CN113559012A - Agilawood toothpaste with function of inhibiting oral helicobacter pylori - Google Patents
Agilawood toothpaste with function of inhibiting oral helicobacter pylori Download PDFInfo
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- CN113559012A CN113559012A CN202110948224.5A CN202110948224A CN113559012A CN 113559012 A CN113559012 A CN 113559012A CN 202110948224 A CN202110948224 A CN 202110948224A CN 113559012 A CN113559012 A CN 113559012A
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- agilawood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses agilawood toothpaste with an effect of inhibiting oral helicobacter pylori, which comprises the following components: humectant, abrasive, surfactant, essence, adhesive, whitening agent, sweetener, colorant, antiseptic, deionized water and functional materials, wherein the functional materials are dipotassium glycyrrhizinate and lignum Aquilariae Resinatum essential oil extract. The toothpaste disclosed by the invention is compounded by the dipotassium glycyrrhizinate and the agilawood essential oil extract in a specific weight ratio, has a synergistic effect in the aspect of performance, and has good biological safety. The toothpaste of the invention not only has the functions of anti-inflammation, whitening and deodorization, but also can inhibit harmful flora in the oral cavity and helicobacter pylori, thereby achieving the effect of preventing various diseases in the oral cavity.
Description
Technical Field
The invention relates to oral care products in the field of daily chemicals, in particular to agilawood toothpaste with an effect of inhibiting helicobacter pylori in an oral cavity.
Technical Field
Helicobacter pylori is a very old bacterium that is mainly present in our stomach, and is known to be a class I carcinogen that causes our stomach cancer, to which the general public has a certain understanding. With the intensive modern scientific research in recent years, scientists culture and separate active helicobacter pylori in dental plaque and saliva of patients with chronic gastritis, and the oral cavity becomes another important accumulation of the helicobacter pylori besides the stomach, is an important factor causing repeated infection of the helicobacter pylori in the stomach and indirectly causes harm to the stomach. Meanwhile, oral health is an important sign of human personal health and civilization, and with the continuous improvement of living standard and the acceleration of life rhythm of people, the attention degree on oral diseases and oral health prevention is gradually improved. Therefore, the elimination and killing of oral helicobacter pylori is an important step of the principle of oral-gastric homoeosis treatment of helicobacter pylori and is also key to the maintenance of oral health.
The most direct and effective way to improve oral health problems, in addition to maintaining good oral care habits, is to control the growth of pathogenic bacteria in the oral environment using oral care products that are effective in anti-inflammatory and bacteriostatic, a modern, common approach. The toothpaste is a necessary oral care product every day, and the efficacy of the toothpaste plays an important role in inhibiting or killing bacteria and preventing and improving oral diseases. The toothpaste on the market at present has a single function, and cannot simultaneously achieve the functions of cleaning, whitening, inhibiting helicobacter pylori and the like. An agilawood toothpaste with the function of inhibiting oral helicobacter pylori comprises the functional components of glycyrrhiza extract dipotassium glycyrrhizinate and agilawood essential oil extract, and has good effect of inhibiting oral helicobacter pylori.
Disclosure of Invention
Chinese patent CN 109010149A discloses an agilawood essential oil toothpaste and a preparation method thereof, wherein the preparation method comprises the step of compounding agilawood essential oil obtained by a steam distillation method with glycerol, sodium carboxymethyl cellulose, deionized water, sodium dodecyl sulfate, saccharin sodium, xanthan gum, calcium carbonate and sodium benzoate, so that the effects of inhibiting oral flora and maintaining oral health are achieved. However, the oral bacteria are various, and the experiments show that the steam distillation of the agilawood essential oil has limitation on inhibiting bacteria, particularly helicobacter pylori, and the effect of inhibiting the bacteria is far lower than that of CO2And performing supercritical extraction to obtain the agilawood essential oil. The compounding of the agilawood essential oil and the licorice extract dipotassium glycyrrhizinate can play a role in synergy and inhibit harmful bacteria in the oral cavity and helicobacter pylori.
The purpose of the invention is as follows: in view of the above-mentioned problems, the present invention aims to provide an agilawood toothpaste with an effect of inhibiting oral helicobacter pylori, which inhibits the growth of oral helicobacter pylori, relieves swelling and pain of gum, and protects the health of oral mucosa and stomach by adding glycyrrhiza extract dipotassium glycyrrhizinate and natural wild agilawood essential oil.
The technical scheme is as follows: in order to achieve the purpose, the technical scheme adopted by the invention is as follows:
an agilawood toothpaste with the effect of inhibiting oral helicobacter pylori is prepared from the following raw materials: humectant, abrasive, surfactant, essence, adhesive, whitening agent, sweetener, colorant, antiseptic, deionized water and functional raw materials.
The agilawood toothpaste with the effect of inhibiting the helicobacter pylori in the oral cavity is prepared from, by weight, 40-50% of a humectant, 20-30% of an abrasive, 2.0-5.0% of a surfactant, 0.8-1.5% of an essence, 1.5-3.0% of a binder, 0.3-0.5% of a whitening agent, 0.2-0.5% of a sweetening agent, 0.2-0.3% of a coloring agent, 0.2-0.5% of a preservative, 0.2-1% of a functional raw material and the balance of water.
Preferably, the humectant is sorbitol and/or polyethylene glycol.
Preferably, the abrasive is hydrated silica DS 100.
Preferably, the surfactant is sodium lauryl sulfate.
Preferably, the binder is a cellulose gum and/or a PVM/MA copolymer.
Preferably, the preservative is sodium benzoate.
Preferably, the whitening agent is phthalimide peroxycaproic acid. Preferably, the colorant is CI 77891.
Preferably, the sweetener is saccharin sodium. Preferably, the flavor is peppermint oil.
Preferably, the agilawood toothpaste with the function of inhibiting the helicobacter pylori in the oral cavity comprises the functional raw materials of the agilawood essential oil extract and the dipotassium glycyrrhizinate in a weight ratio of 1: 1-1: 5.
As a more preferable technical scheme, the weight ratio of the agilawood essential oil extract to the dipotassium glycyrrhizinate is 1: 2.
Preferably, the preparation method of the functional raw material agilawood essential oil extract comprises the following steps:
pulverizing lignum Aquilariae Resinatum raw material from Malaysia import into powder with a pulverizer, sieving with 80 mesh sieve, loading into E420-40-48 type supercritical extraction device, performing carbon dioxide supercritical extraction at 40 deg.C under 18Mpa for 2 hr under controlled carbon dioxide flow rate of 306L/h. Collecting crude extract of lignum Aquilariae Resinatum essential oil, re-purifying with FZL-001 molecular distillation device under vacuum pressure of 10Pa or below, distilling at 120 deg.C, preheating at 80 deg.C with feeding hopper, and collecting to obtain tawny lignum Aquilariae Resinatum essential oil.
The agilawood toothpaste with the function of inhibiting helicobacter pylori in the oral cavity is prepared by compounding the anti-allergic and anti-inflammatory liquorice extract dipotassium glycyrrhizinate and the agilawood essential oil with the antibacterial function. And the composition can play a good synergistic technical effect after being compounded according to the optimal weight ratio, and has good effects of inhibiting harmful bacteria in the oral cavity and helicobacter pylori.
Detailed Description
In order to further understand the present invention, the technical solutions of the present invention are described in detail through specific embodiments.
The preparation method of the agilawood essential oil described in the following embodiments 1-8 comprises the following steps:
pulverizing lignum Aquilariae Resinatum raw material from Malaysia import into powder with a pulverizer, sieving with 80 mesh sieve, loading into E420-40-48 type supercritical extraction device, performing carbon dioxide supercritical extraction at 40 deg.C under 18Mpa for 2 hr under controlled carbon dioxide flow rate of 306L/h. Collecting crude extract of lignum Aquilariae Resinatum essential oil, re-purifying with FZL-001 molecular distillation device under vacuum pressure of 10Pa or below, distilling at 120 deg.C, preheating at 80 deg.C with feeding hopper, and collecting to obtain tawny lignum Aquilariae Resinatum essential oil.
Example 1-example 8:
the following agilawood toothpaste of examples 1-8 was prepared according to the following table 1, and the antibacterial effect was obtained after screening dipotassium glycyrrhizinate and agilawood essential oil in different weight ratios, the specific method was as follows:
according to the formula in the following table 1, 8 groups of agilawood toothpaste samples are prepared according to the weight percentage of each component, namely example 1 to example 8.
The preparation method comprises the following steps:
adding pure water, sorbitol, polyethylene glycol-8, and water at room temperature into a vacuum paste making pot, stirring under vacuum, sequentially adding phytic acid and phthalimide peroxy caproic acid, and stirring. Sequentially adding sodium lauryl sulfate, cellulose gum, dipotassium glycyrrhizinate, CI 77891 and sodium pyrophosphate into a premixing pot, fully stirring and mixing uniformly, adding into a paste making pot by using a pipeline conveying system, and fully stirring and mixing uniformly. And finally, adding the hydrated silica into a paste making pot, fully stirring and uniformly mixing, adding the saccharin sodium, the sodium benzoate, the agilawood essential oil and the essence, fully stirring and uniformly mixing. Stirring and homogenizing for 30Min under vacuum condition to obtain paste.
TABLE 1 weight percent (wt%) of the ingredients in the toothpaste
(Note: in the Table "-" means no addition)
Experimental example 9
In this experimental example, the toothpaste prepared in the above examples 1 to 8 was tested for antibacterial performance by adopting a toothpaste antibacterial ring test, and three types of common pathogenic bacteria in the oral cavity were selected: helicobacter pylori, porphyromonas gingivalis and streptococcus mutans as strains. The experimental toothpastes were 8 groups of toothpaste products prepared in examples 1-8 above using MHA solid medium as the medium. Respectively diluting toothpaste and sterile water according to a ratio of 1:3, stirring uniformly, adding 1.0g of toothpaste into 3mL of sterilized deionized water, dripping 20 mu L of diluted toothpaste solution onto sterile filter paper in a sterile environment, drying the liquid, and placing the liquid into a refrigerator for later use. Melting the culture medium, pouring the culture medium into a flat plate, cooling to room temperature until the culture medium is solidified, adding 0.1mL of indicator bacterium suspension, uniformly coating the suspension on the surface of the culture medium by using a sterilized coating rod, taking filter paper sheets by using tweezers, putting the filter paper sheets on the surface of the culture medium, culturing for 24 hours in a microaerobic incubator at 37 ℃, and measuring the size of a bacteriostatic ring around the filter paper sheets.
TABLE 2 antibacterial toothpaste with lignum Aquilariae Resinatum experimental results (mean diameter of antibacterial ring mm)
(Note: in the table "-" shows no bacteriostatic effect)
As can be seen from the results in table 2, the toothpaste containing the agilawood essential oil extract and the dipotassium glycyrrhizinate can inhibit three pathogenic bacteria, namely helicobacter pylori, porphyromonas gingivalis and streptococcus mutans, wherein the antibacterial effect of the example 6 is the best, so that when 0.1% of agilawood essential oil and 0.2% of dipotassium glycyrrhizinate are added in the agilawood toothpaste according to the weight percentage, the two substances have synergistic effects in the aspects of inflammation diminishing and bacteriostasis, the antibacterial effect is optimal, and a good technical effect can be obtained.
Example 10-example 17
To fully verify CO2The bacteriostatic effect of the supercritical extraction agilawood essential oil toothpaste is that a bacteriostatic development contrast experiment is carried out on the agilawood essential oil toothpaste extracted by steam distillation, and the specific implementation is as follows:
referring to the first method of 2204 volatile oil determination method in 2020 edition of China pharmacopoeia, four ministerial general rules, lignum Aquilariae Resinatum raw material imported from Malaysia is pulverized in a pulverizer, the material granularity is sieved by a 80-mesh sieve, 8 times of water is added, the mixture is heated to boiling, slight boiling is kept for 5h, and the yellow-brown lignum Aquilariae Resinatum essential oil is collected.
The following procedures of example 10-17 were carried out to prepare agilawood toothpaste with distilled essential oil by steam distillation according to the following table 3, and the antibacterial effect of the screened dipotassium glycyrrhizinate and distilled agilawood essential oil by steam distillation was as follows:
according to the formula in the following table 3, 8 groups of agilawood toothpaste samples are prepared according to the weight percentage of each component, namely example 10 to example 17. The preparation method comprises the following steps:
adding pure water, sorbitol, polyethylene glycol-8, and water at room temperature into a vacuum paste making pot, stirring under vacuum, sequentially adding phytic acid and phthalimide peroxy caproic acid, and stirring. Sequentially adding sodium lauryl sulfate, cellulose gum, dipotassium glycyrrhizinate, CI 77891 and sodium pyrophosphate into a premixing pot, fully stirring and mixing uniformly, adding into a paste making pot by using a pipeline conveying system, and fully stirring and mixing uniformly. And finally, adding the hydrated silica into a paste making pot, fully stirring and uniformly mixing, adding the saccharin sodium, the sodium benzoate, the agilawood essential oil and the essence, fully stirring and uniformly mixing. Stirring and homogenizing for 30Min under vacuum condition to obtain paste.
Table 3 weight percent (wt%) of each component in toothpaste)
(Note: in the Table "-" means no addition)
Experimental example 18
In this experimental example, the toothpaste prepared in the above examples 10 to 17 was tested for antibacterial performance by adopting a toothpaste antibacterial ring test, and three types of pathogenic bacteria common in the oral cavity were selected: helicobacter pylori, porphyromonas gingivalis and streptococcus mutans as strains. The experimental toothpastes were 8 groups of toothpaste products prepared in examples 10-17 above using MHA solid medium as the medium. Respectively diluting toothpaste and sterile water according to a ratio of 1:3, stirring uniformly, adding 1.0g of toothpaste into 3mL of sterilized deionized water, dripping 20 mu L of diluted toothpaste solution onto sterile filter paper in a sterile environment, drying the liquid, and placing the liquid into a refrigerator for later use. Melting the culture medium, pouring the culture medium into a flat plate, cooling to room temperature until the culture medium is solidified, adding 0.1mL of indicator bacterium suspension, uniformly coating the suspension on the surface of the culture medium by using a sterilized coating rod, taking filter paper sheets by using tweezers, putting the filter paper sheets on the surface of the culture medium, culturing for 24 hours in a microaerobic incubator at 37 ℃, and measuring the size of a bacteriostatic ring around the filter paper sheets.
TABLE 4 antibacterial toothpaste with lignum Aquilariae Resinatum experimental results (mean diameter of antibacterial ring mm)
(Note: in the table "-" shows no bacteriostatic effect)
As can be seen from the results in Table 4, the toothpaste containing the steam distilled agilawood essential oil and the dipotassium glycyrrhizinate also has an inhibitory effect on three pathogenic bacteria, namely helicobacter pylori, porphyromonas gingivalis and streptococcus mutans, wherein the antibacterial effect of the example 15 is best when 0.1% of the steam distilled agilawood essential oil and 0.2% of the dipotassium glycyrrhizinate are added in percentage by weight. The two substances have synergistic effect in the aspects of diminishing inflammation and inhibiting bacteria.
From the above results, it can be seen that CO is used2Supercritical extraction of agilawood essential oil andthe antibacterial effect of the dipotassium glycyrrhizinate compound agilawood toothpaste is superior to that of the steam distillation agilawood essential oil and dipotassium glycyrrhizinate compound agilawood toothpaste. In particular, the agilawood toothpaste of example 6 is better than the other examples in its inhibitory effect on three pathogenic bacteria, helicobacter pylori, porphyromonas gingivalis and streptococcus mutans. Therefore, 0.1 percent of CO is added into the agilawood toothpaste according to the weight percentage2When the agilawood essential oil and 0.2% dipotassium glycyrrhizinate are subjected to supercritical extraction, the two substances have synergistic effects in the aspects of diminishing inflammation and inhibiting bacteria, the inhibiting effect is optimal, and a good technical effect can be obtained.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and improvements can be made without departing from the principle of the present invention, and these modifications and improvements should also be considered as the protection scope of the present invention.
Claims (10)
1. The agilawood toothpaste with the function of inhibiting the helicobacter pylori in the oral cavity is characterized by comprising the following raw materials: humectant, abrasive, surfactant, essence, adhesive, whitening agent, sweetener, colorant, antiseptic, deionized water and functional raw materials.
2. The agilawood toothpaste with the effect of inhibiting helicobacter pylori in the oral cavity according to claim 1, wherein the functional raw materials comprise dipotassium glycyrrhizinate and agilawood essential oil extract.
3. The agilawood toothpaste with the effect of inhibiting oral helicobacter pylori according to claim 1, wherein the usage amount of the humectant is 40-50%, the usage amount of the abrasive is 20-30%, the usage amount of the surfactant is 2.0-5.0%, the usage amount of the essence is 0.8-1.5%, the usage amount of the binder is 1.5-3.0%, the usage amount of the whitening agent is 0.3-0.5%, the usage amount of the sweetener is 0.2-0.5%, the usage amount of the colorant is 0.2-0.3%, the usage amount of the preservative is 0.2-0.5%, the usage amount of the functional material is 0.2-1%, and the balance is water.
4. The agilawood toothpaste with the effect of inhibiting oral helicobacter pylori according to claim 3, wherein the weight ratio of the agilawood essential oil extract to the dipotassium glycyrrhizinate is 1: 1-1: 5.
5. The agilawood toothpaste with the effect of inhibiting oral helicobacter pylori according to claim 4, wherein the weight ratio of the agilawood essential oil extract to the dipotassium glycyrrhizinate is 1: 2.
6. The agilawood toothpaste having an effect of inhibiting oral helicobacter pylori according to any one of claims 1 to 5, wherein the humectant is sorbitol and/or polyethylene glycol.
7. The agilawood toothpaste having an effect of inhibiting oral helicobacter pylori according to claim 6, wherein the abrasive is hydrated silica DS100 and/or silicon dioxide.
8. The agilawood toothpaste having an effect of inhibiting oral helicobacter pylori according to claim 7, wherein the surfactant is sodium lauryl sulfate.
9. The agilawood toothpaste having an effect of inhibiting helicobacter pylori in the oral cavity according to claim 8, wherein the sweetener is saccharin sodium and the binder is cellulose gum.
10. The agilawood toothpaste with effect of inhibiting oral helicobacter pylori according to claim 9, wherein the preservative is sodium benzoate, the whitening agent is phthalimide peroxycaproic acid, the coloring agent is CI 77891, and the essence is peppermint oil.
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| CN114306151A (en) * | 2021-11-23 | 2022-04-12 | 电子科技大学中山学院 | Nano agilawood suspension, anhydrous agilawood toothpaste and preparation method of anhydrous agilawood toothpaste |
| CN115501140A (en) * | 2022-11-14 | 2022-12-23 | 上海咏旭生物科技有限公司 | Toothpaste with lasting fragrance in oral cavity and preparation method thereof |
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| CN114306151B (en) * | 2021-11-23 | 2023-06-23 | 电子科技大学中山学院 | Nanometer agilawood suspension, anhydrous agilawood toothpaste and preparation methods thereof |
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