CN106581159A - Children oral care composition and combination children toothpaste suitable for use in the morning and in the evening - Google Patents
Children oral care composition and combination children toothpaste suitable for use in the morning and in the evening Download PDFInfo
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- CN106581159A CN106581159A CN201710055001.XA CN201710055001A CN106581159A CN 106581159 A CN106581159 A CN 106581159A CN 201710055001 A CN201710055001 A CN 201710055001A CN 106581159 A CN106581159 A CN 106581159A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a children oral care composition and combination children toothpaste suitable for use in the morning and in the evening, and the children oral care composition comprises magnolia bark extract and oral probiotics, especially aims at 9-12-year-old children oral characteristics, can effectively inhibit the growth of cariogenic bacteria and other oral bacteria, and has the functions of preventing dental caries, preventing and treating periodontitis, preventing and treating ulcers, refreshing breath, making oral cavity healthy and strengthening gums and teeth. The he children oral care composition can be used for the preparation of children's oral care products such as the combination children toothpaste suitable for use in the morning and in the evening, according to different children oral environment in the morning and in the evening, toothpaste suitable for use in the morning and toothpaste suitable for use in the evening are formed respectively, by collocation use of different formulas of the toothpaste suitable for use in the morning and the toothpaste suitable for use in the evening, children's deciduous teeth caries can be effectively prevented, and the children's teeth can be kept in healthy.
Description
Technical field
The present invention relates to oral care techniques field, more particularly to the MC of 9～12 years old children, and in particular to it is a kind of
Pediatric Oral Emergency care composition and a kind of early benefit evening combination children's toothpaste of benefit.
Background technology
The oral problem of children is to perplex a very big problem of children and the heads of a family, and most common of which is exactly to decay tooth
And periodontal disease.
Children are in mixed dentition late period within 9～12 years old, and this stage, existing deciduous teeth in oral cavity also have permanent teeth, are children's jaws
Bone and the main growth and development stage of dental arch, are also the critical period of permanent teeth foundation.If deciduous teeth occur carious tooth, the life of permanent teeth can be affected
Long development；There is carious tooth or corroded by bacterial plaque in the permanent teeth for newly growing, tooth defect can be caused even to lack, induction gingivitis etc.,
Affect the facial development of children.In addition, be within 9～12 years old the best period that children carry out mouth cavity orthodontic, if due to oral cleaning not
In place, cause bacterial plaque to be piled up, cause periodontal disease, such as halitosis to cause great damage to the physical and mental health of children.
Additionally, the oral environment of children's morning and evening has differences.Daytime, children frequently take food, and sugar content is high, constitute bacteria fertilizer
Fertile soil, easily forms bacterial plaque, and the sugar in a large amount of bacterium intake salivas decomposes sugar and produces acid, and saliva is acid after feed increases, many
Secondary feed makes saliva long-time in acid state, and equivalent food of more once taking food is easier to suffer from carious tooth.Evening, children's sleeps
The dormancy time is long, and oral cavity remains static, and salivary secretion is few, and self-cleaning action is poor, is conducive to bacterial reproduction, increase to suffer from dental caries chance.
As can be seen here, the oral environment in children's daytime and the oral environment at night make a big difference, therefore will be for sooner or later different
Oral environment is carried out for nursing, and common oral cavity pathogen mainly includes Streptococcus mutans, porphyromonas list in Pediatric Oral Emergency
Born of the same parents bacterium, Fusobacterium nucleatum, lactobacillus acidophilus etc., these bacteriums are the roots for causing carious tooth, halitosis and gum problem.
There is researcher that probio is used for the nursing in oral cavity, but application of the probio in toothpaste is subject to certain restrictions：
1st, probio generally needs to be preserved in low temperature environment just to can guarantee that its effective active, and toothpaste in production, logistics, sell, make
With during, as a consequence it is hardly possible to accomplish Cord blood.For example, China Patent Publication No. is the patent of invention Shen of CN1947698A
A kind of probio toothpaste with natural mineral salt as culture medium please be disclose, using the sodium chloride of suitable concn live probiotic is made
Bacterium dormancy, but As time goes on the sodium chloride concentration in toothpaste system can change, and cannot also ensure toothpaste
In probio quantity stablize；2nd, probio is added in toothpaste, and the stability in lotion is difficult to control to, and lotion easily occurs
Yellowing phenomenon and have the faint yellow aggregate of macroscopic diameter about 1～3mm and occur, these changes of lotion mainly by
The metabolic waste of probio causes, and badly influences the attractive in appearance of toothpaste and uses.
In the mothproof oral care product of children on the market at present, major part all contains fluoride.Although fluoride is proved to tool
There is good anticaries action, but fluorinated volume is too high in human body, affects larger to tooth, bone, especially children, function of deglutition
Not completely, can be harmful to children's torso if Excess free enthalpy fluorine, therefore it is not recommended that children use toothpaste with fluoride.
There are many children's toothpastes on the market, but mostly in the age bracket of 2～12 years old, minority is 6～12 years old children's tooth
Cream, but all have a problem that, age segment limit is too wide, not for nursing, therefore, research and development are new to ask for Pediatric Oral Emergency
The care product of topic, not only conforms to the demand of consumers in general, and with the wide market space.
The content of the invention
The purpose of the present invention is for the deficiencies in the prior art, there is provided a kind of being specifically designed for 9～12 years old children, can be pre-
Anti-caries can suppress oral cavity harmful bacteria again, eliminate the oral care composition of halitosis.
It is a further object to provide it is a kind of containing above-mentioned oral care composition, it is specifically designed for 9～12 years old
The early benefit evening combination children's toothpaste of benefit that children use.
The above-mentioned purpose of the present invention is achieved by following scheme：
A kind of Pediatric Oral Emergency care composition, said composition is into the thickness by Magnolia cortex P.E with oral cavity probiotic group
The weight ratio of plain extract and oral cavity probio is 0.01:1～1:1, preferably 0.1:1～0.5:1.
The bark of official magnolia, Chinese medicine name is the bark or root skin of the Magnoliacea plant bark of official magnolia or Magnolia bilola, active component be magnolol and
Honokiol, its warm in nature, taste is pungent is bitter, the effect of disappear long-pending with broad-spectrum antiseptic, middle benefit gas qi-regulating, eliminating dampness；The bark of official magnolia of the present invention is extracted
Thing is to adopt supercritical CO2Extraction is prepared, and concrete preparation technology is as follows：
20 mesh sieves are crossed after commercially available magnolia medicament is crushed and obtains bark of official magnolia meal, the bark of official magnolia meal is placed in into supercritical CO2
In extraction kettle, setting extracting pressure is 22MPa, and extraction temperature is 35 DEG C, CO2Flow is 75.80kg/h, the pressure of separating still 1
For 7.5MPa, the temperature of separating still 1 is 40 DEG C, and the pressure of separating still 2 is 6MPa, and the temperature of separating still 2 is 37 DEG C, extraction 4.5
Hour, extract is collected, the extract is required Magnolia cortex P.E.
Above-mentioned oral cavity probio is that commercially available lactobacillus gasseri freeze-dried powder, Lactobacillus plantarum freeze-dried powder or Lactobacillus salivarius freeze
The mixing of any one or two or more arbitrary proportion in dry powder；The oral cavity probio is preferably Lactobacillus salivarius
Freeze-dried powder.
Above-mentioned Pediatric Oral Emergency care composition, Magnolia cortex P.E and oral cavity probio can cooperate with and play a role, and suppress to cause
The growth of dental caries bacterium and other oral cavity pathogens；Said composition can arrange in pairs or groups acceptable carrier on oral cavity well-known in the art
Component is prepared into Pediatric Oral Emergency care product；The carrier component is antitack agent, polyphenoils (such as Co-Q10), desensitizer
(such as potassium nitrate, potassium tartrate, potassium citrate or strontium chloride), brightening agent, tartar control agents, periodontal actives, chlorophyll chemical combination
Thing, abrasive material, breath freshening controlling agent (such as zinc gluconate, zinc citrate or zinc chloride), saliva stimulant are (such as citric acid, breast
Acid or malic acid), viscosity modifier, diluent, surface reactive material, emulsifying agent, pH adjusting agent, abrasive material, NMF, softening
Agent, mouth feel modifying agents, sweetener, flavor enhancement or colouring agent etc.；The oral care product is toothpaste, mouthwash, tooth powder or mouth
The common dosage forms such as chamber cleaning agent.
Above-mentioned Pediatric Oral Emergency care composition arrange in pairs or groups other carrier components prepare Pediatric Oral Emergency care product when, the children
The consumption of oral care composition is 0.01～5%, preferably the 0.01～3% of Pediatric Oral Emergency care product gross weight.
The present invention also provides a kind of benefit early benefit evening combination children's toothpaste, and the benefit morning children's toothpaste and evening used by morning makes
Beneficial evening children's toothpaste composition.
The formula of above-mentioned benefit morning children's toothpaste is by NMF, thickener, abrasive material, xylitol, calcium containing compound, Pediatric Oral Emergency
Care composition, B B-complex, gentle surfactant, essence and deionized water are constituted, the amount ranges of each recipe ingredient
It is as follows：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
Above-mentioned NMF is any one or two or more in glycerine, sorbierite, propane diols or polyethylene glycol
The mixing of arbitrary proportion.
Above-mentioned thickener be any one or two kinds in sodium carboxymethylcellulose, xanthan gum, xanthans or guar gum or
The mixing of two or more arbitrary proportions.
Above-mentioned abrasive material is food grade silicon dioxide.
Above-mentioned calcium containing compound is calcium glycerophosphate.
Above-mentioned Pediatric Oral Emergency care composition is the Pediatric Oral Emergency care composition of the present invention.
Above-mentioned B B-complex is capable of achieving the present invention using commercially available B B-complex, such as can be included using commercially available
The B B-complex of vitamin C, vitamin E, vitamin B3, vitamin B5 and vitamin B6.
Above-mentioned gentle surfactant adopts sodium lauroyl sarcosine, sodium lauroyl glutamate, cocamidopropyl beet
Alkali, N- sodium methyl cocoyl taurates or pool fall husky nurse in any one with laruyl alcohol sodium sulfovinate according to 1:(0.1～3)
Weight than constitute mixture.
The formula of above-mentioned benefit evening children's toothpaste is by NMF, thickener, abrasive material, compound sugar, amino acid composition, children's mouth
Chamber care composition, B B-complex, gentle surfactant, essence and deionized water are constituted, the consumption model of each recipe ingredient
Enclose as follows：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
Above-mentioned NMF is any one or two or more in glycerine, sorbierite, propane diols or polyethylene glycol
The mixing of arbitrary proportion.
Above-mentioned thickener be any one or two kinds in sodium carboxymethylcellulose, xanthan gum, xanthans or guar gum or
The mixing of two or more arbitrary proportions.
Above-mentioned abrasive material is food grade silicon dioxide.
Above-mentioned compound sugar is FOS, xylo-oligosaccharide, isomalto-oligosaccharide, galactooligosaccharide, soyabean oligosaccharides, coupling
Any one in sugar, chitin compound sugar or trehalose.
Above-mentioned amino acid composition is capable of achieving the present invention using commercially available amino acid composition, can such as adopt commercially available bag
Amino acid composition containing cystine, proline, glutamic acid, histidine and methionine.
Above-mentioned Pediatric Oral Emergency care composition is the Pediatric Oral Emergency care composition of the present invention.
Above-mentioned B B-complex is capable of achieving the present invention using commercially available B B-complex, such as can be included using commercially available
The B B-complex of vitamin C, vitamin E, vitamin B3, vitamin B5 and vitamin B6.
Above-mentioned gentle surfactant adopts sodium lauroyl sarcosine, sodium lauroyl glutamate, cocamidopropyl beet
Alkali, N- sodium methyl cocoyl taurates or pool fall husky nurse in any one with laruyl alcohol sodium sulfovinate according to 1:(0.1～3)
Weight than constitute mixture.
The early benefit evening combination children's toothpaste of one kind benefit of the present invention need to be applied regularly to a mouthful face, such as can use daily, also may be used
With two days or three days using once, preferably use daily, more preferably use 1～3 time daily, persistently using at least 2 weeks
～8 weeks, it is also possible to extend use time as needed.Jing inside clinical testings prove that the children of 9～12 years old are using the present invention
The early benefit evening combination children's toothpaste of benefit after 2 weeks, halitosis symptom can be relieved, and bacterial plaque also can be reduced, and carious tooth incidence is significantly
Reduce.
Compared with prior art, the present invention has the advantages that：
1. the Pediatric Oral Emergency care composition of the present invention contains oral cavity probio magnolia obovata two active components of extract, its
Middle Magnolia cortex P.E is that inventor is obtained by extraction by supercritical carbon dioxide extraction method, and rational extraction process ensure that
Active component is extracted to greatest extent in Magnolia cortex P.E, and the Magnolia cortex P.E and the perfect collocation of oral cavity probio,
Synergy, suppresses cariogenic bacteria and the growth of other oral cavity pathogens, and it suppresses the species and ability of bacterium, is all substantially better than list
One active matter, such that it is able to provide pre- anti-caries better than single-activity thing, prevent and treat periodontitis, prevent and treat ulcer, fresh breath,
Effect of healthy mouth, strong gum and firm tooth.
2. in the benefit morning children's toothpaste of the present invention, it is used in combination with calcium containing compound using xylitol, oral cavity can be alleviated
Acid-base value, can improve enamel acid-resisting again.The enamel of deciduous teeth, dentine are thin, and salinity is low, and antiacid power is weak, deciduous teeth enamel ratio
Permanent teeth enamel easily by decalcifying agent effect and decalcification, be also more susceptible to remineralizing agent effect and remineralization.Daytime, children frequently enter
Food, saliva is acid after feed increases, and repeatedly feed makes saliva long-time in acid state, and xylitol is entered in bacterial cell,
Formed and 5- phosphoric acid xylitol and accumulated in the cell, 5- phosphoric acid xylitol and dephosphorylation, afterwards xylitol be discharged to it is extracellular,
The inefficient cycle process of a power consumption is so formed, so as to inhibiting the growth of streptococcus mutans and producing acid, therefore xylitol energy
Enough reduce the quantity of streptococcus mutans.Xylitol is unfavorable for the increment of acid fast bacteria, plays the work for promoting remineralization, suppressing demineralization
With, do not form extracellular polysaccharide in xylitol metabolic process in addition, reduce the formation of bacterial plaque.Xylitol and calcium containing compound can press down
Fermentable processed produces acid, improves ph value of oral cavity, while supplementing calcium ion, strengthens remineralization speed, improves enamel antiacid
Ability.
3. the benefit evening children's toothpaste of the present invention adopts compound sugar, because the oral cavity of evening children remains static, saliva
Secretion is few, and its self-cleaning action is poor, is conducive to bacterial reproduction, and compound sugar can promote beneficial bacteria to grow, and suppresses harmful bacteria numerous
Grow, maintain Oral health behaviours balance, make oral cavity acid-base value maintain normal level, reach anti-caries effect.
4. in the early benefit evening combination children's toothpaste of the benefit of the present invention, amino acid is with the shape of composition by several amino acids composition
Formula is added, and can improve stability of the amino acid during toothpaste is guaranteed the quality, and multivitamin is also to be added in the form of a kind of compound
In being added to toothpaste, so as to also improve stability of the vitamin during toothpaste is guaranteed the quality.
5. the early benefit evening combination children's toothpaste bacterium of the benefit of the present invention uses gentle surfactant, and the gentle surface
Activating agent is using sodium lauroyl sarcosine, sodium lauroyl glutamate, cocamidopropyl betaine, N- methyl cocoyl oxen
Sodium sulfonate or pool fall husky nurse in any one with laruyl alcohol sodium sulfovinate according to 1:Mixing of the weight of (0.1～3) than composition
Thing, such collocation not only can clean oral cavity, remove oil stain, the spot adhered on tooth, also not stimulate oral cavity viscosity, while
The explosive force of essence is improved, mouthfeel is lifted, moreover it is possible to fine and smooth foam is produced, easy-to-use clear water is gargled totally, do not remained；To after brushing not
For liking the children for repeatedly gargling clearly, the number of times gargled can be reduced.
6. benefit morning children's toothpaste described in is frequent for children's feed number of times, the feelings that saliva acidity usury is bred in acid fast bacteria
Condition, using xylitol and calcium containing compound plaque bacteria breeding is suppressed, and is promoted remineralization, is suppressed demineralization, is invaded so as to resist bacterium
Erosion, firm tooth；Beneficial evening children's toothpaste is few for Pediatric Oral Emergency salivary secretion, beneficial to vegetative situation, using compound sugar
Promote beneficial bacteria growth, suppress harmful bacteria breeding, maintain Oral health behaviours balance, make oral cavity acid-base value maintain normal water
It is flat, so as to reach mothproof effect；Beneficial morning children's toothpaste and benefit evening children's toothpaste are used cooperatively, and can effectively prevent Primary Caries
Tooth, protection teenager teeth health.
Specific embodiment
The present invention is further described through with reference to specific embodiment, but specific embodiment is not appointed to the present invention
What is limited.
A kind of early benefit evening combination children's toothpaste of the benefit of embodiment 1
The benefit that the benefit morning children's toothpaste and evening that the early benefit evening combination children's toothpaste of benefit of the present embodiment is used by morning is used
Late children's toothpaste composition.
The formula of the benefit morning children's toothpaste is made up of following component：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
The formula of the benefit evening children's toothpaste is made up of the following raw material：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
The Pediatric Oral Emergency care composition of the present embodiment is by Magnolia cortex P.E with oral cavity probiotic group into the bark of official magnolia is extracted
The weight ratio of thing and oral cavity probio is 0.25:1；The oral cavity probio is Lactobacillus salivarius freeze-dried powder；The bark of official magnolia is extracted
The preparation technology of thing is will to cross 20 mesh sieves after commercially available magnolia medicament crushing to obtain bark of official magnolia meal, and the bark of official magnolia meal is placed in into super facing
Boundary CO2In extraction kettle, setting extracting pressure is 22MPa, and extraction temperature is 35 DEG C, CO2Flow is 75.80kg/h, separating still 1
Pressure is 7.5MPa, and the temperature of separating still 1 is 40 DEG C, and the pressure of separating still 2 is 6MPa, and the temperature of separating still 2 is 37 DEG C, extraction
4.5 hours, extract is collected, the extract is required Magnolia cortex P.E.
The preparation technology of above-mentioned benefit morning children's toothpaste comprises the steps：
Step 1
PEG-4000, sodium carboxymethylcellulose and xanthans are added in container 1, dispersed with stirring is uniform, it is ensured that
Sodium carboxymethylcellulose and xanthans do not have conglomeration, prepare scattered rubber powder；
Pediatric Oral Emergency care composition is added in essence, essence dispersion liquid is made in heating water bath dissolving；
Step 2
Xylitol, B B-complex and calcium glycerophosphate are added in container 2, after adding deionized water stirring and dissolving, plus
Enter sorbierite and glycerine, then add the scattered rubber powder dispersed with stirring of step 1 it is uniform after add food grade silicon dioxide,
Under vacuo mixed at high speed 15～20 minutes, are eventually adding essence dispersion liquid, lauroyl propylhomoserin sodium and the bay of step 1 preparation
Alcohol sulfuric ester sodium, is sufficiently mixed under vacuo dispersion 20 minutes, then prepare the benefit morning children's toothpaste of the present embodiment.
The preparation technology of above-mentioned benefit evening children's toothpaste comprises the steps：
Step 1
PEG-4000, sodium carboxymethylcellulose and xanthans are added in container 1, dispersed with stirring is uniform, it is ensured that
Sodium carboxymethylcellulose and xanthans do not have conglomeration, prepare scattered rubber powder；
Pediatric Oral Emergency care composition is added in essence, essence dispersion liquid is made in heating water bath dissolving；
Step 2
FOS, B B-complex and amino acid composition are added in container 2, deionized water stirring and dissolving is added
Afterwards, sorbierite and glycerine are added, then add the scattered rubber powder dispersed with stirring of step 1 it is uniform after add food-grade dioxy
SiClx, under vacuo mixed at high speed 15～20 minutes, are eventually adding essence dispersion liquid, the lauroyl propylhomoserin sodium of step 1 preparation
And laruyl alcohol sodium sulfovinate, dispersion 20 minutes is sufficiently mixed under vacuo, then prepare the benefit evening children's toothpaste of the present embodiment.
A kind of early benefit evening combination children's toothpaste of the benefit of embodiment 2
The benefit that the benefit morning children's toothpaste and evening that the early benefit evening combination children's toothpaste of benefit of the present embodiment is used by morning is used
Late children's toothpaste composition.
The formula of the benefit morning children's toothpaste is made up of following component：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
The formula of the benefit evening children's toothpaste is made up of following component：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
The Pediatric Oral Emergency care composition of the present embodiment is by Magnolia cortex P.E with oral cavity probiotic group into the bark of official magnolia is extracted
The weight ratio of thing and oral cavity probio is 0.1:1；The oral cavity probio is Lactobacillus salivarius freeze-dried powder；The Magnolia cortex P.E
Preparation technology be will commercially available magnolia medicament crush after cross 20 mesh sieves and obtain bark of official magnolia meal, the bark of official magnolia meal is placed in overcritical
CO2In extraction kettle, setting extracting pressure is 22MPa, and extraction temperature is 35 DEG C, CO2Flow is 75.80kg/h, the pressure of separating still 1
Power is 7.5MPa, and the temperature of separating still 1 is 40 DEG C, and the pressure of separating still 2 is 6MPa, and the temperature of separating still 2 is 37 DEG C, extraction
4.5 hours, extract is collected, the extract is required Magnolia cortex P.E.
The preparation technology of above-mentioned benefit morning children's toothpaste comprises the steps：
Step 1
PEG-4000, sodium carboxymethylcellulose and xanthans are added in container 1, dispersed with stirring is uniform, it is ensured that
Sodium carboxymethylcellulose and xanthans do not have conglomeration, prepare scattered rubber powder；
Pediatric Oral Emergency care composition is added in essence, essence dispersion liquid is made in heating water bath dissolving；
Step 2
Xylitol, B B-complex and calcium glycerophosphate are added in container 2, after adding deionized water stirring and dissolving, plus
Enter sorbierite and glycerine, then add the scattered rubber powder dispersed with stirring of step 1 it is uniform after add food grade silicon dioxide,
Under vacuo mixed at high speed 15～20 minutes, are eventually adding essence dispersion liquid, sodium lauroyl glutamate and the bay of step 1 preparation
Alcohol sulfuric ester sodium, is sufficiently mixed under vacuo dispersion 20 minutes, then prepare the benefit morning children's toothpaste of the present embodiment.
The preparation technology of above-mentioned benefit evening children's toothpaste comprises the steps：
Step 1
PEG-4000, sodium carboxymethylcellulose and xanthans are added in container 1, dispersed with stirring is uniform, it is ensured that
Sodium carboxymethylcellulose and xanthans do not have conglomeration, prepare scattered rubber powder；
Pediatric Oral Emergency care composition is added in essence, essence dispersion liquid is made in heating water bath dissolving；
Step 2
FOS, B B-complex and amino acid composition are added in container 2, deionized water stirring and dissolving is added
Afterwards, sorbierite and glycerine are added, then add the scattered rubber powder dispersed with stirring of step 1 it is uniform after add food-grade dioxy
SiClx, under vacuo mixed at high speed 15～20 minutes, are eventually adding essence dispersion liquid, the sodium lauroyl glutamate of step 1 preparation
And laruyl alcohol sodium sulfovinate, dispersion 20 minutes is sufficiently mixed under vacuo, then prepare the benefit evening children's toothpaste of the present embodiment.
A kind of early benefit evening combination children's toothpaste of the benefit of embodiment 3
The benefit that the benefit morning children's toothpaste and evening that the early benefit evening combination children's toothpaste of benefit of the present embodiment is used by morning is used
Late children's toothpaste composition.
The formula of the benefit morning children's toothpaste is made up of following component：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
The formula of the benefit evening children's toothpaste is made up of the following raw material：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
The Pediatric Oral Emergency care composition of the present embodiment is by Magnolia cortex P.E with oral cavity probiotic group into the bark of official magnolia is extracted
The weight ratio of thing and oral cavity probio is 0.15:1；The oral cavity probio is Lactobacillus salivarius freeze-dried powder；The bark of official magnolia is extracted
The preparation technology of thing is will to cross 20 mesh sieves after commercially available magnolia medicament crushing to obtain bark of official magnolia meal, and the bark of official magnolia meal is placed in into super facing
Boundary CO2In extraction kettle, setting extracting pressure is 22MPa, and extraction temperature is 35 DEG C, CO2Flow is 75.80kg/h, separating still 1
Pressure is 7.5MPa, and the temperature of separating still 1 is 40 DEG C, and the pressure of separating still 2 is 6MPa, and the temperature of separating still 2 is 37 DEG C, extraction
4.5 hours, extract is collected, the extract is required Magnolia cortex P.E.
The preparation technology of above-mentioned benefit morning children's toothpaste comprises the steps：
Step 1
PEG-4000, sodium carboxymethylcellulose and xanthans are added in container 1, dispersed with stirring is uniform, it is ensured that
Sodium carboxymethylcellulose and xanthans do not have conglomeration, prepare scattered rubber powder；
Pediatric Oral Emergency care composition is added in essence, essence dispersion liquid is made in heating water bath dissolving；
Step 2
Xylitol, B B-complex and calcium glycerophosphate are added in container 2, after adding deionized water stirring and dissolving, plus
Enter sorbierite and glycerine, then add the scattered rubber powder dispersed with stirring of step 1 it is uniform after add food grade silicon dioxide,
Mixed at high speed 15～20 minutes under vacuo, be eventually adding the essence dispersion liquid of step 1 preparation, Cocoamidopropyl betaine and
Laruyl alcohol sodium sulfovinate, is sufficiently mixed under vacuo, disperses 20 minutes, then prepare the benefit morning children's toothpaste of the present embodiment.
The preparation technology of above-mentioned benefit evening children's toothpaste comprises the steps：
Step 1
PEG-4000, sodium carboxymethylcellulose and xanthans are added in container 1, dispersed with stirring is uniform, it is ensured that
Sodium carboxymethylcellulose and xanthans do not have conglomeration, prepare scattered rubber powder；
Pediatric Oral Emergency care composition is added in essence, essence dispersion liquid is made in heating water bath dissolving；
Step 2
FOS, B B-complex and amino acid composition are added in container 2, deionized water stirring and dissolving is added
Afterwards, sorbierite and glycerine are added, then add the scattered rubber powder dispersed with stirring of step 1 it is uniform after add food-grade dioxy
SiClx, mixed at high speed 15～20 minutes under vacuo, essence dispersion liquid, the cocamidopropyl propyl amide for being eventually adding step 1 preparation is sweet
Dish alkali and laruyl alcohol sodium sulfovinate, are sufficiently mixed under vacuo, disperse 20 minutes, then prepare the benefit evening children of the present embodiment
Toothpaste.
The stability experiment of embodiment 4
The early benefit evening toothpaste of the benefit of embodiment 1,2 and 3 is placed 3 months respectively in 45 DEG C of insulating box, toothpaste is observed
Stability, as a result as shown in table 1.
The toothpaste stability experiment result of table 1
From the results shown in Table 1, the early benefit evening toothpaste of children's benefit of embodiment 1～3 places 3 at a high temperature of 45 DEG C
The moon still stable performance, illustrates the good stability of toothpaste of the present invention, and lotion is not in yellowing.
The bacteriostatic experiment of embodiment 5
The laboratory sample of the present embodiment is the early benefit evening children's toothpaste of benefit of embodiment 1, the early benefit evening children's tooth of benefit of embodiment 2
Cream, the early benefit evening children's toothpaste of benefit of embodiment 3, control sample 1, control sample 2 and control sample 3；In the formulation of tooth-paste of the control sample 1
Except without Pediatric Oral Emergency care composition of the present invention, remaining is consistent with the formula of embodiment 1；The toothpaste of the control sample 2
Pediatric Oral Emergency care composition in formula is only made up of oral cavity probio, and remaining formula material is consistent with embodiment 1；It is described right
In the same old way the Pediatric Oral Emergency care composition in 3 formulation of tooth-paste is only made up of Magnolia cortex P.E, remaining formula material and embodiment 1
Unanimously.
The experimental strain of the present embodiment is Streptococcus mutans, porphyromonas gingivalis and Fusobacterium nucleatum, according to this area
Routine operation prepare the bacteria suspension of each bacterial classification respectively.
Prepare solid medium (nutrient agar)：Beef extract 5.0g, peptone 10g, agar powder 25g, sodium chloride 5.0g, steam
Distilled water 1000mL, by each composition heating for dissolving in addition to agar after, with NaOH adjust PH as 7.2-7.3, add agar powder, heating
Boil, dissolve agar, be distributed into flask, seal, 0.1MPa steam sterilizing 20min.
The bacteriostatic experiment of each laboratory sample of the present embodiment, comprises the following steps that shown：
Step 1
To in the conical flask containing bead of 250mL, 45mLPBS (phosphate buffer) and 5mL bacterium are separately added into
Suspension, makes concentration of the bacteria suspension in PBS be 1 × 104CFU/mL～5 × 104CFU/mL；
Step 2
Weigh 0.50g experiment toothpaste samples to be put in the conical flask containing PBS and bacteria suspension of step 1, shake 2min,
Draw 1mL PBS and make gradient dilution to 10-2, as sample liquid before vibration；
Weigh 0.50g experiment toothpaste sample be put in the conical flask containing PBS and bacteria suspension of step 1,20 DEG C～
Under conditions of 25 DEG C, 2h is shaken with 300r/min, draw 1mL PBS and make gradient dilution to 10-2, as sample liquid after vibration；
Step 3
Agar tilt-pour process inoculation plate (according to《Disinfection technology standard》(2002) method of regulation carries out viable bacteria culture meter
Number)：The each 1mL of sample liquid after the front sample liquid of vibration and vibration being drawn respectively, being placed in sterilizing plates, each sample liquid is inoculated with two plates,
Sample liquid is moved into after plate, in time cool to 46 DEG C of nutrient agar is injected into plate about 15mL, and rotating plate mixes it
Close uniform.After agar solidification, plate is overturn, be placed under 37 DEG C of constant temperature and cultivate 48h taking-ups, record clump count.
The present embodiment test sets and is not added with sample sets simultaneously.It is not added with sample sets and takes the addition of 45mL PBS and 5mL bacteria suspension respectively
250mL contains in the conical flask of bead, mix, respectively at vibration before and vibration 2min after, respectively take 1.0mL bacteria suspensions and
PBS mixing makees gradient dilution to 10-2.Press《Disinfection technology standard》(2002) 2.1.1.2.3 methods carry out viable bacteria culture counting.
Bacteriostasis rate is calculated, as a result as shown in table 2.
The toothpaste bacteriostasis rate result of table 2
From table 2 it can be seen that the bacteriostasis rate of the toothpaste of control sample 1 without Pediatric Oral Emergency care composition of the present invention is worst,
And Pediatric Oral Emergency care composition only by oral cavity probiotic group into or the toothpaste of control sample 2 that is only made up of Magnolia cortex P.E and control
Although the bacteriostasis rate of the toothpaste of sample 3 is better than the toothpaste of control sample 1, but is significantly worse than embodiment 1,2 and 3.
Thus illustrate, the present invention Pediatric Oral Emergency care composition really to Streptococcus mutans, porphyromonas gingivalis and
Fusobacterium nucleatum these oral cavity harmful bacterias have good inhibition, and oral cavity probio magnolia obovata extract has to oral cavity
The coordinate repression of evil bacterium is substantially better than single use oral cavity probio or single use Magnolia cortex P.E.
The children of embodiment 6 use experiment
The present embodiment chooses 20 children experimenters for having 9-12 year of the oral problems such as carious tooth, halitosis, using embodiment 2
The early benefit evening toothpaste of benefit of preparation one month, daily 2 times, then detects, specifically the following institute of detection program to its result of the test
Show：
The saliva of the early benefit evening toothpaste of the benefit of unused embodiment 2 for collecting 20 experimenters respectively with sterile test tube, and make
With the saliva after the early benefit evening toothpaste of the benefit of embodiment 21 month, after saliva sample is suitably diluted respectively with aseptic PBS, 0.2mL is taken
In coating BHI agar plates, after 37 DEG C of Anaerobic culturel 72h, BHI agar plates are eluted with the aseptic PBS solutions of 2～3mL, collected
Eluent.
The blank group of the present embodiment is referred to：The saliva Jing aforesaid operations of the early benefit evening toothpaste of the benefit of unused embodiment 2 are obtained
Eluent, be diluted to 1 × 10 again with aseptic PBS solution 106～5 × 106Concentration obtains bacteria suspension, then draws 1.0mL bacterium and hangs
Anaerobic culturel 72h after liquid suitably dilution, then calculates clump count.
The experimental group of the present embodiment is referred to：By using the saliva Jing aforesaid operations after the early benefit evening toothpaste of the benefit of embodiment 21 month
The eluent for obtaining, with aseptic PBS solution 10 1 × 10 is diluted to again6～5 × 106Concentration obtains bacteria suspension, then draws 1.0mL
Anaerobic culturel 72h after bacteria suspension suitably dilution, then calculates clump count.
Sterilizing rate is calculated by following equation：
It is 6.2 × 10 that the blank group clump count of 20 experimental subjects is calculated into mean value6CFU/mL, by 20 experimental subjects
Experimental group clump count calculate mean value be<10CFU/mL, is then calculated bacteriostasis rate for 100% according to above-mentioned formula.
As a result show, using the early benefit evening toothpaste of the benefit containing Pediatric Oral Emergency care composition of the present invention after one month, children
The quantity of the anaerobic bacteria in saliva is significantly suppressed, and thus illustrates, the benefit containing Pediatric Oral Emergency care composition of the present invention is early
Beneficial evening toothpaste really can effectively pre- anti-caries, prevent and treat periodontitis, ulcer, fresh breath, healthy mouth, strong gum, firm tooth
Tooth.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, specific embodiment disclosed and described above is the invention is not limited in, to the present invention's
Some modifications and changes should also be as falling in the scope of the claims of the present invention.Although additionally, used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any restriction to the present invention.
Claims (10)
1. a kind of Pediatric Oral Emergency care composition, it is characterised in that the Pediatric Oral Emergency care composition is by Magnolia cortex P.E and mouth
Chamber probiotic group is into the weight ratio of the Magnolia cortex P.E and oral cavity probio is 0.01:1～1:1, the Magnolia cortex P.E is
The bark of official magnolia meal that excessively 20 mesh sieves are obtained after magnolia medicament is crushed is placed in supercritical CO2In extraction kettle, arranging extracting pressure is
22MPa, extraction temperature is 35 DEG C, CO2Flow is 75.80kg/h, and the pressure of separating still 1 is 7.5MPa, and the temperature of separating still 1 is
40 DEG C, the pressure of separating still 2 is 6MPa, and the temperature of separating still 2 is 37 DEG C, is extracted 4.5 hours, extract is collected, so as to prepare
And obtain, the oral cavity probio is in lactobacillus gasseri freeze-dried powder, Lactobacillus plantarum freeze-dried powder or Lactobacillus salivarius freeze-dried powder
The mixing of any one or two or more arbitrary proportion.
2. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that the Magnolia cortex P.E and oral cavity are prebiotic
The weight ratio of bacterium is 0.1:1～0.5:1.
3. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that the oral cavity probio is saliva breast bar
Bacterium freeze-dried powder.
4. application of any one Pediatric Oral Emergency care composition in Pediatric Oral Emergency care product is prepared described in claim 1-3.
5. apply according to claim 4, it is characterised in that the Pediatric Oral Emergency care composition is produced in Pediatric Oral Emergency nursing
Consumption in product is the 0.01～5% of Pediatric Oral Emergency care product gross weight.
6. apply according to claim 5, it is characterised in that the Pediatric Oral Emergency care composition is produced in Pediatric Oral Emergency nursing
Consumption in product is the 0.01～3% of Pediatric Oral Emergency care product gross weight.
7. apply according to claim 4, it is characterised in that the Pediatric Oral Emergency care product is the Pediatric Oral Emergency of 9～12 years old
Care product.
8. a kind of early benefit of benefit containing any one Pediatric Oral Emergency care composition described in claim 1-3 is late combines children's toothpaste,
It is characterized in that the benefit benefit evening children that early benefit evening combination children's toothpaste is used by the early children's toothpaste of benefit and evening that use in the morning
Toothpaste is constituted, and the formula of the benefit morning children's toothpaste is by NMF, thickener, abrasive material, xylitol, calcium containing compound, children's mouth
Chamber care composition, B B-complex, gentle surfactant, essence and deionized water are constituted, and the consumption of each recipe ingredient is such as
Shown in lower：
The formula of the benefit evening children's toothpaste is by NMF, thickener, abrasive material, compound sugar, amino acid composition, Pediatric Oral Emergency shield
Reason composition, B B-complex, gentle surfactant, essence and deionized water are constituted, the following institute of consumption of each recipe ingredient
Show：
Above-mentioned percentage is the percentage that each recipe ingredient accounts for total formula weight.
9. according to claim 8 benefit early benefit evening combines children's toothpaste, it is characterised in that the NMF is glycerine, sorb
The mixing of any one or two or more arbitrary proportion in alcohol, propane diols or polyethylene glycol, the thickener is carboxylic
The mixing of any one or two or more arbitrary proportion in sodium carboxymethylcellulose pyce, xanthan gum, xanthans or guar gum,
The abrasive material is food grade silicon dioxide, and the calcium containing compound is calcium glycerophosphate, and the compound sugar is FOS, oligomeric
Wood sugar, isomalto-oligosaccharide, galactooligosaccharide, soyabean oligosaccharides, coupling sugar, chitin compound sugar or trehalose, the gentle table
Face activating agent is sodium lauroyl sarcosine, sodium lauroyl glutamate, cocamidopropyl betaine, N- methyl cocoyl ox sulphurs
Any one mixing with laruyl alcohol sodium sulfovinate that sour sodium or pool fall in husky nurse.
10. according to claim 9 benefit early benefit evening combines children's toothpaste, it is characterised in that the gentle surfactant is the moon
Osmanthus acylsarcosine sodium, sodium lauroyl glutamate, cocamidopropyl betaine, N- sodium methyl cocoyl taurates moor sand
Any one in nurse is with laruyl alcohol sodium sulfovinate according to 1:Mixture of 0.1～3 weight than composition.
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| CN201710055001.XA CN106581159B (en) | 2017-01-24 | 2017-01-24 | Oral care composition for children and morning and evening benefiting combined toothpaste for children |
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Effective date of registration: 20210508 Address after: 510555 room 922, No.2, Tengfei 1st Street, Zhongxin Guangzhou Knowledge City, Huangpu District, Guangzhou City, Guangdong Province (office only) Patentee after: Guangzhou Shuke Industrial Co.,Ltd. Address before: Room 704, 705, West, No. 64, 66, Jianzhong Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU WEIMEIZI INDUSTRIAL Co.,Ltd. |