CN108653045A - A kind of toothpaste and its manufacturing method improving the black yellow problem of tooth - Google Patents
A kind of toothpaste and its manufacturing method improving the black yellow problem of tooth Download PDFInfo
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- CN108653045A CN108653045A CN201810586144.8A CN201810586144A CN108653045A CN 108653045 A CN108653045 A CN 108653045A CN 201810586144 A CN201810586144 A CN 201810586144A CN 108653045 A CN108653045 A CN 108653045A
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- toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to oral hygienes, and in particular to a kind of toothpaste and its manufacturing method improving the black yellow problem of tooth.The toothpaste for improving the black yellow problem of tooth of the present invention, based on mass fraction, including 0.2 0.8% tetrasodium pyrophosphate, 0.5 2% sodium phytate, 20 35% wetting agents；The wetting agent includes polyethylene glycol 400.The present invention provides a kind of toothpaste having for the exogenous spot effect of tooth, there is removal stain and cigarette stain removal ability well.
Description
Technical field
The present invention relates to oral hygienes, and in particular to a kind of toothpaste improving the black yellow problem of tooth and its manufacturer
Method.
Background technology
With the continuous improvement of toothpaste production technology being constantly progressive with living standards of the people, more and more consumers will
More focus have been transferred to the aesthetic of oral health and tooth, and the emphasis that oral health and teeth appearance are kept exists
In control bacterial plaque, dirt and swill are eliminated, enhances physiological stimulation, making oral cavity and dentognathic system, there are one the good of cleaning health
Good environment safeguards oral health to play its physiological function.And major toothpaste manufacturer be proposed with also emerging one after another it is various
Health care whitening class product is to meet consumer need.
There are the product and technology of many health care tooth-whitenings currently on the market.They mainly pass through dental bleaching or elimination
It is realized with control staining.Dental bleaching treatment is typically that redox reaction or network occurs using in dental surface
Reaction reaches tooth whitening to achieve the effect that eliminate dental surface pigment.This method is expensive, due to being in the short time
Interior rapid removal is easy to cause dentine exposure, a series of problems, such as sensitivity of tooth occurs.Toothpaste is undoubtedly elimination and control is outer
Source property colours relatively mild product.
Invention content
In consideration of it, it is necessary to provide a kind of toothpaste and its manufacturing method of the black yellow problem of improvement tooth regarding to the issue above.
The present invention is achieved by the following technical solutions：
The toothpaste for improving the black yellow problem of tooth of the present invention, based on mass fraction, including 0.2-0.8% tetrasodium pyrophosphates,
Sodium phytate, the 20-35% wetting agents of 0.5-2%.
Further, the composition can be made into paste, watery or spray form oral care substance.
Further, include the paste oral care substance of the composition, including component：The rubbing agent of 40-60%, 20-
35% wetting agent, the surfactant of 1-5%, the adhesive of 0.6-4%, 1-2% fragrance, 0.0001-0.1% iron holly bark
Extract, 0.1-0.5% sweeteners, 0.1-0.5% preservatives, the sodium phytate of 0.5-2%, 0.2-0.8% tetrasodium pyrophosphates,
Coolant agent, the pearl powder 0.2-2% of 0.05-0.3%, the deionized water of surplus.
Further, the wetting agent includes polyethylene glycol 400 (PEG 400)；The polyethylene glycol 400 (PEG 400)
Account for the 3-10% of total composition.
Further, the wetting agent further includes one or both of propylene glycol and D-sorbite；
Further, the rubbing agent includes calcium monohydrogen phosphate and hydrated silica；
Further, the surfactant packet is laruyl alcohol sodium sulfovinate；Fragrance is food flavor；Sweetener is saccharin
Sodium；Preservative is methyl hydroxybenzoate；Adhesive includes one or more of cellulose gum and xanthans；Coolant agent is that methyl two is different
Propyl propanamide and menthanol lactic acid ester.
Further, a kind of toothpaste improving the black yellow problem of tooth, including：48% calcium monohydrogen phosphate, 4% hydration silicon
Stone, 3% propylene glycol, 4% polyethylene glycol 400 (PEG 400), 22% D-sorbite, 2.3% bay alcohol sulfuric ester
Sodium, 1% cellulose gum CMC, 0.55% xanthans, 0.1% Cortex Ilicis Rotundae extract, 1% essence, 0.23% saccharin
Sodium, 0.15% methyl hydroxybenzoate, 0.5% tetrasodium pyrophosphate, 1% sodium phytate, 0.08% menthanol lactic acid ester, 0.04%
Methyl diisopropyl propionamide, 0.2% pearl powder and the deionized water of surplus.
Further, the preparation method of the paste oral care composition, includes the following steps：
1. weighing each raw material by formula ratio；
2. adhesive is added in wetting agent, stir and forms finely dispersed suspension；
3. sweetener, sodium phytate, tetrasodium pyrophosphate are add to deionized water, stirring is to being completely dissolved；
4. the solution described in step 3 is added in step 2 in suspension, uniform rubber cement is stirred into；
5.. coolant agent, preservative are dissolved in proper amount of edible essence (dissolving)；
6.. by rubbing agent, surfactant, Cortex Ilicis Rotundae extract, pearl powder, remaining food flavor are added to above-mentioned rubber cement
In, 3000 turns of stirrings of mixing speed obtain lotion of toothpaste after lotion, then ground degassing is made within 15 minutes, and packaging is completed.
Advantageous effect of the present invention：
1, polyethylene glycol 400 (PEG 400) has the function of dissolving cigarette stain.
2, sodium pyrophosphate can make the tooth stain of fine and close consolidation loose, can pre- antitartar precipitation.
3, sodium phytate is widely used in the antioxidant and antistaling agent of the industries such as food, daily use chemicals, medicine, to cigarette stain, tea stain
There is the special bulk effect of chelating etc. various pigments.Its mechanism of action is that energy and the tartar for being adhered between tooth or surface are multiple
It closes object spot effectively to be chelated, generates water-soluble chelate.Spot is more held when being brushed teeth using the toothpaste containing the substance
It is easy to fall off, to effectively remove the spot of dental surface.
This method is the effect that the chemical constituent being added optimizes whitening.Polyethylene glycol is used cooperatively in toothpaste of the present invention
400 (PEG 400), tetrasodium pyrophosphate, sodium phytate compounding, provide a kind of tooth having for the exogenous spot effect of tooth
Cream has removal stain and cigarette stain removal ability well.Clinical test proves, behind 4 weeks or 8 weeks, because smoking causes
The exogenous color spot of tooth surface significantly reduced on area and degree.
Specific implementation mode
In order to better illustrate technical solution of the present invention problem to be solved, the technical solution of use and reach beneficial
Effect is expanded on further in conjunction with specific implementation mode.It is worth noting that technical solution of the present invention is including but not limited to following
Embodiment.
Particular technique or condition are not specified in the embodiment of the present invention, according to technology described in document in the art or
Condition is carried out according to product description.Reagents or instruments used without specified manufacturer, being can be by purchased in market etc.
The conventional products that approach obtains.
Toothpaste of the embodiment 1 containing the present composition
48% calcium monohydrogen phosphate, 4% hydrated silica, 3% propylene glycol, 4% polyethylene glycol 400 (PEG 400),
22% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 1% cellulose gum CMC, 0.55% xanthans, 0.1%
Cortex Ilicis Rotundae extract, 1% essence, 0.23% saccharin sodium, 0.15% methyl hydroxybenzoate, 0.5% tetrasodium pyrophosphate, 1%
Sodium phytate, 0.08% menthanol lactic acid ester, 0.04% methyl diisopropyl propionamide, 0.2% pearl powder and surplus
Deionized water.
Preparation method：
1. weighing each raw material by formula ratio；
2. adhesive (cellulose gum and xanthans) is added in wetting agent (PEG 400, propylene glycol and D-sorbite),
It stirs and forms finely dispersed suspension；
3. sweetener saccharin sodium, sodium phytate, tetrasodium pyrophosphate are add to deionized water, stirring is to being completely dissolved；
4. the solution described in step 3 is added in step 2 in suspension, uniform rubber cement is stirred into；
5.. coolant agent (methyl diisopropyl propionamide and menthanol lactic acid ester), preservative methyl hydroxybenzoate are dissolved in right amount
In food flavor (dissolving)；
6.. by rubbing agent (calcium monohydrogen phosphate and hydrated silica), surfactant laruyl alcohol sodium sulfovinate, iron holly bark extraction
Object, pearl powder, remaining food flavor are added in above-mentioned rubber cement, and lotion is made in 15 minutes in 3000 turns of stirrings of mixing speed, then passes through
Lotion of toothpaste is obtained after grinding degassing, packaging is completed.
Toothpaste of the embodiment 2 containing the present composition
56% calcium monohydrogen phosphate, 4% hydrated silica, 1% propylene glycol, 10% polyethylene glycol 400 (PEG 400),
9% D-sorbite, 1% laruyl alcohol sodium sulfovinate, 0.3% cellulose gum CMC, 0.45% xanthans, 0.1% are rescued
Must answer extract, 1% essence, 0.1% saccharin sodium, 0.1% methyl hydroxybenzoate, 0.2% tetrasodium pyrophosphate, 0.5% plant
Sour sodium, 0.01% menthanol lactic acid ester, 0.04% methyl diisopropyl propionamide, 1.2% pearl powder and surplus
Deionized water.
The preparation method is the same as that of Example 1.
Toothpaste of the embodiment 3 containing the present composition
38% calcium monohydrogen phosphate, 2% hydrated silica, 10% propylene glycol, 3% polyethylene glycol 400 (PEG 400),
22% D-sorbite, 5% laruyl alcohol sodium sulfovinate, 1.5% cellulose gum CMC, 2.5% xanthans, 0.0001%
Cortex Ilicis Rotundae extract, 2% essence, 0.5% saccharin sodium, 0.5% methyl hydroxybenzoate, 0.8% tetrasodium pyrophosphate, 2%
Sodium phytate, 0.14% menthanol lactic acid ester, 0.16% methyl diisopropyl propionamide, 2% pearl powder and surplus
Deionized water.
The preparation method is the same as that of Example 1.
Present composition measure of merit
One, cleaning capacity is tested
1.1 test specimen
Test group A (toothpaste of the present invention):48% calcium monohydrogen phosphate, 4% hydrated silica, 3% propylene glycol, 4% it is poly-
Ethylene glycol 400 (PEG 400), 22% D-sorbite, 2.3% laruyl alcohol sodium sulfovinate, 1% cellulose gum CMC,
0.55% xanthans, 0.1% Cortex Ilicis Rotundae extract, 1% essence, 0.23% saccharin sodium, 0.15% methyl hydroxybenzoate,
0.5% tetrasodium pyrophosphate, 1% sodium phytate, 0.08% menthanol lactic acid ester, 0.04% methyl diisopropyl propionamide,
0.2% pearl powder, water surplus.
Control group B:48% calcium monohydrogen phosphate, 4% hydrated silica, 3% propylene glycol, 22% D-sorbite, 2.3%
Laruyl alcohol sodium sulfovinate, 1% cellulose gum CMC, 0.55% xanthans, 0.1% Cortex Ilicis Rotundae extract, 1% perfume (or spice)
Essence, 0.23% saccharin sodium, 0.15% methyl hydroxybenzoate, 0.08% menthanol lactic acid ester, 0.04% methyl diisopropyl
Propionamide, 0.2% pearl powder, water surplus.
Sample solution:It takes 15 grams of toothpaste samples to be put into about 200 milliliters of beakers, 30 ml deionized waters is added, dispersion is equal
It is even, it is spare.
The preparation and processing of 1.2 enamel spot samples
Common spot sample:It chooses and the hydroxyapatite (HA pieces, diametric requirements 7mm) of human body enamel closely is made
For spot carrier, after premenstruum (premenstrua) sandblasting cleaning treatment, the mixed liquor in albumin soln, tea and coffee, lemon respectively in order
It impregnates 30 minutes, is repeated the above process to the surface of spot additional HA pieces securely in sour ferrous solution, it is spare.
Cigarette stain sample:Take the above-mentioned common spot sample prepared in vacuum desiccator, by pipeline into drier
Tobacco smoke is injected, stands to smog and re-injects smog after weakening.It repeats the above process to HA on pieces and gathers black smoke stain, in
Two hours of 140 degrees Celsius of dryings make cigarette stain be securely attached to the surfaces of HA pieces, spare.
2.2 test method
It takes spot sample to be put into the sample cell of Tooth-brushing device, makes the surface of stained surface and sample cell in same level
On, adjusting brush head and the arm of force makes it coincide with stained surface.Toothpaste dispersion liquid is poured into sample cell, and loads defined load-carrying,
It carries out simulating experiment of brushing teeth by predetermined condition.
Respectively with the gray scale of the stained surface before colorimeter measurement brush and after brush, then greasiness removal ability can be dirty with HA pieces
The grey scale change on stain surface is weighed:
⊿ L=L1-L2
L1:Gray scale after brush；
L2:Gray scale before brush.
Gray scale is used to indicate that the unit of brightness, ranging from 0~100.If surface is closer to lily, L
Value then closer to 100；, whereas if surface is closer to ater, then the value of L is just closer to 0.
2.3 result
2.3.1 common spot cleaning capacity test result
Test group A toothpaste has high cleaning capacity (⊿ L=16.1), the cleaning capacity Cha , ⊿ L values of control sample B are only
It is 3.3.
2.3.2 cigarette stain cleaning capacity test result
Test group A toothpaste has high cigarette stain cleaning capacity (⊿ L=35.9), the cigarette stain cleaning capacity of control sample B is poor,
⊿ L values are only 14.1 respectively.
2.4 interpretation of result
Test group A toothpaste added with polyethylene glycol 400 (PEG 400), tetrasodium pyrophosphate, sodium phytate compounding has highest
Cleaning capacity.
Two, clinical test
With Nanfang Medical Univ's School of Stomatology cooperation, using double blind, Method of Random Test.
4.1 grouping
Qualified subject is randomly divided into two groups, i.e. test group and control group.It is checked on time in 120 subjects
There are 110, wherein male 50, women 60, for 10 subjects because of the not further consultation on time of personal reason, rate lost to follow-up is 8.3%.
4.2 experiment process
It is randomly assigned as test group A and control group B according to age, gender, the baseline of test group A and control group B checks each
Item batch mark should be comparable (P>0.05).
4.3 statistical analysis
Measurement data uses independent samples t test, enumeration data to use Chi-square Test when baseline；In test result, group
It is interior to use paired-sample t test using toothpaste is front and back, compare between gingival index changing value and check gingival index changing value group between group
Compared with using two independent samples t tests.
4.4 test result
Make toothpaste A, dental calculus exponential average no difference of science of statistics (P before toothpaste B>0.05).After 24 weeks, B group calculus indexes
Dramatically increase (P<0.05), A groups calculus index is without obviously increasing ((P>0.05)) result shows that A group toothpaste controls calculus dentalis shape
At improvement black Huang of tooth and other effects is substantially better than B groups.
Gingival index compares
| Grouping | Number | Baseline calculus index | 24 weeks calculus indexes |
| B | 55 | 1.74±1.47 | 2.24±1.72a |
| A | 55 | 1.87±1.44 | 1.88±1.42b |
a：Paired t-test, P=0.004<Calculus index dramatically increases after 0.05,24 week, as a result statistically significant；b:
Paired t-test, P>Calculus index is without obviously increasing after 0.05,24 week.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (8)
1. a kind of toothpaste improving the black yellow problem of tooth, which is characterized in that based on mass fraction, including 0.2-0.8% pyrophosphoric acids
Four sodium, the sodium phytate of 0.5-2%, 20-35% wetting agents；The wetting agent includes polyethylene glycol 400.
2. the toothpaste according to claim 1 for improving the black yellow problem of tooth, which is characterized in that the composition can be made into cream
Shape, watery or spray form oral care substance.
3. the paste oral care substance of the toothpaste containing the black yellow problem of improvement tooth described in claim 1, which is characterized in that packet
Include component：The rubbing agent of 40-60%, the wetting agent of 20-35%, the surfactant of 1-5%, the adhesive of 0.6-4%, 1-
The Cortex Ilicis Rotundae extract of 2% fragrance, 0.0001-0.1%, 0.1-0.5% sweeteners, 0.1-0.5% preservatives, 0.5-2%
Sodium phytate, 0.2-0.8% tetrasodium pyrophosphates, the coolant agent of 0.05-0.3%, pearl powder 0.2-2%, the deionized water of surplus.
4. the toothpaste for improving the black yellow problem of tooth according to claim 1-3 any one, which is characterized in that the poly- second
Glycol 400 accounts for the 3-10% of total composition.
5. the toothpaste for improving the black yellow problem of tooth according to claim 1-3 any one, which is characterized in that the moistening
Agent further includes one or both of propylene glycol and D-sorbite.
6. the toothpaste according to claim 3 for improving the black yellow problem of tooth, which is characterized in that the rubbing agent includes phosphorus
Sour hydrogen calcium and hydrated silica.
7. the toothpaste according to claim 3 for improving the black yellow problem of tooth, which is characterized in that the fragrance is edible perfume
Essence.
8. the preparation method of the paste oral care composition described in claim 7, includes the following steps：
(1) each raw material is weighed by formula ratio；
(2) adhesive is added in wetting agent, stirs and forms finely dispersed suspension；
(3) sweetener, sodium phytate, tetrasodium pyrophosphate are add to deionized water, stirring is to being completely dissolved；
(4) solution described in step 3 is added in step 2 in suspension, stirs into uniform rubber cement；
(5) coolant agent, preservative are dissolved in proper amount of edible essence；
(6) by rubbing agent, surfactant, Cortex Ilicis Rotundae extract, pearl powder, remaining food flavor are added in above-mentioned rubber cement,
3000 turns of stirrings of mixing speed obtain lotion of toothpaste after lotion, then ground degassing is made within 15 minutes, and packaging is completed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810586144.8A CN108653045A (en) | 2018-06-08 | 2018-06-08 | A kind of toothpaste and its manufacturing method improving the black yellow problem of tooth |
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| CN201810586144.8A CN108653045A (en) | 2018-06-08 | 2018-06-08 | A kind of toothpaste and its manufacturing method improving the black yellow problem of tooth |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494289A (en) * | 2020-04-26 | 2020-08-07 | 广西医科大学 | Compound oyster tooth-protecting toothpaste and preparation method thereof |
| CN111991330A (en) * | 2020-09-23 | 2020-11-27 | 河南水岸汀蘭化妆品有限公司 | Pearl brightening and refreshing toothpaste and preparation method thereof |
| CN112426368A (en) * | 2020-12-08 | 2021-03-02 | 上海美加净日化有限公司 | Toothpaste with tooth stain removing effect and preparation method thereof |
| CN113384487A (en) * | 2021-06-30 | 2021-09-14 | 广州名大实业有限公司 | Formula of toothpaste capable of efficiently removing smoke spots |
| CN113476326A (en) * | 2021-06-30 | 2021-10-08 | 广州名大实业有限公司 | Toothpaste formula with efficient whitening function |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494289A (en) * | 2020-04-26 | 2020-08-07 | 广西医科大学 | Compound oyster tooth-protecting toothpaste and preparation method thereof |
| CN111991330A (en) * | 2020-09-23 | 2020-11-27 | 河南水岸汀蘭化妆品有限公司 | Pearl brightening and refreshing toothpaste and preparation method thereof |
| CN112426368A (en) * | 2020-12-08 | 2021-03-02 | 上海美加净日化有限公司 | Toothpaste with tooth stain removing effect and preparation method thereof |
| CN113384487A (en) * | 2021-06-30 | 2021-09-14 | 广州名大实业有限公司 | Formula of toothpaste capable of efficiently removing smoke spots |
| CN113476326A (en) * | 2021-06-30 | 2021-10-08 | 广州名大实业有限公司 | Toothpaste formula with efficient whitening function |
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