CN102525833A - Anti-caries mouthwash composition - Google Patents

Anti-caries mouthwash composition Download PDF

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Publication number
CN102525833A
CN102525833A CN2010105968966A CN201010596896A CN102525833A CN 102525833 A CN102525833 A CN 102525833A CN 2010105968966 A CN2010105968966 A CN 2010105968966A CN 201010596896 A CN201010596896 A CN 201010596896A CN 102525833 A CN102525833 A CN 102525833A
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CN
China
Prior art keywords
caries
collutory
mouthwash composition
sodium
water
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Pending
Application number
CN2010105968966A
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Chinese (zh)
Inventor
马裕涛
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马裕涛
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Priority to CN2010105968966A priority Critical patent/CN102525833A/en
Publication of CN102525833A publication Critical patent/CN102525833A/en
Pending legal-status Critical Current

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Abstract

The invention relates to chemical articles for daily use, in particular to an anti-caries mouthwash composition. The anti-caries mouthwash composition comprises the following ingredients in percentage by weight: 1-10% of urea, 1-5% of calcium chloride, 0.5-2.0% of sodium dihydrogen phosphate, 0.1-0.5% of sodium monofluorophosphate, 0.005-0.1% of sodium fluoride, 10-20% of ethanol, 0.05-0.1% of saccharin sodium and the balance being water. The anti-caries mouthwash composition is very beneficial to the health of human, so that a product can have the dual functions of medical treatment and health care. The anti-caries mouthwash composition is suitable for the treatment of the caries of people suffering from caries, more suitable for the prevention of the caries of people not suffering from the caries, and particularly suitable for the prevention of the caries of children.

Description

A kind of preventing decayed tooth collutory compositions
Technical field
The present invention relates to a kind of cosmetics of everyday use, be specifically related to a kind of preventing decayed tooth collutory compositions.
Background technology
Secondly how to reduce the quantity of oral microorganism, the most frequently used method is brushed teeth exactly and is gargled, and is exactly controlling clean (being toothwash), using dental floss etc. of specialty.
Routine is brushed teeth and is merely able to remove on the facing 40%~50% bacterial plaque, and is powerless basically for the bacterial plaque of removing oral soft tissue surfaces.(the Food and Drug Administration of U.S. food and drug administration; FDA) collutory of authentication has two types: contain quintessence oil and the collutory that contains hibitane; These two types of collutorys can life-time service, and the shortcoming of latter's life-time service is to be prone to cause that tartar forms, facing is painted and the sense of taste changes.Its outstanding advantage of quintessence oil class collutory is: 1. permeability is strong, may penetrate into the bacterial plaque deep layer; 2. nonspecific antibacterial, all effective to gram positive bacteria bacterium, gram negative bacteria; 3. effect is fast, can in 30s, kill 99.9% oral cavity bacterium through the experiment proof, and keep the antibiotic effect of 12h; 4. especially act on the position that apparatus can not arrive, like tooth proximal surface, oral soft tissue surfaces; 5. there are not phenomenons such as the gingival discoloration of the back of use, dysbacteriosis, secondary infection, though alcoholic ingredient is arranged, harmless to oral cavity partial.
Collutory can go deep into each position, oral cavity, comprises that between the gingival edge and teeth space of the difficult contact of toothbrush, antibacterial reaches 44% between the minimizing teeth space, reduces and causes that the antibacterial of halitosis reaches 90%, reduces dental plaque and reaches 56%, improves gingiva health and reaches 36%.Research shows uses the effect of quintessence oil class collutory almost to be equal to dental floss, and the latter grasps difficult popularizing because of working costs and skill are difficult.On the basis of effectively brushing teeth, use collutory to help to control bacterial plaque, collutory in the back of brushing teeth with collutory this brand-new oral cavity health theory of gargling.Gargle not only can remove and stay the especially interior food detritus of teeth space of oral cavity after the meal, have gargling of antibacterial and anti-inflammation functions if use.
Water is gargled, and can also play kill bacteria, control bacterial plaque, take care of one's teeth and the effect of oral soft tissue.Gargle and to select the different time section to carry out, gargle etc. before gargling, gargle when there is abnormal flavour in the oral cavity, sleep after the sweet food as gargling after the meal, advancing.Gargle after the meal to remove and stay intraoral food detritus when having meal, reduce the chance that antibacterial utilizes the food growth and breeding, especially for the food detritus of interproximal tooth coating, can remove a part through gargling, this is for the very big benefit that taken care of one's teeth.Advance that to gargle after the sweet food also be a kind of good custom that takes care of one's teeth, for those people who has a sweet tooth or drink sweet drink, perhaps gargle is a kind of good remedial measure afterwards, and gargling to make oral pH remain on neutral state, takes care of one's teeth not by acid etching.The people that can help only to brush a tooth those every days gargle before sleeping at the preceding cleaning oral cavity of sleeping, though effect not as brushing teeth, still has certain help for the range protein, the carbohydrate that reduce daytime and stay in the oral cavity.Therefore, to the high situation of present dental caries prevalence, when promotion is brushed teeth and used toothpaste with fluoride, also should propagate other oral sanitary habit more.
Gargling is the most frequently used oral care method, is the basic skills of oral cavity health, when the Where topical administration can reach whole body administration effect same, should at first select topical.Topical application medicine collutory is one of clinical oral care regimen commonly used in oral cavity infection property disease.
Summary of the invention
The purpose of this invention is to provide a kind of highly effective and safe, effectively the preventing decayed tooth collutory.
Technical scheme of the present invention is achieved in that a kind of preventing decayed tooth collutory compositions, and its component and content are:
Technical scheme of the present invention comprises and contains the essence that accounts for composition total weight 0.1~0.5% and an amount of glycine.
Beneficial effect of the present invention
The present invention is a mother solution with the natural mineral water that contains various trace element, and is very useful to health, makes product that medical treatment and health care dual function arranged.The people that the present invention not only is suitable for having suffered from dental caries cures dental caries, is more suitable for being particularly suitable for children's caries prevention in not suffering from dental caries person's caries prevention.
The specific embodiment
Material selection and explanation
Add calcium chloride and sodium dihydrogen phosphate among the present invention to increase calcium ion and the phosphate ion concentration in the collutory; And regulate the pH value of collutory with an amount of phosphoric acid; It is stabilized in 5~6 scopes, is close, can avoid producing simultaneously calcium phosphate precipitation with the pH value of saliva in the oral cavity.
Improve antiacid, the antibacterial ability of tooth, the sodium monofluorophosphate and the sodium fluoride that have used countries in the world generally to adopt among the present invention are to increase the fluorinion concentration of collutory.In addition, sodium monofluorophosphate can also produce phosphate anion, with the composite use of above-mentioned sodium dihydrogen phosphate, more can further improve the preventing decayed tooth ability.
In order to guarantee the palatability of collutory, improve tasty and refreshing sense, in prescription, except that adding flavoring agents such as ethanol, saccharin sodium, essence, also add glycine.Glycine can be covered the bitterness in the solution effectively, and has sterilization, effect such as anticorrosion.Simultaneously, glycine also has ability stable and the buffering pH value, and this is for the pH value of stablizing collutory, and the anti-dental caries ability of giving full play to calcium, fluorine and phosphorus is very favourable.
Raw material selection
(1) carbamide.Use used as stabilizers among the present invention.Select industrial goods for use.
(2) calcium chloride.Colourless hex crystal.Bitter saline taste and hygroscopy are arranged.Lose four molecular waters during heating earlier and form two hydrates, then lose whole water of crystallization when being heated to 20 ℃ and form bibulous anhydride.Soluble in water and emit a large amount of heat, also be dissolved in ethanol and acetone.As desiccant, food preservative, sizing agent, water purification agent etc.Be used as calcium ion source among the present invention.Select pharmaceutical grade for use.
(3) sodium dihydrogen phosphate.Colourless rhomboidal crystal.Contain a part water under the room temperature.Just lose this water of crystallization when being heated to 100 ℃.Soluble in water.Among the present invention as the phosphonium ion source.Select pharmaceutical grade for use.
(4) sodium monofluorophosphate.Claim sodium monofluorophosphate again.Colourless tiny crystallization.In humid air, decompose and emit fluohydric acid gas.Soluble in water, it is neutral that solution is.Facile hydrolysis in acid solution.Heating and decomposition becomes pyrophosphate.Among the present invention as fluorion and phosphonium ion source.Select pharmaceutical grade for use.
(5) sodium fluoride.Colourless shinny crystal is translucent sometimes.Water-soluble and be alkalescence.Be insoluble in ethanol.Be used as fluoride sources among the present invention, and as antiseptic.Select pharmaceutical grade for use.
(6) ethanol.Be used as disinfectant, solvent among the present invention.Select pharmaceutical grade for use.
(7) saccharin sodium.Select food stage for use.
(8) essence.The present invention selects edible essence for use, increases fragrance of the present invention.
(9) glycine.The formal name used at school aminoacetic acid.White crystal or crystalline powder.Among the present invention with used as stabilizers, pH value regulator.
(10) mineralized water.Contain multiple water to the health beneficial trace elements.Also can adopt natural mineral water.
Embodiment 1
Embodiment 2
Embodiment 3
The preparation process
(1) by the prescription requirement carbamide, calcium chloride, sodium dihydrogen phosphate, sodium monofluorophosphate and sodium fluoride are mixed and stirring and evenly mixing, add an amount of mineralized water dissolving.
(2) saccharin sodium, essence and glycine are dissolved in the remaining mineralized water, stir make complete dissolving after, add ethanol, shake up or stirring and evenly mixing after, the solution that makes with step (1) mixes, and continues to stir.
Method for using.With the collutory dilution that makes, general dilution ratio is 1: 500~1: 1000.Promptly get the dense collutory of 1mL, add mineralized water 500~1000mL.
When gargling, generally use rare collutory 15~20mL.In the oral cavity more than the rinsing the mouth 20s.When adopting denseer collutory, need follow the doctor's advice.

Claims (2)

1. preventing decayed tooth collutory compositions, its component and content are:
2. preventing decayed tooth collutory compositions according to claim 1 is characterized in that the present invention contains the essence that accounts for composition total weight 0.1~0.5% and an amount of glycine.
CN2010105968966A 2010-12-20 2010-12-20 Anti-caries mouthwash composition Pending CN102525833A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2010105968966A CN102525833A (en) 2010-12-20 2010-12-20 Anti-caries mouthwash composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2010105968966A CN102525833A (en) 2010-12-20 2010-12-20 Anti-caries mouthwash composition

Publications (1)

Publication Number Publication Date
CN102525833A true CN102525833A (en) 2012-07-04

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CN (1) CN102525833A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107028783A (en) * 2017-03-02 2017-08-11 广州薇美姿实业有限公司 A kind of oral care product containing curcumin and mouthwash and preparation method thereof
CN109260033A (en) * 2018-09-29 2019-01-25 广州艾蓓生物科技有限公司 A kind of solid is gargled grain and preparation method thereof
CN109303715A (en) * 2018-10-10 2019-02-05 云南巴菰生物科技有限公司 A kind of cigarette mouthwash and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107028783A (en) * 2017-03-02 2017-08-11 广州薇美姿实业有限公司 A kind of oral care product containing curcumin and mouthwash and preparation method thereof
CN109260033A (en) * 2018-09-29 2019-01-25 广州艾蓓生物科技有限公司 A kind of solid is gargled grain and preparation method thereof
CN109260033B (en) * 2018-09-29 2021-04-16 广州艾蓓生物科技有限公司 Solid gargle granule and preparation method thereof
CN109303715A (en) * 2018-10-10 2019-02-05 云南巴菰生物科技有限公司 A kind of cigarette mouthwash and preparation method thereof

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Application publication date: 20120704

C02 Deemed withdrawal of patent application after publication (patent law 2001)