CN109908072A - A kind of marine polysaccharide toothpaste and preparation method thereof containing profitable probliotics - Google Patents
A kind of marine polysaccharide toothpaste and preparation method thereof containing profitable probliotics Download PDFInfo
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- CN109908072A CN109908072A CN201910281396.4A CN201910281396A CN109908072A CN 109908072 A CN109908072 A CN 109908072A CN 201910281396 A CN201910281396 A CN 201910281396A CN 109908072 A CN109908072 A CN 109908072A
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Abstract
A kind of marine polysaccharide toothpaste and preparation method thereof containing profitable probliotics, is related to oral care implement field.Each raw material composition and its mass percent are as follows: carboxymethyl chitosan 0.8%~1%；Rubbing agent 20%~30%；Moisturizer 20%~50%；Foaming agent 1%~3%；Probiotics 1%；Thickener 1%~2%；Preservative 0.01%~0.06%；Flavouring agent 1%；Surplus is deionized water.According to the composition and its mass percent of each raw material, carboxymethyl chitosan, probiotics and moisturizer etc. are put into deionized water and stir to get deionized water solution, simultaneously vacuum outgas is mixed with rubbing agent, thickener and foaming agent again, continue to stir after flavouring agent is added, up to the marine polysaccharide toothpaste containing profitable probliotics after vacuum outgas bubble.For the first time by marine polysaccharide in conjunction with probiotics, experimental result is shown, related oral disease caused by lacking of proper care to oral cavity microbial flora has good improvement result.
Description
Technical field
The present invention relates to oral care implement field, more particularly, to adjustable and establish oral cavity normal bio microenvironment
A kind of marine polysaccharide toothpaste and preparation method thereof containing profitable probliotics.
Background technique
Toothpaste is a kind of common detergent for oral cleaning.Currently, have hundreds of functional toothpaste on the market, it is full
Foot difference consumers are for the demand that protects the health of one's mouth.
Probiotics is a kind of microorganism being beneficial to health, currently, common probiotics includes Bifidobacterium, lactic acid
Bacillus, bacillus subtilis etc., shape are rod-shaped or spherical；It exists extensively, acidophilia, and existence optimal pH is 5.5~6.0.
Water soluble chitosan is a kind of form of chitosan, and form may include carboxymethyl chitosan, chitosan hydrochlorate
Deng wherein carboxymethyl chitosan is a kind of carboxyl methylation derivant of common chitosan, good water solubility, while can be certain
Guarantee corresponding bioactivity under concentration.Currently, it is relatively more about the example that chitosan is applied to maintenance oral health, such as in
State patent CN106491389A discloses a kind of chitosan shield tooth children's toothpaste, is made of by mass percentage following components: 0.2%
~0.4% propolis tincture, 0.2%~0.4% tea polyphenols, 0.2%~0.4% xylitol, 0.4%~0.8% citric acid, 1%~
4% vitamin, 10%~15% Silica Using for Toothpaste, 40%~90% glycerol, 40%~70% sorbierite, 8%~12%
Sodium cellulose glycolate, 0.4%~1.2% water soluble chitosan, 0.5%~1.2% sodium fluoride, 0.2%~0.6% saccharin
Sodium, 0.5%~1.5% sucrose fatty ester, 0.2%~0.5% lauryl sodium sulfate, 0.6%~0.8% fruity flavor,
0.8%~1.6% sodium benzoate, 20%~30% deionized water, mention and use chitosan as oral bacteriostasis agent.Liu Jin etc.
(Liu Jin etc., carboxymethyl chitosan is to the inhibiting effect of oral cavity streptococcus mutans and oral cavity Bacillus acidi lactici, and Journal of Nanjing Normal University is (certainly
So science version), 1999,22 (4)) it explicitly points out carboxymethyl chitosan and can effectively inhibit harmful bacteria in oral cavity, such as oral cavity
The pathogenic bacteria such as streptococcus mutans achieve the purpose that protect oral cavity just health.Either soluble chitosan or traditional big
Molecular weight chitosan, antifungal mechanism derive from ammonium cation such as carboxymethyl chitosan therein, can effectively inhibit leather blue
The growth of family name's positive bacteria and gramnegative bacterium, long-acting holding oral health.
Currently, being mainly toothpaste by the oral-cavity article of main active of carboxymethyl chitosan, but mostly grind
Study carefully or finished product also rests in the single formula of carboxymethyl chitosan, is i.e. antibacterial work of the examination carboxymethyl chitosan for oral cavity
With Wu Di etc. is pointed out in its article: carboxymethyl chitosan has the features such as good antibacterial, biocompatibility, can kill big
The bacterium of amount；Yuan Wen etc. points out that carboxymethyl chitosan can kill a large amount of bacteriums such as Escherichia coli, staphylococcus aureus, oral cavity
In common disease such as halitosis, swelling and aching of gum etc. caused by harmful microbe growth, such as porphyromonas gingivalis etc..But it is single
While one carboxymethyl chitosan ingredient inhibits harmful bacteria, part beneficial bacteria can also be inhibited, and people is intracorporal
Oral health needs the balance of multiple-microorganism, this means that and is possible to lead under conditions of only carboxymethyl chitosan is added
The unbalance of oral microorganism environment is caused, and adds probiotics at this time, it is beneficial that killed part in oral microorganism can be supplemented
The problems such as microorganism makes up because microorganism reduces be may cause flora imbalance, and oral immunisation power is low.In addition, microorganism
Between there is competition and synergistic effect, such balance can preferably be consolidated by adding the beneficial microbe that screens from oral cavity, be sent out
The synergistic effect of population is waved, the biological accumulation amount in unit area is improved, and then plays the effect of beneficial microorganism positive feedback,
And the synergistic effect is that can not have in single formula (carboxymethyl chitosan).
Summary of the invention
The object of the present invention is to provide one kind that is a kind of adjustable and establishing oral cavity normal bio microenvironment containing profitable probliotics
Marine polysaccharide toothpaste and preparation method thereof.
Each raw material of the marine polysaccharide toothpaste containing profitable probliotics forms and its mass percent are as follows:
Commercial product can be used in the carboxymethyl chitosan.
Hydrated silica etc. can be used in the rubbing agent.
Polyethylene glycol-400 etc. can be used in the moisturizer.
Laruyl alcohol sodium sulfovinate etc. can be used in the foaming agent.
Freeze-dry Powder of Probioctics can be used in the probiotics, and the freeze-drying of saliva Bacillus acidi lactici can be used in the Freeze-dry Powder of Probioctics
Powder, the cell concentration of probiotics can be 1 × 108CFU/mL, the number of viable of Freeze-dry Powder of Probioctics can be 12,000,000,000 bacterium/100g.
Cellulose gum etc. can be used in the thickener.
Sodium benzoate etc. can be used in the preservative.
Spearmint essence etc. can be used in the flavouring agent.
Following methods preparation can be used in the present invention:
According to the composition and its mass percent of each raw material, carboxymethyl chitosan, probiotics and moisturizer etc. are put into
Deionized water solution is stirred to get in ionized water, then simultaneously vacuum outgas is mixed with rubbing agent, thickener and foaming agent, is added
Continue to stir after flavouring agent, up to the marine polysaccharide toothpaste containing profitable probliotics after vacuum outgas bubble.
The present invention carboxymethyl chitosan can be added in toothpaste and probiotics prepares toothpaste, and wherein carboxymethyl chitosan adds
Dosage is the 0.8% of conventional dentifrices by mass percentage, and the additive amount of probiotics is the 1% of conventional dentifrices by mass percentage
In formulation of tooth-paste, the carboxymethyl chitosan containing Bacillus acidi lactici is added, adjusts oral microorganism bacterium to reach solution
Group's balance and anti-inflammatory and other effects.
For the first time by marine polysaccharide in conjunction with probiotics, experimental result is shown the present invention, and the present invention is to oral microorganism
Related oral disease caused by flora imbalance has good improvement result.Effective component and clear efficacy of the invention, safety
Property it is higher, preparation is simple, is suitble to industrialization production, there is great market development potential.
Specific embodiment
Following embodiment will be further illustrated the present invention.
Embodiment 1: the constituent and mass percent of the biological polyoses toothpaste containing profitable probliotics and contain raw material of toothpaste formula
Amount is as shown in table 1.
Table 1
According to the above ratio by carboxymethyl chitosan, polyethylene glycol-400, sodium benzoate, be put into deionized water and sufficiently stir
It mixes, is mixed with hydrated silica, cellulose gum, laruyl alcohol sodium sulfovinate, be put into Manufacturing medicine extract machine, start high-speed stirred 30min, then
Spearmint essence is added, continues to stir 20min, sterilizing point after the marine polysaccharide toothpaste containing profitable probliotics is made in vacuum outgas
Dress.
Marine polysaccharide toothpaste obtained by above-mentioned example containing profitable probliotics is mainly used for oral cavity dental caries and inhibits mouth
The target group (6 people) of the oral problems such as gas uses, and observes service condition, and experimental subjects has different degrees of oral health to ask
Topic, experimental period 5 days by a definite date, wherein usage mode was brushed teeth twice sooner or later for everyone, and the lotion quality and teeth brushing way used is silent
Think consistent, table 2 be experimenter's data before testing and used the experimental result after toothpaste.
Table 2
From the point of view of above-mentioned experimental program, after 5 days, oral problem involved in experimenter can be different degrees of
On be eased.
Embodiment 2: the constituent and mass percent of the biological polyoses toothpaste containing profitable probliotics and contain raw material of toothpaste formula
Amount is as shown in table 3.
Table 3
Carboxymethyl chitosan, polyethylene glycol-400, sodium benzoate are put into deionized water and are sufficiently stirred according to the above ratio,
Mixed with hydrated silica, cellulose gum, laruyl alcohol sodium sulfovinate, be put into Manufacturing medicine extract machine, start high-speed stirred 30min, then plus
Enter spearmint essence, continues to stir 20min, sterilizing packing after the marine polysaccharide toothpaste containing profitable probliotics is made in vacuum outgas.
Toothpaste obtained by above-mentioned example is mainly used for oral cavity dental caries and inhibits the target group (6 of the oral problems such as implication
People) it uses, service condition is observed, experimental subjects has a different degrees of oral health issue, and experimental period 5 days by a definite date, wherein
Usage mode for everyone sooner or later brush teeth twice, the lotion quality used be defaulted as with teeth brushing way it is consistent, table 4 be test before reality
The person's of testing data and used the experimental result after toothpaste.
Table 4
From the point of view of above-mentioned experimental program, after 5 days, oral problem involved in experimenter can be different degrees of
On be eased.
Embodiment 3: the constituent and mass percent of the biological polyoses toothpaste containing profitable probliotics and contain raw material of toothpaste formula
Amount is as shown in table 5.
Table 5
Carboxymethyl chitosan, polyethylene glycol-400, sodium benzoate are put into deionized water and are sufficiently stirred according to the above ratio,
Mixed with hydrated silica, cellulose gum, laruyl alcohol sodium sulfovinate, be put into Manufacturing medicine extract machine, start high-speed stirred 30min, then plus
Enter spearmint essence, continues to stir 20min, sterilizing packing after the marine polysaccharide toothpaste containing profitable probliotics is made in vacuum outgas.
Toothpaste obtained by above-mentioned example is mainly used for oral cavity dental caries and inhibits the target group (6 of the oral problems such as implication
People) it uses, service condition is observed, experimental subjects has a different degrees of oral health issue, and experimental period 5 days by a definite date, wherein
Usage mode for everyone sooner or later brush teeth twice, the lotion quality used be defaulted as with teeth brushing way it is consistent, table 6 be test before reality
The person's of testing data and used the experimental result after toothpaste.
Table 6
From the point of view of above-mentioned experimental program, after 5 days, oral problem involved in experimenter can be different degrees of
On be eased.From the point of view of the result fed back of experiment member, hence it is evident that the time to work than other groups, effect was more excellent earlier
It is elegant.
Embodiment 4: the constituent and mass percent of the biological polyoses toothpaste containing profitable probliotics and contain raw material of toothpaste formula
Amount is as shown in table 7.
Table 7
Carboxymethyl chitosan, polyethylene glycol-400, sodium benzoate are put into deionized water and are sufficiently stirred according to the above ratio,
Mixed with hydrated silica, cellulose gum, laruyl alcohol sodium sulfovinate, be put into Manufacturing medicine extract machine, start high-speed stirred 30min, then plus
Enter spearmint essence, continues to stir 20min, sterilizing packing after the marine polysaccharide toothpaste containing profitable probliotics is made in vacuum outgas.
Toothpaste obtained by above-mentioned example is mainly used for oral cavity dental caries, inhibits the target group (6 of the oral problems such as implication
People) it uses, service condition is observed, experimental subjects has a different degrees of oral health issue, and experimental period 5 days by a definite date, wherein
Usage mode for everyone sooner or later brush teeth twice, the lotion quality used be defaulted as with teeth brushing way it is consistent, table 8 be test before reality
The person's of testing data and used the experimental result after toothpaste.
Table 8
From the point of view of above-mentioned experimental program, after 5 days, oral problem involved in experimenter can be different degrees of
On be eased.
Embodiment 5: the constituent and mass percent of the biological polyoses toothpaste containing profitable probliotics and contain raw material of toothpaste formula
Amount is as shown in table 9.
Table 9
Carboxymethyl chitosan, polyethylene glycol-400, sodium benzoate are put into deionized water and are sufficiently stirred according to the above ratio,
Mixed with hydrated silica, cellulose gum, laruyl alcohol sodium sulfovinate, be put into Manufacturing medicine extract machine, start high-speed stirred 30min, then plus
Enter spearmint essence, continues to stir 20min, sterilizing packing after the marine polysaccharide toothpaste containing profitable probliotics is made in vacuum outgas.
Toothpaste obtained by above-mentioned example is mainly used for oral cavity dental caries and inhibits the target group (6 of the oral problems such as implication
People) it uses, service condition is observed, experimental subjects has a different degrees of oral health issue, and experimental period 5 days by a definite date, wherein
Usage mode for everyone sooner or later brush teeth twice, the lotion quality used be defaulted as with teeth brushing way it is consistent, table 10 be test before
Experimenter's data and used the experimental result after toothpaste.
Table 10
From the point of view of above-mentioned experimental program, after 5 days, oral problem involved in experimenter can be different degrees of
On be eased.
Claims (10)
1. a kind of marine polysaccharide toothpaste containing profitable probliotics, it is characterised in that its each raw material composition and its mass percent
Are as follows:
Surplus is deionized water.
2. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the rubbing agent is adopted
Use hydrated silica.
3. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the moisturizer is adopted
Use polyethylene glycol-400.
4. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the foaming agent is adopted
Use laruyl alcohol sodium sulfovinate.
5. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the probiotics is adopted
With Freeze-dry Powder of Probioctics, the Freeze-dry Powder of Probioctics uses saliva Bacillus acidi lactici freeze-dried powder.
6. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the thallus of probiotics
Concentration is 1 × 108CFU/mL, the number of viable of Freeze-dry Powder of Probioctics are 12,000,000,000 bacterium/100g.
7. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the thickener is adopted
Use cellulose gum.
8. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the preservative is adopted
Use sodium benzoate.
9. a kind of marine polysaccharide toothpaste containing profitable probliotics as described in claim 1, it is characterised in that the flavouring agent is adopted
With spearmint essence.
10. a kind of preparation method of the marine polysaccharide toothpaste containing profitable probliotics, feature exist as described in claim 1~9
In specific step is as follows:
According to the composition and its mass percent of each raw material, carboxymethyl chitosan, probiotics and moisturizer are put into deionized water
In stir to get deionized water solution, then be mixed with rubbing agent, thickener and foaming agent and vacuum outgas, flavouring agent be added
After continue to stir, up to the marine polysaccharide toothpaste containing profitable probliotics after vacuum outgas bubble.
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| CN111888323A (en) * | 2020-08-25 | 2020-11-06 | 王祥 | Oral bacteriostatic cream for children and preparation method thereof |
| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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| CN109908072B (en) | 2021-07-16 |
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