CN110420133A - A kind of mouthwash containing prebiotics - Google Patents
A kind of mouthwash containing prebiotics Download PDFInfo
- Publication number
- CN110420133A CN110420133A CN201910742547.1A CN201910742547A CN110420133A CN 110420133 A CN110420133 A CN 110420133A CN 201910742547 A CN201910742547 A CN 201910742547A CN 110420133 A CN110420133 A CN 110420133A
- Authority
- CN
- China
- Prior art keywords
- prebiotics
- mouthwash
- oral cavity
- containing prebiotics
- antibacterial agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The present invention relates to a kind of mouthwashes containing prebiotics, it is formulated by prebiotics, antibacterial agent, biosurfactant, D-sorbite, propylene glycol, sodium pyrophosphate, essence, potassium sorbate, water by certain weight ratio, for the mouthwash containing prebiotics using non-digestible functional oligose and polyalcohol as prebiotic component, antibacterial agent is gamma-polyglutamic acid.Mouthwash containing prebiotics of the invention not only has the physicochemical properties such as low-heat, stabilization, safe and nontoxic, and it can be utilized by the beneficial bacteriums such as Bifidobacterium, lactic acid bacteria in oral cavity, promote its breeding, the organic acids such as its tunning lactic acid, acetic acid can inhibit the growth of the spoilage organisms such as Escherichia coli, bacteroid, clostridium simultaneously, with native biopolymer material gamma-polyglutamic acid Synergistic antimicrobial, long-time service does not generate resistance and drug resistance, improve oral cavity sub-health state while cleaning oral cavity, enhances immunity of organisms.
Description
Technical field
The invention belongs to oral cleaning nursing article technical fields, and in particular to a kind of mouthwash containing prebiotics.
Background technique
The subdivision of the oral problems such as plaque, early stage caries, early stage gingivitis, transient dentine hypersensitivity, tooth stain, halitosis
Type is more, but their root both is from the accumulation and maturation in plaque.Plaque is the bacterial deposition object of non-mineralising, is
Bacterium and matrix (saliva glycoprotein, bacterial cell exo polysaccharides) attach to the ecosystem formed on facing or dummy；Bacterium
It grows, breed and becomes feeble and die wherein, and carry out complicated metabolism activity, tooth body and periodontal disease can be caused when condition is appropriate
Suffer from.
Common plaque control method is mechanical bacterial plaque control, is such as brushed teeth and scaling, subgingival debridement on gum, generally
The clearance rate for removing plaque brush teeth 40 ~ 60%, facing still has bacterial plaque residual, especially proximal surface, and with antibacterial effect
Mouthwash can be used as the supplement of bacterial plaque Mechanical course, effectively the difficult brush portion such as infiltration teeth space, gum side and tongue fur position, clean comprehensively
Oral cavity.Safety and validity must be taken into consideration when applying in mouthwash with antibacterial effect, and safety is the application of antibacterial material
Influence to whole body and part, is especially used for a long time the influence to oral cavity Flora dynamics, and validity is that the antibacterial of mouthwash is made
Significant with should not only reduce to bacterial plaque, the also oral healths such as control of reply gingivitis or saprodontia are significant.
Prebiotics refer to it is some not by Host Digestion absorb, can selectively promote the beneficial bacteriums such as its internal Bifidobacterium
Growth and breeding, so as to improve the organic substance of host health.The substance for having prebiotic meta function is mainly some non-(or difficult)
Digestible oligosaccharide, such as oligofructose, galactooligosaccharide, xylo-oligosaccharide, soyabean oligosaccharides, stachyose, gossypose, oligomeric para
Golden sugar, isomaltose, chitosan oligomer etc., in addition there are polysaccharide (coriolan, the nitrogenous polysaccharide of Hu trailing plants), and plant and Chinese herbal medicine mention
Take object, protein hydrolysate (hydrolysate of casein, alpha lactalbumin, lactoferrin), polyalcohol (xylitol, mannitol, mountain
Pears alcohol, lactitol) etc..
Many researchs, which have proven to prebiotics, can promote the breeding of beneficial bacteria in human body, optimize colony balance, and enhancing is exempted from
Epidemic disease power, most of at present clinical and experiment all concentrate on intestinal health, and the research in terms of concern oral health care is relatively rare,
Concrete application of the prebiotics in mouthwash is also seldom in the market.
The Chinese patent of Patent No. CN109172475A discloses a kind of antibacterial whitening mouthwash and preparation method thereof, resists
Bacterium whitening mouthwash is made of antibacterial components and mouthwash matrix components, and antibacterial components are by 0.05~0.5 part of lysozyme, lauroyl
0.01~0.5 part of arginine ethyl ester hydrochloride, 0.01~1 part of dextranase and 1~10 part of sunset abelmoschus root extract composition, gargle
Water-based component includes one of emulsifier, moisturizer, flavoring agent, acid-base modifier and essence or a variety of, surplus be go from
Sub- water, the patent carry out antibacterial only by the synergistic function between natural antibacterial agent and chemical antibacterial agent, and effect is not
Obviously, in addition, being also easy to produce resistance and drug resistance using chemical antibacterial agent to body nocuousness.
Summary of the invention
The object of the present invention is to provide a kind of mouthwash formulas containing prebiotics, have low-heat, stabilization, safe and nontoxic etc.
Physicochemical property promotes beneficial bacterium breeding, inhibits spoilage organisms growth, is not easy to produce resistance and drug resistance, changes while cleaning oral cavity
Kind oral cavity sub-health state, enhances immunity of organisms.
The present invention solves the above problems used technical solution are as follows: a kind of mouthwash formula containing prebiotics, it is described to contain
The mouthwash of prebiotics consists of the following components in percentage by weight:
Prebiotics 2-10%
Antibacterial agent 0.5-5%
Biosurfactant 1-5%
D-sorbite 10-25%
Propylene glycol 1-5%
Sodium pyrophosphate 0.1-1%
Essence 0.5-2%
Potassium sorbate 0.1-1%
Water surplus,
The sum of weight percent of each component is 100%.
Wherein, the prebiotics are non-digestible functional oligose and polyalcohol, and the antibacterial agent is γ-polyglutamic
Acid.
Wherein, the non-digestible functional oligose is at least one of soyabean oligosaccharides, palatinose-oligosaccharides.
Wherein, the polyalcohol is lactitol.
Wherein, the biosurfactant is sophorolipid.
Compared with the prior art, the advantages of the present invention are as follows:
(1) on the basis of traditional mouthwash formula, add non-digestible functional oligose and polyalcohol as prebiotics at
Point, it can be utilized by the beneficial bacteriums such as Bifidobacterium, lactic acid bacteria in oral cavity, and harmful bacteria lacks relevant enzyme and these cannot be utilized prebiotic
Member will not cause tooth dental caries to become.
(2) beneficial bacterium is preferentially able to vigorous growth using prebiotics, and the organic acids such as tunning lactic acid, acetic acid can drop
Low pH adds native biopolymer material γ-to inhibit the growth of the spoilage organisms such as Escherichia coli, bacteroid, clostridium
Polyglutamic acid replaces antibiotic and chemical antibacterial agent, and collaboration is antibacterial, reduces the combination of pathogen and biomembrane, mitigates plaque
Accumulation, long-time service do not generate resistance and drug resistance.
(3) prebiotics have sweet taste, can replace sweetener.
(4) mouthwash is adjusted using sodium pyrophosphate as acid-base buffer agent in alkalinity, can neutralize the excessive organic acid of generation,
Avoid the invasion to tooth.
(5) low foaming biosurfactant sophorolipid, nontoxicity safe to the human body, when mouthwash flows in oral cavity are selected
Preferably cleaning oral cavity effect is played in impact.
Specific embodiment
Present invention is further described in detail with reference to embodiments.
Embodiment 1
Mouthwash in embodiment 1 containing prebiotics consists of the following components in percentage by weight:
Soyabean oligosaccharides 8%
Lactitol 2%
Gamma-polyglutamic acid 1.5%
D-sorbite 20%
Propylene glycol 5%
Sophorolipid 1%
Sodium pyrophosphate 0.2%
Essence 1%
Potassium sorbate 0.1%
Water surplus,
The sum of weight percent of each component is 100%.
Embodiment 2
Mouthwash in embodiment 2 containing prebiotics consists of the following components in percentage by weight:
Palatinose-oligosaccharides 8%
Lactitol 2%
Gamma-polyglutamic acid 1.5%
D-sorbite 20%
Propylene glycol 5%
Sophorolipid 1%
Sodium pyrophosphate 0.2%
Essence 1%
Potassium sorbate 0.1%
Water surplus,
The sum of weight percent of each component is 100%.
Embodiment 3
Mouthwash in embodiment 3 containing prebiotics consists of the following components in percentage by weight:
Soyabean oligosaccharides 5%
Palatinose-oligosaccharides 5%
Lactitol 2%
Gamma-polyglutamic acid 1.5%
D-sorbite 20%
Propylene glycol 5%
Sophorolipid 1%
Sodium pyrophosphate 0.2%
Essence 1%
Potassium sorbate 0.1%
Water surplus,
The sum of weight percent of each component is 100%.
Comparative example 1, the difference with embodiment 1 are only that: being free of soyabean oligosaccharides.
Comparative example 2, the difference with embodiment 1 are only that: being free of lactitol.
Comparative example 3, the difference with embodiment 1 are only that: being free of soyabean oligosaccharides and lactitol.
Comparative example 4, the difference with embodiment 1 are only that: being free of gamma-polyglutamic acid.
Using the mouthwash fungistatic effect evaluation prepared by the present invention containing prebiotics:
Selected part Bifidobacterium, Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa are as test strain, observation
Whether the mouthwash of prebiotics works to these bacteriums.
。
* "+" indicates to promote growth, and "-" indicates to inhibit growth, and "/" expression does not work.
The above results explanation, add the mouthwashes of prebiotics to oral cavity beneficial bacterium bifidobacterium adolescentis, bifidobacterium infantis,
Bifidobacterium longum, short Bifidobacterium Bifidum (B.breve) have promotion growth, and selected non-digestible functional oligose has obviously Bifidobacterium
Facilitation, polyalcohol facilitation effect is weaker, mainly plays sweetener；Prebiotics have the breeding of harmful bacteria Escherichia coli
There is inhibiting effect, but does not work to staphylococcus aureus, the false single pole bacterium of verdigris；Gamma-polyglutamic acid is to harmful bacteria large intestine
The false single pole bacterium of bacillus, staphylococcus aureus, verdigris has apparent inhibiting effect.
In addition to the implementation, all to use equivalent transformation or equivalent replacement the invention also includes there is an other embodiments
The technical solution that mode is formed should all be fallen within the scope of the hereto appended claims.
Claims (4)
1. a kind of mouthwash containing prebiotics, it is characterised in that: the mouthwash containing prebiotics is by following weight percent
Group is grouped as:
Prebiotics 2-10%
Antibacterial agent 0.5-5%
Biosurfactant 1-5%
D-sorbite 10-25%
Propylene glycol 1-5%
Sodium pyrophosphate 0.1-1%
Essence 0.5-2%
Potassium sorbate 0.1-1%
Water surplus,
The sum of weight percent of each component is 100%；
Wherein, the prebiotics are non-digestible functional oligose and polyalcohol, and the antibacterial agent is gamma-polyglutamic acid.
2. the mouthwash according to claim 1 containing prebiotics, it is characterised in that: the non-digestible functionality is oligomeric
Sugar is at least one of soyabean oligosaccharides, palatinose-oligosaccharides.
3. the mouthwash according to claim 1 containing prebiotics, it is characterised in that: the polyalcohol is lactitol.
4. the mouthwash according to claim 1 containing prebiotics, it is characterised in that: the biosurfactant is Chinese scholartree
Glycolipid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910742547.1A CN110420133A (en) | 2019-08-13 | 2019-08-13 | A kind of mouthwash containing prebiotics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910742547.1A CN110420133A (en) | 2019-08-13 | 2019-08-13 | A kind of mouthwash containing prebiotics |
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| Publication Number | Publication Date |
|---|---|
| CN110420133A true CN110420133A (en) | 2019-11-08 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910742547.1A Pending CN110420133A (en) | 2019-08-13 | 2019-08-13 | A kind of mouthwash containing prebiotics |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113143825A (en) * | 2021-05-10 | 2021-07-23 | 广东省农业科学院蚕业与农产品加工研究所 | A collutory containing Chinese medicinal prebiotics and its preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127329A (en) * | 2013-05-03 | 2014-11-05 | 林峰辉 | Mouthwash composition being non-alcoholic and free of chemical antibacterial agent |
| CN105919829A (en) * | 2016-06-29 | 2016-09-07 | 贵州扬生医用器材有限公司 | Mouthwash and preparation method thereof |
| CN106061485A (en) * | 2013-12-27 | 2016-10-26 | 高露洁-棕榄公司 | Prebiotic oral care methods using a saccharide |
-
2019
- 2019-08-13 CN CN201910742547.1A patent/CN110420133A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127329A (en) * | 2013-05-03 | 2014-11-05 | 林峰辉 | Mouthwash composition being non-alcoholic and free of chemical antibacterial agent |
| CN106061485A (en) * | 2013-12-27 | 2016-10-26 | 高露洁-棕榄公司 | Prebiotic oral care methods using a saccharide |
| CN105919829A (en) * | 2016-06-29 | 2016-09-07 | 贵州扬生医用器材有限公司 | Mouthwash and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113143825A (en) * | 2021-05-10 | 2021-07-23 | 广东省农业科学院蚕业与农产品加工研究所 | A collutory containing Chinese medicinal prebiotics and its preparation method |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20191108 |