CN105455126A - Preparation method of chewable tablets containing chitosan oligosaccharide - Google Patents
Preparation method of chewable tablets containing chitosan oligosaccharide Download PDFInfo
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- CN105455126A CN105455126A CN201510859420.XA CN201510859420A CN105455126A CN 105455126 A CN105455126 A CN 105455126A CN 201510859420 A CN201510859420 A CN 201510859420A CN 105455126 A CN105455126 A CN 105455126A
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- chitosan oligosaccharide
- collagen
- gelatin
- chewable tablets
- preparation
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- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 title claims abstract description 77
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 108010035532 Collagen Proteins 0.000 claims abstract description 34
- 102000008186 Collagen Human genes 0.000 claims abstract description 34
- 229920001436 collagen Polymers 0.000 claims abstract description 34
- 108010010803 Gelatin Proteins 0.000 claims abstract description 28
- 229920000159 gelatin Polymers 0.000 claims abstract description 28
- 239000008273 gelatin Substances 0.000 claims abstract description 28
- 235000019322 gelatine Nutrition 0.000 claims abstract description 28
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000004108 freeze drying Methods 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 238000005520 cutting process Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 108010025899 gelatin film Proteins 0.000 claims abstract description 5
- 239000007787 solid Substances 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 2
- 238000010297 mechanical methods and process Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 description 5
- 229920001542 oligosaccharide Polymers 0.000 description 5
- 150000002482 oligosaccharides Polymers 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- -1 amine group oligosaccharides Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 235000013406 prebiotics Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- LXJOYRVJPWDJBZ-UHFFFAOYSA-N (2-acetamido-3-hydroxyphenyl)arsonic acid Chemical compound OC=1C(=C(C=CC1)[As](O)(O)=O)NC(C)=O LXJOYRVJPWDJBZ-UHFFFAOYSA-N 0.000 description 1
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 235000007926 Craterellus fallax Nutrition 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 240000007175 Datura inoxia Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000020604 functional milk Nutrition 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000005067 joint tissue Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of chewable tablets containing chitosan oligosaccharide. In terms of the total weight of the chewable tablets containing the chitosan oligosaccharide, the ratio of the chitosan oligosaccharide to collagen to gelatin is (1%-5%):(20%-40%):(60%-80%). The method comprises steps as follows: (1) the chitosan oligosaccharide, the collagen and the gelatin are mixed in solid states; (2) a chitosan oligosaccharide, collagen and gelatin mixture obtained in Step (1) is added to purified water with the weight 20-40 times that of the mixture, and a mixture is stirred at the temperature of 61-85 DEG C for 10-20 min and introduced to a filter net for press filtering treatment twice; (3) chitosan oligosaccharide, collagen and gelatin homogenate obtained in Step (2) is poured into a die, and the thickness of a homogenate layer is controlled to range from 5 mm to 30 mm; (4) the die containing the chitosan oligosaccharide, collagen and gelatin homogenate in Step (3) is placed into a freezing dryer to be prefreezed at the temperature of subzero 40 DEG C for 40-60 min and then subjected to vacuum pumping for freeze-drying until the moisture content of a freeze-dried film is controlled to range from 3wt% to 8wt%; (5) the chewable tablets are prepared from the chitosan oligosaccharide, collagen and gelatin film prepared in Step (4) with a die cutting method.
Description
Technical field
The invention belongs to field of food science, particularly, the present invention relates to a kind of preparation method containing chitosan oligosaccharide chewable tablets.
Technical background
Shitosan is the binary linearity polymer be connected by β-(1-4) glycosidic bond with a small amount of 2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-D-glucopyranose by most of 2-amino-2-deoxidation-D-glucopyranose; a kind of pure natural polysaccharide organic polymer that the chitin normally extracted with the shell of shrimp, crab, insect or the cell membrane such as Mycophyta, algae obtains through deacetylation is a kind of alkaline polysaccharide that the abundance of occurring in nature existence is higher.
Chitosan oligosaccharide, also known as chitin oligo saccharide, is the oligosaccharide that shitosan will be formed after its backbone breaking through modes such as physics, chemistry or enzyme degradeds, is the basic amine group oligosaccharides of occurring in nature uniquely containing positive charge.The molecular structure of poly oligosaccharide uniqueness makes it have multiple biologically active, the biologically active be identified at present comprise calcium and iron in develop immunitypty, antitumor, adjusting blood lipid, adjustment blood pressure, acceleration bodies absorption, reduce blood sugar and promote the function (BA of functional chitosan oligosaccharide such as reparation of joint tissue, the chemistry of life, 2012,32 (5): 460-463); In addition, also have and regulate pH value of human body and fungistatic effect, be also the key character that chitosan oligosaccharide is different from other oligosaccharides, current chitosan oligosaccharide one becomes emerging functional oligose in the world.The degree of polymerization be 2 ~ 10 chitosan oligosaccharide better and easily absorbed by body because it is water-soluble, its pharmacological action can be played better.
Due to special construction and various biologically active, chitosan oligosaccharide has become the focus of the research and development such as food and health food in the world, Korea S, Japan and the country such as American-European develop the multiple food containing chitosan oligosaccharide, within 2014, chitosan oligosaccharide is listed in new raw-food material list by China, and the product such as food, drink based on chitosan oligosaccharide also becomes increasingly abundant.As application number be 201210118210.1 patent discloses a kind of preparation method with the functional milk beverage of the interpolation chitosan oligosaccharide of prebiotic function, prebiotics is allowed to enter enteron aisle, play a role with probio, improve microorganism species distribution in enteron aisle, chitosan oligosaccharide can be used as the natural antiseptic agent of beverage simultaneously.Chitosan oligosaccharide drinking water (patent No. 101653283B) discloses a kind of chitosan oligosaccharide drinking water preparation method; At the product also comparatively horn of plenty of field of food containing chitosan oligosaccharide, as the production method (201110134693.X) of chitosan oligosaccharide instant vegetable; A kind of preparation method's (application number: 201310648917.8) containing chitosan oligosaccharide biscuit.Chitosan oligosaccharide and other raw material being carried out composite is also focus in recent years, as patent (201210338284.6) discloses the preparation method of a kind of chitosan oligosaccharide and cross-linking hyaluronic acid gel, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride crosslinking agent is adopted to prepare the plural gel of hyaluronic acid-chitosan oligosaccharide, avoid hyaluronic acid acid degradation problem, promote that the amino of hyaluronic carboxyl and chitosan oligosaccharide reacts formation gel; The raw material such as chitosan oligosaccharide and collagen peptide is carried out composite patent application (201110290660.4) and disclose a kind of chitosan oligosaccharide-collpeptide peptide compound health food and preparation method thereof.Traditional product containing chitosan oligosaccharide mainly applies the functions such as its develop immunitypty, antitumor, adjusting blood lipid and adjustment blood pressure; Chitosan oligosaccharide also has sterilization, antibacterial, anti-inflammatory and the effect such as to eliminate the unusual smell, but corresponding product or patent application less, chitosan oligosaccharide oral cavity cleaning tablet (application number 201010500093.6) discloses a kind of chitosan oligosaccharide oral cavity cleaning tablet and preparation method thereof, formulated by chitosan oligosaccharide, xylitol, D-sorbite, stearic acid town, rubbing agent, sweetener, essence, but products taste is not satisfactory and application is not very convenient.
Summary of the invention
The present invention aims to provide a kind of preparation method containing chitosan oligosaccharide chewable tablets, the effect making full use of chitosan oligosaccharide sterilization, antibacterial, anti-inflammatory and eliminate the unusual smell, be composite raw material with collagen and gelatin, by fully mixing and cryodesiccated technology, prepare chewable tablets easy to carry, to be beneficial to preservation, be beneficial to oral hygiene.
The invention provides a kind of preparation method containing chitosan oligosaccharide chewable tablets, it is characterized in that, with the gross weight of described chitosan oligosaccharide chewable tablets for benchmark, chitosan oligosaccharide, collagen and gelatin mixed proportion are 1% ~ 5%:20% ~ 40%:60% ~ 80%, and preparation method comprises following preparation process:
(1) chitosan oligosaccharide, collagen and gelatin are mixed in proportion, mixed proportion is 1% ~ 5%:20% ~ 40%:60% ~ 80%;
(2) chitosan oligosaccharide, collagen and gelatin mixture that step (1) obtains are joined the pure water of 20 ~ 40 times of this mixture weight, 10min ~ 20min is stirred under 61 DEG C ~ 85 DEG C conditions, carry out press filtration process 2 times through filter screen, cause it to be thoroughly mixed to form homogenate;
(3) mould is poured in chitosan oligosaccharide step (2) obtained, collagen and gelatin homogenate into, and homogenate layer thickness controls at 5mm ~ 30mm, adopts Mechanical Method to make its surface uniform;
(4) step (3) is filled chitosan oligosaccharide, the mould of collagen and gelatin homogenate puts into freeze drier, precooling 40min ~ 60min under-40 DEG C of conditions, then vacuumize and carry out freeze drying, until the water content of membrane after freeze-drying controls 3 ~ 8 % by weight;
(5) that step (4) is prepared forms chewable tablets containing chitosan oligosaccharide, collagen and gelatin film by the method for cross cutting.
Preferably, in described step (1), the degree of polymerization of chitosan oligosaccharide is for controlling at 3-15.
Preferably, in described step (1), the molecular weight of collagen peptide controls at 3100Da ~ 5000Da.
Preferably, in described step (1), gelatin mean molecule quantity is 20000Da ~ 60000Da.
Preferably, in described step (2), prepare the screen diameter used in homogenization process and control at 200 order ~ 500 orders.
A kind of preparation method containing chitosan oligosaccharide chewable tablets provided by the invention, the chewable tablets containing chitosan oligosaccharide, collagen and gelatin prepared eats by the mode such as sucking or chew, and its advantage is that preparation process is simple, and the water content of product is low, carrying portable, can long-term storage at normal temperatures.By the hardness selecting the molecular weight of gelatin can control chitosan oligosaccharide chewable tablets, the intensity of chitosan oligosaccharide chewable tablets can be controlled by the content controlling collagen.
Figure of description
Fig. 1 is the flow chart of a kind of preparation method containing chitosan oligosaccharide chewable tablets of the present invention
Specific embodiment
Below by embodiment, the present invention is specifically described; what be worth proposition is; embodiment is just to the explanation of a kind of preparation method containing chitosan oligosaccharide chewable tablets of the present invention; the whole of patent of the present invention can not be represented; more limiting the scope of the invention can not be interpreted as; under the precondition of design not departing from essence of the present invention, some adjustment or improvement can also be made, all belong to protection scope of the present invention.
Embodiment 1
(1) chitosan oligosaccharide (polymer 12) 0.3kg, collagen (mean molecule quantity 3200Da) 2kg and gelatin (mean molecule quantity 25000Da) 7.7kg is taken, Homogeneous phase mixing.
(2) chitosan oligosaccharide, collagen and gelatin mixture that step (1) obtains are joined in 400kg pure water, under 70 DEG C of conditions, stir 15min, carry out press filtration process 2 times by 300 object silk screens, cause it to be thoroughly mixed to form homogenate.
(3) mould is poured in chitosan oligosaccharide step (2) obtained, collagen and gelatin homogenate into, and homogenate layer depth controls at 10mm, adopts scraper to be struck off on its surface.
(4) step (3) is filled chitosan oligosaccharide, the mould of collagen and gelatin homogenate puts into freeze drier, precooling 60min under-40 DEG C of conditions, then vacuumizes and carries out freeze drying 16h, and the water content of membrane after freeze-drying controls 4.8%.
(5) that step (4) is prepared carries out cross cutting containing chitosan oligosaccharide, collagen and gelatin film, and the length of side controlling the chewable tablets after cross cutting is 20mm, forms square chitosan oligosaccharide chewable tablets.
Embodiment 2
(1) chitosan oligosaccharide (polymer 14) 0.2kg, collagen (mean molecule quantity 3600Da) 3kg and gelatin (mean molecule quantity 30000Da) 6.8kg is taken, Homogeneous phase mixing.
(2) chitosan oligosaccharide, collagen and gelatin mixture that step (1) obtains are joined in 300kg pure water, under 65 DEG C of conditions, stir 20min, carry out press filtration process 2 times by 250 object silk screens, cause it to be thoroughly mixed to form homogenate.
(3) mould is poured in chitosan oligosaccharide step (2) obtained, collagen and gelatin homogenate into, and homogenate layer depth controls at 15mm, adopts scraper to be struck off on its surface.
(4) step (3) is filled chitosan oligosaccharide, the mould of collagen and gelatin homogenate puts into freeze drier, precooling 40min under-40 DEG C of conditions, then vacuumizes and carries out freeze drying 20h, and the water content of membrane after freeze-drying controls 3.6%.
(5) that step (4) is prepared carries out cross cutting containing chitosan oligosaccharide, collagen and gelatin film, and the chitosan oligosaccharide chewable tablets prepared is the disk being of a size of diameter 20mm.
Claims (4)
1. the preparation method containing chitosan oligosaccharide chewable tablets, it is characterized in that, with the gross weight of described chitosan oligosaccharide chewable tablets for benchmark, the ratio of chitosan oligosaccharide, collagen and gelatin is 1% ~ 5%:20% ~ 40%:60% ~ 80%, and described preparation method comprises following preparation process:
(1) chitosan oligosaccharide, collagen and gelatin are mixed in proportion in the solid state;
(2) chitosan oligosaccharide, collagen and gelatin mixture that step (1) obtains are joined the pure water of 20 ~ 40 times of this mixture weight, 10min ~ 20min is stirred under 61 DEG C ~ 85 DEG C conditions, logical filter screen carries out press filtration process 2 times, causes it to be thoroughly mixed to form homogenate;
(3) mould is poured in chitosan oligosaccharide step (2) obtained, collagen and gelatin homogenate into, and homogenate layer thickness controls at 5mm ~ 30mm, adopts Mechanical Method to make its surface uniform;
(4) step (3) is filled chitosan oligosaccharide, the mould of collagen and gelatin homogenate puts into freeze drier, precooling 40min ~ 60min under-40 DEG C of conditions, then vacuumize and carry out freeze drying, until the water content of membrane after freeze-drying controls 3 ~ 8 % by weight;
(5) that step (4) is prepared is prepared into chewable tablets containing chitosan oligosaccharide, collagen and gelatin film by the method for cross cutting.
2. a kind of preparation method containing chitosan oligosaccharide chewable tablets as claimed in claim 1, it is characterized in that in described step (1), the chitosan oligosaccharide degree of polymerization is 3-15, collagen peptide molecular weight ranges 3100Da ~ 5000Da, gelatin mean molecule quantity is 20000Da ~ 60000Da.
3. a kind of preparation method containing chitosan oligosaccharide chewable tablets as claimed in claim 1, is characterized in that in described step (2), prepares the screen diameter used in homogenization process and control at 200 order ~ 500 orders.
4. a kind of preparation method containing chitosan oligosaccharide chewable tablets as claimed in claim 1, is characterized in that in described step (3), in mould, homogenate layer thickness controls at 5mm ~ 30mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510859420.XA CN105455126A (en) | 2015-12-01 | 2015-12-01 | Preparation method of chewable tablets containing chitosan oligosaccharide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510859420.XA CN105455126A (en) | 2015-12-01 | 2015-12-01 | Preparation method of chewable tablets containing chitosan oligosaccharide |
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| Publication Number | Publication Date |
|---|---|
| CN105455126A true CN105455126A (en) | 2016-04-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107296261A (en) * | 2016-04-14 | 2017-10-27 | 宋永升 | A kind of processing method of gelatine leaves |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972215A (en) * | 2010-10-09 | 2011-02-16 | 苗辉 | Chitosan oligosaccharide oral cavity cleaning tablet |
-
2015
- 2015-12-01 CN CN201510859420.XA patent/CN105455126A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972215A (en) * | 2010-10-09 | 2011-02-16 | 苗辉 | Chitosan oligosaccharide oral cavity cleaning tablet |
Non-Patent Citations (2)
| Title |
|---|
| 张兆旺: "《中药药剂学》", 31 March 2007 * |
| 李爱民: "无糖型胶原蛋白刺梨咀嚼片的研制", 《明胶科学与技术》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107296261A (en) * | 2016-04-14 | 2017-10-27 | 宋永升 | A kind of processing method of gelatine leaves |
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Application publication date: 20160406 |