composition: in terms of 100 parts of raw materials:
20 parts of oranges and tangerines powder, mung bean flour 6 parts, 0.05 part of folic acid, lactoperoxidase 0.5 part, glucose oxygen Change enzyme 0.5 part, oxidoreducing enzyme 0.5 part, D-sorbite 28 parts, polyethylene glycol 2 parts, locust bean gum 0.5 part, guar gum 0.5 part, APG 8 parts, sucrose 2 parts, maltose 2 parts, strawberry fruit juice powder 4 parts, peach dried fruit juice 1 part, "Hami" melon dried fruit juice 1 part, 1 part of Litchi Juice powder, cystine 1 part, dried meat Propylhomoserin 1 part, 1 part of glutamic acid, vitamin B2 0.5 part, vitamin B12 0.5 part, probio 1 part, Water surplus.Described oranges and tangerines powder, the particle diameter of mung bean flour are 60-100 mesh, and soluble fibre contents is less than 20%.
The preparation method of above-mentioned edible toothpaste, comprises the steps:
(1) by above-mentioned folic acid, lactoperoxidase, glucose oxidase, oxidoreducing enzyme, APG, Cystine, proline, glutamic acid, vitamin B2, vitamin B12 add D-sorbite and polyethylene glycol mixes In compound, high-speed stirred is uniformly dispersed, and is prepared as solution or suspension;
(2) adding in above-mentioned solution or suspension by locust bean gum, guar gum, dispersed with stirring is uniform, Mixture A;
(3) water intaking is appropriate, adds strawberry fruit juice powder, peach dried fruit juice, "Hami" melon dried fruit juice, Litchi Juice Powder, is uniformly dispersed, and adds sucrose, maltose, and dispersed with stirring is uniform, obtains mixture B;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add oranges and tangerines powder, mung bean Powder, dispersed with stirring is uniform;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product.
Embodiment 2
A kind of edible toothpaste, formula composition: in terms of 100 parts of raw materials:
Oatmeal 30 parts, wheat flour 5 parts, soy meal 5 parts, 0.1 part of folic acid, 1 part of protease, glucose 0.5 part of oxidizing ferment, oxidoreducing enzyme 0.5 part, D-sorbite 25 parts, propane diols 10 parts, ripple Irish moss 1.5 parts of glue, APG 2 parts, xylitol 0.05 part, Sucralose 0.05 part, orange dried fruit juice 0.03 Part, 0.03 part of lemon juice powder, sweet orange dried fruit juice 0.04 part, methionine 1.5 parts, tryptophan 1 part, dimension Raw element B10.5 part, vitamin C 1 part, vitamin e1 part, probio 0.1 part, water surplus.Described swallow Flour, wheat flour, the particle diameter of soy meal are 100-200 mesh, and soluble fibre contents is less than 20%.
The preparation method of above-mentioned edible toothpaste, comprises the steps:
(1) by above-mentioned folic acid, protease, glucose oxidase, oxidoreducing enzyme, APG, egg ammonia Acid, tryptophan, vitamin B1, vitamin C, vitamin E add D-sorbite and propylene glycol mixture In, high-speed stirred is uniformly dispersed, and is prepared as solution or suspension;
(2) adding in above-mentioned solution or suspension by ripple carrageenan, dispersed with stirring is uniform, obtains mixture A;
(3) water intaking is appropriate, adds orange dried fruit juice, lemon juice powder, sweet orange dried fruit juice, is uniformly dispersed, Adding xylitol, Sucralose, dispersed with stirring is uniform, obtains mixture B;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add oatmeal, wheat Powder, soy meal, dispersed with stirring is uniform;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product.
Embodiment 3
A kind of edible toothpaste, formula composition: in terms of 100 parts of raw materials:
Apple powder 4 parts, celery powder 1 part, 0.001 part of folic acid, amylase 0.2 part, lysozyme 0.5 part, Exceed superoxide dismutase 0.4 part, D-sorbite 20 parts, glycerine 5 parts, pectin 0.5 part, agar 1.5 Part, APG 5 parts, lactose 2 parts, mannitol 15 parts, compound sugar 3 parts, juice of Fructus vaccini vitis-idaeae powder 4 Part, Cranberry dried fruit juice 8 parts, 4 parts of blackberry fruit juice powder, 3 parts of red bayberry juice powder, black currant juice powder 5 Part, lysine 0.005 part, threonine 0.005 part, leucine 0.005 part, vitamin A 0.001 part, Vitamin D 0.004 part, probio 2 parts, water surplus.Described apple powder, the particle diameter of celery powder are 200-350 Mesh, soluble fibre contents is less than 20%.
The preparation method of above-mentioned edible toothpaste, comprises the steps:
(1) by above-mentioned folic acid, amylase, lysozyme, exceed superoxide dismutase, APG, rely Propylhomoserin, threonine, leucine, vitamin A, vitamin D add in D-sorbite and glycerol mixture, High-speed stirred is uniformly dispersed, and is prepared as solution or suspension;
(2) adding in above-mentioned solution or suspension by pectin, agar, dispersed with stirring is uniform, obtains mixture A;
(3) water intaking is appropriate, adds juice of Fructus vaccini vitis-idaeae powder, Cranberry dried fruit juice, blackberry fruit juice powder, red bayberry fruit Juice powder, black currant juice powder, be uniformly dispersed, and adds lactose, mannitol, compound sugar, dispersed with stirring Uniformly, mixture B is obtained;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add apple powder, celery Powder, dispersed with stirring is uniform;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product.
Embodiment 4
A kind of edible toothpaste, formula composition: in terms of 100 parts of raw materials:
Banaina 25 parts, carrot meal 25 parts, 0.01 part of folic acid, glucose oxidase 0.5 part, oxidation Reductase 0.5 part, D-sorbite 8 parts, glycerine 2 parts, xanthans 0.05 part, APG 0.1 part, Glucose 5 parts, mannose 5 parts, cherry dried fruit juice 2 parts, 3 parts of carambola juice powder, pineapple fruit juice powder 2 parts, carambola dried fruit juice 3 parts, methionine 0.5 part, arginine 0.5 part, phenylalanine 0.4 part, dimension Raw element PP 0.5 part, vitamin B6 0.6 part, probio 0.5 part, water surplus.Described banaina, recklessly The particle diameter of carrot powder is 300-420 mesh, and soluble fibre contents is less than 20%.
The preparation method of above-mentioned edible toothpaste, comprises the steps:
(1) by above-mentioned folic acid, glucose oxidase, oxidoreducing enzyme, APG, methionine, essence ammonia Acid, phenylalanine, nicotinic acid, vitamin B6 add in D-sorbite and glycerol mixture, high-speed stirring Mix and be uniformly dispersed, be prepared as solution or suspension;
(2) being added by xanthans in above-mentioned solution or suspension, dispersed with stirring is uniform, obtains mixture A;
(3) water intaking is appropriate, adds cherry dried fruit juice, carambola juice powder, pineapple fruit juice powder, Carambola fruit Juice powder, is uniformly dispersed, and adds glucose, mannose, and dispersed with stirring is uniform, obtains mixture B;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add banaina, Hu Luo Bu Fen, dispersed with stirring is uniform;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product.
Embodiment 5
A kind of edible toothpaste, formula composition: in terms of 100 parts of raw materials:
Rice meal 8 parts, millet powder 1 part, peameal 1 part, 0.03 part of folic acid, proteinase-10 .05 part, Lysozyme 0.05 part, D-sorbite 40 parts, polyethylene glycol 4 parts, glycerine 6 parts, carragheen 0.8 part, APG 10 parts, lactitol 2 parts, 4 parts of fructose, pawpaw dried fruit juice 1 part, 1 part of mango juice powder, 1 part of apple juice powder, banana dried fruit juice 1 part, 1 part of pear juice powder, histidine 0.3 part, isoleucine 0.4 part, valine 0.2 part, adenine phosphate 0.05 part, vitamin K 0.05 part, probio 1.5 Part, water surplus.Described rice meal, millet powder, the particle diameter of peameal are 400-500 mesh, and soluble fibre contains Amount is less than 20%.
The preparation method of above-mentioned edible toothpaste, comprises the steps:
(1) by above-mentioned folic acid, protease, lysozyme, APG, histidine, isoleucine, figured silk fabrics Propylhomoserin, adenine phosphate, vitamin K add in D-sorbite, polyethylene glycol and glycerine mixed liquor, high-speed stirring Mix and be uniformly dispersed, be prepared as solution or suspension;
(2) being added by carragheen in above-mentioned solution or suspension, dispersed with stirring is uniform, obtains mixture A;
(3) water intaking is appropriate, adds pawpaw dried fruit juice, mango juice powder, apple juice powder, banana fruit juice Powder, pear juice powder, be uniformly dispersed, and adds lactitol, fructose, and dispersed with stirring is uniform, obtains mixture B;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add rice meal, millet Powder, peameal, dispersed with stirring is uniform;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product.
Comparative example 1
Toothpaste in this comparative example, compared with Example 1, rubbing agent employing silica replacement Fruit powder, Vegetable powder and grain dust, remaining component and consumption are the most identical with embodiment 1, and use the side in embodiment 1 Prepared by method.
Comparative example 2
Toothpaste in this comparative example, compared with Example 1, removes described APG, remaining component and use Measure the most identical with embodiment 1, and use the method in embodiment 1 to prepare.
Comparative example 3
Toothpaste in this comparative example, compared with Example 1, described APG uses equivalent dodecyl sulphur Acid sodium substitutes, and remaining component and consumption are the most identical with embodiment 1, and uses the method in embodiment 1 to prepare.
Comparative example 4
Toothpaste in this comparative example, compared with Example 1, removes described ferment, remaining component and consumption with Embodiment 1 is the most identical, and uses the method in embodiment 1 to prepare.
Comparative example 5-1:
Toothpaste in this comparative example, compared with Example 1, uses oranges and tangerines powder and mung bean flour, its grain of equivalent Footpath 15-55 mesh, remaining component and consumption are the most identical with embodiment 1, and use the method system in embodiment 1 Standby.
Comparative example 5-2:
Toothpaste in this comparative example, compared with Example 1, uses oranges and tangerines powder and mung bean flour, its grain of equivalent Footpath 550-650 mesh, remaining component and consumption are the most identical with embodiment 1, and use the method in embodiment 1 Preparation.
Comparative example 6:
Toothpaste in this comparative example, compared with Example 1, removes described folic acid, remaining component and consumption with Embodiment 1 is the most identical, and uses the method in embodiment 1 to prepare.
Test example 1: toothpaste friction test
1) get out long * a width of 2*1cm copper sheet, be placed in the box of size coupling;
2) weigh the toothpaste sample 20g of embodiment 1-5 and comparative example 1, add distilled water 20g and be sufficiently stirred for Pour into after Jun Yun in box, the rotation bar being provided with head toothbrushes is pressed in copper sheet surface, open motor, toothbrush Head rubs 2 minutes on copper sheet, shuts down, takes out and rinse copper sheet, drying up, and weighs copper sheet weight loss amount. Parallel it is repeated 6 times.The results are shown in Table 1.
Table 1 toothpaste friction test
Conclusion: comparative example 1 is relative to embodiment 1-5, and copper sheet loss amount is big, illustrates that the toothpaste of comparative example exists During use, the abrasion to tooth is big, and the toothpaste of the application is little to the wear intensity of tooth.
Test example 2: the easy washability of toothpaste is tested
Weigh the toothpaste sample 1g of embodiment 1-5 and comparative example 2 respectively in glass dish, drip a 3ml go from Sub-water, turn-takes with toothbrush and uses 10ml deionized water rinsing after brush 5 times, and sight glass ware surface lotion is tied Group's situation.
The glass dish naked eyes invisible residual lotion of embodiment 1-5 toothpaste sample, and comparative example 2 toothpaste sample Glass dish in clearly visible conglomeration residual lotion.
Conclusion: comparative example 2 remains conglomeration lotion seen from lotion naked eyes relative to embodiment 1-5, glass dish, The easy conglomeration of toothpaste of comparative example 2 is described, is difficult to rinse well, and the toothpaste of the application is difficult to conglomeration, Yi Chong Wash clean.
Test example 3: toothpaste foam size is tested
1) apparatus is prepared: metal table top, toothbrush, deionized water.
2) metal table top is placed on electronic balance, after clearing, Example 1-5 and comparative example 3 respectively Toothpaste sample 1g, drip 3ml deionized water, turn-take brush 10 times with toothbrush, observe metal table top toothpaste The size of foam.
Conclusion: comparative example 3 is relative to embodiment 1-5, and foam is relatively large, and foam heterogeneity, and The toothpaste foam of the application is fine and smooth, is evenly distributed.
Test example 4: toothpaste biocidal property is tested
With LB flat board recovery EHEC, the EHEC of resistance to ampicillin, MRSE and Bacillus subtilis obtains single bacterium colony, picking list bacterium colony, and constant-temperature table incubated overnight obtains bacterium solution.By bacterium solution Coat on LB flat board, the toothpaste filter paper made is affixed in flat board, see after 37 DEG C of incubated 24h Examine inhibition zone size.
Conclusion: in the culture dish of 4 kinds of bacterium bacterial strains, the inhibition zone of embodiment 1-5 is all higher than comparative example 4 Inhibition zone, illustrate add ferment toothpaste fungistatic effect more excellent.
Test example 5: toothpaste cleanliness testing
1) prepare: strong tea repeatedly soaks the white pottery porcelain plate one piece of drying and processing, calibrated whiteness instrument.
2) ceramic wafer is equally divided into 8 regions, accurately weighs comparative example 5-1 of 1g, 5-2 and embodiment 1-5 toothpaste, remains a region and does blank, does not use toothpaste, and each region uses toothbrush to turn Circle brush 10 times, after clear water rinses, before and after contrast, whiteness is poor, is shown in Table 2.
Table 2 toothpaste cleanliness testing
Conclusion: use embodiment 1-5 toothpaste stain-removing effect to be better than comparative example 5-1 and comparative example 5-2.
Test example 6: toothpaste alleviates gingivitis test
Using comparative example 6 and embodiment 1-5 to carry out clinical experimental study, before and after record test, bleeding gums refer to Number BI and GI GI;Evaluating toothpaste to alleviating the effect of gingivitis, evaluation result is shown in Table 3.
Table 3 toothpaste alleviates gingivitis test
Conclusion: embodiment 1-5 and comparative example 6 are after using 12 weeks, and embodiment 1-5 has significantly to alleviate and Blood index and GI, illustrate to use the edible toothpaste adding folic acid, can effectively alleviate gingivitis.
Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and also Non-is the restriction to embodiments of the present invention, for those of ordinary skill in the field, above-mentioned Can also make other changes in different forms on the basis of explanation, here cannot be to all of enforcement Mode gives exhaustive, every belongs to the obvious change or variation that technical scheme extended out Row still in protection scope of the present invention.

Claims (10)

1. an edible toothpaste, in terms of gross weight 100 parts, it is characterised in that including:
One or more in 5-50 fruits powder, Vegetable powder, grain dust, and described Fruit powder, Vegetable powder, The particle diameter of grain dust is 60-500 mesh, and soluble fibre contents is less than 20%;
0.001-0.1 part folic acid;
0.1-2 part ferment;
One or more in 10-50 part D-sorbite, glycerine, propane diols, polyethylene glycol, polyalcohol;
0.05-2 part pectin, carragheen, locust bean gum, ripple carrageenan, xanthans, agar, guar gum In one or more;
0.1-10 part APG;
Deionized water surplus.
Edible toothpaste the most according to claim 1, it is characterised in that: preferably, described fruit Powder is one or more in oranges and tangerines powder, banaina, apple powder;Vegetable powder be celery powder, carrot meal, One or more in peameal;Grain dust be oatmeal, wheat flour, soy meal, mung bean flour, millet powder, One or more in rice meal;
Preferably, described ferment is amylase, protease, lysozyme, lactoperoxidase, glucose oxidation Enzyme, one or more exceeded in superoxide dismutase, oxidoreducing enzyme.
Edible toothpaste the most according to claim 1, it is characterised in that: in described edible toothpaste The sweetener of 0.1-20 part can also be included.
Edible toothpaste the most according to claim 3, it is characterised in that: described sweetener includes wood Sugar alcohol, Sucralose, glucose, fructose, sucrose, maltose, lactose, lactitol, mannitol, One or more in mannose, compound sugar.
Edible toothpaste the most according to claim 4, it is characterised in that: preferably, described oligomeric Sugar includes FOS, xylo-oligosaccharide, oligomeric maltose, isomaltose, galactooligosaccharide, soy oligosaccharides One or more in sugar, trehalose.
Edible toothpaste the most according to claim 1, it is characterised in that: in described edible toothpaste The dried fruit juice of 0.1-20 part can also be included.
Edible toothpaste the most according to claim 6, it is characterised in that: described dried fruit juice includes grass Certain kind of berries dried fruit juice, apple juice powder, grape juice powder, juice of Fructus vaccini vitis-idaeae powder, cherry dried fruit juice, pineapple fruit juice powder, Lemon juice powder, sweet orange dried fruit juice, carambola juice powder, watermelon dried fruit juice, banana dried fruit juice, orange fruit Juice powder, pear juice powder, peach dried fruit juice, "Hami" melon dried fruit juice, pawpaw dried fruit juice, mango juice powder, black add Logical sequence dried fruit juice, Litchi Juice powder, Cranberry dried fruit juice, blackberry fruit juice powder, carambola dried fruit juice, red bayberry juice One or more in powder.
Edible toothpaste the most according to claim 1, it is characterised in that: in described edible toothpaste Amino acid or the vitamin of 0.02-5 part can also be included.
Edible toothpaste the most according to claim 8, it is characterised in that: described amino acid includes relying Propylhomoserin, threonine, leucine, isoleucine, valine, methionine, tryptophan, phenylalanine, Guang One or more in propylhomoserin, proline, glutamic acid, methionine, serine, arginine, histidine; Described vitamin includes vitamin A, vitamin B1, vitamin B2, nicotinic acid, adenine phosphate, dimension Raw element B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K In one or more.
10. the preparation method of the edible toothpaste of claim described above, it is characterised in that include as follows Step:
(1) above-mentioned folic acid, ferment, APG, amino acid, vitamin are added in wetting agent, high Speed dispersed with stirring is uniform, is prepared as solution or suspension;
(2) being added by thickener in above-mentioned solution or suspension, dispersed with stirring is uniform, obtains mixture A;
(3) water intaking is appropriate, adds dried fruit juice, is uniformly dispersed, adds sweetener, and dispersed with stirring is uniform, Obtain mixture B;
(4) being added in mixture A by mixture B, dispersed with stirring is uniform;Add rubbing agent, stirring It is uniformly dispersed;Adding probio, dispersed with stirring is uniform;
(5) continuing stirring under vacuum condition is 0.08-0.12MPa and make lotion, sterile filling prepares and produces Product.
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CN106729656A (en) * 2016-12-07 2017-05-31 江山 A kind of oral care composition for treating dry and its application in toothpaste
CN106880584A (en) * 2017-01-17 2017-06-23 广州薇美姿实业有限公司 A kind of Pediatric Oral Emergency care composition and its application
CN107049810A (en) * 2016-12-22 2017-08-18 山东海创工贸有限公司 A kind of pet edible toothpaste and production method
CN107714611A (en) * 2017-11-13 2018-02-23 常州麒通国际贸易有限公司 A kind of edible toothpaste for children
CN108379137A (en) * 2017-12-04 2018-08-10 陈军瑞 A kind of Kiwi berry toothpaste and preparation method thereof
CN109481343A (en) * 2018-12-22 2019-03-19 阮朝君 A kind of edibility rose of Sharon jelly toothpaste and preparation method thereof
CN114557939A (en) * 2022-02-21 2022-05-31 广州市名俐日用化工有限公司 Preparation method of stain-removing, whitening, refreshing and breath-freshening dentifrice

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Publication number Priority date Publication date Assignee Title
CN106729656A (en) * 2016-12-07 2017-05-31 江山 A kind of oral care composition for treating dry and its application in toothpaste
CN106729656B (en) * 2016-12-07 2020-11-10 江山 Oral care composition for treating dry mouth and application of oral care composition in toothpaste
CN107049810A (en) * 2016-12-22 2017-08-18 山东海创工贸有限公司 A kind of pet edible toothpaste and production method
CN106880584A (en) * 2017-01-17 2017-06-23 广州薇美姿实业有限公司 A kind of Pediatric Oral Emergency care composition and its application
CN107714611A (en) * 2017-11-13 2018-02-23 常州麒通国际贸易有限公司 A kind of edible toothpaste for children
CN108379137A (en) * 2017-12-04 2018-08-10 陈军瑞 A kind of Kiwi berry toothpaste and preparation method thereof
CN109481343A (en) * 2018-12-22 2019-03-19 阮朝君 A kind of edibility rose of Sharon jelly toothpaste and preparation method thereof
CN114557939A (en) * 2022-02-21 2022-05-31 广州市名俐日用化工有限公司 Preparation method of stain-removing, whitening, refreshing and breath-freshening dentifrice

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