CN106880584A - A kind of Pediatric Oral Emergency care composition and its application - Google Patents
A kind of Pediatric Oral Emergency care composition and its application Download PDFInfo
- Publication number
- CN106880584A CN106880584A CN201710031657.8A CN201710031657A CN106880584A CN 106880584 A CN106880584 A CN 106880584A CN 201710031657 A CN201710031657 A CN 201710031657A CN 106880584 A CN106880584 A CN 106880584A
- Authority
- CN
- China
- Prior art keywords
- freeze
- dried powder
- pediatric oral
- oral emergency
- care composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention disclose a kind of Pediatric Oral Emergency care composition and its application, the Pediatric Oral Emergency care composition by xylitol, calcium containing compound and probiotic group into, wherein, the weight ratio of xylitol and calcium containing compound is 1:2~50:1, the weight ratio of xylitol and probiotics is 1:8~50:1.Composition of the invention gives full play to the synergy of xylitol, calcium containing compound and probiotics three, in the pre- anti-caries of different links, its preventing decayed tooth ability is all substantially better than single active matter, such that it is able to provide the suppression oral bacteria better than single-activity thing, normal oral microorganism flora can also be maintained simultaneously, oral health is ensured, the effect for be finally reached and dispel oral peculiar smell, pre- anti-caries, promoting tooth calcification, firm tooth, nutrition gum and healthy periodontal.Pediatric Oral Emergency care composition of the invention can be used to prepare the Pediatric Oral Emergency care products such as children's toothpaste, children's mouthwash or Pediatric Oral Emergency cleaning agent.
Description
Technical field
The present invention relates to oral care product technical field, more particularly to children MC, and in particular to Yi Zhongshi
Composition and its application for Pediatric Oral Emergency nursing.
Background technology
Chinese children mouth disease illness rate is higher, and wherein dental caries and periodontal disease are the most common mouth diseases of children.
Third National oral health epidemiological investigation result shows within 2005,5 years old deciduous teeth of China and 12 years old dental caries of dental caries
Illness rate is up to 66.0% and 28.9% respectively.The sclerous tissues of infant or teenager teeth is thin, salinity is low, solubility is high, ooze
Permeability is strong, in addition plus children improperly feeding patterns and bad oral hygiene, causes tooth easy in growth and development process
Generation lesion, the good hair crowd as carious tooth, and with the mouth disease such as swelling and aching of gum, halitosis, to children's study, life and
Physical and mental health is generated and directly affected.
Fluoride is also conventional auti-cariosity material, but because the control of children is poor, function of deglutition not completely,
During long-term use toothpaste, easy excess intake fluorine and to healthy unfavorable.
Xylitol can suppress the growth of main cariogenic bacteria-streptococcus mutans and produce acid as conventional auti-cariosity material, because
This xylitol can reduce the quantity of streptococcus mutans, play a part of to promote remineralization, suppress demineralization.Though however, xylitol
So there is anticaries efficacy, but must be added to it is a certain amount of after just have significant mothproof effect, increased formulation cost and stability
Risk.
The Chinese invention patent application of Publication No. CN105434322A discloses a kind of toothpaste containing oral cavity probiotics,
After the oral cavity probiotics enters oral cavity with toothpaste, the field planting of harmful bacteria can be reduced, suppress the growth and breeding of pathogenic bacteria, reduced
The quantity of the harmful bacterias such as cariogenic bacteria, Periodontal Pathogens and oral Candida.Probiotics can also be with decayed tooth bacterium, periodontal germ, mouth
There is aggreation in the harmful bacterias such as cavity foreign flavor bacterium, after being wrapped up outside band outlet plenum.But single probiotics answering in toothpaste
With being subject to certain restrictions：1st, probiotics generally needs to be preserved in low temperature environment just to can guarantee that its effective active, and toothpaste exists
During production, logistics, sale, use, as a consequence it is hardly possible to accomplish Cord blood.2nd, probiotics is added in toothpaste, part
Lotion yellowing phenomenon occurs and have macroscopic diameter about 1-3mm faint yellow aggregate occur, badly influence tooth
Cream it is attractive in appearance with use, additionally, the probiotics preventing decayed tooth for passing through single work, active bacteria formulation will generally possess a number of viable bacteria
Quantity just has significant curative effect, and substantial amounts of probiotics can influence the outward appearance of lotion, using and stability, it is and living prebiotic
Bacterium its stability in toothpaste is uncontrollable.
In sum, although prior art has the research to the pre- anti-caries effect of oral care product, but is directed to children
The characteristics of MC, special research and development have suppression oral bacteria, pre- anti-caries concurrently and promote tooth calcification, and safety non-toxic, steady
The correlative study of qualitative good oral care product is there is not yet report.
The content of the invention
The purpose of the present invention is directed to the deficiencies in the prior art, there is provided a kind of to be used for children, can effectively suppress
Oral bacteria, removes oral peculiar smell, and pre- anti-caries can promote tooth calcification, firm tooth, and have a safety feature, stability again
Good oral care composition.
It is a further object to provide above-mentioned oral care composition in Pediatric Oral Emergency care product is prepared
Using.
Foregoing invention purpose is achieved by following scheme：
A kind of Pediatric Oral Emergency care composition, the oral care composition is by xylitol, calcium containing compound and probiotic group
Into；The weight ratio of xylitol and calcium containing compound is 1 in the oral care composition:2~50:1, preferably 1:2~15:1, institute
The weight ratio for stating xylitol and probiotics in oral care composition is 1:8~50:1, preferably 1:4~6:1.
In above-mentioned Pediatric Oral Emergency care composition, xylitol is commercially available prod.
In above-mentioned Pediatric Oral Emergency care composition, calcium containing compound is any one in commercially available soluble calcium or slightly soluble calcium
Or the combination of two or more arbitrary proportion；The calcium containing compound is preferably calcium lactate, calcium glycerophosphate or glucose
Any one in sour calcium；The calcium containing compound is more preferably calcium lactate.
In above-mentioned Pediatric Oral Emergency care composition, probiotics is using commercially available probiotics inactivation freeze-dried powder；The probiotics
Preferably bifidobacterium adolescentis freeze-dried powder, bifidobacterium lactis freeze-dried powder, bifidobacterium bifidum freeze-dried powder, Lactobacillus crispatus are freezed
It is powder, bifidobacterium longum freeze-dried powder, bifidobacterium breve freeze-dried powder, lactobacillus bulgaricus freeze-dried powder, lactobacillus gasseri freeze-dried powder, auspicious
Scholar's lactobacillus freeze-dried powder, Yue Shi lactobacillus freeze-dried powder, Lactobacillus plantarum freeze-dried powder, lactobacillus reuteri freeze-dried powder, rhamnose breast
Any one or two or more in bacillus freeze-dried powder, Lactobacillus salivarius freeze-dried powder or streptococcus thermophilus freeze-dried powder is any
The combination of ratio；The probiotics is more preferably Lactobacillus salivarius freeze-dried powder.
Pediatric Oral Emergency care composition of the invention experiments verify that, its good stability, three component concertednesses are good, for
The characteristics of Pediatric Oral Emergency, it is possible to achieve suppress Pediatric Oral Emergency bacterium, remove oral peculiar smell, prevention children caries, promote children's tooth
Tooth calcification and the effect of firm tooth.
Pediatric Oral Emergency care composition of the invention can arrange in pairs or groups acceptable carrier on oral cavity well-known in the art
Component is prepared into Pediatric Oral Emergency care product；The carrier component is surfactant, colouring agent, NMF, thickener, perfume (or spice)
Material, flavor enhancement, chelating agent, preservative, foaming agent, rubbing agent, sweetener or nutriment etc.；The oral care product is tooth
The common dosage forms such as cream, mouthwash, tooth powder or mouthwass；The Pediatric Oral Emergency care composition is in other carrier components of arranging in pairs or groups
When preparing oral care product, the consumption of said composition is 0.1~5%, preferably the 0.2~3% of oral care product gross weight.
In order to most optimally realize effect of Pediatric Oral Emergency care composition of the present invention, the present inventor protects to the Pediatric Oral Emergency
The reason carrier component that can arrange in pairs or groups of composition is studied, so as to can guarantee that selected carrier component with children of the present invention mouthful
When chamber care composition collocation prepares Pediatric Oral Emergency care product, can concertedness more preferably, it is specific as follows shown in：
The carrier component is preservative, and the preservative is in Sodium Benzoate, potassium sorbate, benzoic acid or nipagin esters
Any one；The preservative is preferably Sodium Benzoate；The consumption of the preservative is child care dental products gross weight
0.05~5%, preferable amount is the 0.1~2% of child care dental products gross weight.
The carrier component is sweetener, and the sweetener is in saccharin sodium, Sucralose, Momordia grosvenori aglycone or steviol glycoside
The combination of any one or two or more arbitrary proportion；The consumption of the sweetener is child care dental products gross weight
The 0.05~5% of amount, preferable amount is the 0.1~2% of child care dental products gross weight.
The carrier component is colouring agent, and the colouring agent uses food grade colorant；The consumption of the colouring agent is protector for children
The 0.0001~0.004% of reason dental products gross weight.
The carrier component is NMF, and the NMF is any one in glycerine, polyethylene glycol, sorbierite or propane diols
The combination of kind or two or more arbitrary proportion；The consumption of the NMF is the 10 of child care dental products gross weight
~80%, preferable amount is the 25~70% of child care dental products gross weight.
The carrier component is foaming agent, and the foaming agent is lauryl sodium sulfate, sodium lauroyl sarcosine or cocounut oil acyl
The combination of any one or two or more arbitrary proportion in amine CAB；The consumption of the foaming agent is children
The 0.4~10% of nursing dental products gross weight, preferable amount is the 1~5% of child care dental products gross weight.
The carrier component is rubbing agent, and the rubbing agent is calcium carbonate or silica；The consumption of the rubbing agent is youngster
The 5~60% of child's nursing dental products gross weight, preferable amount is the 15~40% of child care dental products gross weight.
The carrier component is thickener, and the thickener is any in sodium carboxymethylcellulose, xanthans or carragheen
The combination of kind or two or more arbitrary proportion；The consumption of the thickener is child care dental products gross weight
0.1~5%, preferable amount is the 0.1~3% of child care dental products gross weight.
The carrier component be flavor enhancement, the flavor enhancement be essence, Natural menthol or coolant agent in any one or
The combination of two or more arbitrary proportion；The consumption of the flavor enhancement for child care dental products gross weight 0.05~
5%, preferable amount is the 0.5~2% of child care dental products gross weight.
The carrier component be nutriment, the nutriment be NAP, Retinol Palmitate,
The combination of any one or two or more arbitrary proportion in tocopherol acetate, vitamin B3；The nutriment
Consumption be the 0.05~5% of child care dental products gross weight, preferable amount is for child care dental products gross weight
0.1~1%.
Compared with prior art, the present invention has the advantages that：
1. the present inventor has found that children are accustomed to often feed by studying, and organic acid can be reduced in oral cavity after oral cavity is entered
PH, acid etching tooth, and the xylitol in Pediatric Oral Emergency care composition of the invention can promote salivary secretion, rinse oral cavity
The bacterium on tooth is reduced simultaneously, the concentration of basic amino acid and ammonia at increase saliva and carious tooth spot, while slowing down in oral cavity
The decline of pH promotes remineralization of teeth effect, and acid etching is prevented since source；Calcium containing compound can in time supplement the calcium in saliva
Ion concentration, prevents tooth demineralization, promotes remineralization of teeth, calcium containing compound that suppression is played during the entire process of pre- anti-caries
Demineralization promotes the effect of remineralization, and probiotics can also occur with the harmful bacterias such as bacterium, periodontal germ, oral peculiar smell bacterium that decay tooth in addition
Self aggregation, aggregation effect, form biomembrane, after being wrapped up outside band outlet plenum, so as to suppress the growth of pathogenic bacteria, form resistance
Only the barrier of pathogenic bacteria field planting and infection, fundamentally reduces oral cavity pathogen, in terminal preventing decayed tooth.
2. in Pediatric Oral Emergency care composition of the invention, xylitol, calcium containing compound and probiotics three synergy,
In the pre- anti-caries of different links, its preventing decayed tooth ability is all substantially better than single active matter, such that it is able to provide better than single-activity
The suppression oral bacteria of thing, while normal oral microorganism flora can also be maintained, ensures oral health, is finally reached and dispels mouth
Cavity foreign flavor, pre- anti-caries, the effect for promoting tooth calcification, firm tooth, nutrition gum and healthy periodontal；
3. the present inventor has found that the secretory volume of different salivas, contains in different amounts of xylitol decision oral cavity by studying
Calcium compound can in time supplement the calcium ion in saliva, promote remineralization of teeth；While saliva washes away oral cavity, probiotics is not
It is washed disconnectedly, its effectively aggregation and adhesive attraction is restricted, then needs a certain amount of probiotics to reach supplement and balance, because
This, the present inventor is respectively used xylitol in oral care composition with calcium containing compound, xylitol and probiotics
Amount optimization, and found by Optimum Experiment, if usage ratio is less than optimization range, oral cavity DeGrain is nursed, if consumption
Ratio is higher than optimization range, then can have a strong impact on the outward appearance and stability of toothpaste, therefore final Pediatric Oral Emergency nursing group of the present invention
The consumption of component is conditioned each other two-by-two in compound, and the effect and synergy of each component are played to greatest extent, it is ensured that invention
Finally realize destination.
Brief description of the drawings
Fig. 1 is growth OD inhibitory action block diagram of the children's toothpaste to Streptococcus mutans；
Fig. 2 is growth OD inhibitory action block diagram of the children's toothpaste to Fusobacterium nucleatum.
Specific embodiment
The present invention is further described through with reference to specific embodiment, but specific embodiment is not appointed to the present invention
What is limited.
The children's toothpaste of embodiment 1
The present embodiment provides application of the Pediatric Oral Emergency care composition in children's toothpaste, and the formula of the children's toothpaste is by such as
Lower component is constituted：
Above-mentioned percentage is the percentage that the component accounts for children's toothpaste gross weight.
Above-mentioned Pediatric Oral Emergency care composition is made up of xylitol, calcium lactate and Lactobacillus salivarius freeze-dried powder；The wood
The weight ratio of sugar alcohol and calcium lactate is 5:1, the weight ratio of the xylitol and Lactobacillus salivarius freeze-dried powder is 5:2.
The preparation method of the present embodiment children's toothpaste, comprises the following steps：
Step 1
According to formula consumption by xylitol, calcium lactate, Lactobacillus salivarius freeze-dried powder, saccharin sodium, Sodium Benzoate, ascorbic acid
Sodium phosphate, vitamin B3, food coloring dissolve in adding deionized water, are subsequently adding sorbierite, glycerine, and polyethylene glycol-
400, stir, obtain mixture 1；
Silica, sodium carboxymethylcellulose and xanthans are mixed and is uniformly dispersed, obtain mixture 2；
Retinol Palmitate, tocopherol acetate are added into essence, water-bath dissolving obtains mixture 3；
Step 2
Mixture 1 prepared by step 1 and mixture it is 2-in-1 and together with and vacuum high-speed stirred after 10~20 minutes, plus
Enter the mixture 3, sodium lauroyl sarcosine and Cocoamidopropyl betaine of step 1 preparation, be sufficiently mixed under vacuum, disperse 10
~15 minutes, obtain final product the children's toothpaste containing Pediatric Oral Emergency care composition of the present embodiment.
The children's toothpaste of embodiment 2
The present embodiment provides application of the Pediatric Oral Emergency care composition in children's toothpaste, and the formula of the children's toothpaste is by such as
Lower component is constituted：
Above-mentioned percentage is the percentage that the component accounts for children's toothpaste gross weight.
Above-mentioned Pediatric Oral Emergency care composition is made up of xylitol, calcium lactate and Lactobacillus salivarius freeze-dried powder；The wood
The weight ratio of sugar alcohol and calcium lactate is 4：1, the weight ratio of the xylitol and Lactobacillus salivarius freeze-dried powder is 8:5.
The preparation method of the present embodiment is with embodiment 1.
The children's toothpaste of embodiment 3
The present embodiment provides application of the Pediatric Oral Emergency care composition in children's toothpaste, and the formula of the children's toothpaste is by such as
Lower component is constituted：
Above-mentioned percentage is the percentage that the component accounts for children's toothpaste gross weight.
Above-mentioned Pediatric Oral Emergency care composition is made up of xylitol, calcium lactate and Lactobacillus salivarius freeze-dried powder；The wood
Sugar alcohol is 3 with the weight ratio of calcium lactate:1, the xylitol is 3 with the weight ratio of Lactobacillus salivarius freeze-dried powder:2.
The preparation method of the present embodiment is with embodiment 1.
The stability test of the children's toothpaste of embodiment 4
The present embodiment carries out outward appearance and quality stability test to the children's toothpaste of embodiment 1-3, specifically by embodiment
Children's toothpaste the stability of the children's toothpaste is tested after aging three months under 45 DEG C of high temperature, test result is as shown in table 1.
The children's toothpaste stability test result of table 1
As can be seen from Table 1, the children's toothpaste of embodiment 1-3 aging trimestral stability under 45 DEG C of high temperature is normal.
The bacteriostatic test of the children's toothpaste of embodiment 5
The present embodiment carries out bacteriostatic test by laboratory sample of the children's toothpaste of embodiment 2, specifically to Streptococcus mutans
With the antibacterial test of Fusobacterium nucleatum.
Specific experiment method is the toothpaste stoste of the embodiment 2 that will adjust absorbance and causing a disease in exponential phase
Bacterium solution mixed in equal amounts, respectively in 0h, 1.5h, 3h, 4.5h, 6h, 7.5h, the growth curve of pathogenic bacteria is determined using absorbance method,
Represented with △ OD.△ OD are smaller, and inhibitory action is stronger.
Negative control：Except being not added with Pediatric Oral Emergency care composition of the present invention, remaining is formulated and preparation method and implementation
The identical toothpaste of example 2.
Toothpaste is as shown in Figure 1 to the growth OD inhibitory action results of Streptococcus mutans；Growth OD suppressions to Fusobacterium nucleatum
Exercising result processed is as shown in Figure 2；In Fig. 1 and Fig. 2, each growth time point left side be negative control result, the right is
The result of the children's toothpaste of embodiment 2.
Pediatric Oral Emergency care composition of the present invention is can be seen that from Fig. 1 and Fig. 2 to have Streptococcus mutans and Fusobacterium nucleatum
There is obvious inhibitory action, the toothpaste that with the addition of the present composition is bright to the inhibitory action of Streptococcus mutans and Fusobacterium nucleatum
Aobvious enhancing.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in specific embodiment disclosed and described above, to of the invention
Some modifications and changes should also be as falling into scope of the claims of the invention.Although additionally, being used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any limitation to the present invention.
Claims (8)
1. a kind of Pediatric Oral Emergency care composition, it is characterised in that the Pediatric Oral Emergency care composition is by xylitol, calcic chemical combination
Thing and probiotic group into；The weight ratio of the xylitol and calcium containing compound is 1:2~50:1, the xylitol and probiotics
Weight ratio is 1:8~50:1；The calcium containing compound is calcium lactate, calcium glycerophosphate or calcium gluconae；The probiotics is
Bifidobacterium adolescentis freeze-dried powder, bifidobacterium lactis freeze-dried powder, bifidobacterium bifidum freeze-dried powder, Lactobacillus crispatus freeze-dried powder, length are double
Discrimination bacillus freeze-dried powder, bifidobacterium breve freeze-dried powder, lactobacillus bulgaricus freeze-dried powder, lactobacillus gasseri freeze-dried powder, Switzerland's breast bar
Bacterium freeze-dried powder, Yue Shi lactobacillus freeze-dried powder, Lactobacillus plantarum freeze-dried powder, lactobacillus reuteri freeze-dried powder, Lactobacillus rhamnosus are frozen
Any one or two or more arbitrary proportion in dry powder, Lactobacillus salivarius freeze-dried powder or streptococcus thermophilus freeze-dried powder
Combination.
2. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that the xylitol and calcium containing compound
Weight ratio is 1:2~15:1, the weight ratio of the xylitol and probiotics is 1:4~6:1.
3. Pediatric Oral Emergency care composition according to claim 1 or claim 2, it is characterised in that the calcium containing compound is lactic acid
Calcium.
4. Pediatric Oral Emergency care composition according to claim 1 or claim 2, it is characterised in that the probiotics is Lactobacillus salivarius
Freeze-dried powder.
5. application of the Pediatric Oral Emergency care composition in Pediatric Oral Emergency care product is prepared described in claim 1 or 2.
6. apply according to claim 5, it is characterised in that the consumption of the Pediatric Oral Emergency care composition is Pediatric Oral Emergency
The 0.1~5% of care product gross weight.
7. apply according to claim 6, it is characterised in that the consumption of the Pediatric Oral Emergency care composition is Pediatric Oral Emergency
The 0.2~3% of care product gross weight.
8. apply according to claim 5, it is characterised in that the Pediatric Oral Emergency care product is children's toothpaste, children gargle
Water or Pediatric Oral Emergency cleaning agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710031657.8A CN106880584B (en) | 2017-01-17 | 2017-01-17 | Oral care composition for children and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710031657.8A CN106880584B (en) | 2017-01-17 | 2017-01-17 | Oral care composition for children and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106880584A true CN106880584A (en) | 2017-06-23 |
| CN106880584B CN106880584B (en) | 2020-05-12 |
Family
ID=59176324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710031657.8A Active CN106880584B (en) | 2017-01-17 | 2017-01-17 | Oral care composition for children and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106880584B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107794237A (en) * | 2017-10-26 | 2018-03-13 | 广州能靓生物技术有限公司 | A kind of probiotic composition and its application, product |
| CN109043542A (en) * | 2018-09-11 | 2018-12-21 | 内蒙古伊利实业集团股份有限公司 | The application of human milk oligosaccharides and/or its precursor in the composition of preparation prevention children caries disease |
| CN110123662A (en) * | 2019-04-30 | 2019-08-16 | 杭州伊瑟奇生物科技有限公司 | Based on the gutta-percha for ionizing peeling effect and to the stripping means of oral bacteria and tartar |
| CN111888323A (en) * | 2020-08-25 | 2020-11-06 | 王祥 | Oral bacteriostatic cream for children and preparation method thereof |
| CN113144002A (en) * | 2021-03-15 | 2021-07-23 | 北京亿康倍尔生物科技有限公司 | Probiotic composition for maintaining oral health and application thereof |
| CN114983889A (en) * | 2022-04-22 | 2022-09-02 | 云南西草资源开发有限公司 | Bacteriostatic toothpaste for promoting salivary secretion and preparation method thereof |
| CN115006341A (en) * | 2022-07-21 | 2022-09-06 | 重庆登康口腔护理用品股份有限公司 | Oral cleaning and nursing composition capable of adjusting oral micro-ecological balance and preparation method thereof |
| CN115606805A (en) * | 2022-09-29 | 2023-01-17 | 广州能靓生物技术有限公司 | Metabiotic composition and application thereof in oral health |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09175963A (en) * | 1995-12-26 | 1997-07-08 | Sangi Co Ltd | Toothpaste composition |
| CN101123939A (en) * | 2004-12-21 | 2008-02-13 | 高露洁-棕榄公司 | Anti-caries oral care composition with xylitol |
| CN101234078A (en) * | 2007-02-01 | 2008-08-06 | 大连森佰澳科技有限公司 | Preparation technique of blood streptococcus signal molecule micro-ecological preparations and oral health products thereof |
| CN103385805A (en) * | 2013-07-18 | 2013-11-13 | 广州薇美姿个人护理用品有限公司 | Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening |
| KR20150098953A (en) * | 2014-02-21 | 2015-08-31 | 대한민국(관리부서:국립수산과학원) | A novel Bacillus sp. strain and use thereof |
| CN105434322A (en) * | 2015-12-22 | 2016-03-30 | 南昌理工学院 | Toothpaste containing oral cavity probiotics |
| CN105748344A (en) * | 2016-02-26 | 2016-07-13 | 北京斯利安药业有限公司 | Edible toothpaste and preparation method thereof |
-
2017
- 2017-01-17 CN CN201710031657.8A patent/CN106880584B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09175963A (en) * | 1995-12-26 | 1997-07-08 | Sangi Co Ltd | Toothpaste composition |
| CN101123939A (en) * | 2004-12-21 | 2008-02-13 | 高露洁-棕榄公司 | Anti-caries oral care composition with xylitol |
| CN101234078A (en) * | 2007-02-01 | 2008-08-06 | 大连森佰澳科技有限公司 | Preparation technique of blood streptococcus signal molecule micro-ecological preparations and oral health products thereof |
| CN103385805A (en) * | 2013-07-18 | 2013-11-13 | 广州薇美姿个人护理用品有限公司 | Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening |
| KR20150098953A (en) * | 2014-02-21 | 2015-08-31 | 대한민국(관리부서:국립수산과학원) | A novel Bacillus sp. strain and use thereof |
| CN105434322A (en) * | 2015-12-22 | 2016-03-30 | 南昌理工学院 | Toothpaste containing oral cavity probiotics |
| CN105748344A (en) * | 2016-02-26 | 2016-07-13 | 北京斯利安药业有限公司 | Edible toothpaste and preparation method thereof |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107794237A (en) * | 2017-10-26 | 2018-03-13 | 广州能靓生物技术有限公司 | A kind of probiotic composition and its application, product |
| CN109043542A (en) * | 2018-09-11 | 2018-12-21 | 内蒙古伊利实业集团股份有限公司 | The application of human milk oligosaccharides and/or its precursor in the composition of preparation prevention children caries disease |
| CN110123662A (en) * | 2019-04-30 | 2019-08-16 | 杭州伊瑟奇生物科技有限公司 | Based on the gutta-percha for ionizing peeling effect and to the stripping means of oral bacteria and tartar |
| CN111888323A (en) * | 2020-08-25 | 2020-11-06 | 王祥 | Oral bacteriostatic cream for children and preparation method thereof |
| CN113144002A (en) * | 2021-03-15 | 2021-07-23 | 北京亿康倍尔生物科技有限公司 | Probiotic composition for maintaining oral health and application thereof |
| CN114983889A (en) * | 2022-04-22 | 2022-09-02 | 云南西草资源开发有限公司 | Bacteriostatic toothpaste for promoting salivary secretion and preparation method thereof |
| CN115006341A (en) * | 2022-07-21 | 2022-09-06 | 重庆登康口腔护理用品股份有限公司 | Oral cleaning and nursing composition capable of adjusting oral micro-ecological balance and preparation method thereof |
| CN115006341B (en) * | 2022-07-21 | 2023-12-19 | 重庆登康口腔护理用品股份有限公司 | Oral cavity cleaning and nursing composition capable of regulating oral cavity microecological balance and preparation method thereof |
| CN115606805A (en) * | 2022-09-29 | 2023-01-17 | 广州能靓生物技术有限公司 | Metabiotic composition and application thereof in oral health |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106880584B (en) | 2020-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106880584A (en) | A kind of Pediatric Oral Emergency care composition and its application | |
| CN105534875B (en) | Antibacterial antiallergic perception compositions and its toothpaste and preparation method for oral-cavity article | |
| CN103385805B (en) | A kind of benefit is benefit combination children's toothpaste in evening and one benefit children's toothpaste in evening early | |
| US9603791B2 (en) | Oral care product formulation | |
| CN106963662B (en) | Color-changing toothpaste for children and preparation method and application thereof | |
| CN106619193B (en) | A kind of antibacterial whitening toothpaste and preparation method thereof | |
| CN107794237A (en) | A kind of probiotic composition and its application, product | |
| CN108338361A (en) | Food, oral cleaning and pharmaceutical composition for inhibiting lactic acid bacteria strain of oral pathogenic bacteria | |
| CN106562923B (en) | Oral care composition containing profitable probliotics and its application in toothpaste | |
| CN105748344B (en) | A kind of edible toothpaste and preparation method thereof | |
| CN107920986A (en) | Self-contained film composition for oral care | |
| CN106821950A (en) | The oral care composition and its application of a kind of antibacterial and whitening | |
| CN112826789B (en) | Anti-caries and antibacterial toothpaste containing probiotics and preparation method thereof | |
| CN106691883A (en) | Toothpaste and preparation method thereof | |
| CN106581159B (en) | Oral care composition for children and morning and evening benefiting combined toothpaste for children | |
| US20200179258A1 (en) | Compositions, uses and methods for treating or preventing dental caries | |
| JP6468559B2 (en) | Oral composition for animals, periodontal disease preventive agent for animals using the same, and oral bad breath preventive agent for animals | |
| CN107049828A (en) | A kind of anti-caries toothpaste and preparation method thereof | |
| RU2457829C2 (en) | Mineral and vitamin complex for strengthening tooth enamel, composition for oral cavity hygiene and toothpaste | |
| CN109908072B (en) | Marine organism polysaccharide toothpaste containing probiotics and preparation method thereof | |
| JP6351985B2 (en) | Oral composition | |
| US11564878B2 (en) | Oral care product formulation | |
| CN107897881A (en) | A kind of probiotic composition for being used to improve oral health | |
| US11957738B1 (en) | Water soluble composition and production method thereof | |
| KR101419110B1 (en) | Cosmetic pack composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210514 Address after: 510555 room 922, No.2, Tengfei 1st Street, Zhongxin Guangzhou Knowledge City, Huangpu District, Guangzhou City, Guangdong Province (office only) Patentee after: Guangzhou Shuke Industrial Co.,Ltd. Address before: Room 704, 705, West, No. 64, 66, Jianzhong Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU WEIMEIZI INDUSTRIAL Co.,Ltd. |