CN101972215A - Chitosan oligosaccharide oral cavity cleaning tablet - Google Patents
Chitosan oligosaccharide oral cavity cleaning tablet Download PDFInfo
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- CN101972215A CN101972215A CN 201010500093 CN201010500093A CN101972215A CN 101972215 A CN101972215 A CN 101972215A CN 201010500093 CN201010500093 CN 201010500093 CN 201010500093 A CN201010500093 A CN 201010500093A CN 101972215 A CN101972215 A CN 101972215A
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- oral cavity
- chitosan oligosaccharide
- oligochitosan
- cavity cleaning
- cleaning tablet
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Abstract
The invention discloses a chitosan oligosaccharide oral cavity cleaning tablet and a preparation method thereof. The chitosan oligosaccharide oral cavity cleaning tablet is prepared by chitosan oligosaccharide, xylitol, sorbitol, magnesium stearate, abradant, sweetener and essence; when in use, the chitosan oligosaccharide oral cavity cleaning tablet can be placed in the mouth and chewed repeatedly for achieving the effect of cleaning oral cavity. The chitosan oligosaccharide oral cavity cleaning tablet has the effects of sterilizing, removing halitosis, treating ulcers, periodontitis, ngivitis and pericoronitis and cleaning the oral cavity, and can further remove peculiar smell of the oral cavity caused by eating irritating food and eliminate the need of mouth washing after the use. The chitosan oligosaccharide oral cavity cleaning tablet is simple and convenient to use and can be used anytime and anywhere, as components in the formula are the edible materials, the chitosan oligosaccharide oral cavity cleaning tablet has no toxicity or side effects, can be used for patients with diabetes and is harmless during long-term use.
Description
Technical field
A kind of cleaning tablet of oral cavity belongs to the dental care products field.
Background technology
Known oral-cavity cleaning products mainly contains toothpaste, dentifrice, collutory etc., be unable to do without water when being characterized in using, after finishing, cleaning to gargle repeatedly thoroughly to dispel cleaning agent, toothpaste such as functional type such as fluoride more will repeatedly be gargled, when particularly the child uses toothpaste such as fluoride, because swallowing reflex is zoon not as yet, and lacks relevant functional training, can swallow part toothpaste when brushing teeth.If young child's method for brushing teeth is incorrect, it is clean inadequately to gargle, the amount of paste that the deutostoma intracavity of brushing teeth is detained is also more, the number of times of brushing teeth is more frequent, and each amount of paste of using is bigger, the people that takes the photograph of fluorine measures just many more, if fluoride forms and saves bit by bit effect, can influence systems such as bone, nerve and the intestines and stomach.This shows, dental care products bring to people salubrious in, also brought problems.
Above-mentioned oral-cavity cleaning products can only play the effect of cleaning and caries prevention usually, and lacks effects such as eliminating oral inflammation, treatment dental caries, antihalitosis, ulcer.And being subjected to site limitation when using, inconvenience is used at any time, carries also inconvenient.
Summary of the invention
A kind of oligochitosan oral cavity cleaning foil.Oligochitosan unique physical and chemical properties and biological activity make it have sterilization, antibacterial, antiinflammatory, effect such as eliminate the unusual smell.
Oligochitosan is that chitosan passes through 2～10 glucosamine that the enzyme depolymerization obtains with β-1, and the oligomeric amido glucose that the 4-glycosidic bond is formed by connecting, oligochitosan are the positively charged alkaline aminopolysaccharides of unique a large amount of existence in the natural sugar.Because oligochitosan has free amino and hydroxyl simultaneously, so have special physiologically active; Nontoxic, biodegradable, good biocompatibility.Oligochitosan water solublity＞99%, human absorptivity 〉=98%, thus have more superior biological activity than chitosan.Zoopery shows: oligochitosan is to the subacute toxicity of rat, adopt 500,1000 respectively, afterwards observe in 4 weeks of 2000mgP (kgd) administration, the result shows, matched group and experimental group not only there are no significant at aspects such as behavior, appearance, body weight, food consumptions difference, and at aspects such as urinalysis, hematology and histopathology also there was no significant difference.The subacute toxicity of prompting oligochitosan is very little, we can say that oligochitosan is safe pure natural health-care.Oligochitosan also is continue protein, sugar, fat, vitamin, mineral the sixth-largest vital principle in addition.Outstanding features such as oligochitosan has good water solubility, biological activity height, efficacy effect is big, application extensively, easily is absorbed by the body; Be widely used in fields such as daily use chemicals, medicine, functional food, agriculturals.By comparative experiments, the existence that has proved free amine group is the basis of oligochitosan antibacterial and bacteriostasis.On the one hand, since the protonated ammonium of the positively charged formation of the free amino of oligochitosan, the NH of positive charge
4 +Adsorb the cell wall of electronegative antibacterial, make oligochitosan be adsorbed on surface of cell membrane, changed the selection permeability of cell membrane, stop nutrient substance, cause Cytoplasm to run off to intracellular transportation, cell plasmolysis, thus play the bacteriostasis and sterilization effect.On the other hand, oligochitosan has certain water solublity again because molecular weight is very little, can directly enter within the thalline, upsets its normal physiological metabolism, makes it to disintegrate decline by inside, thereby reaches the bacteriostatic effect, and these two model of action are complementary.
Oligochitosan has deactivation to actinobacillus actinomycetem comitans and two kinds of oral pathology substances of streptococcus mutans.By electron microscopic observation, oligochitosan can cause breaking of actinobacillus actinomycetem comitans cell membrane, so oligochitosan can treatment and the periodontal that causes of actinobacillus actinomycetem comitans and two kinds of oral pathology substances of streptococcus mutans.Oligochitosan also helps the rehabilitation of oral mucosa, the effect of promotion wound healing, and its principle is that oligochitosan can promote fibroblasts proliferation, increases the release of type i collagen enzyme in the fibroblast, and oligochitosan has mitogenetic effect.Therefore can promote wound healing.
Oligochitosan all has inhibitory action to escherichia coli, sarcina, yeast, and its bacteriostasis rate has obviously surpassed contrast, and along with the increase of mass concentration, to all corresponding enhancing of bacteriostasis of each bacterium, antibacterial is subject to suppress; When the mass concentration 1g/L, suppressed the growth of escherichia coli, sarcina fully, yeast is secondly.Oligochitosan is 2g/L to saccharomycetic minimum antibacterial mass concentration.Free amino group on the oligochitosan can also suppress the generation of ulcer, so oligochitosan still be a kind of good antiulcer material in conjunction with the acidic materials of equivalent.Oligochitosan has inhibitory or killing effect to harmful bacterium, but the probiotics of human body such as bacillus bifidus, lactobacillus are then had facilitation.
The present invention solves the technical scheme that its technical problem takes: can not be whenever and wherever possible in order to remedy that existing oral-cavity cleaning products uses, be unable to do without water, swallow because of carelessness can bring uncomfortable, carry the deficiency of inconvenience etc., the invention provides a kind of oligochitosan oral cavity cleaning foil, by oligochitosan 0.2～1.0% (percentage by weight), xylitol 30～60% (percentage by weight), Sorbitol 10～30%, magnesium stearate 0.1～0.3%, abrasivus 3.0～8.0%, sweeting agent 0.1～0.3%, essence 0.5～1.2% is formulated, be the oral-cavity cleaning products of can immediate access chewing, can be made into the tablet of any geometry.Put into mouth during use and chew the effect that can reach cleaning oral cavity repeatedly as eating chewing gum, oligochitosan wherein has the effect of sterilization, antihalitosis, treatment ulcer, periodontitis, gingivitis, pericoronitis and cleaning oral cavity; The oligochitosan oral cavity cleaning foil also can be removed the halitosis that causes because of edible irritable food; Abrasivus can be removed the food debris that adheres on dental plaque and the facing, can prevent effectively that the dental plaque calcification from forming dental calculus; Gum base can be removed the food debris that is embedded in the teeth crevice well, removes the effect ratio and brushes teeth better, more direct; Need not after the use to gargle.Have more and use simply, convenient, can use whenever and wherever possible, nontoxic, have no side effect owing to all be the edible material in the prescription, do not contain raw sugar the diabetes patient can be used, life-time service is nontoxic.Raw material sources are easy, and production technology is simple.
The invention has the beneficial effects as follows: because dental caries, ulcer and most halitosis all are to be caused by intraoral antibacterial, people are using (suck or chew) when containing the cleaning tablet of oral cavity of oligochitosan, oligochitosan wherein directly acts on tooth and oral mucosa, can effectively sterilize, antibacterial, prevent and treat dental caries, remove dental plaque, inflammation such as treatment ulcer, periodontitis, gingivitis, pericoronitis; After noxious bacteria in the oral cavity was pressed down extremely, halitosis, dental caries, dental plaque, ulcer had not just had yet; Also can effectively remove the halitosis that edible irritable food causes.Immediate access is chewed during use, and chewing gum sugar is convenient as eating, and does not need after the use to gargle.The present invention is easy to use, simple, is easy to carry about with one, preserves, and the diabetes patient can use, and life-time service has no side effect, and can not produce any pollution to environment.
The present invention solves the technical scheme that its technical problem takes: the oligochitosan oral cavity cleaning foil raw material that will prepare in proportion, with tablet forming technique production, use tablet machine to make the tablet of any geometry, grammes per square metre on demand, carry out different packings then on request.Have production technology characteristics simple, with low cost.
The specific embodiment
The oligochitosan oral cavity cleaning foil raw material for preparing is in proportion carried out processing on tablet machine get final product.Can pack as required after making tablet, manner of packing is optional.
Claims (4)
1. oligochitosan oral cavity cleaning foil.
2. according to the described oligochitosan oral cavity cleaning foil of claim 1, it is characterized in that: oligochitosan is added in the constitutive material in proportion produce.
3. according to the described oligochitosan oral cavity cleaning foil of claim 1, it is characterized in that: contain gum base and abrasivus.
4. according to the described oligochitosan oral cavity cleaning foil of claim 1, it is characterized in that: dosage form is a tablet, can be any geometry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010500093 CN101972215A (en) | 2010-10-09 | 2010-10-09 | Chitosan oligosaccharide oral cavity cleaning tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010500093 CN101972215A (en) | 2010-10-09 | 2010-10-09 | Chitosan oligosaccharide oral cavity cleaning tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101972215A true CN101972215A (en) | 2011-02-16 |
Family
ID=43572146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010500093 Pending CN101972215A (en) | 2010-10-09 | 2010-10-09 | Chitosan oligosaccharide oral cavity cleaning tablet |
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| CN (1) | CN101972215A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202014009376U1 (en) | 2014-11-26 | 2015-02-27 | Sven Bahrke | Cosmetic products containing chitosan / chitooligosaccharides for the care of teeth, mouth and throat |
| CN105410913A (en) * | 2015-12-01 | 2016-03-23 | 辽宁三合酒业有限公司 | Preparation method of chitosan oligosaccharide mouth cleaning buccal tablets |
| CN105455126A (en) * | 2015-12-01 | 2016-04-06 | 辽宁三合酒业有限公司 | Preparation method of chewable tablets containing chitosan oligosaccharide |
| CN106176284A (en) * | 2016-08-25 | 2016-12-07 | 青岛明药堂医疗股份有限公司 | A kind of natural bacteriostatic whitening dentifrice and preparation method thereof |
| WO2017107627A1 (en) * | 2015-12-24 | 2017-06-29 | 广东药科大学 | Chitosan oligosaccharide tablet and preparation method therefor |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN101181293A (en) * | 2007-12-07 | 2008-05-21 | 武乾鹰 | Oral health lozenge for preventing tooth decay |
-
2010
- 2010-10-09 CN CN 201010500093 patent/CN101972215A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN101181293A (en) * | 2007-12-07 | 2008-05-21 | 武乾鹰 | Oral health lozenge for preventing tooth decay |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202014009376U1 (en) | 2014-11-26 | 2015-02-27 | Sven Bahrke | Cosmetic products containing chitosan / chitooligosaccharides for the care of teeth, mouth and throat |
| CN105410913A (en) * | 2015-12-01 | 2016-03-23 | 辽宁三合酒业有限公司 | Preparation method of chitosan oligosaccharide mouth cleaning buccal tablets |
| CN105455126A (en) * | 2015-12-01 | 2016-04-06 | 辽宁三合酒业有限公司 | Preparation method of chewable tablets containing chitosan oligosaccharide |
| WO2017107627A1 (en) * | 2015-12-24 | 2017-06-29 | 广东药科大学 | Chitosan oligosaccharide tablet and preparation method therefor |
| CN106176284A (en) * | 2016-08-25 | 2016-12-07 | 青岛明药堂医疗股份有限公司 | A kind of natural bacteriostatic whitening dentifrice and preparation method thereof |
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| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20110216 |