CN108056930A - A kind of children's toothpaste and its preparation process - Google Patents
A kind of children's toothpaste and its preparation process Download PDFInfo
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- CN108056930A CN108056930A CN201810133653.5A CN201810133653A CN108056930A CN 108056930 A CN108056930 A CN 108056930A CN 201810133653 A CN201810133653 A CN 201810133653A CN 108056930 A CN108056930 A CN 108056930A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
The present invention provides a kind of children's toothpaste and its preparation processes, have preferable bacteriostasis, effectively prevent saprodontia, smaller to the abrasion of dentine.The present invention adds in second material in first material, then adds in vitamine supplement, children's toothpaste is made.First material is to be dissolved in first portion's deionized water being made using laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides, builds surfactant aqueous systems；Second material is to be obtained using soyabean protein powder and xylitol as stock dispersion in second portion deionized water.Soyabean protein powder is rich in a variety of amino acid, nutrition can be provided for the development of enamel, vitamine supplement can provide nutrition for children's gum, prevent oral inflammation, take good care of Children Oral Mucosal, the introducing of soyabean protein powder and vitamine supplement fundamentally provides nutritional support for Pediatric Oral Emergency enhancement of environment, realizes oral health.
Description
Technical field
The present invention relates to daily necessities technical field, more particularly to a kind of children's toothpaste and its preparation process.
Background technology
With the improvement of people ' s living standards with the enhancing of health consciousness, oral hygiene has been to be concerned by more and more people,
And toothpaste is essential oral cleaning amenities in people's daily life.
Sugar prod is the cariogenic big inducement of production, and most of children especially have a sweet tooth, and can cause dental surface
Bacterial plaque increases, wherein cariogenic streptococcus rolls up, causes the mouth diseases incidence such as saprodontia higher.
Since the gum of children, tooth are all in growth and development stage, tooth calcification degree is low, acid-resisting and anti-friction energy
Force difference easily corrodes injury in the acidic materials that food generates by bacterial action, and then forms saprodontia.Therefore, children are to oral cavity
Cleaning it is particularly significant, children special-purpose toothpaste should be used to carry out oral cleaning, good oral health custom is formed, so as to right
Pediatric Oral Emergency disease plays good prevention effect.
Gum, tooth feature for children, children's toothpaste will not only have mothproof effect, and should be guaranteed that anti-when brushing teeth
Multiple friction will not injure tender dental surface, to adapt to the budding physiological stage feature of teenager teeth.
There is the children's toothpaste product that beautiful jade meets currently on the market, but it is most of in order to pursue security, sacrifice portion
Divide effect, can not effectively prevent saprodontia.
The content of the invention
Present invention aim to provide a kind of children's toothpaste and its preparation process, there is preferable bacteriostasis, have
Effect prevents saprodontia, smaller to the abrasion of dentine.
To achieve the above object, the present invention is achieved by the following scheme：
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, 2~3 points of 150~300W microwave treatments
Clock obtains carrier material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20~30 minutes, so
After add in xylitol, continue supersonic oscillations 20~30 minutes, obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Preferably, in step (1) and step (2), the matter of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Amount is than being 1:3~4:0.1~0.2.
Preferably, in step (1), the grain size of attapulgite clay powder is 200 mesh.
Preferably, in step (1), the chitosan-acetic acid solution is the acetic acid for dissolving the chitosan in mass concentration 2%
It is obtained in solution, wherein the mass concentration of chitosan is 1%.
Preferably, in step (2), the multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, dimension
Raw 0.5~0.6 part of element E, 0.3~0.4 part of vitamin B3,0.3~0.4 part of vitamin B5,0.2~0.3 part of vitamin B6.
Preferably, in step (2), high-pressure homogeneous processing pressure is 12~15MPa.
Preferably, in step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion
The mass ratio of deionized water is 0.1~0.2：0.1~0.2：0.2~0.3：100.
Preferably, in step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into quality
In the sodium hydroxide solution of concentration 5%, 60 DEG C stirring 30 minutes to get；Wherein, contained by soyabean protein powder and sodium hydroxide solution
The mass ratio of sodium hydroxide is 25:1.
Preferably, in step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20~30:
4~5:100.
Preferably, in step (5), the mass ratio of second material, first material and vitamine supplement is 1:20~30:5
~6.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
The beneficial effects of the invention are as follows：
1st, the present invention adds in second material in first material, then adds in vitamine supplement, children's toothpaste is made.The
One material is to be dissolved in using laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides in first portion's deionized water
It is made, builds surfactant-aqueous systems；It using soyabean protein powder and xylitol is stock dispersion in second portion that second material, which is,
It is obtained in deionized water.Soyabean protein powder is rich in a variety of amino acid, and nutrition, vitamin addition can be provided for the development of enamel
Agent can provide nutrition for children's gum, prevent oral inflammation, take good care of Children Oral Mucosal, soyabean protein powder and vitamin addition
The introducing of agent fundamentally provides nutritional support for Pediatric Oral Emergency enhancement of environment, realizes oral health.
2nd, vitamine supplement be by multi-vitamins with carrier material load and, help to improve each vitamin into
The stability divided prevents from preparing and oxidation deterioration during product storage.The present invention utilizes attapulgite clay powder and chitosan
Carrier material is made, carrier material size is nanoscale, plays the role of similar rubbing agent, right without in addition adding rubbing agent
The abrasion of dentine is smaller.Attapulgite clay powder has good suction-operated, can adsorb intraoral residue, Jin Ersui
Discharge oral cavity of gargling of brushing teeth, reaches clean purpose.Chitosan-coated is on the surface of each vitamin ingredients, to each vitamin ingredients
It plays a protective role, chitosan also has bacteriostasis, helps to kill bacterium, pre- anti-caries.
3rd, soyabean protein powder carries out alkali modification processing, discharges emplastic, assigns whole system certain stickiness, and plays
Thickening power so that children's toothpaste has preferable uniformity and stability.
Specific embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's all other embodiments obtained without making creative work belong to the model that the present invention protects
It encloses.
Attapulgite clay powder of the present invention is good for stone ore powder factory purchased from Lingshou County；Soyabean protein powder, purchased from Shandong
The rich honest bio tech ltd in field.
Embodiment 1
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20 minutes, obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3:0.1.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.5 part of vitamin E,
0.3 part of vitamin B3,0.3 part of vitamin B5,0.2 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 12MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.1：0.1：0.2：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20:4:100.
In step (5), the mass ratio of second material, first material and vitamine supplement is 1:20:5.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Embodiment 2
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 3 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 30 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 30 minutes, obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:4:0.2.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.6 part of vitamin E,
0.4 part of vitamin B3,0.4 part of vitamin B5,0.3 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 15MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.2：0.2：0.3：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 30:5:100.
In step (5), the mass ratio of second material, first material and vitamine supplement is 1:30:6.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Embodiment 3
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150W microwave treatments 3 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 30 minutes, obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3:0.2.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.5 part of vitamin E,
0.4 part of vitamin B3,0.3 part of vitamin B5,0.3 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 12MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.2：0.1：0.3：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20:5:100.
In step (5), the mass ratio of second material, first material and vitamine supplement is 1:20:6.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Embodiment 4
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 30 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20 minutes, obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:4:0.1.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.6 part of vitamin E,
0.3 part of vitamin B3,0.4 part of vitamin B5,0.2 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 15MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.1：0.2：0.2：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 30:4:100.
In step (5), the mass ratio of second material, first material and vitamine supplement is 1:30:5.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Embodiment 5
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 25 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 25 minutes, obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3.5:0.15.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 13MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.15：0.15：0.25：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 25:4.5:100.
In step (5), the mass ratio of second material, first material and vitamine supplement is 1:25:5.5.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Comparative example 1
A kind of preparation process of children's toothpaste, including step：
(1) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(2) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 25 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 25 minutes, obtain second material；
(3) second material obtained by step (2) is added in first material obtained by step (1), then adds in multi-vitamins,
It is transferred in Scattered Kettle and disperses, mixes, finally obtain children's toothpaste using cream kettle processed.
Wherein, in step (1), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion go
The mass ratio of ionized water is 0.15：0.15：0.25：100.
In step (2), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (2), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 25:4.5:100.
In step (3), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (3), the mass ratio of second material, first material and multi-vitamins is 1:25:5.5.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Comparative example 2
A kind of preparation process of children's toothpaste, including step：
(1) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(2) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 25 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 25 minutes, obtain second material；
(3) second material obtained by step (2) is added in first material obtained by step (1), then adds in multi-vitamins
And hydrated silica, it is transferred in Scattered Kettle and disperses, mixes, finally obtain children's toothpaste using cream kettle processed.
Wherein, in step (1), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion go
The mass ratio of ionized water is 0.15：0.15：0.25：100.
In step (2), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (2), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 25:4.5:100.
In step (3), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (3), second material, first material, multi-vitamins, the mass ratio of hydrated silica are 1:25:5.5：8.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Comparative example 3
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) xylitol is added in second portion deionized water, and supersonic oscillations 25 minutes obtain second material；
(5) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
Vitamine supplement is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3.5:0.15.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 13MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.15：0.15：0.25：100.
In step (4), the mass ratio of xylitol and second portion deionized water is 4.5:100.
In step (5), the mass ratio of second material, first material and vitamine supplement is 1:25:5.5.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Comparative example 4
A kind of preparation process of children's toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides, the soyabean protein powder of alkali modification, wood are taken
Sugar alcohol, vitamine supplement are added in deionized water (including first portion's deionized water and second portion deionized water), ultrasound
Ripple vibrates 25 minutes, is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3.5:0.15.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 13MPa.
In step (3), first material：Laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first
The mass ratio for dividing deionized water is 0.15：0.15：0.25：100.Second material：Soyabean protein powder, xylitol and second portion are gone
The mass ratio of ionized water is 25:4.5:100.The mass ratio of second material, first material and vitamine supplement is 1:25:5.5.
The specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in the sodium hydroxide of mass concentration 5%
In solution, 60 DEG C stirring 30 minutes to get；Wherein, the mass ratio of soyabean protein powder and sodium hydroxide contained by sodium hydroxide solution
For 25:1.
A kind of children's toothpaste is obtained by above-mentioned preparation process.
Test example
1st, stability test
The children's toothpaste of Examples 1 to 5 and comparative example 1~4 carries out stability under the conditions of 4 DEG C, 25 DEG C and 35 DEG C respectively
It investigates 3 months, HPLC measures ascorbic changes of contents and (measures within 0 month and 3 months numerical value respectively as first measured value and terminal
Value), it turns out that：The children's toothpaste of Examples 1 to 5, comparative example 3 and comparative example 4, end point values for first measured value 99.5% with
On；The children's toothpaste of comparative example 1 and comparative example 2, end point values are less than the 30% of first measured value.
The children's toothpaste of Examples 1 to 5 and comparative example 1~4, each weighs 2g, is placed in centrifuge tube, rotating speed 5000rpm
The separation situation of children's toothpaste is observed in centrifugation 30 minutes, it turns out that：The children of Examples 1 to 5, comparative example 1 and comparative example 2
Toothpaste, no layering；The children's toothpaste of comparative example 3 and comparative example 4 is layered.
2nd, dentin abrasion is tested
It is tested according to ISO11609-2010Annex B, the results are shown in Table 1.
1. dentin abrasion test result of table
As shown in Table 1, Examples 1 to 5 is smaller to dentin abrasion, and comparative example 2 adds water on the basis of comparative example 1
Silica is closed as abrasive material, it is larger to the abrasion of dentine.
3rd, morbidity of dental caries is tested
100 purebred Wistar big white mouse, half male and half female, weight 55g or so are chosen, 10 groups is equally divided into, chain will be deformed
Coccus and Bacillus acidi lactici are put into culture in TSB enrichment liquids (culture density is 50/mL), are picked when culture 24 is small and then with swab stick
Enrichment liquid is embrocated in the alveolus ground one's teeth in sleep under big white mouse and (is inoculated with weekly once), and sucrose is selected to feed, and is raised two months, is being raised
During supporting, wherein 6 points of nine groups of every mornings and at night 7 points pick Examples 1 to 5, comparative example 1~4 using swab stick respectively
Children's toothpaste is embrocated in the alveolus ground one's teeth in sleep under big white mouse, and remaining one group is not embrocated toothpaste as a control group, observation saprodontia hair
Raw situation (no matter saprodontia specific number, as long as having saprodontia appearance to be considered as occurs saprodontia), the results are shown in Table 2.
2. morbidity of dental caries test result of table
| Morbidity of dental caries (%) | |
| Embodiment 1 | 0 |
| Embodiment 2 | 0 |
| Embodiment 3 | 0 |
| Embodiment 4 | 0 |
| Embodiment 5 | 0 |
| Comparative example 1 | 90 |
| Comparative example 2 | 90 |
| Comparative example 3 | 70 |
| Comparative example 4 | 40 |
| Control group | 100 |
As shown in Table 2, the children's toothpaste of Examples 1 to 5 can effectively prevent saprodontia, the compound dimension in comparative example 1
Raw element is not loaded using carrier material, and comparative example 2 adds hydrated silica as abrasive material, comparative example 3 on the basis of comparative example 1
Soyabean protein powder is omitted, comparative example 4 does not carry out step-by-step processing, and morbidity of dental caries has different degrees of increase.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (10)
1. a kind of preparation process of children's toothpaste, which is characterized in that including step：
（1）Attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150~300W microwave treatments 2~3 minutes obtain
To carrier material；
（2）Multi-vitamins are poured into step（1）In resulting vehicle material, through high-pressure homogeneous processing, vitamine supplement is obtained,
It is spare；
（3）Laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water, is stirred
Dissolving is mixed, obtains first material, it is spare；
（4）Soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20~30 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20~30 minutes, obtain second material；
（5）By step（4）Gained second material adds in step（3）In gained first material, step is then added in（2）Gained dimension life
Plain additive is transferred in Scattered Kettle and disperses, mixes, finally obtains children's toothpaste using cream kettle processed.
2. preparation process according to claim 1, which is characterized in that step（1）And step（2）In, attapulgite clay powder,
The mass ratio of chitosan-acetic acid solution and multi-vitamins is 1:3~4:0.1~0.2.
3. preparation process according to claim 1, which is characterized in that step（1）In, the chitosan-acetic acid solution be by
Chitosan is dissolved in the acetum of mass concentration 2% and obtains, and wherein the mass concentration of chitosan is 1%.
4. preparation process according to claim 1, which is characterized in that step（2）In, the multi-vitamins include with
The vitamin of lower parts by weight：1 part of vitamin C, 0.5~0.6 part of vitamin E, 0.3~0.4 part of vitamin B3, vitamin B5
0.3~0.4 part, 0.2~0.3 part of vitamin B6.
5. preparation process according to claim 1, which is characterized in that step（2）In, high-pressure homogeneous processing pressure is 12
~15MPa.
6. preparation process according to claim 1, which is characterized in that step（3）In, laruyl alcohol sodium sulfovinate, cocounut oil acyl
The mass ratio of amine propyl betaine, alkyl glycosides and first portion's deionized water is 0.1~0.2：0.1~0.2：0.2~0.3：
100。
7. preparation process according to claim 1, which is characterized in that step（4）In, soyabean protein powder alkali modification it is specific
Method is as follows：By soyabean protein powder add in mass concentration 5% sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein,
The mass ratio of soyabean protein powder and sodium hydroxide contained by sodium hydroxide solution is 25:1.
8. according to claim 1-7 any one of them preparation processes, which is characterized in that step（4）In, soyabean protein powder, wood
Sugar alcohol and the mass ratio of second portion deionized water are 20~30:4~5:100.
9. according to claim 1-8 any one of them preparation processes, which is characterized in that step（5）In, second material, first
The mass ratio of material and vitamine supplement is 1:20~30:5~6.
10. a kind of children's toothpaste is obtained by preparation process according to any one of claims 1 to 9.
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| WO2020219511A1 (en) * | 2019-04-26 | 2020-10-29 | Basf Se | Oral care composition |
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