CN101849893A - Oligochitosan oral cavity cleaning agent - Google Patents
Oligochitosan oral cavity cleaning agent Download PDFInfo
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- CN101849893A CN101849893A CN 201010192609 CN201010192609A CN101849893A CN 101849893 A CN101849893 A CN 101849893A CN 201010192609 CN201010192609 CN 201010192609 CN 201010192609 A CN201010192609 A CN 201010192609A CN 101849893 A CN101849893 A CN 101849893A
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- oligochitosan
- oral cavity
- cleaning agent
- cavity cleaning
- convenient
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Abstract
The invention discloses oligochitosan oral cavity cleaning agent and a preparation method thereof. The oligochitosan oral cavity cleaning agent is made from oligochitosan, lower polyxylose, sorbitol, magnesium stearate, sweetening agent and essence, and is eatable. When in use, the oligochitosan oral cavity cleaning agent can be directly swallowed without needing to spit and gargle after orally taking or chewing; is convenient as sugar; can achieve the aims of sterilizing, halitosis removing, dental plaque removing, curing the ulcer, the periodontitis, the gingivitis and the pericoronitis, and cleaning the oral cavity; and removing the peculiar smell of the oral cavity by eating stimulating foods. The invention is simple and convenient in use, can be used at any place and any time, has no toxic side effect, can be used for diabetics, is harmless after being used for a long time, and is environment-friendly.
Description
Technical field
A kind of cleaning agent for mouth cavity belongs to the dental care products field.
Background technology
Known cleaning agent for mouth cavity mainly contains toothpaste, dentifrice, collutory etc., be unable to do without water when being characterized in using, after finishing, cleaning to gargle repeatedly to remove cleaning agent, toothpaste such as functional type such as fluoride more will repeatedly be gargled, child particularly, because swallowing reflex is zoon not as yet, and lacks relevant functional training, can swallow part toothpaste when brushing teeth.If young child's method for brushing teeth is incorrect, it is clean inadequately to gargle, the amount of paste that the deutostoma intracavity of brushing teeth is detained is also more, the number of times of brushing teeth is more frequent, and each amount of paste of using is bigger, the people that takes the photograph of fluorine measures just many more, if form and save bit by bit effect, can influence systems such as bone, nerve and the intestines and stomach.This shows, dental care products bring to people salubrious in, also brought problems.
Auxiliary oral-cavity cleaning products commonly used also has chewing gum, can remove intraoral residue preferably, but because of its gum base can produce environmental pollution, and easy-clear not, and a lot of at present countries have limited the use of chewing gum as Singapore etc.
Above-mentioned cleaning agent for mouth cavity can only play the effect of cleaning and caries prevention usually, and does not eliminate effects such as oral inflammation, treatment dental caries, antihalitosis, ulcer.And being subjected to site limitation when using, inconvenience is used at any time, carries also inconvenient.
Summary of the invention
A kind of oligochitosan oral cavity cleaning agent.Oligochitosan is that chitosan passes through 2～10 glucosamine that the enzyme depolymerization obtains with β-1, and the oligomeric amido glucose that the 4-glycosidic bond is formed by connecting, oligochitosan are the positively charged alkaline aminopolysaccharides of unique a large amount of existence in the natural sugar.Because oligochitosan has free amino and hydroxyl simultaneously, so have special physiologically active; Nontoxic, biodegradable, good biocompatibility.Oligochitosan water solublity＞99%, human absorptivity 〉=99.88%, thus have more superior biological activity than chitosan.Zoopery shows: oligochitosan is to the subacute toxicity of rat, adopt 500,1000 respectively, afterwards observe in 4 weeks of 2000mgP (kgd) administration, the result shows, matched group and experimental group not only there are no significant at aspects such as behavior, appearance, body weight, food consumptions difference, and at aspects such as urinalysis, hematology and histopathology also there was no significant difference.The subacute toxicity of prompting oligochitosan is very little, we can say that oligochitosan is safe pure natural health-care.Oligochitosan also is continue protein, sugar, fat, vitamin, mineral the sixth-largest vital principle in addition.Outstanding features such as oligochitosan has good water solubility, biological activity height, efficacy effect is big, application extensively, easily is absorbed by the body; Be widely used in fields such as daily use chemicals, medicine, functional food, agriculturals.By comparative experiments, the existence that has proved free amine group is the basis of oligochitosan antibacterial and bacteriostasis.On the one hand, because the protonated ammonium of the positively charged formation of the free amino of oligochitosan, the cell wall of the antibacterial that the NH4+ absorption of positive charge is electronegative, make oligochitosan be adsorbed on surface of cell membrane, changed the selection permeability of cell membrane, stoped nutrient substance, caused Cytoplasm to run off to intracellular transportation, cell plasmolysis, thus play the bacteriostasis and sterilization effect.On the other hand, oligochitosan has certain water solublity again because molecular weight is very little, can directly enter within the thalline, upsets its normal physiological metabolism, makes it to disintegrate decline by inside, thereby reaches the bacteriostatic effect, and these two model of action are complementary.
Oligochitosan has deactivation to actinobacillus actinomycetem comitans and two kinds of oral pathology substances of streptococcus mutans.By electron microscopic observation, oligochitosan can cause breaking of actinobacillus actinomycetem comitans cell membrane, so oligochitosan can treatment and the periodontal that causes of actinobacillus actinomycetem comitans and two kinds of oral pathology substances of streptococcus mutans.Oligochitosan also helps the rehabilitation of oral mucosa, the effect of promotion wound healing, and its principle is that oligochitosan can promote fibroblasts proliferation, increases the release of type i collagen enzyme in the fibroblast, and oligochitosan has mitogenetic effect.Therefore can promote wound healing.
Oligochitosan all has inhibitory action to escherichia coli, sarcina, yeast, and its bacteriostasis rate has obviously surpassed contrast, and along with the increase of mass concentration, to all corresponding enhancing of bacteriostasis of each bacterium, antibacterial is subject to suppress; When the mass concentration 1g/L, suppressed the growth of escherichia coli, sarcina fully, yeast is secondly.Oligochitosan is 2g/L to saccharomycetic minimum antibacterial mass concentration.Free amino group on the oligochitosan can also suppress the generation of ulcer, so oligochitosan still be a kind of good antiulcer material in conjunction with the acidic materials of equivalent.Oligochitosan has inhibitory or killing effect to harmful bacterium, but the probiotics of human body such as bacillus bifidus, lactobacillus are then had facilitation.
The present invention solves the technical scheme that its technical problem takes: for remedy existing oral-cavity cleaning products use can not be whenever and wherever possible, be unable to do without water, swallow and can bring uncomfortable, as to carry inconvenience etc. deficiency because of carelessness, the invention provides a kind of oligochitosan oral cavity cleaning agent, formulated by oligochitosan 0.2～0.8% (percentage by weight), oligomeric xylose 0.7～1.4% (percentage by weight), Sorbitol, magnesium stearate, sweeting agent, essence, be eatable cleaning agent for mouth cavity.Can be made into the tablet of any geometry, directly swallow after sucking during use or chewing and need not to spue and gargle, convenient as eating sugar, can reach sterilization, antihalitosis, removal dental plaque, the effect of treatment ulcer, periodontitis, gingivitis, pericoronitis and cleaning oral cavity, and because of eating the halitosis that irritable food causes.Have and use simply, convenient, can use whenever and wherever possible, nontoxic, have no side effect owing to all be the edible material in the prescription, the diabetes patient can use, and life-time service is harmless.Raw material sources are easy, and production technology is simple, and common tabletting production gets final product.
The invention has the beneficial effects as follows: because dental caries, ulcer and most halitosis all are to be caused by intraoral antibacterial, people are using (suck or chew) when containing the cleaning agent for mouth cavity of oligochitosan, oligochitosan wherein directly acts on tooth and oral mucosa, can effectively sterilize, antibacterial, prevent and treat dental caries, remove dental plaque, inflammation such as treatment ulcer, periodontitis, gingivitis, pericoronitis; After noxious bacteria in the oral cavity was pressed down extremely, halitosis, dental caries, dental plaque, ulcer had not just had yet; Also can effectively remove the halitosis that edible irritable food causes.Directly swallow after sucking during use or chewing and need not to spue and gargle, convenient as eating sugar.The present invention is easy to use, simple, is easy to carry about with one, preserves, and the diabetes patient can use, and life-time service has no side effect, and can not produce any pollution to environment.
The present invention solves the technical scheme that its technical problem takes: the oligochitosan oral cavity cleaning agent raw material that will prepare in proportion, with conventional production process, use tablet machine to make the tablet of any geometry, grammes per square metre on demand, carry out different packings then on request.Have production technology characteristics simple, with low cost.
The specific embodiment
The oligochitosan oral cavity cleaning agent raw material for preparing is in proportion carried out processing with conventional production process on common tablet machine get final product.Can pack as required after making tablet, manner of packing is optional.
Claims (4)
1. oligochitosan oral cavity cleaning agent.
2. according to the described oligochitosan oral cavity cleaning agent of claim 1, it is characterized in that: oligochitosan is added in the constitutive material in proportion produce.
3. according to the described oligochitosan oral cavity cleaning agent of claim 1, it is characterized in that: oligomeric xylose is added in the constitutive material in proportion produce.
4. according to the described oligochitosan oral cavity cleaning agent of claim 1, it is characterized in that: dosage form can be solid-state, also can be liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010192609 CN101849893A (en) | 2010-06-07 | 2010-06-07 | Oligochitosan oral cavity cleaning agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010192609 CN101849893A (en) | 2010-06-07 | 2010-06-07 | Oligochitosan oral cavity cleaning agent |
Publications (1)
| Publication Number | Publication Date |
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| CN101849893A true CN101849893A (en) | 2010-10-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010192609 Pending CN101849893A (en) | 2010-06-07 | 2010-06-07 | Oligochitosan oral cavity cleaning agent |
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| CN (1) | CN101849893A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102440845A (en) * | 2011-09-09 | 2012-05-09 | 长春市安惠科技有限公司 | Occlusive type tooth cleaning method through tooth tray |
| CN103385805A (en) * | 2013-07-18 | 2013-11-13 | 广州薇美姿个人护理用品有限公司 | Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening |
| CN106176284A (en) * | 2016-08-25 | 2016-12-07 | 青岛明药堂医疗股份有限公司 | A kind of natural bacteriostatic whitening dentifrice and preparation method thereof |
| CN106726667A (en) * | 2016-12-27 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of cleaning agent for mouth cavity and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN101181293A (en) * | 2007-12-07 | 2008-05-21 | 武乾鹰 | Oral health lozenge for preventing tooth decay |
-
2010
- 2010-06-07 CN CN 201010192609 patent/CN101849893A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN101181293A (en) * | 2007-12-07 | 2008-05-21 | 武乾鹰 | Oral health lozenge for preventing tooth decay |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102440845A (en) * | 2011-09-09 | 2012-05-09 | 长春市安惠科技有限公司 | Occlusive type tooth cleaning method through tooth tray |
| CN103385805A (en) * | 2013-07-18 | 2013-11-13 | 广州薇美姿个人护理用品有限公司 | Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening |
| CN103385805B (en) * | 2013-07-18 | 2016-06-29 | 广州薇美姿实业有限公司 | A kind of benefit is benefit combination children's toothpaste in evening and one benefit children's toothpaste in evening early |
| CN106176284A (en) * | 2016-08-25 | 2016-12-07 | 青岛明药堂医疗股份有限公司 | A kind of natural bacteriostatic whitening dentifrice and preparation method thereof |
| CN106726667A (en) * | 2016-12-27 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of cleaning agent for mouth cavity and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20101006 |