CN110448480A - A kind of oral-care toothpaste containing prebiotics - Google Patents
A kind of oral-care toothpaste containing prebiotics Download PDFInfo
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- CN110448480A CN110448480A CN201910742548.6A CN201910742548A CN110448480A CN 110448480 A CN110448480 A CN 110448480A CN 201910742548 A CN201910742548 A CN 201910742548A CN 110448480 A CN110448480 A CN 110448480A
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- oral
- prebiotics
- digestible
- functional oligose
- care toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of oral-care toothpastes containing prebiotics, it is formulated by prebiotics, calcium monohydrogen phosphate, D-sorbite, propylene glycol, Cocoamidopropyl betaine, sodium lauroyl sarcosine, sodium carboxymethylcellulose, carragheen, xanthan gum, sodium pyrophosphate, essence, potassium sorbate, water by certain weight ratio, the prebiotics are the mixture of alkalinity non-digestible functional oligose and the non-digestible functional oligose of non-alkaline.Oral-care toothpaste of the invention has the physicochemical properties such as low-heat, stabilization, safe and nontoxic, and it can be utilized by the beneficial bacteriums such as Bifidobacterium, lactic acid bacteria in oral cavity, promote its breeding, the organic acids such as its tunning lactic acid, acetic acid can inhibit the growth of the spoilage organisms such as Escherichia coli, bacteroid, clostridium simultaneously, optimize Bacterial community, improve oral cavity sub-health state, enhances immunity of organisms.
Description
Technical field
The invention belongs to oral cleaning nursing article technical fields, and in particular to a kind of oral care tooth containing prebiotics
Cream.
Background technique
Oral cavity inferior health is a kind of state that oral cavity is between health and morbid state, is existed under the state a kind of or more
Reversible, the preventible early stage oral problem of kind.According to the national sector standard and sanitary standard of both effectiveness toothpaste, mainly
The oral problems such as plaque, early stage caries, early stage gingivitis, transient dentine hypersensitivity, tooth stain, halitosis.These oral problems
Subdivision type it is more, but their root both is from the accumulation and maturation in plaque.Plaque is that the bacterium of non-mineralising is heavy
Product object, is that bacterium and matrix (saliva glycoprotein, bacterial cell exo polysaccharides) attach to the ecosystem formed on facing or dummy
System；Bacterium grows wherein, breeds and becomes feeble and die, and carries out complicated metabolism activity, and tooth body can be caused when condition is appropriate
And parodontopathy.Therefore, the problem of essence of these oral problems is oral microorganism.
Oral microorganism is colonized in human oral cavity, mostly with biological form membrane complicated composition group, balances when being in host
When state, oral microbial community can prevent the invasion of exogenous pathogenic bacteria, play physiological barriers effect；Work as microbiologic population
When unbalance with host's parabiosis relationship, multiple oral disease, including dental caries, pulp vitality test, periodontosis, wisdom tooth hat can be induced
Zhou Yan, mandibular osteomyelitis etc. seriously endanger oral health.
Prebiotics refer to it is some not by Host Digestion absorb, can selectively promote the beneficial bacteriums such as its internal Bifidobacterium
Growth and breeding, so as to improve the organic substance of host health.The substance for having prebiotic meta function is mainly some non-(or difficult)
Digestible oligosaccharide, as oligofructose, galactooligosaccharide, xylo-oligosaccharide, soyabean oligosaccharides, stachyose, gossypose, sweet dew are oligomeric
Sugar, isomaltose, chitosan oligomer etc., in addition there are polysaccharide (coriolan, the nitrogenous polysaccharide of Hu trailing plants), plant and Chinese herbal medicine are extracted
Object, protein hydrolysate (hydrolysate of casein, alpha lactalbumin, lactoferrin), polyalcohol (xylitol, mannitol, sorb
Alcohol, lactitol) etc..
Many researchs, which have proven to prebiotics, can promote the breeding of beneficial bacteria in human body, optimize colony balance, and enhancing is exempted from
Epidemic disease power, most of at present clinical and experiment all concentrate on intestinal health, and the research in terms of concern oral health care is relatively rare,
Concrete application of the prebiotics in toothpaste is also seldom in the market.
The Chinese patent of Patent No. CN105147530A discloses a kind of spherical activated charcoal toothpaste, by following by weight hundred
Divide the raw material composition than meter: rubbing agent 6-45%, thickener 0.3-20%, moisturizer 10-52%, sweetener 0.01-10%, bacteriostatic agent
0.03-3%, foaming agent 0.8-5%, toothpaste essence 0.4-3%, pigment 0-4%, spherical activated charcoal 0.01-40%, deionized water surplus,
The patent adsorbs the spot in oral cavity by the way that spherical activated charcoal particle is added in toothpaste, by physical method, and absorption has selection
Property, and when the capacity of activated carbon adsorption after reaching the upper limit, due to saturation effect, lose adsorption capacity rapidly, this can not be from
Fundamentally improve oral environment problem, optimization balance cannot be accomplished for flora in oral cavity, be difficult to avoid the generation of mouth disease.
The Chinese patent of Patent No. CN107049810A discloses a kind of edible toothpaste of pet, by following weight percent
Ratio at being grouped as: water 10-30%, D-sorbite 30-50%, glycerol 5-10%, alkyl glycosides 3-8%, precipitated calcium carbonate 5-10%,
Sodium alginate 2-3%, sodium bicarbonate 5-10%, xylitol 1-6%, potassium sorbate 0.05-0.1%, pet cleaning food calling material 1-2%, benefit
Raw member additive 1-3%, prebiotics additive are the mixture of one or both of oligofructose, inulin and garlic fructosan.
Can only there be facilitation to beneficial bacterium using non-alkaline oligosaccharide in the patent, and there is no good inhibiting effect to harmful bacteria,
When oral cavity is in unhealthy status, original microbial balance is broken, and profitable strain content is low, and pernicious bacteria content is high,
Micro non-alkaline oligosaccharide, which rises, to have little effect, in practical applications vulnerable to limitation.
Summary of the invention
The object of the present invention is to provide a kind of oral-care toothpaste containing prebiotics, there is low-heat, stabilization, safe and nontoxic
Etc. physicochemical properties, can also optimize Bacterial community, improve oral cavity sub-health state, enhance immunity of organisms.
The present invention solves the above problems used technical solution are as follows: a kind of oral-care toothpaste containing prebiotics, it is described
Oral-care toothpaste containing prebiotics consists of the following components in percentage by weight:
Prebiotics 0.1-10%
Calcium monohydrogen phosphate 20-50%
D-sorbite 10-30%
Propylene glycol 5-10%
Cocoamidopropyl betaine 1-5%
Sodium lauroyl sarcosine 1-5%
Sodium carboxymethylcellulose 0.2-1%
Carragheen 0.2-1%
Xanthan gum 0.2-1%
Sodium pyrophosphate 0.2-1%
Essence 0.5-2%
Potassium sorbate 0.1-1%
Water surplus；
The sum of weight percent of each component is 100%.
The prebiotics are the mixed of the non-digestible functional oligose of alkalinity and the non-digestible functional oligose of non-alkaline
Close object.
Wherein, the mass ratio of the alkalinity non-digestible functional oligose and the non-digestible functional oligose of non-alkaline
For 1:1-2.
Wherein, the non-digestible functional oligose of alkalinity is chitosan oligomer.
Wherein, the non-digestible functional oligose of the non-alkaline is galactooligosaccharide, in oligofructose, isomaltose
It is at least one.
Compared with the prior art, the advantages of the present invention are as follows:
(1) on the basis of conventional toothpaste is formulated, while alkalinity and the non-digestible functional oligose of non-alkaline being added as benefit
Raw metamember, the non-digestible functional oligose of non-alkaline is to oral cavity beneficial bacterium bifidobacterium adolescentis, bifidobacterium infantis, long pair
Discrimination bacillus, lactobacillus acidophilus have promotion growth, and the non-digestible functional oligose of alkalinity is to the numerous of harmful bacteria Escherichia coli
It grows with stronger inhibiting effect, alkalinity, which is used cooperatively more preferably to play with the non-digestible functional oligose of non-alkaline, adjusts bacterium
The effect of group structure.
(2) beneficial bacterium is preferentially able to vigorous growth using prebiotics, and the organic acids such as tunning lactic acid, acetic acid can drop
Low pH is to inhibit the growth of the spoilage organisms such as Escherichia coli, bacteroid, clostridium.
(3) oligosaccharide structures by physical efficiency in conjunction with the lectin of pathogen cell surface, reduce pathogen and life
The combination of object film, to mitigate the accumulation of plaque.
(4) prebiotics have sweet taste, can reduce the use of sweetener.
(5) toothpaste system pH can neutralize the excessive organic acid of generation, the invasion to tooth be avoided, with phosphoric acid in alkalinity
Hydrogen calcium is rubbing agent, promotes calcium, phosphorus absorption and ossification using oligosaccharides prebiotics, is beneficial to prevent dental caries.
(6) optimize Bacterial community, improve oral cavity sub-health state, enhance immunity of organisms.
Specific embodiment
Present invention is further described in detail with reference to embodiments.
Embodiment 1
Oral-care toothpaste in embodiment 1 containing prebiotics consists of the following components in percentage by weight:
Chitosan oligomer 1%
Galactooligosaccharide 1%
Calcium monohydrogen phosphate 40%
D-sorbite 25%
Propylene glycol 5%
Cocoamidopropyl betaine 2%
Sodium lauroyl sarcosine 4%
Sodium carboxymethylcellulose 0.5%
Carragheen 0.4%
Xanthan gum 0.4%
Sodium pyrophosphate 0.5%
Essence 1%
Potassium sorbate 0.1%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 2
Oral-care toothpaste in embodiment 2 containing prebiotics consists of the following components in percentage by weight:
Chitosan oligomer 1%
Oligofructose 2%
Calcium monohydrogen phosphate 35%
D-sorbite 30%
Propylene glycol 5%
Cocoamidopropyl betaine 2%
Sodium lauroyl sarcosine 4%
Sodium carboxymethylcellulose 0.5%
Carragheen 0.4%
Xanthan gum 0.4%
Sodium pyrophosphate 0.5%
Essence 1%
Potassium sorbate 0.1%
Water surplus；
The sum of weight percent of each component is 100%.
Embodiment 3
Oral-care toothpaste in embodiment 3 containing prebiotics consists of the following components in percentage by weight:
Chitosan oligomer 2%
Isomaltose 2%
Calcium monohydrogen phosphate 40%
D-sorbite 25%
Propylene glycol 5%
Cocoamidopropyl betaine 2%
Sodium lauroyl sarcosine 4%
Sodium carboxymethylcellulose 0.5%
Carragheen 0.4%
Xanthan gum 0.4%
Sodium pyrophosphate 0.5%
Essence 1%
Potassium sorbate 0.1%
Water surplus；
The sum of weight percent of each component is 100%.
Comparative example 1, the difference with embodiment 3 are only that: being free of chitosan oligomer and isomaltose.
Comparative example 2, the difference with embodiment 3 are only that: being free of chitosan oligomer.
Comparative example 3, the difference with embodiment 3 are only that: being free of isomaltose.
Using the oral-care toothpaste performance test methods prepared by the present invention containing prebiotics are as follows:
(1) physical and chemical index and estimation of stability
The oral-care toothpaste containing prebiotics of embodiment 1-3 and comparative example 1-3 are detected by GB/T 8372, evaluate it
Stability.
。
(2) fungistatic effect is evaluated
Selected part Bifidobacterium, lactobacillus, Escherichia coli observe the oral-care toothpaste of prebiotics to this as test strain
Whether a little bacteriums work.
。
* "+" indicates to promote growth, and "-" indicates to inhibit growth, and "/" expression does not work.
The above results explanation, the prebiotics of addition do not influence the stability of lotion of toothpaste；The non-digestible functionality of non-alkaline
Oligosaccharide has promotion growth to make oral cavity beneficial bacterium bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium longum, lactobacillus acidophilus
With to the facilitation effect of different strain, there is also differents；The non-digestible functional oligose of alkalinity is to oral cavity beneficial bacterium
Facilitation is unobvious, but has stronger inhibiting effect, alkalinity and the non-digestion of non-alkaline to the breeding of harmful bacteria Escherichia coli
The effect of sexual function oligosaccharide is with the use of can more preferably play adjusting Bacterial community.
In addition to the implementation, all to use equivalent transformation or equivalent replacement the invention also includes there is an other embodiments
The technical solution that mode is formed should all be fallen within the scope of the hereto appended claims.
Claims (4)
1. a kind of oral-care toothpaste containing prebiotics, it is characterised in that: the oral-care toothpaste containing prebiotics is by following
The component of weight percent forms:
Prebiotics 0.1-10%
Calcium monohydrogen phosphate 20-50%
D-sorbite 10-30%
Propylene glycol 5-10%
Cocoamidopropyl betaine 1-5%
Sodium lauroyl sarcosine 1-5%
Sodium carboxymethylcellulose 0.2-1%
Carragheen 0.2-1%
Xanthan gum 0.2-1%
Sodium pyrophosphate 0.2-1%
Essence 0.5-2%
Potassium sorbate 0.1-1%
Water surplus,
The sum of weight percent of each component is 100%,
The prebiotics are the mixture of alkalinity non-digestible functional oligose and the non-digestible functional oligose of non-alkaline.
2. the oral-care toothpaste according to claim 1 containing prebiotics, it is characterised in that: the non-digestible function of alkalinity
The mass ratio of energy property oligosaccharide and the non-digestible functional oligose of non-alkaline is 1:1-2.
3. the oral-care toothpaste according to claim 1 or 2 containing prebiotics, it is characterised in that: the non-digestion of alkalinity
Sexual function oligosaccharide is chitosan oligomer.
4. the oral-care toothpaste according to claim 1 or 2 containing prebiotics, it is characterised in that: non-alkaline is non-digestible
Functional oligose is at least one of galactooligosaccharide, oligofructose, isomaltose.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910742548.6A CN110448480A (en) | 2019-08-13 | 2019-08-13 | A kind of oral-care toothpaste containing prebiotics |
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| CN201910742548.6A CN110448480A (en) | 2019-08-13 | 2019-08-13 | A kind of oral-care toothpaste containing prebiotics |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111701014A (en) * | 2020-08-12 | 2020-09-25 | 好易康生物科技(广州)有限公司 | Toothpaste for children and preparation method thereof |
| CN113101250A (en) * | 2021-05-10 | 2021-07-13 | 广东省农业科学院蚕业与农产品加工研究所 | Method for preparing traditional Chinese medicine prebiotics toothpaste by using water extraction and alcohol precipitation waste and application thereof |
| CN114099361A (en) * | 2021-10-26 | 2022-03-01 | 量子高科(广东)生物有限公司 | Prebiotics toothpaste and application thereof |
| CN114712298A (en) * | 2022-03-28 | 2022-07-08 | 桂龙药业(安徽)有限公司 | Prebiotic and metabiotic composition for promoting oral health and application thereof |
| CN115006341A (en) * | 2022-07-21 | 2022-09-06 | 重庆登康口腔护理用品股份有限公司 | Oral cleaning and nursing composition capable of adjusting oral micro-ecological balance and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111701014A (en) * | 2020-08-12 | 2020-09-25 | 好易康生物科技(广州)有限公司 | Toothpaste for children and preparation method thereof |
| CN113101250A (en) * | 2021-05-10 | 2021-07-13 | 广东省农业科学院蚕业与农产品加工研究所 | Method for preparing traditional Chinese medicine prebiotics toothpaste by using water extraction and alcohol precipitation waste and application thereof |
| CN114099361A (en) * | 2021-10-26 | 2022-03-01 | 量子高科(广东)生物有限公司 | Prebiotics toothpaste and application thereof |
| CN114099361B (en) * | 2021-10-26 | 2023-11-21 | 量子高科(广东)生物有限公司 | Prebiotic toothpaste and application thereof |
| CN114712298A (en) * | 2022-03-28 | 2022-07-08 | 桂龙药业(安徽)有限公司 | Prebiotic and metabiotic composition for promoting oral health and application thereof |
| CN115006341A (en) * | 2022-07-21 | 2022-09-06 | 重庆登康口腔护理用品股份有限公司 | Oral cleaning and nursing composition capable of adjusting oral micro-ecological balance and preparation method thereof |
| CN115006341B (en) * | 2022-07-21 | 2023-12-19 | 重庆登康口腔护理用品股份有限公司 | Oral cavity cleaning and nursing composition capable of regulating oral cavity microecological balance and preparation method thereof |
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Application publication date: 20191115 |
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