CN103385805B - A kind of benefit is benefit combination children's toothpaste in evening and one benefit children's toothpaste in evening early - Google Patents
A kind of benefit is benefit combination children's toothpaste in evening and one benefit children's toothpaste in evening early Download PDFInfo
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Abstract
The present invention relates to a kind of benefit early benefit combination in evening children's toothpaste, being made up of the benefit used morning early children's toothpaste and the benefit children's toothpaste in evening used evening, described benefit early children's toothpaste includes wetting agent, thickening agent, mild abrasive, xylitol, calcium containing compound, compound vitamin, gentle surfactant, essence, deionized water；Benefit children's toothpaste in evening includes wetting agent, thickening agent, mild abrasive, oligosaccharide, amino acid composition, compound vitamin, gentle surfactant, essence, deionized water；Change the impact on tooth according to child's oral environment sooner or later, adopt benefit of the present invention early benefit combination in evening children's toothpaste, it is possible to maintenance Oral health behaviours balance, balance oral cavity acid-base value, there is effect of anti-caries, firm tooth.
Description
Technical field
The present invention relates to a kind of benefit early benefit combination children's toothpaste in evening and one benefit children's toothpaste in evening, belong to field of oral care, the toothpaste feature according to oral cavity environment and child's deciduous teeth and permanent teeth sooner or later, is that 2～12 years old child develops specially.
Background technology
After people's birth, 6～7 months deciduous teeth start eruption, within 3～6 years old, complete primary dentition and grow, within namely 6 months～6 years old, are the primary dentition stages.6～12 years old is the mixed dentition stage, exuviation, permanent teeth eruption successively, until all deciduous teeth is replaced complete.This stage, existing deciduous teeth in oral cavity, also there is permanent teeth, be child's jawbone and dental arch primary growth period of development, be also the critical period of permanent teeth jaw foundation.And show according to Third National oral health epidemiological investigation report result, 5 years old child's Primary Caries rate of China is 66.0%, the 12 years old average caries prevalence rate 28.9% of student's permanent teeth in the whole nation, and the probability of Primary Caries rate is more than 2 times of permanent teeth.Compared with decaying with permanent teeth, deciduous teeth decay has features such as falling ill early, scope is wide, fast-growth, subjective symptoms is inconspicuous.Deciduous teeth are susceptible to suffer from the main associated factors of dental caries: child takes food the number of times of sweet food and the dynamics of oral cavity cleaning every day.Daytime, child frequently takes food, and diet mostly is soft food, and toughness is strong, sugar content is high, constituting antibacterial fertile soil, it is easy to form bacterial plaque, a large amount of antibacterials take in the sugar in saliva, decompose sugar and produce acid, after feed, saliva acidity increases, and repeatedly feed makes saliva be in acid state for a long time, and more once feed equivalent food is easier to suffer from dental caries.The length of one's sleep of child is long, and oral cavity remains static, and salivation is few, and self-cleaning action is poor, is conducive to bacterial reproduction, increases and suffers from dental caries chance.As can be seen here, oral environment and the oral environment at night in child daytime make a big difference, and the oral cavity at night is easier to cause oral disease.
The current mothproof oral care product of child on the market, these products have fluoride, because fluoride is proved to have good anticaries action.But people's excess intake fluorine with the calcium ion effect in human body, can cause calcium loss, also can form dental fluorosis, make tooth become fragile.In the period of 2 ~ 12 years old formal child's supplementing calcium elements, calciprivia can cause body development bad.
The Chinese invention patent that publication number is CN1864660A discloses a kind of natural child's mothproof toothpaste, it adopts propolis as mothproofing agent, propolis is a kind of natural health care product, gathered by Apis, and the collection of Apis has randomness, the different flowers in different places gather former propolis component bigger difference, and composition cannot clearly be estimated, produced effect is also just different, and therefore the stability of effect of toothpaste is difficult to ensure that.
The Chinese invention patent application that publication number is CN103040636A discloses a kind of anti-caries toothpaste adding enzyme, this enzyme can affect bacterial metabolism or breaks down proteins thus suppressing the formation of bacterial plaque, but the activity of enzyme is more easily damaged in toothpaste, not easily preserves, and soft tissue is harmful to by some enzyme.And the mastic meta-alkalescence of toothpaste of being grown up, pharmaceutical quantities is high, it is easy to destroy the oral cavity ecological environment of child, and children's toothpaste should improve, on the basis reducing drug dose, the ability of cleaning the teeth to the full extent.
Although the technology of above-mentioned patent disclosure is not fluorine-containing and there is anticariogenic effect, but there is disadvantages described above, and do not have not do for the oral environment that child is different round the clock to be correspondingly improved.In essence, the bad acidity being because enamel external environment condition of tooth generation dental caries increases, and makes the balance of adamantine demineralization and remineralization be broken, and hydroxyapatite runs off.If the acid-base value that can make enamel external environment condition keeps certain limit, making the balance of adamantine demineralization and remineralization continue, dental caries will not occur, the acid-base value main cause changing enamel external environment condition is that in oral cavity, bacterial fermentation produces acid.
Now there are some researches show that oligosaccharide can improve microecological environment in human body, be conducive to the propagation of bacillus bifidus and other probiotics, promote synthetic vitamin, promote to absorb mineral, and oligosaccharide can not be utilized by caries bacteria makes the energy, producing insoluble glucan and a large amount of lactic acid without being utilized by them, therefore it is low dental caries.Oligosaccharide is widely used in milk product, lactobacillus beverage, Yoghourt, cereal foods and health food as a kind of food ingredients, but its concrete application on toothpaste is not open.
Summary of the invention
It is an object of the invention to solve the problems referred to above, environmental difference according to child oral cavity sooner or later, a kind of benefit early benefit combination children's toothpaste in evening and the one benefit children's toothpaste in evening that add different efficacies composition respectively are provided, the real nursing difficult problem solving Pediatric Oral Emergency environment difference sooner or later, maintenance Oral health behaviours balances, balance oral cavity acid-base value, plays pre-anti-caries, firm tooth.
The object of the invention is achieved through the following technical solutions:
A kind of benefit is benefit combination in evening children's toothpaste early, is made up of evening the benefit used morning early children's toothpaste and the benefit used evening described in children's toothpaste；
The raw material of described benefit early children's toothpaste includes wetting agent, thickening agent, mild abrasive, xylitol, calcium containing compound, compound vitamin, gentle surfactant, essence, deionized water；Mark meter by weight, the content range of each raw material is:
The raw material of described benefit children's toothpaste in evening includes wetting agent, thickening agent, mild abrasive, oligosaccharide, amino acid composition, compound vitamin, gentle surfactant, essence, deionized water；Mark meter by weight, the content range of each raw material is:
Preferably, described benefit early children's toothpaste and benefit children's toothpaste in evening also include sodium lauryl sulfate, and sodium lauryl sulfate has good emulsifying, foaming, infiltration, decontamination and dispersive property, is widely used in toothpaste with cleaning raw material.Described sodium lauryl sulfate uses with gentle surfactant compound, and composite weight ratio is 1:0.1～3, it is possible to reduce sodium lauryl sulfate addition in toothpaste, reduces its zest, improves again the stability of toothpaste simultaneously.
Preferably, described gentle surfactant is that sodium lauroyl sarcosine, sodium lauroyl glutamate, cocamidopropyl betaine, N-sodium methyl cocoyl taurate, pool fall the one of which or several composite of husky nurse, alkyl polyglucoside.Gentle surfactant cleaning tooth does not hinder oral mucosa, and safe and non-stimulating, it can be used alone, it is also possible to by gentleness surfactant and the composite use of sodium lauryl sulfate.
Preferably, the compound vitamin in benefit early benefit combination in evening children's toothpaste comprises vitamin C, vitamin E, vitamin B3, vitamin B5 and vitamin B6, and vitamin C is important gingiva nutrient substance, has important effect to improving gingival hemorrhage；Vitamin E is a kind of Natural antioxidant, it is prevented that the active substance such as xylitol etc in toothpaste is oxidized, concurrently disinfects free radical, repairs gingiva tissue；The coenzyme differed from one another in vitamin B, has comprehensive important function to the multiple physiological metabolism of each organ-tissue of human body, and the absorption supplementing the appropriate vitamin B pair indispensable element relevant with the health of tooth is particularly significant.Vitamin series can promote tooth calcification, firm deciduous teeth, promotes dental germ during development, and puts the oral diseases such as angular cheilitis in advance, the inmature oral mucosa of care.Various vitamin add in toothpaste with the form of complex, not only supplement multivitamin, and vitamin can be kept in the stability of toothpaste shelf-life.
Preferably, the one of which that calcium containing compound is soluble calcium or slightly soluble calcium or several composite of described benefit early children's toothpaste.Described soluble calcium or slightly soluble calcium are the one of which or several composite of calcium lactate, calcium glycerophosphate, calcium gluconate.Benefit early toothpaste is also added with xylitol, and xylitol is natural plant sweeting agent, will not produce to cause the acidic materials of decayed tooth, do not corrode dentine, formation dental caries, moreover it is possible to intercept the deposition of tartar after brushing teeth.The combination of xylitol and calcium containing compound uses, and one is to alleviate oral cavity acid-base value, and two is to improve enamel acid-resisting.The enamel of deciduous teeth, dentin are thin, and salinity is low, and antiacid power is weak, and deciduous teeth enamel is subject to the effect of decalcifying agent and decalcification than permanent teeth enamel, is also more susceptible to remineralizing agent effect and remineralization.Daytime, child frequently takes food, after feed, saliva acidity increases, and repeatedly feed makes saliva be in acid state for a long time, and xylitol enters in bacterial cell, form 5-phosphoric acid xylitol and at intracellular accumulation, 5-phosphoric acid xylitol dephosphorylation again, xylitol is discharged to extracellular afterwards, so forms the inefficient cycle process of a power consumption, thus inhibiting the growth of Streptococcus mutans and producing acid, therefore xylitol can reduce the quantity of Streptococcus mutans.Xylitol is unfavorable for the increment of acid fast bacteria, plays the effect promoting remineralization, suppressing demineralization, is formed without extracellular polysaccharide in addition in xylitol metabolic process, reduces the formation of bacterial plaque.Xylitol and calcium containing compound can suppress fermentable to produce acid, improve ph value of oral cavity, supplement calcium ion simultaneously, make remineralization speed strengthen, improve enamel capacity antacid.
Preferably, the weight fraction content of the oligosaccharide of described benefit children's toothpaste in evening is 1～10%.Described oligosaccharide is that the oligofructose in low-function carbohydrate, oligomeric xylose, Oligomeric maltose, dextrinosan, oligomeric galactose, soybean oligo saccharide, coupling sugar, oligomeric sucrose, oligo-chitosan and trehalose one or more of which are composite.Due to evening, the oral cavity of child remains static, and salivation is few, and its self-cleaning action is poor, be conducive to bacterial reproduction, and oligosaccharide can promote that beneficial bacteria grows, it is suppressed that noxious bacteria is bred, maintenance Oral health behaviours balances, and makes oral cavity acid-base value maintain normal level, reaches anti-caries effect.
Preferably, the amino acid composition of described benefit children's toothpaste in evening includes cystine, proline, glutamic acid, histidine and methionine.Toothpaste adds this several seed amino acids, provides nutrition for adamantine growth.Described several amino acids composition is to add with the formation of compositions, can improve aminoacid stability during toothpaste is guaranteed the quality.
A kind of benefit children's toothpaste in evening, its raw material includes wetting agent, thickening agent, mild abrasive, oligosaccharide, amino acid composition, compound vitamin, gentle surfactant, essence, deionized water；Mark meter by weight, the content range of each raw material is:
Preferably, also including sodium lauryl sulfate, described sodium lauryl sulfate is 1: 0.1～3 with gentle surfactant weight ratio, uses together and can reduce sodium lauryl sulfate addition in toothpaste, reduces its zest.
Preferably; the gentle surfactant of benefit children's toothpaste in evening is that sodium lauroyl sarcosine, sodium lauroyl glutamate, cocamidopropyl betaine, N-sodium methyl cocoyl taurate, pool fall in husky nurse, alkyl polyglucoside that one or more are composite; having good decontamination and emulsifiability, spumescence is good.
Preferably, the compound vitamin in benefit children's toothpaste in evening comprises vitamin C, vitamin E, vitamin B3, vitamin B5 and vitamin B6.Vitamin series can promote tooth calcification, firm deciduous teeth, promotes dental germ during development, and puts the oral diseases such as angular cheilitis in advance, the inmature oral mucosa of care.Various vitamin add in toothpaste with the form of complex, not only supplement multivitamin, and vitamin can be kept in the stability of toothpaste shelf-life.
Preferably, the weight fraction content of described oligosaccharide is 1～10%.Described oligosaccharide is that in oligofructose, oligomeric xylose, Oligomeric maltose, dextrinosan, oligomeric galactose, soybean oligo saccharide, coupling sugar, oligomeric sucrose, oligo-chitosan and trehalose, one or more are composite, the growth of beneficial bacteria can be promoted, maintain the acid-base value in oral cavity by maintaining Oral health behaviours balance.
Preferably, described amino acid composition includes cystine, proline, glutamic acid, histidine and methionine, provides nutrition for adamantine growth.
Beneficial effects of the present invention:
Benefit early children's toothpaste adds xylitol and calcium containing compound, reduces oral cavity acidity, supplements calcium ion simultaneously, makes remineralization speed strengthen, improves enamel capacity antacid.
Benefit children's toothpaste in evening adds several amino acids, provides nutrition for adamantine growth.Several amino acids addition manner is to add with the formation of compositions, can improve aminoacid stability during toothpaste is guaranteed the quality.Benefit children's toothpaste in evening is also added with oligosaccharide, promotes beneficial bacteria growth, it is suppressed that noxious bacteria is bred, and maintains Oral health behaviours balance, makes oral cavity acid-base value maintain normal level, pre-anti-caries.Oligosaccharide is a kind of prebiotic component, it is possible to adjusts microbial state treatment, improve body health level.
Benefit benefit morning combination in evening children's toothpaste all with the addition of multivitamin, provides nutrition for child's gingiva, puts the oral diseases such as angular cheilitis in advance, and multivitamin is to add in toothpaste with the form of a kind of complex, can improve vitamin stability during toothpaste is guaranteed the quality.
Benefit early benefit combination in evening children's toothpaste all adopts gentle surfactant, is possible not only to cleaning oral cavity, removes the oil stain, the spot that adhere on tooth, also do not stimulate oral cavity viscosity, improve the explosive force of essence simultaneously, promote mouthfeel, can also producing the foam of exquisiteness, easy-to-use clear water is gargled totally, does not remain.For after brushing not liking the child repeatedly gargled clearly, the number of times gargled can be reduced.
Benefit early children's toothpaste takes food number of times frequently for child, the situation that saliva acidity usury is bred in acid fast bacteria, utilizes xylitol and calcium containing compound to suppress plaque bacteria breeding, promoting remineralization, suppression demineralization, corroding thus resisting antibacterial, firm tooth；Benefit children's toothpaste in evening is few for Pediatric Oral Emergency salivation, is beneficial to vegetative situation, utilizes oligosaccharide to promote beneficial bacteria growth, suppress noxious bacteria breeding, maintenance Oral health behaviours balances, and makes oral cavity acid-base value maintain normal level, thus reaching mothproof effect；Benefit early children's toothpaste and benefit children's toothpaste in evening with the use of, effectively prevent Primary Caries tooth, child protection dental health.
Detailed description of the invention
The present invention is expanded on further, but is not limiting as the present invention by the examples below and in conjunction with manufacture method, result of use data.
Embodiment 1
Component mark by weight is calculated as follows:
A, benefit early children's toothpaste
Preparation technology is as follows:
(1) xylitol, tetrasodium pyrophosphate, compound vitamin, calcium glycerophosphate are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-4000 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) it is eventually adding essence, sodium lauroyl sarcosine and sodium lauryl sulfate, is sufficiently mixed under vacuo, disperses, about 20 minutes.
B, benefit children's toothpaste in evening
Preparation technology is as follows:
(1) oligofructose, tetrasodium pyrophosphate, compound vitamin, aminoacids complex are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-8 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) be eventually adding essence, sodium lauroyl sarcosine, sodium lauryl sulfate are sufficiently mixed under vacuo, disperse, about 20 minutes.
Embodiment 2
Component mark by weight is calculated as follows:
A, benefit early children's toothpaste
Preparation technology is as follows:
(1) xylitol, tetrasodium pyrophosphate, compound vitamin, calcium lactate are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-4000 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) it is eventually adding essence, sodium lauroyl glutamate and sodium lauryl sulfate, is sufficiently mixed under vacuo, disperses, about 20 minutes.
B, benefit children's toothpaste in evening
Preparation technology is as follows:
(1) oligomeric isomaltose, tetrasodium pyrophosphate, compound vitamin, aminoacids complex are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-8 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) be eventually adding essence, sodium lauroyl glutamate, sodium lauryl sulfate are sufficiently mixed under vacuo, disperse, about 20 minutes.
Embodiment 3
Component mark by weight is calculated as follows:
A, benefit early children's toothpaste
Preparation technology is as follows:
(1) xylitol, tetrasodium pyrophosphate, compound vitamin, calcium gluconate are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-4000 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) it is eventually adding essence, N-sodium methyl cocoyl taurate and sodium lauryl sulfate, is sufficiently mixed under vacuo, disperses, about 20 minutes.
B, benefit children's toothpaste in evening
Preparation technology is as follows:
(1) soybean oligo saccharide, tetrasodium pyrophosphate, compound vitamin, aminoacids complex are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-8 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) be eventually adding essence, N-sodium methyl cocoyl taurate, sodium lauryl sulfate are sufficiently mixed under vacuo, disperse, about 20 minutes.
Embodiment 4
Component mark by weight is calculated as follows:
A, benefit early children's toothpaste
Preparation technology is as follows:
(1) xylitol, tetrasodium pyrophosphate, compound vitamin, calcium gluconate, calcium lactate are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-4000 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) it is eventually adding essence, cocamidopropyl betaine and alkyl polyglucoside, is sufficiently mixed under vacuo, disperses, about 20 minutes.
B, benefit children's toothpaste in evening
Preparation technology is as follows:
(1) oligomeric xylose, Oligomeric maltose, tetrasodium pyrophosphate, compound vitamin, aminoacids complex are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-8 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) be eventually adding essence, cocamidopropyl betaine, alkyl polyglucoside are sufficiently mixed under vacuo, disperse, about 20 minutes.
Embodiment 5
Component mark by weight is calculated as follows:
A, benefit early children's toothpaste
Preparation technology is as follows:
(1) xylitol, tetrasodium pyrophosphate, compound vitamin, calcium gluconate, calcium glycerophosphate are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-4000 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) it is eventually adding essence, sodium lauroyl glutamate, alkyl polyglucoside and sodium lauryl sulfate, is sufficiently mixed under vacuo, disperses, about 20 minutes.
B, benefit children's toothpaste in evening
Preparation technology is as follows:
(1) oligomeric galactose, oligo-chitosan, tetrasodium pyrophosphate, compound vitamin, aminoacids complex are added in container 1, add deionized water stirring and dissolving；After having dissolved, add sorbitol and glycerol.
(2) PEG-8 and sodium carboxymethyl cellulose being joined in container 2, dispersed with stirring is uniform, it is ensured that sodium carboxymethyl cellulose does not have conglomeration.By the rubber powder after scattered, join in container 1, dispersed with stirring.
(3) to above-mentioned scattered system, silicon dioxide mild abrasive, under vacuo mixed at high speed 15 to 20 minutes are added；
(4) it is eventually adding essence, sodium lauroyl glutamate, alkyl polyglucoside and sodium lauryl sulfate, is sufficiently mixed under vacuo, disperses, about 20 minutes.
Use embodiment 1:
Select to agree to that 33 are suffered from dental caries child volunteer for 3～6 years old through the head of a family, requirement suffers from dental caries child without whole body system disease, grow normal, fortnight does not take antibiotic before the test, do not carry out oral local administration and be coated with fluorine, a few days ago not carrying out oral hygiene measures (not including clear water to gargle) at first test baseline, dental caries tooth is untreated, be not filled by.Volunteer is randomly divided into two groups: matched group and test group, matched group 16 people, test group 17 people.Morning and evening toothpaste described in test group use-case 1, matched group uses common clean type toothpaste.Experimenter uses toothpaste to brush teeth by regulation requirement.(baseline) before test experimenter test, the mean ph value of dental plaque fluid after test 4 weeks, 8 weeks respectively, test result is table 1 such as.
Table 1 experimenter's dental plaque fluid mean ph value
| Project | Baseline | 4 weeks | 8 weeks |
| Matched group | 6.10±0.58 | 6.11±0.63 | 6.07±0.66 |
| Test group | 6.15±0.52 | 6.47±0.45 | 6.61±0.42* |
* significant difference, P < 0.05 is had with baseline
Result shows, compared with matched group, uses the benefit late combined tooth-paste of early benefit of the present invention after 4 weeks, 8 weeks, and the pH value of dental plaque fluid is significantly raised, and both have significant difference, uses benefit of the present invention early benefit combination in evening children's toothpaste can make pH value rising in oral cavity.
Same, embodiment 2-5 carries out the test method that above-mentioned use embodiment 1 is identical, and result of the test shows, in oral cavity, the pH value of dental plaque fluid is significantly raised, uses benefit of the present invention early benefit combination in evening children's toothpaste that pH value in oral cavity can be made to raise.
PH of dental plaque fluid is mainly determined by bacterial metabolism activity in bacterial plaque, is an important parameter of dental plaque microecological balance.Plaque microbial ecology is an equilibrium system, and wherein bacterial interactions maintains plaque pH about neutrality.Then inducing an illness when the homeostatic mechanism of bacterial plaque is broken, the acid-base balance in oral cavity is broken.Bacterial metabolism in bacterial plaque, produces acid, makes plaque pH reduce；The cleaning capacity in oral cavity self, such as salivary flow, buffer capacity etc., can improve the pH value in oral cavity.Homeostatic mechanism in oral cavity is broken, and acid-base balance is destroyed, and when pH value is chronically at low acid number in oral cavity, makes enamel run off, causes the direct material of tissue of tooth demineralization.Benefit of the present invention early benefit combined tooth-paste in evening maintains Oral health behaviours balance, the oral environment making unstability maintains normal condition, acid-base value in oral cavity is allowed to maintain normal level, promote remineralization of teeth, enamel is prevented to run off, suppress harmful bacterial growth, breeding simultaneously, there is the effects such as mothproof, fresh breath, care gingiva.
Claims (4)
1. benefit early benefit combination in an evening children's toothpaste, it is made up of the benefit used morning early children's toothpaste and the benefit children's toothpaste in evening used evening, it is characterised in that: the raw material of described benefit early children's toothpaste includes wetting agent, thickening agent, mild abrasive, xylitol, calcium containing compound, compound vitamin, gentle surfactant, essence, deionized water；Mark meter by weight, the content range of each raw material is:
The raw material of described benefit children's toothpaste in evening includes wetting agent, thickening agent, mild abrasive, oligosaccharide, amino acid composition, compound vitamin, gentle surfactant, essence, deionized water；Mark meter by weight, the content range of each raw material is:
Described compound vitamin is vitamin C, vitamin E, vitamin B3, vitamin B5 and vitamin B6；
The weight fraction content of the oligosaccharide of described benefit children's toothpaste in evening is 1～10%, and described oligosaccharide is that in oligomeric xylose, Oligomeric maltose, dextrinosan, oligomeric galactose, coupling sugar, oligomeric sucrose, oligo-chitosan and trehalose, one or more are composite.
2. early benefit combination in the evening children's toothpaste of a kind of benefit described in claim 1, it is characterised in that: described benefit early children's toothpaste and benefit children's toothpaste in evening also include sodium lauryl sulfate, and described sodium lauryl sulfate is 1:0.1～3 with gentle surfactant weight ratio.
3. early benefit combination in the evening children's toothpaste of a kind of benefit described in claim 1, it is characterised in that: the calcium containing compound of described benefit early children's toothpaste is that in soluble calcium or slightly soluble calcium, one or more are composite；Described soluble calcium or slightly soluble calcium are that in calcium lactate, calcium glycerophosphate, calcium gluconate, one or more are composite.
4. early benefit combination in the evening children's toothpaste of a kind of benefit described in claim 1, it is characterised in that: the amino acid composition of described benefit children's toothpaste in evening includes cystine, proline, glutamic acid, histidine and methionine.
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| CN105125417A (en) * | 2015-08-18 | 2015-12-09 | 纳诺神蜂（福建）个人护理用品有限公司 | Fluoride-free, non-pigment and saccharin-sodium-free micro-foam type edible children toothpaste and preparation method thereof |
| CN105342894A (en) * | 2015-11-12 | 2016-02-24 | 邹文君 | Yizao toothpaste added with functional modified composite micromolecule material with high permeability and preparation method of Yizao toothpaste |
| CN105748344B (en) * | 2016-02-26 | 2019-03-26 | 北京斯利安药业有限公司 | A kind of edible toothpaste and preparation method thereof |
| CN105832614B (en) * | 2016-05-16 | 2018-10-30 | 上海儿童营养中心有限公司 | A kind of edible natural children's toothpaste and preparation method |
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