CN108014055A - A kind of Lignum Aquilariae Resinatum extract and the plant multiple-effect type toothpaste of licorice compounding - Google Patents
A kind of Lignum Aquilariae Resinatum extract and the plant multiple-effect type toothpaste of licorice compounding Download PDFInfo
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- CN108014055A CN108014055A CN201810113173.2A CN201810113173A CN108014055A CN 108014055 A CN108014055 A CN 108014055A CN 201810113173 A CN201810113173 A CN 201810113173A CN 108014055 A CN108014055 A CN 108014055A
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/37—Esters of carboxylic acids
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/63—Steroids; Derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses a kind of Lignum Aquilariae Resinatum extract and the plant multiple-effect type toothpaste of licorice compounding with bactericidal antiphlogistic, hemostatic analgesia, it is related to oral hygiene field.The Lignum Aquilariae Resinatum extract and the plant multiple-effect type toothpaste of licorice compounding, in terms of mass percentage, including agilawood essential oil 0.05% 0.3%, agalloch eaglewood powder 0.5% 5.0%, dipotassium glycyrrhizinate 0.05% 0.3% plant extract functional component, and tranexamic acid 0.05% 0.3%, the auxiliary functional component of allantoin 0.1% 0.6%.The plant multiple-effect type toothpaste of the present invention not only has the function that to clean oral cavity also have effects that bactericidal antiphlogistic, hemostatic analgesia, the certain improvement result having to oral problems such as periodontitis, bleeding gums, swelling and aching of gum.
Description
Technical field
The present invention relates to oral hygiene field, and in particular to a kind of Lignum Aquilariae Resinatum extract and the plant of licorice compounding are more
Acting type toothpaste.
Background technology
Periodontal disease is common disease and frequently-occurring disease in Human Oral Cavity, is mainly caused by bacteria breed, is invaded according to lesion
The position of criminal can be divided into two class of gingivitis and periodontitis.Periodontosis illness rate is high, harmfulness is big, and gingivitis is the early stage of periodontosis
Symptom, can cause the oral problems such as bleeding gums, swelling and aching of gum.Existing tooth paste product mainly by suppress plaque and effectively
Supragingival plaque is controlled to prevent and treat periodontosis, more using the antibacterial anti-inflammatory hemostat such as chlorhexidine, triclosan, eugenol.This
Lignum Aquilariae Resinatum extract and licorice are added in invention in toothpaste, by the compounding of two kinds of extracted form natural plant components, make toothpaste
There is bactericidal antiphlogistic, hemostatic analgesia, have some improvement to oral problem tool.
The content of the invention
For this reason, the technical problems to be solved by the invention, based on ordinary toothpaste of the prior art, are asked for above oral cavity
Topic, so as to propose there is that bactericidal antiphlogistic, a kind of Lignum Aquilariae Resinatum extract of hemostatic analgesia and the plant of licorice compounding are more
Acting type toothpaste.
A kind of Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by following quality proportioning
Component composition:Agilawood essential oil 0.05%-0.3%, agalloch eaglewood powder 0.5%-5.0%, dipotassium glycyrrhizinate 0.05%-0.3%, ammonia first
Naphthenic acid 0.05%-0.3%, allantoin 0.1%-0.6%, toothpaste matrix 93.5%-99.25%;
The toothpaste is included with matrix:Colouring agent 0-2.0%, rubbing agent 15.0%-50.0%, moisturizer 19.0%-
53.0%th, thickener 0.6%-1.2%, sweetener 0.2%-0.35%, foaming agent 2.0%-2.5%, preservative 0.05%-
0.15%th, acid-base buffer agent 0-0.7%, essence 1.0%-1.5%, surplus are deionized water.
The colouring agent is titanium dioxide;The rubbing agent is in silica, dicalcium phosphate dihydrate, calcium carbonate
One or more;The moisturizer is sorbierite and propane diols;The thickener is sodium carboxymethylcellulose and xanthans;Institute
It is saccharin sodium to state sweetener;The foaming agent is lauryl sulfate ester sodium;The preservative is methyl hydroxybenzoate;The soda acid delays
Electuary is sodium pyrophosphate;The essence is toothpaste essence;The deionized water is the plastic decentralized medium of toothpaste.
The effect of of the invention component effect is as follows:
Agilawood essential oil and agalloch eaglewood powder are Lignum Aquilariae Resinatum extract, and Chinese medicine agalloch eaglewood contains the wood of resin for Isolated From Thymelaeaceae Species suspension culture of Aquilaria sinensis
Material, main product predominantly cultivate product in Guangdong Lufeng, Luhe, Heshan, Huidong.Agalloch eaglewood mainly contains volatile oil and resin, slightly warm in nature,
Acrid flavour, hardship, have the effect of promoting qi circulation and relieving pain, warming middle energizer to arrest vomiting, gas of receiving is relievingd asthma.
Dipotassium glycyrrhizinate is the extract of Chinese medicine glycyrrhizic legume, has effects that bactericidal antiphlogistic.
Tranexamic acid, INCI Chineses are tranexamic acid, for various hemorrhagic diseases, have auxiliary treatment to bleeding gums
Effect.
Allantoin, is present in natural plants and animal, and security is good, can promote cell growth, accelerates gingivitis, oral cavity
The healing of ulcer.
The matrix components effect of the present invention is as follows:
Colouring agent is titanium dioxide, as brightening agent, weakens silica toothpaste transparent feel, obtains toothpaste preferably white
Colored appearance.
Rubbing agent is can to wipe the soft dirt of dental surface with toothbrush collective effect in toothpaste, mitigates tooth stain, plaque, tooth
The solid material component of the foreign substances such as calculus, the present invention select one in silica, dicalcium phosphate dihydrate, calcium carbonate
Kind or a variety of be used as rubbing agent.
Moisturizer is sorbierite and propane diols, the moisture for keeping lotion, the mobility for safeguarding lotion, the ice for reducing lotion
Point.
Thickener is sodium carboxymethylcellulose and xanthans, and suspension toothpaste solid phase, prevents solid phase components and liquid phase in toothpaste
Component separates.
Sweetener is saccharin sodium, covers toothpaste poor taste, improves the mouthfeel of toothpaste.
Foaming agent is lauryl sulfate ester sodium, has the security and low irritant of higher, can form fine and smooth, lasting bubble
Foam.
Preservative is methyl hydroxybenzoate, prevents from fermenting, inhibits bacteria propagation and sterilizing ability with good, being in toothpaste
Common preservative.
Acid-base buffer agent is sodium pyrophosphate, the pH of stability contorting toothpaste within the shelf-life, to avoid because rubbing agent dissociation and
The water outlet of generation, gas are risen phenomenon.
Essence, does odorant in toothpaste, assigns odor type and refrigerant mouthfeel that toothpaste is stablized, covers the different of toothpaste component
Taste simultaneously has bacteriostasis.
Deionized water is the plastic decentralized medium of toothpaste.
The preparation method of the present invention includes the following steps:
(1) each raw material is weighed according to the quality proportioning of constitutive material;
(2) it is dipotassium glycyrrhizinate, tranexamic acid, allantoin, sweetener, foaming agent, preservative, acid-base buffer agent etc. is water-soluble
Property component is dissolved in deionized water, obtains predissolve liquid;
(3) agalloch eaglewood powder, thickener etc. are homogeneously dispersed in propane diols, obtain pre-dispersed liquid;
(4) predissolve liquid, sorbierite are uniformly mixed, are slowly added to pre-dispersed liquid, it is further spread, be swelled into
Even glue;
(5) after a few hours are still aging, then glue, rubbing agent, colouring agent, essence, agilawood essential oil etc. passed through into system
Lotion of toothpaste is made after the stirring of cream machine, homogeneous, grinding, vacuum outgas.
The above-mentioned technical proposal of the present invention has the following advantages:
The Lignum Aquilariae Resinatum extract and the plant multiple-effect type toothpaste of licorice compounding, in terms of mass percentage, bag
Include agilawood essential oil 0.05%-0.3%, agalloch eaglewood powder 0.5%-5.0%, plant extract effect of dipotassium glycyrrhizinate 0.05%-0.3%
Component, and tranexamic acid 0.05%-0.3%, the auxiliary functional component of allantoin 0.1%-0.6%, not only has cleaning mouth
The effect of chamber, also has effects that bactericidal antiphlogistic, hemostatic analgesia.Lignum Aquilariae Resinatum extract of the present invention is compounded with licorice
Plant multiple-effect type toothpaste its effect be higher than ordinary toothpaste, there is bactericidal antiphlogistic, hemostatic analgesia.
Embodiment
The specific of the plant multiple-effect type toothpaste that Lignum Aquilariae Resinatum extract of the present invention is compounded with licorice is given below
Embodiment:
Embodiment 1
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.05%, agalloch eaglewood powder 0.5%, dipotassium glycyrrhizinate 0.05%, tranexamic acid 0.05%, allantoin
0.1%th, titanium dioxide 0.5%, silica 1 5.0%, sorbierite 25.0%, propane diols 4.0%, sodium carboxymethylcellulose
0.3%th, xanthans 0.3%, saccharin sodium 0.2%, lauryl sulfate ester sodium 2.0%, essence 1.0%, methyl hydroxybenzoate 0.05%,
Balance deionized water.
Embodiment 2
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.175%, agalloch eaglewood powder 2.75%, dipotassium glycyrrhizinate 0.175%, tranexamic acid 0.175%, allantoin
0.35%th, titanium dioxide 1.25%, silica 21.5%, sorbierite 35.0%, propane diols 6.0%, sodium carboxymethylcellulose
0.45%th, xanthans 0.45%, saccharin sodium 0.275%, lauryl sulfate ester sodium 2.25%, essence 1.25%, methyl hydroxybenzoate
0.1%th, balance deionized water.
Embodiment 3
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.3%, agalloch eaglewood powder 5.0%, dipotassium glycyrrhizinate 0.3%, tranexamic acid 0.3%, allantoin 0.6%, two
Titanium oxide 2.0%, silica 28.0%, sorbierite 45.0%, propane diols 8.0%, sodium carboxymethylcellulose 0.6%, xanthan
Glue 0.6%, saccharin sodium 0.35%, lauryl sulfate ester sodium 2.5%, essence 1.5%, methyl hydroxybenzoate 0.15%, surplus go from
Sub- water.
Embodiment 4
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.05%, agalloch eaglewood powder 0.5%, dipotassium glycyrrhizinate 0.05%, tranexamic acid 0.05%, allantoin
0.1%th, dicalcium phosphate dihydrate 40.0%, silica 4.0%, sodium pyrophosphate 0.3%, sorbierite 15.0%, propane diols
4.0%th, sodium carboxymethylcellulose 0.3%, xanthans 0.3%, saccharin sodium 0.2%, lauryl sulfate ester sodium 2.0%, essence
1.0%th, methyl hydroxybenzoate 0.05%, balance deionized water.
Embodiment 5
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.175%, agalloch eaglewood powder 2.75%, dipotassium glycyrrhizinate 0.175%, tranexamic acid 0.175%, allantoin
0.35%th, dicalcium phosphate dihydrate 45.0%, silica 2.0%, sodium pyrophosphate 0.5%, sorbierite 20.0%, propane diols
6.0%th, sodium carboxymethylcellulose 0.45%, xanthans 0.45%, saccharin sodium 0.275%, lauryl sulfate ester sodium 2.25%, perfume
Essence 1.25%, methyl hydroxybenzoate 0.1%, balance deionized water.
Embodiment 6
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.3%, agalloch eaglewood powder 5.0%, dipotassium glycyrrhizinate 0.3%, tranexamic acid 0.3%, allantoin 0.6%, phosphorus
Sour hydrogen calcium dihydrate 50%, sodium pyrophosphate 0.7%, sorbierite 25.0%, propane diols 8.0%, sodium carboxymethylcellulose
0.6%th, xanthans 0.6%, saccharin sodium 0.35%, lauryl sulfate ester sodium 2.5%, essence 1.5%, methyl hydroxybenzoate
0.15%th, balance deionized water.
Embodiment 7
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.05%, agalloch eaglewood powder 0.5%, dipotassium glycyrrhizinate 0.05%, tranexamic acid 0.05%, allantoin
0.1%th, natural whiting 30.0%, silica 1 2.0%, sodium pyrophosphate 0.1%, sorbierite 15.0%, propane diols 4.0%,
Sodium carboxymethylcellulose 0.3%, xanthans 0.3%, saccharin sodium 0.2%, lauryl sulfate ester sodium 2.0%, essence 1.0%, Buddhist nun
Moor tortoise beetle ester 0.05%, balance deionized water.
Embodiment 8
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.175%, agalloch eaglewood powder 2.75%, dipotassium glycyrrhizinate 0.175%, tranexamic acid 0.175%, allantoin
0.35%th, natural whiting 37.5%, silica 7.0%, sodium pyrophosphate 0.4%, sorbierite 20.0%, propane diols 6.0%,
Sodium carboxymethylcellulose 0.45%, xanthans 0.45%, saccharin sodium 0.275%, lauryl sulfate ester sodium 2.25%, essence
1.25%th, methyl hydroxybenzoate 0.1%, balance deionized water.
Embodiment 9
The Lignum Aquilariae Resinatum extract of the present invention and the plant multiple-effect type toothpaste of licorice compounding, by the group of following quality proportioning
It is grouped into:Agilawood essential oil 0.3%, agalloch eaglewood powder 5.0%, dipotassium glycyrrhizinate 0.3%, tranexamic acid 0.3%, allantoin 0.6%, day
Right calcium carbonate 45.0%, silica 2.0%, sodium pyrophosphate 0.7%, sorbierite 25.0%, propane diols 8.0%, carboxymethyl are fine
The plain sodium 0.6% of dimension, xanthans 0.6%, saccharin sodium 0.35%, lauryl sulfate ester sodium 2.5%, essence 1.5%, methyl hydroxybenzoate
0.15%th, balance deionized water.
Clinical test results
Suppress plaque clinical test
Test method:The subject 70 for choosing plaque index >=1 is tested, wherein male 37, women 33, year
In 18~45 years old age, carry out balanced packet, subject enters it in two groups at random by dental plaque index, gender and age by subject
One group, test group and control group, every group of 35 people are randomly divided into by two groups.Scaling is carried out to 70 subjects respectively, removes dental calculus,
Rubber polishing cup removes bacterial plaque, soft dirt, and record soft tissue checks situation, and provides toothpaste by packet.Checked, remembered after 6 weeks
The Quigley-Hein plaque indexs and soft tissue for recording Turesky improvement check situation.
Specific scoring criteria is as follows:
0=facings are without bacterial plaque
The point-like bacterial plaque being dispersed at 1=necks portion gum edge
2=necks portion bacterial plaque width is no more than 1mm
3=necks portion bacterial plaque width cover width is more than 1mm, but in facing below 1/3
4=bacterial plaque area coverages are accounted between facing 1/3 and 2/3
5=bacterial plaque area coverages account for facing more than 2/3
Result of the test:Compared with control group, the Quigley-Hein plaque indexs of test group subject Turesky improvement are put down
Average 1.10 is less than control cell mean 1.68 (being shown in Table 1).Two groups of independence mean t are examined, statistically significant (the P values < of difference
0.01)。
1 Quigley-Hein plaque indexs of table
Test group A (x ± s) | Control group B (x ± s) |
1.10±0.72 | 1.68±0.69 |
Mitigate gingivitis clinical test
Test method:Selection has gingivitis and a Periodontal Probing Depth PD≤3mm, the subject of index of gingivitis >=1 70 into
Row experiment, wherein male 30, women 40, at 18~45 years old age, carried out subject by index of gingivitis, gender and age
Weighing apparatus packet, subject enter one of two groups groups, test group and control group, every group of 35 people are randomly divided into by two groups at random.Respectively
70 subjects are carried out with baseline inspection, recordIndex of gingivitis and soft tissue check situation, and are provided by packet
Toothpaste.Checked, recorded after 6 weeksIndex of gingivitis and soft tissue check situation.Checked after finally carrying out 12 weeks,
RecordIndex of gingivitis and soft tissue check situation.
Specific scoring criteria is as follows:
0=gums healthies
1=gum mild inflammations:The color of gum has mild change and Mild edema, and not bleeding is examined in spy
2=gum moderate inflammations:Gum color is red, and oedema is bright, and bleeding is examined in spy
3=gum extensive inflammations:Gum is obvious red and swollen or has ulcer, and has automatic hemorrhagic tendency
Result of the test:Baseline checkout facility group and control groupIndex of gingivitis is respectively 1.36 and 1.33, and two
The independent mean t of group examines difference not have significant (P >=0.05).After testing 6 weeks, test groupOulitis refers to
Number decline 5.88%, control group compared with baselineIndex of gingivitis declines -2.26% compared with baseline.Two groups independent
Mean t is examined, and p < 0.05, test group and control group index of gingivitis comparing difference are statistically significant.After testing 12 weeks, experiment
GroupIndex of gingivitis decline 11.03% compared with baseline, control groupIndex of gingivitis is compared with baseline
Decline 0%.Two groups of independence mean t are examined, and p < 0.05, test group and control group index of gingivitis comparing difference are statistically significant
(being shown in Table 2).
2 two groups of tableThe comparison (x ± s) of index of gingivitis
Time | Test group A (x ± s) | Control group B (x ± s) |
Baseline | 1.36±0.10 | 1.33±0.09 |
6 weeks | 1.28±0.11 | 1.36±0.11 |
12 weeks | 1.21±0.11 | 1.33±0.13 |
Analgesia clinical test
Test method:Selection has swelling and aching of gum symptom subject 40 to be tested, wherein male 16, women 24,
At 18~50 years old age, carry out balanced packet, subject enters one of two groups groups at random, by two by gender and age by subject
Group is randomly divided into test group and control group, every group of 20 people.After all patients enter seat position, illustrate test method, it is same to obtain patient
After meaning, VAS, VRS analgesia measuring method are instructed.Initial pain index is observed and recorded before experiment, by questionnaire survey, using VAS
(Visual analogue scale) measures, and pain intensity is recorded using 0-10 digital quantizations.It is painless with 0,10 is have an intense pain, 1-
3 be mild pain, and 4-6 is moderate pain, and more than 7 be severe pain, allows patient to mark pain degree on scale.Initial results
Toothpaste is provided by packet after record, patient spreads on painful area using toothpaste.Experiment carries out questionnaire survey after ten minutes, remembers
Record pain index.Questionnaire survey is carried out after 30 minutes again, records pain index.
Result of the test:The pain index of test group and control group is respectively 3.96 and 3.57 before experiment, two groups of independence it is equal
Number t examines difference not have significant (P >=0.05).Experiment after ten minutes, test group pain index and initial value relatively under
Drop 27.02%, control group pain index decline 8.68% compared with initial value.Two groups of independence mean t are examined, p < 0.05, experiment
Group and control group pain index comparing difference are statistically significant.After experiment 30 minutes, test group pain index and initial value ratio
Compared with decline 48.74%, control group pain index decline 16.25% compared with initial value.Two groups of independence mean t are examined, p <
0.05, test group and control group pain index comparing difference are statistically significant (being shown in Table 3).
The comparison (x ± s) of 3 two groups of pain indexes of table
Time | Test group A (x ± s) | Control group B (x ± s) |
Before experiment | 3.96±0.19 | 3.57±0.25 |
10 minutes | 2.89±0.19 | 3.26±0.22 |
30 minutes | 2.03±0.23 | 2.99±0.18 |
Conclusion (of pressure testing)
Testing toothpaste has suppression plaque, mitigates gingivitis and analgesic clinical efficacy.With good security,
Any adverse events and adverse reaction are not found during experiment.
Embodiment described above only expresses embodiments of the present invention, its describe it is more specific and in detail, but cannot be because
This and be interpreted as the scope of the claims of the present invention limitation, it should be noted that without departing from the inventive concept of the premise, can also do
Go out several modifications and improvements invention, therefore, the scope of the present invention should be subject to appended claims.
Claims (4)
1. a kind of Lignum Aquilariae Resinatum extract and the plant multiple-effect type toothpaste of licorice compounding, it is characterised in that its component presses quality
Degree includes:Agilawood essential oil 0.05%-0.3%, agalloch eaglewood powder 0.5%-5.0%, dipotassium glycyrrhizinate 0.05%-0.3%,
Tranexamic acid 0.05%-0.3%, allantoin 0.1%-0.6%, toothpaste matrix 93.5%-99.25%;
The toothpaste is included with matrix:Colouring agent 0-2.0%, rubbing agent 15.0%-50.0%, moisturizer 19.0%-53.0%,
Thickener 0.6%-1.2%, sweetener 0.2%-0.35%, foaming agent 2.0%-2.5%, preservative 0.05%-0.15%, acid
Alkali buffer 0-0.7%, essence 1.0%-1.5%, surplus are deionized water.
2. a kind of Lignum Aquilariae Resinatum extract according to claim 1 and the plant multiple-effect type toothpaste of licorice compounding, it is special
Sign is that content includes its component by mass percentage:Agilawood essential oil 0.05%, agalloch eaglewood powder 0.5%, dipotassium glycyrrhizinate
0.05%th, tranexamic acid 0.05%, allantoin 0.1%, toothpaste matrix 99.25%.
3. a kind of Lignum Aquilariae Resinatum extract according to claim 1 and the plant multiple-effect type toothpaste of licorice compounding, it is special
Sign is that content includes its component by mass percentage:Agilawood essential oil 0.3%, agalloch eaglewood powder 5.0%, dipotassium glycyrrhizinate 0.3%,
Tranexamic acid 0.3%, allantoin 0.6%, toothpaste matrix 93.5%.
4. the plant multiple-effect type tooth compounded according to a kind of Lignum Aquilariae Resinatum extract of claim 1-3 any one of them and licorice
Cream, it is characterised in that the colouring agent is titanium dioxide;The rubbing agent is selected from silica, dicalcium phosphate dihydrate, carbon
One or more in sour calcium;The moisturizer is sorbierite and propane diols;The thickener is sodium carboxymethylcellulose and Huang
Virgin rubber;The sweetener is saccharin sodium;The foaming agent is lauryl sulfate ester sodium;The preservative is methyl hydroxybenzoate;Institute
It is sodium pyrophosphate to state acid-base buffer agent;The essence is toothpaste essence;The deionized water is the plastic decentralized medium of toothpaste.
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CN109010149A (en) * | 2018-10-25 | 2018-12-18 | 海南师范大学 | A kind of agilawood essential oil toothpaste and preparation method thereof |
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CN114306151A (en) * | 2021-11-23 | 2022-04-12 | 电子科技大学中山学院 | Nano agilawood suspension, anhydrous agilawood toothpaste and preparation method of anhydrous agilawood toothpaste |
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