CN107998010A - A kind of virgin growth toothpaste of benefit - Google Patents
A kind of virgin growth toothpaste of benefit Download PDFInfo
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- CN107998010A CN107998010A CN201711120555.XA CN201711120555A CN107998010A CN 107998010 A CN107998010 A CN 107998010A CN 201711120555 A CN201711120555 A CN 201711120555A CN 107998010 A CN107998010 A CN 107998010A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of virgin growth toothpaste of benefit.Based on dentifrice composition percentage by weight, which is prepared from the following materials：0.05~5% rose hip extract, 0.05~5% calcium berry extract, 0.05~5% mulberries extract, 0.1~5% chitosan oligosaccharide, moisturizer, abrasive, thickener, surfactant, sweetener, preservative, essence and deionized water etc..The present invention is using natural rose hip, calcium fruit, mulberries extract as nutrient, using chitosan oligosaccharide as immunomodulator, using toothpaste as carrier, there is provided a kind of that there is cleaning oral cavity, promote lead discharging, replenishing vitamins and trace element, enhancing to be immune to the virgin growth toothpaste of integral benefit.
Description
Technical field
The present invention relates to a kind of toothpaste, more particularly to a kind of virgin growth toothpaste of benefit, belong to oral care product technical field.
Background technology
With industrialized fast development, especially environmental pollution getting worse, lead contamination.Although China was at 2000 7
Stopped sale comprehensively on the moon 1 and using doped fuel, vehicle exhaust lead contamination is under control, but is also widely present it in environment
The lead contamination of its form, such as industrial wastewater, old and useless battery, finishing paint, paint, fire coal.
Lead in children's body mostlys come from leaded article (such as oil-containing of air pollution, food pollution and everyday exposure
The toy of paint, oil painting brush, pencil etc.).The characteristics of due to metabolism and development, children have special neurological susceptibility to lead.Lead enters
After human body, cranial nerve tissue is invaded by blood, makes nutriment and oxygen supply deficiency, causes brain tissue impairment.For youngster
For child, lead mainly causes harmful effect to nervous system and growth and development aspect, and such as apocleisis, absent minded, study is tired
Difficult, active, irritability etc., at the same can also absorption of the interference body to the trace element such as calcium, iron, zinc, cause trace element shortage
Even anaemia, there is also the symptoms such as growth retardation, feeblemindedness, hypoimmunity when serious.
Disease prevention and control center of the U.S. explicitly points out, and blood lead 100ug/L is not construed as causing the lower limit of adverse effect.
It recent studies have shown that within 2011, even if the only 25ug/L of the lead concentration in blood, it is possible to cause children for learning teaching.Generation
Boundary's health organization confirms as lead to influence children the toxic chemical substance of most serious, it is believed that blood lead concentration, which reaches 50ug/L, just to be had
IQ may be caused to decline.Some investigators appeal that lead concentration, which reaches 20ug/L, in children's blood should just take action, as early as possible
For child's lead discharging, avoid causing damage to child's growth and development and intellectual development.
The therapy mechanism of lead poisoning at present is broadly divided into complexing mechanism, Antagonizing and enhancing, and body is anti-oxidant and immunity energy
Power.Clinical treatment lead poisoning is mainly complexing mechanism, such as injection or oral sodium calcium edetate, sodium dimercaptosuccinate complexing
Agent, although lead discharging effect is good, also has the other essential trace elements of human body very strong complexing, can at the same time will in lead discharging
The element beneficial to human body such as iron, zinc excretes, and causes relevant enzyme physiological activity to reduce or even inactivate, and has certain secondary work
With being only suitable for serious blood lead patient.In view of influence of the lead contamination to upgrowth and development of children, should accomplish early prevention, and it is early to find, it is early
Treatment, accomplishes to prevent trouble before it happens, and usually prevention should be based on dietotherapy and health products.There are many lead discharging factors in natural food, such as
Food rich in protein, vitamin and trace mineral, can inhibit trace element in absorption and balanced body of the human body to lead, makes
The shortage that lead is excreted without causing body trace element.
Children's toothpaste has the characteristics that to clean oral cavity, pre- anti-caries, easy to use, as oral cavity cleaning and nursing product
As the daily required oral health-care product of children.Children's toothpaste currently on the market based on preventing decayed tooth, does not have decorporation lead also mostly
The children's toothpaste of effect occurs.
Therefore, how to provide a kind of immune with cleaning oral cavity, promotion lead discharging, replenishing vitamins and trace element, enhancing
In the virgin growth toothpaste of the benefit of one be the technical barrier that current art technical staff is badly in need of solving.
The content of the invention
To solve the above-mentioned problems, it is an object of the invention to provide a kind of virgin growth toothpaste of benefit, it is naturally to pierce rose
Fruit, calcium fruit, mulberries extract are nutrient, using chitosan oligosaccharide as immunomodulator, using toothpaste as carrier, have cleaning oral cavity, promote
Integral multi-efficiency is immune into lead discharging, replenishing vitamins and trace element, enhancing.
The object of the present invention is achieved like this：
A kind of virgin growth toothpaste of benefit, by toothpaste weight percentages, comprising 0.05~5% rose hip extract, 0.05
~5% calcium berry extract, 0.05~5% mulberries extract, 0.1~5% chitosan oligosaccharide, 55~70% moisturizer, 12
~20% abrasive, 0.6~1.0% thickener, 0.5~1.5% surfactant, 0.05~0.2% sweetener,
0.1~0.3% preservative, 0.5~1.0% essence, deionized water are added to 100%.
The rose hip extract is the active ingredient extracted from the ripening fruits of rose family rose Rosa bella,
To keep the natural activity of rose hip, using supercritical CO2Extraction, preferably additive amount are 0.5~2%.
The calcium berry extract is the active ingredient extracted from the ripening fruits of rose department cherry genus Europe Lee, to keep calcium
The natural activity of fruit, using supercritical CO2Extraction, preferably additive amount are 0.5~2%.
The mulberries extract is the active ingredient extracted from the ripening fruits of moraceae plants mulberry tree, to keep mulberries
Natural activity, using SCF-CO 2, preferably additive amount is 0.5~2%.
The extraction process of the rose hip extract is：
Fresh, complete rose hip is cleaned and dried, pulp shape is ground into beater, is quantitatively adding supercritical extract
In the extraction kettle of device, start extraction equipment, dynamic extraction, 30 DEG C of extraction temperature, extracting pressure are carried out by imposing a condition
30Mpa, extraction time 3h, CO2Flow 10L/h；After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains rose hip
Supercritical extract；
The extraction process of the calcium berry extract is：
Fresh, complete calcium fruit is cleaned and dried, pulp shape is ground into beater, is quantitatively adding supercritical extract dress
In the extraction kettle put, start extraction equipment, dynamic extraction is carried out by imposing a condition, 30 DEG C, extracting pressure 30Mpa of extraction temperature,
Extraction time 3h, CO2Flow 10L/h；After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains that calcium fruit is overcritical to be carried
Take thing；
The extraction process of the mulberries extract is：
Fresh, complete mulberries are cleaned and dried, pulp shape is ground into beater, are quantitatively adding supercritical extract dress
In the extraction kettle put, start extraction equipment, dynamic extraction is carried out by imposing a condition, 30 DEG C, extracting pressure 30Mpa of extraction temperature,
Extraction time 3h, CO2Flow 10L/h；After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains that mulberries are overcritical to be carried
Take thing.
The chitosan oligosaccharide is the chitin for utilizing the crustacean (shrimp, crab shell etc.) in ocean internal through deacetylated processing
It is raw material to obtain chitosan, by digesting the oligo-glucosamine obtained, in order to be conducive to absorption of human body, present invention selection point
Chitosan oligosaccharide of the son amount below 3000 dalton, preferred molecular weight in 1000~2000 dalton, preferably additive amount for 0.5~
2%.
The moisturizer is glycerine, one or more mixtures in sorbierite, polyethylene glycol, propane diols.
The abrasive is soft silicon abrasive material, including friction type silica, mixed type silica, thickening type titanium dioxide
Silicon one or more mixture.Children are made not damage enamel again while oral cavity is cleaned；Due to abrasive silica
Inertia, makes it not chemically reacted with active matter, ensures storage stability of the active matter in lotion.
The thickener is sodium carboxymethylcellulose, one or more mixtures in xanthans, melon glue, carragheen.
The surfactant is laruyl alcohol sodium sulfovinate, in sodium lauroyl sarcosine, Cocoamidopropyl betaine
One or more mixtures.
The sweetener is saccharin sodium, one or more mixtures in acesulfame potassium, button sweet tea.
The preservative is one or both of sodium benzoate, parabens mixture.
Above-mentioned toothpaste component can also include other additives, such as sodium pyrophosphate, fluoride, xylitol, mica etc..
The invention has the advantages that and beneficial effect：
1st, the present invention uses natural rose hip, calcium fruit, mulberries extract as nutrient, using chitosan oligosaccharide as immunomodulator,
Using toothpaste as carrier, there is provided one kind has cleaning oral cavity, promotes lead discharging, replenishing vitamins and trace element, enhancing to be immune to one
The virgin growth toothpaste of benefit of body.Natural rose hip, calcium fruit, mulberries are as integration of drinking and medicinal herbs food materials, institute's nutrient containing and synthesis nutrient
Compare, have the advantages that absorption is fast, utilization ratio is high, safety is without side-effects, especially suitable for child health care product.Natural thorn rose
Fruit, calcium fruit, mulberries contain abundant vitamin and calcium, iron, zinc, selenium and other trace elements, these vitamins and trace element can be competing
Striving property suppresses absorption and transhipment of the lead in intestines and stomach, activates histaminase, promotes lead to dissociate and excrete from tissue, so as to recover
Body eubolism, reduces or eliminates damage of the lead to body.Chitosan oligosaccharide can pass through suction-operated and vivotoxin, chemical pigment
And heavy metal forms larger particle, and discharged with metabolism product, it can also dissociate the heavy metal being deposited in bone
And excrete.Chitosan oligosaccharide can also promote the absorption of rose hip, calcium fruit, the vitamin in mulberries and trace element, improve activity
The bioavilability of thing.So natural rose hip, calcium fruit, mulberries and chitosan oligosaccharide form synergistic mechanism in the present invention, altogether
With the discharge for promoting lead, harmful effect of the lead to upgrowth and development of children is eliminated or reduced.
Zinc, the selenium being rich in natural rose hip, calcium fruit, mulberries can remove the free radical produced in vivo, de- in protective
Oxygen ribonucleic acid exempts from harmful substance invasion and attack, helps cell repair and enhancing body resistance against diseases；Chitosan oligosaccharide has body entirety
Regulatory function, can adjust human body pathogen, strengthen human immunity.Natural rose hip, calcium fruit, mulberries and chitosan oligosaccharide in the present invention
Joint-action mechanism is formd, by the integrally-regulated come strengthen immunity, promotion upgrowth and development of children of body.
2nd, the virgin growth toothpaste of benefit of the invention, using natural rose hip, calcium fruit, mulberries extract and chitosan oligosaccharide as decorporation lead because
Son, vitamin and trace element necessary to can also supplement upgrowth and development of children while decorporation lead, and then strengthen immunization programs for children
Power, promotes children's healthy growth, avoids causing Trace Elements in Children using complexing agents such as sodium calcium edetate, sodium dimercaptosuccinates
Missing, influence proper child development.The modern toothpaste making process of present invention fusion, is designed that children like, virgin with benefit
The gel toothpaste for function of growing up, during children brush teeth, active ingredient is directly absorbed into by oral mucosa and sublingual vein
Enter blood circulation system, avoid the destruction of the first pass effect and the degradation of gastrointestinal enzyme and acid of liver to active matter, carry
The high bioavilability of active matter, preferably plays the virgin growth effect of benefit.
3rd, the present invention is first using natural rose hip, calcium fruit, mulberries extract as nutrient, and chitosan oligosaccharide is as immunological regulation
Agent is applied in children's toothpaste, in addition to lead-expelling function is promoted, moreover it is possible to vitamin and micro necessary to supplement upgrowth and development of children
Element, and immunity of organisms can be adjusted, promote children's healthy growth.Invention increases children to obtain the virgin growth nutrient of benefit
Approach, is no longer limited to food, medicine or health products, and beneficial virgin nutrient can be just obtained while common oral cleaning-nursing,
So as to reach decorporation lead and strengthen immune double effects, there is very strong practicality and realistic meaning, while enrich children
The category of toothpaste.
4th, the present invention proves it with the immune double effects of decorporation lead and enhancing by clinical test.
Embodiment
The virgin growth toothpaste of one kind benefit of the present invention, includes 0.05~5% rose hip extract, 0.05~5% calcium fruit
Extract, 0.05~5% mulberries extract, 0.1~5% chitosan oligosaccharide, 55~70% moisturizer, 12~20% friction
Agent, 0.6~1.0% thickener, 0.5~1.5% surfactant, 0.05~0.2% sweetener, 0.1~0.3%
Preservative, 0.5~1.0% essence, deionized water are added to 100%.
Wherein, the preferred additive amount of rose hip extract is 0.5~2%, and the preferred additive amount of calcium berry extract is 0.5~2%,
The preferred additive amount of mulberries extract is 0.5~2%, and chitosan oligosaccharide preferred molecular weight is in 1000~2000 dalton, preferably additive amount
For 0.5~2%.These natural extracts and chitosan oligosaccharide interaction, are on the one hand used to promote lead-eliminating effect, on the other hand supplement micro-
Secondary element and vitamin, adjust body allomeric function, and enhancing is immune, promote children's healthy growth.
Be below to the present invention relates to the virgin growth factor of benefit brief statement：
Rose hip, for the ripening fruits of rose family rose Rosa bella, also known as the wooden fruit of siberian rose, thorn, Rosa bella, is
The homologous precious resources of a kind of rare medicine, food.Rose hip contains 17 kinds of amino acid, 28 kinds of elements, wherein having
14 kinds of necessary trace elements of human body such as the clearer and more definite zinc of abundant bioactivity, iron, selenium.And the content of zinc is very high, warp
Health ministry clinical examination center is examined, and per in hectogram fruit, the content of zinc is 19.43 milligrams, its content is higher than other plant
Fruit, is known as " flowers of life "；At the same time also containing multivitamins such as VA, VC, VE, VB1, VB2, VP, beta carotenes.Wherein VC
Content highest, it first of all veterinary antibiotics, is " hat of the earth fruit " to occupy, and is known as " king of VC ", is regarded by European Countries
For " treatment scurvy specific drug ", there is the title of " vitamin record holder ".
Rose hip also has medical value in addition to nutritive value, clinical experiments have proved that rose hip have significant anti-aging,
Antifatigue, radioresistance, resist oxygen lack, brain, the effect promoted longevity, and the good medicine for the treatment of vitamin-deficiency, to youngster
Child's malnutritive, feeblemindedness caused by zinc-deficiency also has significant curative effect.
Calcium fruit, for the ripening fruits of rose department cherry genus Europe Lee, also known as star, Ou Li, mountain plum, the semen pruni humilidis et japonicae replenished the calcium, is
China fruit tree expert professor Du Junjie undergoes time more than ten years, and the China for finding and selecting from Lee of wild plant Europe is exclusive
Fruit new varieties.Its fruit calcium content is high, is referred to as " star replenished the calcium ".Calcium fruit contains abundant protein and mineral matter
Element, vitamin and amino acid.80mg and 1.5mg are respectively reached per hectogram fresh fruit calcium iron, is six times of apple, contains in fruit
17 kinds of amino acid, particularly vitamin C, B2The content of content and potassium, phosphorus, iron, zinc, selenium and lysine with E is above existing
There are Common Fruits, be the high-class healthy fruit of children, old man, pregnant woman.
Mulberry fruit, also known as sorosis, are the fruit of moraceae plants mulberry tree, and acid sweet in flavor, cold nature, enters the heart, liver and kidney channel, have and mend
Blood, enriching yin, promote the production of body fluid to quench thirst, relax bowel and other effects, is a kind of good fruit of nourishing heart intelligence development, is referred to as " sage fruit among the people ".Mulberries contain
Abundant activated protein, provitamin A, B1、B2And C, amino acid, malic acid, butanedioic acid, tartaric acid, carrotene, mineral matter
The components such as calcium, phosphorus, iron, copper, zinc, selenium.Mulberries can promote hematopoietic stem cell growth, strengthen the weight of immune organ, have and exempt from
Epidemic disease facilitation, can strengthen nonspecific immunity function, improve humoral immunity, T cell mediated immunity function, have to cell mutation
Prevention effect, can slow down aging, and be a kind of good fruit of medicine-food two-purpose, and " the optimal health-care fruit of 21st century is described as by medical field
Product ".
Chitosan oligosaccharide, also known as chitin oligo saccharide, amino-oligosaccharide, is to utilize the crustacean (shrimp, crab shell etc.) in ocean internal
Chitin through deacetylated processing, to obtain chitosan be raw material, pass through enzymolysis acquisition oligo-glucosamine, i.e. chitosan oligosaccharide.Shell
Oligosaccharides has that molecular weight is low, good water solubility, bioactivity are high, in human body internal absorption factor close to 100%, its bioactivity and effect
It is the decades of times of chitosan.
Chitosan oligosaccharide is because containing special hydroxyl (- OH) and amino (- NH2) group, being that nature is unique positively charged moves
Fibres element (sugar chain), its cyclic structure have superpower absorption and recognition capability.The virus of human body, toxin cell surface are most
Number is negatively charged, and chitosan oligosaccharide can adsorb vivotoxin, chemical pigment and heavy metal, and be excreted with metabolism product,
Reduce damage of the toxin to liver, moreover it is possible to excrete the heavy metal being deposited in bone.Chitosan oligosaccharide, which also has to improve, to be immunized
Power, promotes the absorption of calcium and mineral matter, is widely used in the fields such as medicine, functional food.
Chitosan oligosaccharide is set in protein, fat, carbohydrate, vitamin and mineral five by Japan and American-European medical field
" the 6th vital principle " after big vital principle.Scientific research proves：Chitosan oligosaccharide has the function of that body is integrally-regulated, can adjust
Human body pathogen is saved, strengthens the resistivity of human body, removes the harmful ions such as chlorine unnecessary in vivo, heavy metal, by world authority
Expert is likened to " human body environment-friendly agent ", " human body antivirus software ", " human immunity bodyguard ".
Rose hip extract, calcium berry extract and mulberries extract extraction process in the embodiment of the present invention are：
Fresh, complete rose hip is cleaned and dried, pulp shape is ground into beater, is quantitatively adding supercritical extract
In the extraction kettle of device, start extraction equipment, dynamic extraction, 30 DEG C of extraction temperature, extracting pressure are carried out by imposing a condition
30Mpa, extraction time 3h, CO2Flow 10L/h.After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains rose hip
Supercritical extract.
The extraction process of calcium berry extract and mulberries extract is same as above.
Below by specific embodiment, the present invention is further explained, but these embodiments are only used for that it is described in more detail
With, and be not applied to limit the present invention in any form.
Embodiment 1
A kind of virgin growth toothpaste of benefit, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) parabens, essence are added in container A, stirring and dissolving；
2) deionized water is added in premix pot B, then adds button sweet tea, sodium pyrophosphate, rose hip extract, the extraction of calcium fruit
Thing, mulberries extract, chitosan oligosaccharide, mica and stirring and dissolving；
3) polyethylene glycol, sorbierite are added in premix pot C；
4) silica, sodium carboxymethylcellulose, carragheen, laruyl alcohol sodium sulfovinate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can
Go out cream.
Embodiment 2
A kind of virgin growth toothpaste of benefit, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) deionized water is added in premix pot B, then adds saccharin sodium, sodium benzoate, sodium fluoride, rose hip extraction
Thing, calcium berry extract, mulberries extract, chitosan oligosaccharide, xylitol, Cocoamidopropyl betaine and stirring and dissolving；
2) propane diols, glycerine, sorbierite are added in premix pot C；
3) silica, sodium carboxymethylcellulose, melon glue, laruyl alcohol sodium sulfovinate are added in meal mixer；
4) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, essence is sucked, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
Embodiment 3
A kind of virgin growth toothpaste of benefit, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) deionized water is added in premix pot B, then adds acesulfame potassium, sodium benzoate, rose hip extract, calcium fruit and carry
Take thing, mulberries extract, chitosan oligosaccharide, sodium lauroyl sarcosine and stirring and dissolving；
2) polyethylene glycol, sorbierite are added in premix pot C；
3) silica, sodium carboxymethylcellulose, xanthans, laruyl alcohol sodium sulfovinate are added in meal mixer；
4) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, essence is sucked, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
Embodiment 4
A kind of virgin growth toothpaste of benefit, by weight percentage, includes following raw material components：
Manufacture craft is as follows：
1) parabens, essence are added in container A, stirring and dissolving；
2) deionized water is added in premix pot B, then adds saccharin sodium, sodium pyrophosphate, rose hip extract, calcium fruit and carry
Take thing, mulberries extract, chitosan oligosaccharide, mica and stirring and dissolving；
3) polyethylene glycol, sorbierite are added in premix pot C；
4) silica, sodium carboxymethylcellulose, laruyl alcohol sodium sulfovinate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir
Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, raw material in container A is sucked, then homogeneous deaerates 10 minutes, can go out after the assay was approved
Cream.
Clinical test part
1st, the virgin growth toothpaste of present invention benefit promotes the zoopery evaluation of lead-eliminating effect
Healthy ICR mouse 50,18~20g of weight, half male and half female are randomly divided into 5 groups, every group 10, i.e. blank control
Group, contaminates lead model group, and high, medium and low dosage group, lead acetate is dissolved in distilled water, by 40mg/kg to model group and dosage group
Mouse peritoneal is injected, and establishes mouse dye lead stamp type, and continuous contamination stops contamination after 7 days, allows mouse ad lib and drinking-water, is recovered
3 days, start within the 10th day to distinguish gavage to each group mouse.
Above-described embodiment 2 is taken to be used as given the test agent, the sample that toothpaste is diluted to various dose with distilled water is administered, including
High dose group (40g/kg), middle dose group (20g/kg), low dose group (10g/kg), dosage group gavages given the test agent, remaining is each
Group gavages the physiological saline of equivalent, and successive administration is after 8 weeks, 24h fasting for solids and liquids, takes 40 μ l of mouse right femoral vein blood to be put into Sheng respectively
The plastic centrifuge tube with cover for having 0.36ml1% nitric acid shakes up；Then mouse is put to death respectively, is taken 50% femur of side, is weighed laggard
Row digestion, adds dust technology to be settled to 5ml；Liver and brain tissue are accordingly taken with method.With sampling Graphite Furnace Atomic Absorption spectrophotometer into
Promoting circulation of blood, bone, the measure of liver and brain lead content, above-mentioned data statistic analysis are examined using T.It the results are shown in Table 1.
1 toothpaste of the present invention of table to mouse blood lead, bone lead, liver lead and brain lead content (mg/kg) influence (N=10)
△ is represented compares P ＜ 0.01 with blank group, and * is represented compares P ＜ 0.01 with model group,
2 various dose group of the embodiment of the present invention influences substantially, with mould mouse blood lead, bone lead, liver lead and brain lead content
Type group relatively has significant difference (P ＜ 0.01).Mouse lead discharging is promoted to make the result shows that the virgin growth toothpaste of benefit of the invention has
With, it was demonstrated that rose hip, calcium fruit, mulberries and chitosan oligosaccharide make an addition to as the lead discharging factor has feasibility and practicality in toothpaste.
2nd, the virgin growth toothpaste of present invention benefit is to children's lead discharging effect assessment
Choosing 70 has a close contact lead history, Pb-B 10.0ug/dL (100ug/L) 100ug/L children, at random
It is divided into 2 groups, every group of 35 people, control group uses the toothpaste without the lead discharging factor, and test group uses the toothpaste of embodiment 3, early daily,
In, evening respectively brush teeth 1 time, every time be no less than 2 minutes, be used continuously 3 months.During experiment, do not change lifestyles, academic environment
And drinking habit.Table 2 is influence of the embodiment to subject's blood lead.
Influence (ug/dL, X ± S) of 2 embodiment of table to subject's blood lead
| Group | Number | Before experiment | After experiment |
| Control group | 35 | 11.52±1.12 | 11.46±0.75 |
| Test group | 35 | 11.56±0.98 | 9.29±0.79* |
* test group blood lead content compared with the control group, significant difference (P ＜ 0.01).
Known by table 2, by the experiment of brushing teeth of 3 months, the change of test group and control group Pb-B had significant system
Meter learns difference (P ＜ 0.01), and further demonstrating the present invention has the clinical effectiveness of decorporation lead.
In addition to checking above children blood lead content, also its daily performance is investigated, there is apocleisis, note before
The children of the symptoms such as meaning power is not concentrated, difficulty of learning, active, irritability pass through on probation, the test group overwhelming majority that brushes teeth of 3 months
Virgin above symptom is clearly better or disappears, the improvement or disappearance of these symptoms will bring the raising of immunity, and immunity
Raising bring the improvement or disappearance of these symptoms.The virgin growth toothpaste of benefit of the invention has reached decorporation lead and enhancing as can be seen here
The double effects of immunization programs for children.
It is only to the preferred embodiment of the present invention above, is not construed as limitation of the present invention, protection of the invention
Scope should be subject to claim limited range.For those skilled in the art, do not departing from
Under the conditions of the spirit and scope of the present invention, the appropriate change of some conditions can be carried out, however it is not limited to what the present invention was disclosed and described
Embodiment, and should be attributed to scope of the claims.
Claims (9)
- A kind of 1. virgin growth toothpaste of benefit, it is characterised in that：By weight percentage, it is composed of the following components：0.05~5% Rose hip extract, 0.05~5% calcium berry extract, 0.05~5% mulberries extract, 0.1~5% chitosan oligosaccharide, 55 ~70% moisturizer, 12~20% abrasive, 0.6~1.0% thickener, 0.5~1.5% surfactant, 0.05~0.2% sweetener, 0.1~0.3% preservative, 0.5~1.0% essence, deionized water are added to 100%.
- 2. the virgin growth toothpaste of benefit according to claim 1, it is characterised in that：The rose hip extract is from rose family rose The active ingredient extracted in the ripening fruits of common vetch platymiscium Rosa bella, using supercritical CO2Extraction, preferably additive amount for 0.5~ 2%.
- 3. the virgin growth toothpaste of benefit according to claim 1, it is characterised in that：The calcium berry extract is from rose family cherry Belong to the active ingredient extracted in the ripening fruits of Europe Lee, using supercritical CO2Extraction, preferably additive amount are 0.5~2%.
- 4. the virgin growth toothpaste of benefit according to claim 1, it is characterised in that：The mulberries extract is from moraceae plants mulberry The active ingredient extracted in the ripening fruits of tree, using supercritical CO2Extraction, preferably additive amount are 0.5~2%.
- 5. the virgin growth toothpaste of benefit according to claim 1, it is characterised in that：The extraction process of the rose hip extract For：Fresh, complete rose hip is cleaned and dried, pulp shape is ground into beater, is quantitatively adding supercritical extraction unit Extraction kettle in, start extraction equipment, by impose a condition carry out dynamic extraction, 30 DEG C, extracting pressure 30Mpa of extraction temperature, extraction Take time 3h, CO2Flow 10L/h；After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains that rose hip is overcritical to be carried Take thing；The extraction process of the calcium berry extract is：Fresh, complete calcium fruit is cleaned and dried, is ground into pulp shape with beater, is quantitatively adding supercritical extraction unit In extraction kettle, start extraction equipment, dynamic extraction is carried out by imposing a condition, 30 DEG C, extracting pressure 30Mpa of extraction temperature, extraction Time 3h, CO2Flow 10L/h；After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains calcium fruit supercritical extract；The extraction process of the mulberries extract is：Fresh, complete mulberries are cleaned and dried, pulp shape is ground into beater, is quantitatively adding supercritical extraction unit In extraction kettle, start extraction equipment, dynamic extraction is carried out by imposing a condition, 30 DEG C, extracting pressure 30Mpa of extraction temperature, extraction Time 3h, CO2Flow 10L/h；After extraction, extract is concentrated, be dried under reduced pressure, is crushed, obtains mulberries supercritical extract.
- 6. the virgin growth toothpaste of benefit according to claim 1, it is characterised in that：The chitosan oligosaccharide be utilize ocean in shrimp, It is raw material that chitin in the crustacean body of crab obtains chitosan through deacetylated processing, by digesting the oligomeric amino obtained Glucose.
- 7. the virgin growth toothpaste of benefit according to claim 6, it is characterised in that：Its molecular weight of the chitosan is in 3000 dongles Below, for preferred molecular weight in 1000~2000 dalton, additive amount is 0.5~2%.
- 8. the virgin growth toothpaste of benefit according to claim 1, it is characterised in that：The moisturizer is glycerine, one or more mixtures in sorbierite, polyethylene glycol, propane diols；The abrasive is soft silicon abrasive material, including friction type silica, mixed type silica, thickening type silica one Kind or a variety of mixtures；The thickener is sodium carboxymethylcellulose, one or more mixtures in xanthans, melon glue, carragheen；The surfactant is laruyl alcohol sodium sulfovinate, one kind in sodium lauroyl sarcosine, Cocoamidopropyl betaine Or a variety of mixtures；The sweetener is saccharin sodium, one or more mixtures in acesulfame potassium, button sweet tea；The preservative is one or both of sodium benzoate, parabens mixture.
- 9. the virgin growth toothpaste of benefit according to any one of claim 1-8, it is characterised in that：It is also included in above-mentioned toothpaste His additive, one or more of other the described additives in sodium pyrophosphate, fluoride, xylitol, mica.
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Application publication date: 20180508 |