JP5754711B2 - Oral hygiene composition effective in promoting salivation and oral care product - Google Patents

Description

The present invention contains an organic acid mixture, a natural extract such as a pickled strawberry fruit extract or a blueberry extract, and a sugar such as xylitol or maltitol, and an oral hygiene composition excellent in saliva secretion promoting effect, and , Oral care products.

  Saliva plays an important role in maintaining the oral environment and oral function. That is, saliva has two functions: a food and drink intake function and an oral environment maintenance function. In the food and beverage intake function of saliva, saliva exhibits digestive action such as bolus formation and digestive enzyme action, or taste maintenance action by solubilization of taste stimulating substances or secretion of gastin (carboxylate dehydrogenase). In the oral environment maintenance function, saliva exhibits a self-cleaning effect of teeth or mucous membranes, a tooth remineralization effect, an antibacterial effect, an immunity effect, a tissue repair enhancement effect by growth factors, and an anti-inflammatory effect.

Recently, an increasing number of patients complained of reduced salivation caused by various factors. Therefore, the social demand for the treatment is increasing. Severely, even healthy individuals experience a period of reduced salivation due to high stress, physical fatigue, or diurnal fluctuations in hormones. For example, many individuals experience a phase of decreased salivary secretion while resting from chewing activity, during which general irritation to the salivary glands is reduced. Most people ignore temporary salivary decline, but it is preferable to avoid it if possible.
Such decreased salivary secretion is induced by systemic diseases such as Sjogren's syndrome, medical diseases such as diabetes, liver cirrhosis, and kidney disease, aging, or various diseases that cause physical changes in salivary glands, and radiation by cancer treatment. It can also be triggered by the side effects of various drugs.
Recently, with the aging of the population, the number of patients complaining of decreased salivary gland function due to aging and decreased salivary secretion as a result of various drug therapies for various complex diseases that develop in the elderly is increasing.

  Decreased salivation results in dry mouth. This makes the tongue red, and sometimes the tongue cracks and complains of pain when eating, making it difficult to chew and swallow. In addition, a decrease in saliva secretion may cause inconvenience to the oral cavity, induce taste disorders and pronunciation problems, and cause denture instability, bad breath, caries, periodontitis, stomatitis, pneumonia and digestive dysfunction. Are known.

  Local treatment with artificial saliva has been applied to the treatment of decreased salivary secretion, but the effect is temporary and limited. Hyaluronic acid can make the oral cavity a little moist, but cannot promote salivation. A muscarinic receptor agonist is applied as a salivary secretion promoter, and specifically, anethole trithione and cevimeline hydrochloride are used. However, these effects are unstable, and gastrointestinal side effects such as irritations, vomiting, loss of appetite, and abdominal discomfort have been raised as problems.

  As mentioned above, most of the compounds known to have the effect of preventing and treating salivary secretion are synthetic substances and have been reported to have side effects. Therefore, there is an urgent need for the development of a new prevention and treatment agent for salivary secretion that fundamentally treats the decrease in salivation and exhibits no side effects.

An object of the present invention is to provide an oral hygiene composition effective in promoting salivary secretion.
Another object of the present invention is to provide a use of the oral hygiene composition as an additive for promoting salivation.
Another object of the present invention is to provide an oral care product containing the oral hygiene composition as an additive for promoting salivation.

In order to achieve the above object, the first aspect of the present invention provides:
10 to 50% by weight of an organic acid mixture consisting of fumaric acid, citric acid and malic acid,
10 to 50% by weight of a natural extract selected from a pickled strawberry fruit extract, a blueberry extract and a composite extract thereof,
There is provided an oral hygiene composition for promoting salivation, comprising 30 to 70% by weight of a sugar selected from xylitol, maltitol and mixtures thereof.
The other viewpoint of this invention provides the use which uses said oral hygiene composition as an additive for salivary secretion promotion.

  Another aspect of the present invention provides an oral care product in which the additive for promoting salivation is contained in chewing gum, candy, beverage, chocolate, ice cream, fermented product, soy milk, tofu, or gargle liquid.

The oral hygiene composition of the present invention has an excellent effect in promoting saliva secretion.
The oral hygiene composition of the present invention contains a natural product and is harmless to the human body and has a side effect reducing effect.
The oral hygiene composition of the present invention is useful as an additive for promoting saliva secretion.
According to the present invention, an oral care product including the oral hygiene composition as an additive for promoting salivation is provided.

The present invention is characterized in that it is an oral hygiene composition that contains a specific organic acid mixture, natural extract and sugar and is effective in promoting salivary secretion.
The organic acid mixture of the present invention is a mixture containing fumaric acid, citric acid and malic acid as active ingredients. The organic acid mixture is selected carefully only from organic acids having excellent saliva secretion effect among various organic acids. When these organic acid mixtures have a specific content ratio, the saliva secretion effect is maximized. It was proposed after confirming that That is, according to the experiment of the present inventors, when the content of fumaric acid 30 to 80% by weight, citric acid 15 to 50% by weight, and malic acid 5 to 30% by weight is maintained as the organic acid mixture, the saliva secretion effect is It was confirmed that it was maximized (see Table 1 below). If necessary, the organic acid mixture may be selected from other organic acids such as tartaric acid, adipic acid, malic acid and the like, and may be contained in a content of less than 20% by weight, preferably 5 to 20% by weight. Good.

  The organic acid mixture is included in the range of 10 to 50% by weight, preferably 15 to 35% by weight, based on the oral hygiene composition. When the content of the organic acid mixture contained in the oral hygiene composition of the present invention is too small, such as less than 10% by weight, the salivation efficiency is reduced, and when it is contained in a large amount exceeding 50% by weight, May affect taste.

The oral hygiene composition of the present invention contains a natural extract as an active ingredient. The natural extract may be a pickled strawberry fruit extract, a blueberry extract or a composite extract thereof. The natural extract is a natural product that is expected to have a salivary secretion effect, such as Tokuri strawberry fruit, blueberry, Rahan fruit, lemon balm, Yablanc, wolfberry fruit, pomegranate, Toki, Yamasakuyaku, Okera root, crust , Licorice, Kemponashi, Mulberry, Gummy, Lemon, etc. were examined for salivary secretion effect. Among them, Tokkuri strawberry fruit, blueberry, which has the most excellent salivary secretion effect, was carefully selected and included as an active ingredient in the present invention. (See Table 2 below). The pickled strawberry fruit extract and blueberry extract as natural extracts to be selectively used by the present invention are extracts extracted from nature and are harmless to human bodies even if used. Moreover, the natural extract contained in the oral hygiene composition of this invention can be manufactured with a normal extraction method, and there is no special restriction | limiting in this invention about such an extraction method. A specific example of a method for producing a natural extract is as follows. After mixing a dry sample of a natural product into 5 to 100 mesh and mixing a sample pulverized product with 5 to 20 times volume of distilled water, the mixture is stirred at 40 to 70 ° C. While extracting. The extracted sample is filtered and concentrated under reduced pressure to obtain a natural extract.

The natural extract may be contained in the range of 10 to 50% by weight, preferably 20 to 40% by weight, based on the solid content. When the content of the natural extract contained in the oral hygiene composition of the present invention is too small, such as less than 10% by weight, the efficacy is reduced, and when it is contained in a large amount exceeding 50% by weight, May have an effect.
The oral hygiene composition of the present invention contains sugar as an active ingredient. In the present invention, xylitol, maltitol or a mixture thereof is used as the sugar. In addition to xylitol and maltitol, sorbitol, sugar, and the like can be used as the sugar, but according to the experiments of the present inventor, it was confirmed that xylitol and maltitol had the most excellent salivary secretion effect (described below). (See Table 3).

  The sugar may be included in the range of 20 to 70% by weight, preferably 45 to 65% by weight, based on the oral hygiene composition. When the content of sugar contained in the oral hygiene composition of the present invention is too small, such as less than 20% by weight, the efficacy decreases, and when it is contained in a large amount exceeding 70% by weight, the taste is affected. There is a risk.

The oral hygiene composition of the present invention is useful as a food additive for promoting salivary secretion.
That is, the oral hygiene composition of the present invention can be used as a food additive such as chewing gum, candy, beverage, chocolate, ice cream, fermented product, soy milk, tofu, or added to oral hygiene products such as gargle liquid and saliva. It can be used for the purpose of promoting secretion. The oral hygiene composition of the present invention as the food additive is added in an appropriate amount within the range of contents applied in the technical field, and specifically can be appropriately added within a range of 0.01 to 20% by weight.

The present invention described above will be described in more detail based on the following examples. However, these examples do not limit the present invention.
[Reference Example] Selection of the most effective organic acid mixture, natural extract and sugar In order to select the organic acid, natural extract and sugar used in the oral hygiene composition for promoting saliva secretion of the present invention, the following experiment was conducted. Went.
Reference Example 1) Selection of organic acid mixture For this experiment, six researchers who had no problem with saliva secretion participated.
Each organic acid mixture having a composition ratio as shown in Table 1 below was produced. Each organic acid mixture was dissolved in distilled water to produce a 0.3% concentration solution. After rinsing with 10 mL of the produced solution for 10 seconds, saliva secreted for 2 minutes was collected in a saliva tube and the amount was repeatedly measured 10 times or more. The average results are shown in Table 1 below. For 2 hours before the start of the experiment, food and drink were restrained and all saliva in the mouth was removed immediately before the experiment. The results of measuring the amount of saliva secreted by each organic acid are shown in Table 1 below.

  According to Table 1, when the contents of fumaric acid 30 to 80% by weight, citric acid 15 to 50% by weight, and malic acid 5 to 30% by weight are maintained, the saliva secretion effect is excellent, and the organic composition of the above composition Even when tartaric acid, adipic acid, malic acid or the like was further added to the acid mixture, it was confirmed that the salivary secretion effect was maintained as it was.

Reference Example 2) Selection of natural extract Natural products as shown in Table 2 below were prepared. The prepared natural product dry sample was mixed with 100 g of a sample pulverized product obtained by pulverizing to 80 mesh and 900 mL of distilled water was mixed, followed by extraction with stirring at 50 ° C. for 1 hour. The extracted sample was filtered and concentrated under reduced pressure to obtain a natural extract powder. The natural extract powder was diluted with distilled water at a concentration of 5% and used. The amount of saliva secretion was measured by the method of Reference Example 1. Distilled water was used as a control group. The results of measuring the amount of saliva secreted by each natural extract are shown in Table 2 below.

According to the results of Table 2, it was possible to confirm that excellent as a natural product berry extract sake bottle strawberry, blueberry extract, or salivation efficacy in complex extracts of fruit and blueberry sake bottle strawberry.

Reference Example 3) Selection of sugars Sugars as shown in Table 3 below were prepared. Each sugar was used in the experiment by making an appropriately sized tablet. The amount of saliva secreted by the prepared sugar tablets was measured by the method of Reference Example 1. Distilled water was used as a control group. The results of measuring the amount of saliva secreted by each sugar are shown in Table 3 below.

  According to the results in Table 3 above, it was confirmed that the salivary secretion efficacy of xylitol, maltitol, sorbitol, or a mixture thereof as a sugar was excellent.

[Example]
Examples 1-5 and Comparative Examples 1-2: Oral hygiene compositions for saliva secretion After mixing an organic acid mixture, a natural extract and sugar at the composition ratio shown in Table 4 below, the mixture was dissolved in distilled water to a concentration of 0.3 % Solution was produced.
The amount of saliva secretion was measured by the method of Reference Example 1. The results are shown in Table 4 below.

Example 6 Chewing Gum Containing Saliva Secretion Promoting Composition A chewing gum containing a saliva secretion promoting composition having the composition ratio shown in Table 2 below as an additive was produced. Based on 100 parts by weight of the gum base, 100 parts by weight of the saliva secretion promoting composition shown in Table 5 below was blended to produce chewing gum.
Saliva secreted while chewing each manufactured chewing gum for 10 minutes was collected in a saliva tube, and the amount was repeatedly measured 10 times or more. The average results are shown in Table 5. For 2 hours before the start of the experiment, food and drink were restrained and all saliva in the mouth was removed immediately before the experiment.

  According to Table 5, the oral hygiene composition of the present invention is used as a food additive such as chewing gum, and enables production of foods having the effect of promoting the secretion of saliva. Therefore, the oral hygiene composition of the present invention is useful as an additive that promotes salivation in chewing gum, candy, beverages, chocolate, ice cream, fermented products, foods such as soy milk, tofu, and health supplements such as gargle liquid. It is.

Claims (6)

10 to 50% by weight of an organic acid mixture consisting of fumaric acid, citric acid and malic acid,
10 to 50% by weight of a natural extract selected from a pickled strawberry fruit extract, a blueberry extract and a composite extract thereof,
An oral hygiene composition that promotes salivation, comprising 30 to 70% by weight of a sugar selected from xylitol, maltitol, and mixtures thereof.   The oral hygiene for promoting salivation according to claim 1, wherein the organic acid mixture comprises 30-80 wt% fumaric acid, 15-50 wt% citric acid, and 5-30 wt% malic acid. Composition. Oral said organic acid mixture, to promote tartaric, and, characterized in that it further comprises 5 to 20 wt.% Other organic acids selected from O adipic acid Li Cheng group, salivation according to claim 2 Hygiene composition. The additive for promoting saliva secretion, which is the oral hygiene composition according to any one of claims 1 to 3 . An oral care product comprising the additive for promoting saliva secretion according to claim 4 . 6. An oral care product according to claim 5 , characterized in that it is a chewing gum, candy, beverage, chocolate, ice cream, fermented product, soy milk, tofu or gargle liquid.