CN108056963A - A kind of chitosan tooth-caring toothpaste and its preparation process - Google Patents
A kind of chitosan tooth-caring toothpaste and its preparation process Download PDFInfo
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- CN108056963A CN108056963A CN201810134441.9A CN201810134441A CN108056963A CN 108056963 A CN108056963 A CN 108056963A CN 201810134441 A CN201810134441 A CN 201810134441A CN 108056963 A CN108056963 A CN 108056963A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention provides a kind of chitosan tooth-caring toothpaste and its preparation process, the present invention adds in second material in first material, then adds in vitamine supplement, 3 material and Fructus Monordicae extract, chitosan tooth-caring toothpaste is made.First material, which is dissolved in using laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides in first portion's deionized water, to be made, and builds surfactant aqueous systems；Second material is to be obtained using soyabean protein powder and xylitol as stock dispersion in second portion deionized water.Soyabean protein powder is rich in a variety of amino acid, nutrition can be provided for the development of enamel, vitamine supplement can provide nutrition for gum, prevent oral inflammation, water soluble chitosan in 3 material not only avoids damage of the toothpaste to tooth and oral soft tissue, and it is antibacterial, bactericidal effect is notable.The chitosan tooth-caring toothpaste excellent combination property, adaptation population is wide, effectively prevents saprodontia, bactericidal antiphlogistic, improves oral health.
Description
Technical field
The present invention relates to daily necessities technical field, more particularly to a kind of chitosan tooth-caring toothpaste and its preparation process.
Background technology
Toothpaste is to protect oral hygiene, a kind of daily necessities safe to the human body together for cleaning tooth with toothbrush.
With the improvement of people ' s living standards with the enhancing of health consciousness, oral hygiene has been to be concerned by more and more people, to toothpaste
Quality requirement also steps up.According to the definition of toothpaste, toothpaste should comply with the following requirement：Dental surface can be removed
Film and bacterial plaque are without damaging enamel and dentine；With good cleaning oral cavity effect；Nontoxicity, it is stingless to oral mucosa
Swash；There are comfortable fragrance and taste, there is cool and sweet-smelling sensation after use；It is easy to use, into uniform, bright, soft during extrusion
Bar；It is easy to from oral cavity clean on tooth, toothbrush；With good chemically and physically stability, protected in the storage phase
Card indices are met the requirements of the standard；With rational cost performance.
In recent years, due to the continuous improvement of consumer healthcare's consciousness, more requirements are proposed to toothpaste, in addition to cleaning the teeth
Some auxiliary prevention mouth diseases are also needed to, there is the function that nursing health acts on to oral cavity.Also have in the prior art using various
Active ingredient of Chinese herbs is as toothpaste ancillary drug.In these medicated toothpaste, some toothpaste have a variety of Chinese medicine composition, but add
Work complex process；Although some processing technologys are simple, effect is bad.
Chitosan is also known as chitosan, is that the chitin (chitin) being widely present by nature passes through deacetylated work
With what is obtained, chemical name is Chitosan (1-4) -2- amino-B-D glucose.The bullet that chitosan is formed after water-swellable
Property particle, is a kind of good friction material；In addition, chitosan has stronger bactericidal antiphlogistic effect, it is treatment mouth disease
High-quality drug.At present, had developed both at home and abroad according to chitosan not damage tooth and the friction function of oral soft tissue
The chitosan toothpaste of heterogeneity and proportioning, wherein, chitosan has given full play to not damaged rubbing action.
However, related chitosan toothpaste is also single there are performance in the prior art, comprehensive performance is poor, adaptation population's mistake
Narrow, the defects of anti-microbial property is insufficient, developing a kind of chitosan toothpaste of excellent combination property seems very necessary.
The content of the invention
It is an object of the invention to provide a kind of excellent combination property, adaptation population is wide, effectively prevents saprodontia, sterilization from disappearing
Chitosan toothpaste and its preparation process scorching, that improve oral health.
To achieve the above object, the present invention is achieved by the following scheme：
A kind of preparation process of chitosan tooth-caring toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, 2~3 points of 150~300W microwave treatments
Clock obtains carrier material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20~30 minutes, so
After add in xylitol, continue supersonic oscillations 20~30 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 30~
60 minutes, obtain 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with decolorizing resin；Decolorizing resin after washing absorption afterwards is 75-80% to colourless, then with concentration
Ethanol solution elution collect eluent；It finally filters, recycles the ethyl alcohol in eluent, and pass it through concentration, spray drying,
It crushes, obtains Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, the mass ratio of water soluble chitosan in step (5), tea polyphenols, sorbierite and Part III deionized water is 1
~3:0.5~2:10~30：100~150.
Preferably, decolorizing resin described in step (6) is D201 styrene type copolymer macroporous absorbent resins.
Preferably, in step (1) and step (2), the matter of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Amount is than being 1:3~4:0.1~0.2.
Preferably, in step (1), the chitosan-acetic acid solution is the acetic acid for dissolving the chitosan in mass concentration 2%
It is obtained in solution, wherein the mass concentration of chitosan is 1%.
Preferably, in step (2), the multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, dimension
Raw 0.5~0.6 part of element E, 0.3~0.4 part of vitamin B3,0.3~0.4 part of vitamin B5,0.2~0.3 part of vitamin B6；
In step (2), high-pressure homogeneous processing pressure is 12~15MPa.
Preferably, in step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion
The mass ratio of deionized water is 0.1~0.2：0.1~0.2：0.2~0.3：100.
Preferably, in step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into quality
In the sodium hydroxide solution of concentration 5%, 60 DEG C stirring 30 minutes to get；Wherein, contained by soyabean protein powder and sodium hydroxide solution
The mass ratio of sodium hydroxide is 25:1；In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water
For 20~30:4~5:100.
Preferably, in step (7), second material, first material, vitamine supplement, 3 material and Siraitia grosvenorii extraction
The mass ratio of object is 1:20~30:5~6：2~5:1~3.
In addition, the chitosan tooth-caring toothpaste obtained by the preparation process is also claimed in the present invention.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) present invention adds in second material in first material, then adds in vitamine supplement, 3 material and arhat
Chitosan toothpaste is made in berry extract.First material is to utilize laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl
Glucosides, which is dissolved in first portion's deionized water, to be made, and builds surfactant-aqueous systems；Second material be with soyabean protein powder and
Xylitol obtains for stock dispersion in second portion deionized water.Soyabean protein powder is rich in a variety of amino acid, can be tooth enamel
The development of matter provides nutrition, and vitamine supplement can provide nutrition for gum, prevent oral inflammation, take good care of mucous membrane of mouth, greatly
The introducing of legumin powder and vitamine supplement fundamentally provides nutritional support for oral environment improvement, realizes oral health；
Water soluble chitosan in 3 material not only avoids damage of the toothpaste to tooth and oral soft tissue, and antibacterial, sterilization
Effect is notable, can effectively prevent tooth and make scorching and periodontosis generation, and chitosan toothpaste is safe to use, convenient, can eliminate tartar,
Prevent early stage caries, whitening function is notable；And the addition of tea polyphenols has stronger antioxidation, it is different in adsorbable food
Taste has certain deodorization；There is protective effect to the pigment in food, it can not only play the role of natural pigment, but also
It can prevent food from fading, tea polyphenols also have the formation and summation for inhibiting nitrite.Fructus Monordicae extract can be effective
Inhibit sticking for deformation ball chain bacterium, greatly to reduce the quantity for deforming ball chain bacterium in oral cavity, and can effectively inhibit to deform ball chain
The production acid of bacterium, reduces the acidity in oral cavity, pre- anti-caries；
(2) vitamine supplement is to load to obtain with carrier material by multi-vitamins, helps to improve each vitamin
The stability of ingredient prevents from preparing and oxidation deterioration during product storage.The present invention is gathered using attapulgite clay powder and shell
Carrier material is made in sugar, and carrier material size is nanoscale, plays the role of similar rubbing agent, without in addition adding rubbing agent,
It is smaller to the abrasion of dentine.Attapulgite clay powder has good suction-operated, can adsorb intraoral residue, and then
With discharge oral cavity of gargling of brushing teeth, reach clean purpose.Chitosan-coated on the surface of each vitamin ingredients, to each vitamin into
Divide and play a protective role, chitosan also has bacteriostasis, helps to kill bacterium, pre- anti-caries；
(3) soyabean protein powder carries out alkali modification processing, discharges emplastic, assigns whole system certain stickiness, and rises
To thickening power so that toothpaste has preferable uniformity and stability；
(4) the toothpaste wide adaptation range prepared by the present invention, is applicable not only to be grown up, also can be suitably used for children, before
Scape is wide.
Specific embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's all other embodiments obtained without making creative work belong to the model that the present invention protects
It encloses.
Attapulgite clay powder of the present invention is good for stone ore powder factory purchased from Lingshou County；Soyabean protein powder, purchased from Shandong
The rich honest bio tech ltd in field.
Embodiment 1
A kind of preparation process of chitosan tooth-caring toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 45 are divided
Clock obtains 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；Decolorizing resin after washing absorption afterwards
D201 styrene type copolymer macroporous absorbent resins collect eluent to colourless, then with the ethanol solution elution that concentration is 76%；
It finally filters, recycles the ethyl alcohol in eluent, and pass it through concentration, spray drying, crush, obtain Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3:0.1.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.5 part of vitamin E,
0.3 part of vitamin B3,0.3 part of vitamin B5,0.2 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 12MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.1：0.1：0.2：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20:4:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 2:1:
20：120.
In step (7), second material, first material, vitamine supplement, the quality of 3 material and Fructus Monordicae extract
Than for 1:25:5：3:2.
Embodiment 2
A kind of preparation process of chitosan tooth-caring toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 3 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 30 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 30 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 50 are divided
Clock obtains 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；D201 styrene after washing absorption afterwards
Type copolymer macroporous absorbent resin collects eluent to colourless, then with the ethanol solution elution that concentration is 78%；It finally filters, returns
The ethyl alcohol in eluent is received, and passes it through concentration, spray drying, crushes, obtains Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:4:0.2.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.6 part of vitamin E,
0.4 part of vitamin B3,0.4 part of vitamin B5,0.3 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 15MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.2：0.2：0.3：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 30:5:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 3:2:
30：150.
In step (7), second material, first material, vitamine supplement, the quality of 3 material and Fructus Monordicae extract
Than for 1:28:6：4:3.
Embodiment 3
A kind of preparation process of chitosan tooth-caring toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150W microwave treatments 3 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 30 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 40 are divided
Clock obtains 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；D201 styrene after washing absorption afterwards
Type copolymer macroporous absorbent resin collects eluent to colourless, then with the ethanol solution elution that concentration is 80%；It finally filters, returns
The ethyl alcohol in eluent is received, and passes it through concentration, spray drying, crushes, obtains Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3:0.2.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.5 part of vitamin E,
0.4 part of vitamin B3,0.3 part of vitamin B5,0.3 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 12MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.2：0.1：0.3：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20:5:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 1:0.5:
10：100.
In step (7), second material, first material, vitamine supplement, the quality of 3 material and Fructus Monordicae extract
Than for 1:24:6：4:3.
Embodiment 4
A kind of preparation process of chitosan tooth-caring toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 30 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 60 are divided
Clock obtains 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；D201 styrene after washing absorption afterwards
Type copolymer macroporous absorbent resin collects eluent to colourless, then with the ethanol solution elution that concentration is 75%；It finally filters, returns
The ethyl alcohol in eluent is received, and passes it through concentration, spray drying, crushes, obtains Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:4:0.1.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.6 part of vitamin E,
0.3 part of vitamin B3,0.4 part of vitamin B5,0.2 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 15MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.1：0.2：0.2：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 30:4:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 1:2:
30：150.
In step (7), second material, first material, vitamine supplement, the quality of 3 material and Fructus Monordicae extract
Than for 1:30:6：3:3.
Embodiment 5
A kind of preparation process of chitosan tooth-caring toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 25 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 25 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 45 are divided
Clock obtains 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；D201 styrene after washing absorption afterwards
Type copolymer macroporous absorbent resin collects eluent to colourless, then with the ethanol solution elution that concentration is 77%；It finally filters, returns
The ethyl alcohol in eluent is received, and passes it through concentration, spray drying, crushes, obtains Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3.5:0.15.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 13MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.15：0.15：0.25：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 25:4.5:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 1.5:
1.5:15：100.
In step (7), second material, first material, vitamine supplement, the quality of 3 material and Fructus Monordicae extract
Than for 1:20:5：2:1.
Comparative example 1
A kind of preparation process of chitosan tooth-caring toothpaste, including step：
(1) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(2) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 25 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 25 minutes, obtain second material；
(3) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 45 are divided
Clock obtains 3 material；
(4) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；D201 styrene after washing absorption afterwards
Type copolymer macroporous absorbent resin collects eluent to colourless, then with the ethanol solution elution that concentration is 77%；It finally filters, returns
The ethyl alcohol in eluent is received, and passes it through concentration, spray drying, crushes, obtains Fructus Monordicae extract；
(5) second material obtained by step (2) is added in first material obtained by step (1), then add in multi-vitamins,
The Fructus Monordicae extract that 3 material that step (3) obtains, step (4) obtain is transferred in Scattered Kettle and disperses, mixes, finally
Chitosan tooth-caring toothpaste is made using cream kettle processed.
Wherein, in step (1), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion go
The mass ratio of ionized water is 0.15：0.15：0.25：100.
In step (2), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (2), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 25:4.5:100.
Water soluble chitosan in step (3), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 2:1:
20：120.
In step (5), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (5), second material, first material, multi-vitamins, the mass ratio of 3 material and Fructus Monordicae extract
For 1:25:5.5：2:1.
Comparative example 2
A kind of preparation process of toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20 minutes, obtain second material；
(5) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；Decolorizing resin after washing absorption afterwards
D201 styrene type copolymer macroporous absorbent resins collect eluent to colourless, then with the ethanol solution elution that concentration is 76%；
It finally filters, recycles the ethyl alcohol in eluent, and pass it through concentration, spray drying, crush, obtain Fructus Monordicae extract；
(6) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that vitamine supplement, step (6) obtain is transferred in Scattered Kettle and disperses, mixes, finally utilizes cream kettle processed
Toothpaste is made.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3:0.1.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.5 part of vitamin E,
0.3 part of vitamin B3,0.3 part of vitamin B5,0.2 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 12MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.1：0.1：0.2：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20:4:100.
In step (6), second material, first material, the mass ratio of vitamine supplement and Fructus Monordicae extract are 1:25:
5:2。
Comparative example 3
A kind of preparation process of chitosan tooth-caring toothpaste, including step：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 300W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) xylitol is added in second portion deionized water, and supersonic oscillations 25 minutes obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 45 are divided
Clock obtains 3 material；
(6) Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decocts to obtain Aqueous extracts, then Aqueous extracts are filtered, are filtered
Liquid concentrates, and cleaner liquid is adsorbed with D201 styrene type copolymer macroporous absorbent resin；D201 styrene after washing absorption afterwards
Type copolymer macroporous absorbent resin collects eluent to colourless, then with the ethanol solution elution that concentration is 77%；It finally filters, returns
The ethyl alcohol in eluent is received, and passes it through concentration, spray drying, crushes, obtains Fructus Monordicae extract；
(7) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The Fructus Monordicae extract that 3 material that vitamine supplement, step (5) obtain, step (6) obtain, is transferred in Scattered Kettle point
It dissipates, mixing, chitosan tooth-caring toothpaste finally is made using cream kettle processed.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3.5:0.15.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, vitamin E 0.55
Part, 0.35 part of vitamin B3,0.35 part of vitamin B5,0.25 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 13MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.15：0.15：0.25：100.
In step (4), the mass ratio of xylitol and second portion deionized water is 4.5:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 2:1:
20：120.
In step (7), second material, first material, vitamine supplement, the quality of 3 material and Fructus Monordicae extract
Than for 1:20:5：2:1.
Comparative example 4
A kind of preparation process of chitosan tooth-caring toothpaste, includes the following steps：
(1) attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150W microwave treatments 2 minutes are carried
Body material；
(2) multi-vitamins are poured into step (1) resulting vehicle material, through high-pressure homogeneous processing, obtains vitamin and add
Add agent, it is spare；
(3) laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water
In, stirring and dissolving obtains first material, spare；
(4) soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20 minutes, obtain second material；
(5) water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, supersonic oscillations 45 are divided
Clock obtains 3 material；
(6) second material obtained by step (4) is added in first material obtained by step (3), then added in obtained by step (2)
The 3 material that vitamine supplement, step (5) obtain, which is transferred in Scattered Kettle, to be disperseed, mixes, and is finally made using cream kettle processed
Chitosan tooth-caring toothpaste.
Wherein, in step (1) and step (2), the quality of attapulgite clay powder, chitosan-acetic acid solution and multi-vitamins
Than for 1:3:0.1.
In step (1), the grain size of attapulgite clay powder is 200 mesh.
In step (1), chitosan-acetic acid solution is obtained in the acetum for dissolve the chitosan in mass concentration 2%,
Wherein the mass concentration of chitosan is 1%.
In step (2), multi-vitamins include the vitamin of following parts by weight：1 part of vitamin C, 0.5 part of vitamin E,
0.3 part of vitamin B3,0.3 part of vitamin B5,0.2 part of vitamin B6.
In step (2), high-pressure homogeneous processing pressure is 12MPa.
In step (3), laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, alkyl glycosides and first portion's deionization
The mass ratio of water is 0.1：0.1：0.2：100.
In step (4), the specific method of soyabean protein powder alkali modification is as follows：Soyabean protein powder is added in into mass concentration 5%
Sodium hydroxide solution in, 60 DEG C stirring 30 minutes to get；Wherein, soyabean protein powder and hydroxide contained by sodium hydroxide solution
The mass ratio of sodium is 25:1.
In step (4), the mass ratio of soyabean protein powder, xylitol and second portion deionized water is 20:4:100.
Water soluble chitosan in step (5), tea polyphenols, the mass ratio of sorbierite and Part III deionized water are 2:1:
20：120.
In step (6), second material, first material, vitamine supplement, the mass ratio of 3 material are 1:25:5：3.
Test example
1st, dentin abrasion is tested
It is tested according to ISO11609-2010Annex B, the results are shown in Table 1.
1. dentin abrasion test result of table
| Dentin abrasion (RDA) | |
| Embodiment 1 | 11.6 |
| Embodiment 2 | 10.2 |
| Embodiment 3 | 11.1 |
| Embodiment 4 | 10.7 |
| Embodiment 5 | 10.4 |
| Comparative example 1 | 19.1 |
| Comparative example 2 | 20.2 |
| Comparative example 3 | 20.1 |
| Comparative example 4 | 22.5 |
As shown in Table 1, Examples 1 to 5 is smaller to dentin abrasion, and comparative example 1-4 is larger to the abrasion of dentine.
2nd, morbidity of dental caries is tested
100 purebred Wistar big white mouse, half male and half female, weight 55g or so are chosen, 10 groups is equally divided into, chain will be deformed
Coccus and Bacillus acidi lactici are put into culture in TSB enrichment liquids (culture density is 50/mL), are picked when culture 24 is small and then with swab stick
Enrichment liquid is embrocated in the alveolus ground one's teeth in sleep under big white mouse and (is inoculated with weekly once), and sucrose is selected to feed, and is raised two months, is being raised
During supporting, wherein 6 points of nine groups of every mornings and at night 7 points pick Examples 1 to 5, comparative example 1~4 using swab stick respectively
Toothpaste is embrocated in the alveolus ground one's teeth in sleep under big white mouse, and remaining one group is not embrocated toothpaste as a control group, and feelings occur for observation saprodontia
Condition (no matter saprodontia specific number, as long as having saprodontia appearance to be considered as occurs saprodontia), the results are shown in Table 2.
2. morbidity of dental caries test result of table
As shown in Table 2, the toothpaste of Examples 1 to 5 can effectively prevent saprodontia, and comparative example 1-4 morbidity of dental caries is equal
There is different degrees of increase.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (10)
1. a kind of preparation process of chitosan tooth-caring toothpaste, which is characterized in that include the following steps：
（1）Attapulgite clay powder is added in chitosan-acetic acid solution, crushes mashing, and 150~300W microwave treatments 2~3 minutes obtain
To carrier material；
（2）Multi-vitamins are poured into step（1）In resulting vehicle material, through high-pressure homogeneous processing, vitamine supplement is obtained,
It is spare；
（3）Laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine and alkyl glycosides is taken to add in first portion's deionized water, is stirred
Dissolving is mixed, obtains first material, it is spare；
（4）Soyabean protein powder is added in after alkali modification in second portion deionized water, supersonic oscillations 20~30 minutes, Ran Houjia
Enter xylitol, continue supersonic oscillations 20~30 minutes, obtain second material；
（5）Water soluble chitosan, tea polyphenols, sorbierite are added in Part III deionized water, 30~60 points of supersonic oscillations
Clock obtains 3 material；
（6）Siraitia grosvenorii is placed in the water of 7 times of its weight and impregnates, decoct to obtain Aqueous extracts, then Aqueous extracts are filtered, filtrate it is dense
Contracting adsorbs cleaner liquid with decolorizing resin；Decolorizing resin after washing absorption afterwards is to colourless, then the ethyl alcohol for being 75-80% with concentration
Eluent is collected in solution elution；It finally filters, recycles the ethyl alcohol in eluent, and pass it through concentration, spray drying, crush,
Obtain Fructus Monordicae extract；
（7）By step（4）Gained second material adds in step（3）In gained first material, step is then added in（2）Gained dimension life
Plain additive, step（5）Obtained 3 material, step（6）Obtained Fructus Monordicae extract, be transferred in Scattered Kettle disperse,
Mixing, is finally made chitosan tooth-caring toothpaste using cream kettle processed.
2. preparation process according to claim 1, which is characterized in that step（5）Middle water soluble chitosan, tea polyphenols, mountain
Pears alcohol and the mass ratio of Part III deionized water are 1~3:0.5~2:10~30：100~150.
3. preparation process according to claim 1, which is characterized in that step（6）Described in decolorizing resin be D201 benzene second
Ene-type copolymer macroporous absorbent resin.
4. preparation process according to claim 1, which is characterized in that step（1）And step（2）In, attapulgite clay powder,
The mass ratio of chitosan-acetic acid solution and multi-vitamins is 1:3~4:0.1~0.2.
5. preparation process according to claim 1, which is characterized in that step（1）In, the chitosan-acetic acid solution be by
Chitosan is dissolved in the acetum of mass concentration 2% and obtains, and wherein the mass concentration of chitosan is 1%.
6. preparation process according to claim 1, which is characterized in that step（2）In, the multi-vitamins include with
The vitamin of lower parts by weight：1 part of vitamin C, 0.5~0.6 part of vitamin E, 0.3~0.4 part of vitamin B3, vitamin B5
0.3~0.4 part, 0.2~0.3 part of vitamin B6；Step（2）In, high-pressure homogeneous processing pressure is 12~15MPa.
7. according to claim 1-6 any one of them preparation processes, which is characterized in that step（3）In, bay alcohol sulfuric ester
Sodium, Cocoamidopropyl betaine, the mass ratio of alkyl glycosides and first portion's deionized water are 0.1~0.2：0.1~0.2：
0.2~0.3：100.
8. according to claim 1-7 any one of them preparation processes, which is characterized in that step（4）In, soyabean protein powder alkali changes
The specific method of property is as follows：By soyabean protein powder add in mass concentration 5% sodium hydroxide solution in, 60 DEG C stir 30 minutes, i.e.,
；Wherein, the mass ratio of soyabean protein powder and sodium hydroxide contained by sodium hydroxide solution is 25:1；Step（4）In, soybean protein
The mass ratio of powder, xylitol and second portion deionized water is 20~30:4~5:100.
9. according to claim 1-8 any one of them preparation processes, which is characterized in that step（7）In, second material, first
Material, vitamine supplement, the mass ratio of 3 material and Fructus Monordicae extract are 1:20~30:5~6：2~5:1~3.
10. a kind of chitosan tooth-caring toothpaste, is obtained by preparation process according to any one of claims 1 to 9.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464371A (en) * | 2018-11-12 | 2019-03-15 | 魏楚杰 | A kind of children's toothpaste |
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Application publication date: 20180522 |