CN110013443A - A kind of Chinese medicine composition toothpaste containing functional oligose - Google Patents
A kind of Chinese medicine composition toothpaste containing functional oligose Download PDFInfo
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- CN110013443A CN110013443A CN201910057747.3A CN201910057747A CN110013443A CN 110013443 A CN110013443 A CN 110013443A CN 201910057747 A CN201910057747 A CN 201910057747A CN 110013443 A CN110013443 A CN 110013443A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of Chinese medicine composition toothpaste containing functional oligose, raw material components comprising following weight percent: 0.5~10% functional oligose, 0.1~5% anemarrhena asphodefoides extract, 0.1~5% Senna P.E, 0.1~5% Fructus Cannabis extract, 0.1~5% Semen Pruni extract, 20~50% moisturizer, 15~45% abrasive, 0.8~1.5% thickener, 1.8~2.5% surfactant, 0.15~0.3% sweetener, 0.1~0.3% preservative, 0.8~1.5% essence, deionized water is added to 100%.Specifically using functional oligose as probiotics (Bifidobacterium/lactobacillus) proliferation factor；Using rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed as clearing away heat and moistening the bowels regulator；Using toothpaste as carrier, providing one kind has cleaning oral cavity, has both and adjusts intestinal microecology and heat-clearing disperse accumulation in the Chinese medicine composition toothpaste of one.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition containing functional oligose, more particularly to it is a kind of containing functional oligose
Chinese medicine composition toothpaste belongs to oral care product technical field.
Background technique
In daily life, some people cause to get angry because diet is irregular, operating pressure is big, stays up late etc., lead to internal poison
Element accumulation causes constipation；For some people because of unreasonable diet structure, the food of intake is meticulous, lacks dietary fiber, stimulates enteron aisle
Deficiency, reflexive wriggle weakness cause constipation；Also some people because activity deficiency influence colonic peristalsis caused by constipation.
All it is the constipation as caused by bad life habits above, the hair of constipation can be reduced by changing lifestyles
It is raw, some health care products for having and promoting bowel movement function can also be taken.Also a kind of constipation and intestinal flora are unbalance related, Ke Yitong
Normal intestinal flora is overregulated, restores normal intestinal flora balance, constipation symptom is enable to alleviate.
In the various bacteriums of human body intestinal canal, lactobacillus and Bifidobacterium are the probiotics being widely recognized that.Lactobacillus is the mankind
The ancestral home flora with health care function recognized earliest, Bifidobacterium are most one of dominant bacterias in known human body intestinal canal flora,
It is the flora that newborn's enteron aisle is colonized earliest.Bifidobacterium can will generate lactic acid and acetic acid after sugar decomposition, making enteron aisle is in acidity,
As a result it can control the abnormal fermentation as caused by harmful bacteria, and stimulate enterocinesia, play the role of releasing constipation.People can lead to
It crosses and drinks Yoghourt containing Bifidobacterium (or lactobacillus) or beverage to supplement internal profitable strain, can also directly drink Bifidobacterium or cream
The probiotics of sour bacterium.But Bifidobacterium is very fragile, and viable bacteria meets air and is easy death, saves difficult, after eating and easy quilt
Gastric acid, bile etc. kill, and can enter the very little of large intestine safely, and because human body intestinal canal environment is different, are practised by food, life
The influence of used, health etc., can external Bifidobacterium settle down in human body large intestine and mass propagation remains query.Therefore not
Few scientist thinks that edible bifidus factor keeps the Bifidobacterium mass propagation in itself enteron aisle safer effectively.
So-called bifidus factor refers mainly to some functional oligoses, its property of can choose by Bifidobacterium as nutrition
To utilize.The quantity of profitable strain (Bifidobacterium), the proliferation of Bifidobacterium in functional oligose energy selective proliferative enteron aisle
Intestinal environment can be improved, the growth for inhibiting intestinal harmful bacillus, improve immunity of organisms, played an important role to prevent constipation.
Currently, the various functional oligoses with bifidus factor effect mass production, and be widely used in food,
But non-discovery feature oligosaccharide in toothpaste, is not also sent out as addition for the purpose of proliferation beneficial bacteria of intestinal tract, maintenance intestinal health
Existing traditional Chinese medicine rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed are as addition for the purpose of heat-clearing disperse accumulation, relax bowel and defecation in toothpaste.For
Meet the growing diversification of consumer, effect product demand, develop it is a kind of there is cleaning oral cavity, have both proliferation enteron aisle
The Chinese medicinal toothpaste that probiotics (Bifidobacterium/lactobacillus) and heat-clearing disperse accumulation are integrated is imperative.
Summary of the invention
The purpose of the present invention is to solve the above problem, theoretical according to intestinal microecology regulation mechanism and traditional Chinese medicine, with
Functional oligose is probiotics (Bifidobacterium/lactobacillus) proliferation factor；It is clear with rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed
Hot ease constipation regulator；Using toothpaste as carrier, providing one kind has cleaning oral cavity, has both adjusting intestinal microecology and heat-clearing disperse accumulation is
The Chinese medicine composition toothpaste of one.
The purpose of the present invention is what is realized by technical solution below.
A kind of Chinese medicine composition toothpaste containing functional oligose, is made of the raw material components of following weight percent:
0.5~10% functional oligose, 0.1~5% anemarrhena asphodefoides extract, 0.1~5% Senna P.E,
0.1~5% Fructus Cannabis extract, 0.1~5% Semen Pruni extract, 20~50% moisturizer, 15~45% friction
Agent, 0.8~1.5% thickener, 1.8~2.5% surfactant, 0.15~0.3% sweetener, 0.1~0.3%
Preservative, 0.8~1.5% essence, deionized water are added to 100%.
The functional oligose is " bifidus factor " with proliferation beneficial bacteria of intestinal tract (Bifidobacterium/lactobacillus), packet
Include one of xylo-oligosaccharide, oligofructose, oligoisomaltose, galactooligosaccharide, soyabean oligosaccharides, cow's milk oligosaccharide or more
Kind mixing；
The functional oligose preferred additive amount in toothpaste matrix is 1~5%.
The Chinese medicine composition is rhizoma anemarrhenae, folium sennae, four kinds of fructus cannabis, brush-cherry seed Chinese medical extracts；
The Chinese medical extract is extracted respectively from rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed with corresponding biology
Active pure powdered extract；
The preferred additive amount of Chinese medical extract additive amount in toothpaste matrix is respectively 0.5~2%, and Chinese medicine composition exists
Total addition level is not more than 8% in toothpaste matrix.
The anemarrhena asphodefoides extract is the pure powdered extract extracted from the dry rhizome of monocotyledon Liliaceae rhizoma anemarrhenae.
The Senna P.E is that the pure powdery extracted from the leaflet of the narrow leaf cassia angustifolia of leguminous plant or cassia acutifolia Delile mentions
Take object.
The Fructus Cannabis extract is the pure powdered extract extracted from the dry mature seed of moraceae plants hemp.
The Semen Pruni extract is the pure powdered extract extracted from the seed of rosaceous plant Europe Lee.
The anemarrhena asphodefoides extract extraction process are as follows: rhizoma anemarrhenae is crushed, 75% ethyl alcohol of 8 times of amounts, heating temperature 100 are added
DEG C, flow back 2h, extracts 3 times, combined extract, and then vacuum distillation recycling ethyl alcohol, is condensed into rhizoma anemarrhenae medicinal extract, after being dried under reduced pressure,
It is ground into 150 mesh or so anemarrhena asphodefoides extract.
The Senna P.E extraction process are as follows: folium sennae is crushed, 8 times of 0.5% sodium bicarbonate solution is added, is heated
90 DEG C, 1h is extracted, is extracted 2 times, is then concentrated, is dry, being ground into 150 mesh or so Senna P.E.
The Fructus Cannabis extract extraction process are as follows: fructus cannabis is crushed, it is molten to be added to the ethyl alcohol that mass concentration is 95%
It in liquid, is ultrasonically treated 30 minutes, the frequency of ultrasonic wave is 30kHZ, the water-bath reflux 2h at 85 DEG C, by the filter of collection after filtering
Liquid is placed in rotary evaporator, is set vacuum degree as -0.07~-0.1MPa, is evaporated under reduced pressure under conditions of 50 DEG C, powder after drying
It is broken into the Fructus Cannabis extract of 150 mesh or so.
The Semen Pruni extract extraction process are as follows: brush-cherry seed is crushed, it is molten to be added to the ethyl alcohol that mass concentration is 95%
It in liquid, is ultrasonically treated 30 minutes, the frequency of ultrasonic wave is 30kHZ, the water-bath reflux 2h at 85 DEG C, by the filter of collection after filtering
Liquid is placed in rotary evaporator, is set vacuum degree as -0.07~-0.1MPa, is evaporated under reduced pressure under conditions of 50 DEG C, powder after drying
It is broken into the Semen Pruni extract of 150 mesh or so.
The rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed extracting method be not limited to the above method, can also use
Other advanced technologies are extracted, and existing commercially available extract also can be used.
The moisturizer is one of glycerol, sorbierite, polyethylene glycol, propylene glycol or a variety of mixtures.
The abrasive is one or both of calcium carbonate, calcium monohydrogen phosphate, silica mixture.
The thickener is one or both of sodium carboxymethylcellulose, xanthan gum, melon rubber, carragheen mixture.
The surfactant is laruyl alcohol sodium sulfovinate, in sodium lauroyl sarcosine, Cocoamidopropyl betaine
One or two kinds of mixtures.
The sweetener is one or both of saccharin sodium, Sucralose, Aspartame, stevioside mixture.
The preservative is one or both of sodium benzoate, parabens mixture.
Above-mentioned toothpaste component also may include other additives, such as hydroxyapatite, sodium pyrophosphate, sodium phytate, potassium nitrate, chlorine
Change strontium, fluoride, xylitol, titanium dioxide, mica etc..
Chinese medicine composition containing functional oligose of the invention, however it is not limited to be applied in toothpaste, only consider tooth
Cream is the highest oral care product of people's routine use frequency, is to apply also for mouthwash, tooth in optimum carrier
Other oral care products such as powder, mouth spray, effervescent tablet.
The invention has the advantages that and the utility model has the advantages that
1, a kind of Chinese medicine composition and its toothpaste containing functional oligose of the invention, is added by functional oligose
It is added in toothpaste and promotes the growth and breeding of the intrinsic probiotics of human body (Bifidobacterium/lactobacillus), it is (double to solve external probiotics
Discrimination bacillus/lactobacillus) the problem of being difficult in enteron aisle field planting and mass propagation, also solve external probiotics (Bifidobacterium/cream
Bacillus) by the inhibiting effect of surfactant, essence, preservative etc. in toothpaste, it is unfavorable for the preservation of viable bacteria and leads to product most
Eventually the problem of failure.
Functional oligose adjusts intestinal microecology mainly for the proliferation of beneficial bacteria of intestinal tract (Bifidobacterium/lactobacillus)
Balance can be obviously improved enteric microorganism population ratio, and harmful bacteria is inhibited to breed in enteron aisle, reduce and inhibit enteron aisle corrupt substance
It generates, promotes intestines peristalsis, accelerate the discharge of enteron aisle residue, there is good righting to make constipation caused by intestinal bacilli illness
With.Intestinal microecology health is inseparable with oral health, and constipation often causes the oral problems such as halitosis, to caused by constipation
It is another beneficial effect of the invention that halitosis, which carries out root elimination,.
Functional oligose is also a kind of sweetener, and addition can reduce the use of (or cancellation) high sweetener in toothpaste
Amount reduces adverse effect of the Chinese medicine composition to toothpaste mouthfeel, keeps toothpaste mouthfeel more Shu Rou pure.
2, a kind of Chinese medicine composition and its toothpaste containing functional oligose of the invention, passes through rhizoma anemarrhenae, folium sennae, fire
In toothpaste, which has heat-clearing disperse accumulation, effect of relaxing bowel for edestan, brush-cherry seed composition Chinese medicine composition addition,
Constipation caused by scorching to enteron aisle has good relaxation effect.Rhizoma anemarrhenae, clearing heat-fire, moisturizing dryness and lubricating intestine, effect mitigate, and are hair conditioning
Cathartic；Folium sennae, heat-clearing row is stagnant, diuresis defaecation, is the violent medicine of irritation, and the cooperation of two medicines tempers toughness with gentleness, refinforces each other.Fructus cannabis is grown
It supports and moisturizes, effect mitigates, and without hurting saliva under rushing down, brush-cherry seed laxation defaecation, effect is stronger, and it rushes down lower and makes one body fluid deficiency, the cooperation of two medicines,
It can be increased discharge function, and it can be made and hurt saliva consumption liquid, one upon soft, refinforces each other.
3, a kind of Chinese medicine composition and its toothpaste containing functional oligose of the invention, functional oligose is enteron aisle
Probiotics provides nutrition, promotes the proliferation of probiotics, improves human body intestinal canal environment rapidly, forms chemical barrier and microorganism screen
Barrier enhances probiotics intestinal colonisation power, inhibits harmful bacteria, improves function of intestinal canal, is the adjustment process to intestinal microecology balance.
Four kinds of rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed Chinese medicine composition energy clearing heat and moistening dryness stimulate intestinal mucosa, increase secretion, wriggle
Accelerate, reduce absorption of the large intestine to moisture, reaches quick decorporation effect.Quick decorporation may cause one or two people slight abdomen occur
Rush down, functional oligose can alleviate diarrhea, be it is a kind of not only decorporation but also the bidirectional modulation agent of diarrhea can be can be relieved, so functional
Oligosaccharide compatibility Chinese medicine composition, can decorporation be not easy diarrhea again.
4, a kind of Chinese medicine composition and its toothpaste containing functional oligose of the invention, can not only clean oral cavity, also
Vivotoxin can be discharged in time, reduce the accumulation of toxin in vivo, intestinal health is safeguarded, to because in intestinal bacilli illness and enteron aisle
Constipation caused by fire has good removal effect.Although efficacy effect point of the invention is in enteron aisle, digestion is one
A entirety, intestinal health is inseparable with oral health, and constipation often causes halitosis, this tooth for having effects that consolidate righting
Cream can more play the health-care effect that disease is not controlled first subtlely.
Specific embodiment
A kind of Chinese medicine composition and its toothpaste containing functional oligose of the invention, the original comprising following weight percent
Material component: 0.5~10% functional oligose, 0.1~5% anemarrhena asphodefoides extract, 0.1~5% Senna P.E,
0.1~5% Fructus Cannabis extract, 0.1~5% Semen Pruni extract, 20~50% moisturizer, 15~45% friction
Agent, 0.8~1.5% thickener, 1.8~2.5% surfactant, 0.15~0.3% sweetener, 0.1~0.3%
Preservative, 0.8~1.5% essence, deionized water are added to 100%.
Be below to the present invention relates to active constituent brief statement:
Functional oligose is to be polymerized by 2-10 identical or different monosaccharide with glycosidic bond, the spy with carbohydrate
Property, it can be used as sweetener, but not by human body alimentary canal enzyme and gastric acid degradation, not by (or difficult quilt) small intestinal absorption.Therefore it can after eating
It is utilized into large intestine by the Bifidobacterium in large intestine, makes internal Bifidobacterium mass propagation, inhibit harmful bacteria, it is micro- to adjust enteron aisle
The ecological balance promotes intestines peristalsis, improves function of intestinal canal, prevents the generation of constipation, be internationally recognized " colon food " and intestines
Road probiotics growth-promoting object.
Rhizoma anemarrhenae is the dry rhizome of monocotyledon Liliaceae rhizoma anemarrhenae.Bitter, cold in nature, return lung, stomach, kidney channel have heat-clearing
The effect of purging intense heat, moisturizing dryness and lubricating intestine, is used for pyreticosis and polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, the diseases such as dry constipation of intestines.
The anemarrhena asphodefoides extract extraction process are as follows: rhizoma anemarrhenae is crushed, 75% ethyl alcohol of 8 times of amounts, heating temperature 100 are added
DEG C, flow back 2h, extracts 3 times, combined extract, and then vacuum distillation recycling ethyl alcohol, is condensed into rhizoma anemarrhenae medicinal extract, after being dried under reduced pressure,
It is ground into 150 mesh or so anemarrhena asphodefoides extract.
Folium sennae is the leaflet of the narrow leaf cassia angustifolia of leguminous plant or cassia acutifolia Delile.It is sweet in flavor, bitter, it is cold in nature, return large intestine channel, has
Heat-clearing row is stagnant, defaecation, diuresis effect stagnate for irritant laxative for heat knot, constipation abdominal pain, the diseases such as edema swelling.
The Senna P.E extraction process are as follows: folium sennae is crushed, 8 times of 0.5% sodium bicarbonate solution is added, is heated
90 DEG C, 1h is extracted, is extracted 2 times, is then concentrated, is dry, being ground into 150 mesh or so Senna P.E.
Fructus cannabis is the dry mature seed of moraceae plants hemp.Sweet in flavor, mild-natured, returns spleen, stomach, large intestine channel have ease constipation
The effect of desinsection, is moisturized in defaecation, is used for blood deficiency and depleted fluid, the diseases such as dry constipation of intestines.
The Fructus Cannabis extract extraction process are as follows: fructus cannabis is crushed, it is molten to be added to the ethyl alcohol that mass concentration is 95%
It in liquid, is ultrasonically treated 30 minutes, the frequency of ultrasonic wave is 30kHZ, the water-bath reflux 2h at 85 DEG C, by the filter of collection after filtering
Liquid is placed in rotary evaporator, is set vacuum degree as -0.07~-0.1MPa, is evaporated under reduced pressure under conditions of 50 DEG C, powder after drying
It is broken into the Fructus Cannabis extract of 150 mesh or so.
Brush-cherry seed is the seed of rosaceous plant Europe Lee.Acrid flavour, hardship, sweet, mild-natured, returns spleen, large intestine, small intestinl channel have profit
The effect of dry laxation, lower gas row is stagnant, inducing diuresis for removing edema, for diseases such as intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, difficult urinations.
The Semen Pruni extract extraction process are as follows: brush-cherry seed is crushed, it is molten to be added to the ethyl alcohol that mass concentration is 95%
It in liquid, is ultrasonically treated 30 minutes, the frequency of ultrasonic wave is 30kHZ, the water-bath reflux 2h at 85 DEG C, by the filter of collection after filtering
Liquid is placed in rotary evaporator, is set vacuum degree as -0.07~-0.1MPa, is evaporated under reduced pressure under conditions of 50 DEG C, powder after drying
It is broken into the Semen Pruni extract of 150 mesh or so.
Below by specific embodiment, the present invention is further explained, but these embodiments are used only for that it is described in more detail
With, and it is not applied to that present invention is limited in any form.
Embodiment 1
A kind of toothpaste of the Chinese medicine composition containing functional oligose includes by weight percentage following raw material group
Point:
Manufacture craft is as follows:
1) methylparaben, nipalgin third, essence are added in container A, stirring and dissolving；
2) deionized water is added in premix pot B, it is oligomeric that saccharin sodium, sodium pyrophosphate, xylo-oligosaccharide, cow's milk is then added
Sugar, anemarrhena asphodefoides extract, Senna P.E, Fructus Cannabis extract, Semen Pruni extract and stirring and dissolving；
3) polyethylene glycol, sorbierite are added in premix pot C；
4) calcium carbonate, silica, sodium carboxymethylcellulose, xanthan gum, laruyl alcohol sodium sulfovinate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
It mixes, sucks the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can
Cream out.
Embodiment 2
A kind of Chinese medicine composition toothpaste containing functional oligose includes by weight percentage following raw material components:
Manufacture craft is as follows:
1) deionized water is added in premix pot B, Sucralose, Aspartame, sodium pyrophosphate, benzoic acid is then added
Sodium, oligofructose, soyabean oligosaccharides, anemarrhena asphodefoides extract, Senna P.E, Fructus Cannabis extract, Semen Pruni extract, laurel
Acylsarcosine sodium and stirring and dissolving；
2) propylene glycol, glycerol, sorbierite are added in premix pot C；
3) meal mixer is added in calcium monohydrogen phosphate, silica, sodium carboxymethylcellulose, melon rubber, laruyl alcohol sodium sulfovinate
In；
4) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
It mixes, sucks the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, essence is sucked, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
Embodiment 3
A kind of Chinese medicine composition toothpaste containing functional oligose includes by weight percentage following raw material components:
Manufacture craft is as follows:
1) methylparaben, essence are added in container A, stirring and dissolving；
2) deionized water is added in premix pot B, sodium pyrophosphate, sodium fluoride, galactooligosaccharide, rhizoma anemarrhenae is then added and extracts
Object, Senna P.E, Fructus Cannabis extract, Semen Pruni extract, mica and stirring and dissolving；
3) polyethylene glycol, sorbierite are added in premix pot C；
4) silica, sodium carboxymethylcellulose, carragheen, laruyl alcohol sodium sulfovinate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
It mixes, sucks the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in A container is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can
Cream out.
Embodiment 4
A kind of Chinese medicine composition toothpaste containing functional oligose includes by weight percentage following raw material components:
Manufacture craft is as follows:
1) deionized water is added in premix pot B, stevioside, sodium pyrophosphate, sodium benzoate, oligosaccharide malt is then added
Sugar, anemarrhena asphodefoides extract, Senna P.E, Fructus Cannabis extract, Semen Pruni extract, cocamidopropyl propyl amide beet simultaneously stir molten
Solution；
2) polyethylene glycol, sorbierite are added in premix pot C；
3) mixed powder is added in silica, hydroxyapatite, sodium carboxymethylcellulose, carragheen, laruyl alcohol sodium sulfovinate
In device；
4) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
It mixes, sucks the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, essence is sucked, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
Effete test embodiment
Test example one: disperse accumulation removal effect evaluation
60 volunteers are chosen, without great or systemic disease, there is constipation symptom, and defecation frequency is less than 4 times weekly
Constipation crowd, the age at 20~50 years old, is randomly divided into test group and control group, every group of 30 people.Test group uses 1 function of embodiment
Toothpaste is imitated, control group is brushed teeth 3 times daily using the blank toothpaste of embodiment 1 (being free of functional component), and it is early, middle and late each primary,
No less than 3 minutes every time, defecation frequency weekly is recorded in use process, recalling surveys after continuous use 4 weeks the results are shown in Table 1.
Evaluation criterion:
Recovery from illness: defecation frequency is at 7 times weekly.
Effective: defecation frequency is at 6 times weekly.
Improve: defecation frequency is at 5 times weekly.
Invalid: defecation frequency is at 4 times weekly.
Utility efficiency result statistics is shown in Table 1.
1 disperse accumulation decorporation investigation result of table statistics
| Group | Number | Recovery from illness | It is effective | It improves | In vain | Efficient % |
| Test group | 30 | 8 | 14 | 5 | 3 | 90% |
| Control group | 30 | 0 | 2 | 6 | 22 | 27% |
By 1 disperse accumulation decorporation of table, the survey showed that: using after 4 weeks, test group crowd's defecation frequency significantly increases, constipation phase
It closes symptom to be eased, enteron aisle feels more comfortable, does not find diarrhea, abdominal pain phenomenon, does not also occur other adverse reactions, tests
Group is also fed back, and also has good effect after use to halitosis；Control group is invalid as the result is shown.Illustrate of the invention containing functionality
The Chinese medicine composition toothpaste of oligosaccharide has the effect of certain in adjusting intestinal microecology and Qingre Xiaoji Recipe face.
Test example two: functional oligose and the evaluation of Chinese medicine composition synergy
60 volunteers are chosen, without great or systemic disease, there is constipation symptom, and defecation frequency is less than 4 times weekly
Constipation crowd, the age at 20~50 years old, is randomly divided into test group and control group, every group of 30 people.Test group uses 2 tooth of embodiment
Cream, control group are free of other component combines of functional oligose using embodiment 2, are the toothpaste containing only Chinese medicine composition, with
The synergistic function of this authentication functionality oligosaccharide and Chinese medicine composition.Subject brushes teeth 3 times daily, and early, middle and late each one
It is secondary, no less than 3 minutes every time, defecation frequency weekly and defecation state were recorded in use process, pays a return visit and adjusts after continuous use 4 weeks
It looks into, the results are shown in Table 2.
2 investigation result of table statistics
Known by table 2: test group does not occur the adverse reaction of abdominal pain, diarrhea, control group makes using in 2 toothpaste of embodiment
Functional oligose is free of with embodiment 2,3 abdominal pain and 4 diarrhea phenomenons, explanation occurs in the toothpaste containing only Chinese medicine composition
Functional oligose and Chinese medicine composition compatibility have the abdominal pain and abdomen for eliminating that Chinese medicine composition occurs during disperse accumulation decorporation
Rush down phenomenon；Test group effective percentage is higher than control group, and functions oligosaccharide and Chinese medicine composition compounding are than single Chinese traditional medicine composition
Object is with more improvement function of intestinal canal.Thus functions oligosaccharide and Chinese medicine composition have synergistic function.
Test example three: improve the evaluation of intestinal microecology health and oral health
30 volunteers are chosen, without great or systemic disease, there is constipation symptom, and defecation frequency is less than 4 times weekly
Constipation crowd, the age, subject used the toothpaste of embodiment 3, brushes teeth daily 3 times at 20~50 years old, early, middle and late each primary,
No less than 3 minutes every time.On the day before subject's use (the 0th day), using the 14th day and use progress implication measurement in the 28th day,
Record subject's implication average value.Implication is measured, using Halimeter implication analyzer, by causing in measurement implication
The concentration of the volatile sulfur compounds (hydrogen sulfide, methyl mercaptan) of halitosis evaluates halitosis intensity, and implication average value is shown in Table 3.
3 implication average value of table
Known by 3 implication measurement result of table, after subject has used the toothpaste of embodiment 3, in the 14th day and the 28th day implication
Hydrogen sulfide and the concentration of methyl mercaptan be decreased obviously than the 0th day, illustrate that oral peculiar smell is gradually eliminated, it was demonstrated that embodiment toothpaste is logical
Intestinal microecology health and heat-clearing disperse accumulation are overregulated, is gradually recovered enteron aisle normally, internal heat toxin is gradually discharged, oral peculiar smell
(because constipation causes) is gradually eliminated.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of Chinese medicine composition toothpaste containing functional oligose, it is characterised in that: be by the original of following weight percent
Material group is grouped as:
0.5~10% functional oligose, 0.1~5% anemarrhena asphodefoides extract, 0.1~5% Senna P.E, 0.1~
5% Fructus Cannabis extract, 0.1~5% Semen Pruni extract, 20~50% moisturizer, 15~45% abrasive,
0.8~1.5% thickener, 1.8~2.5% surfactant, 0.15~0.3% sweetener, 0.1~0.3% it is anti-
Rotten agent, 0.8~1.5% essence, deionized water are added to 100%.
2. the Chinese medicine composition toothpaste according to claim 1 containing functional oligose, it is characterised in that: the function
Property oligosaccharide be " bifidus factor " with proliferation beneficial bacteria of intestinal tract (Bifidobacterium/lactobacillus), including xylo-oligosaccharide, oligomeric fruit
One of sugar, oligoisomaltose, galactooligosaccharide, soyabean oligosaccharides, cow's milk oligosaccharide or a variety of mixing, in toothpaste matrix
Middle additive amount is 1~5%.
3. the Chinese medicine composition toothpaste according to claim 1 containing functional oligose, it is characterised in that: the Chinese medicine
Extract is that the pure powdery with corresponding bioactivity extracted respectively from rhizoma anemarrhenae, folium sennae, fructus cannabis, brush-cherry seed extracts
Object, additive amount is respectively 0.5~2% in toothpaste matrix, and Chinese medicine composition total addition level in toothpaste matrix is no more than 8%.
4. the Chinese medicine composition toothpaste according to claim 3 containing functional oligose, it is characterised in that: the rhizoma anemarrhenae
Extract extraction process are as follows:
Rhizoma anemarrhenae is crushed, 75% ethyl alcohol of 8 times of amounts is added, heating temperature is 100 DEG C, and flow back 2h, it extracts 3 times, combined extract,
Then vacuum distillation recycling ethyl alcohol, is condensed into rhizoma anemarrhenae medicinal extract, after being dried under reduced pressure, is ground into the anemarrhena asphodefoides extract of 150 mesh or so.
5. the Chinese medicine composition toothpaste according to claim 3 containing functional oligose, it is characterised in that: the cassia angustifolia
Leaf extract extraction process are as follows:
Folium sennae is crushed, 8 times of 0.5% sodium bicarbonate solution is added, heats 90 DEG C, extracts 1h, is extracted 2 times, is then concentrated, is dry
Dry, to be ground into 150 mesh or so Senna P.E.
6. the Chinese medicine composition toothpaste according to claim 3 containing functional oligose, it is characterised in that: the fire fiber crops
Benevolence extract extraction process are as follows:
Fructus cannabis is crushed, is added in the ethanol solution that mass concentration is 95%, is ultrasonically treated 30 minutes, the frequency of ultrasonic wave
For 30kHZ, water-bath flows back 2h at 85 DEG C, and the filtrate of collection is placed in rotary evaporator after filtering, set vacuum degree as-
0.07~-0.1MPa is evaporated under reduced pressure under conditions of 50 DEG C, crushed after being dried at 150 mesh or so Fructus Cannabis extract.
7. the Chinese medicine composition toothpaste according to claim 3 containing functional oligose, it is characterised in that: strongly fragrant Lee
Benevolence extract extraction process are as follows:
Brush-cherry seed is crushed, is added in the ethanol solution that mass concentration is 95%, is ultrasonically treated 30 minutes, the frequency of ultrasonic wave
For 30kHZ, water-bath flows back 2h at 85 DEG C, and the filtrate of collection is placed in rotary evaporator after filtering, set vacuum degree as-
0.07~-0.1MPa is evaporated under reduced pressure under conditions of 50 DEG C, crushed after being dried at 150 mesh or so Semen Pruni extract.
8. the Chinese medicine composition toothpaste according to claim 1 containing functional oligose, it is characterised in that:
The moisturizer is one of glycerol, sorbierite, polyethylene glycol, propylene glycol or a variety of mixtures；
The abrasive is one or both of calcium carbonate, calcium monohydrogen phosphate, silica mixture；
The thickener is one or both of sodium carboxymethylcellulose, xanthan gum, melon rubber, carragheen mixture；
The surfactant is one of laruyl alcohol sodium sulfovinate, sodium lauroyl sarcosine, Cocoamidopropyl betaine
Or two kinds of mixtures；
The sweetener is one or both of saccharin sodium, Sucralose, Aspartame, stevioside mixture；
The preservative is one or both of sodium benzoate, parabens mixture.
9. the Chinese medicine composition toothpaste according to claim 1 containing functional oligose, it is characterised in that: the toothpaste
Component also may include other additives, and other additives are selected from hydroxyapatite, sodium pyrophosphate, sodium phytate, potassium nitrate, chlorine
Change one of strontium, fluoride, xylitol, titanium dioxide, mica or a variety of mixtures.
10. a kind of application of the Chinese medicine composition containing functional oligose, it is characterised in that: described to contain functional oligose
Chinese medicine composition, however it is not limited to be applied in toothpaste, only consider that toothpaste is people's routine use frequency highest oral cavity shield
Product is managed, is to apply also for other oral care products such as mouthwash, tooth powder, mouth spray, effervescent tablet in optimum carrier；
The Chinese medicine composition containing functional oligose includes the material component of following parts by weight:
5~10 parts of functional oligose, 1~5 part of anemarrhena asphodefoides extract, 0.1~5 part of Senna P.E, 0.1~5 part
Fructus Cannabis extract, 0.1~5 part of Semen Pruni extract；The functional oligose is (double with proliferation beneficial bacteria of intestinal tract
Discrimination bacillus/lactobacillus) " bifidus factor ", including xylo-oligosaccharide, oligofructose, oligoisomaltose, galactooligosaccharide, soybean
One of oligosaccharide, cow's milk oligosaccharide or a variety of mixing.
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Cited By (1)
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| CN111701014A (en) * | 2020-08-12 | 2020-09-25 | 好易康生物科技(广州)有限公司 | Toothpaste for children and preparation method thereof |
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Application publication date: 20190716 |