TWI224508B - Olive oil-containing toothpaste - Google Patents

Abstract

The present invention relates to the use of olive oil in preparation of a toothpaste in order to eliminate or reduce bacterial plaque and/or bacteria present in the oral cavity, thus achieving a reduced occurrence of dental illness (cavities, periodontal disease) and halitosis.

Description

1224508 A7 B7 V. Description of the invention (01 Name ·· Use of olive oil in the preparation of oral hygiene for oral hygiene W Wang 0 mouth to eliminate or reduce plaque and / or fine particles in the oral cavity Abstract: Describe olive oil in the preparation Mouth and Moon Guardian & Tian σ i L π Gu r 丨 Words and Words fl. Good use of raw materials such as toothpaste, mouthwash, oral spray or chewing gum. Use 乂 4 ^ + ^ to remove or reduce the presence of 4 Plaques and / or fine spots in the oral cavity, and the technique of stone 丨, formula, bu & this reduce the incidence of V dental disease (face cavity, periodontal disease) and halitosis. Detailed description: The purpose of the invention The invention relates generally to the use of olive oil in the preparation of oral hygiene products to eliminate or reduce plaque and / or bacteria in the mouth. BACKGROUND OF THE INVENTION Plaque is a thin, colorless, and viscous film that is almost invisible to the naked eye and is fastened.疋 It is formed in large quantities on dental blocks, but also on the back of the tongue, cheeks, vestibular membranes and lips. It contains bacteria, saliva and food residues, and is the main cause of the two most common dental diseases: cavity cavity and periodontal disease. Daily hygiene for removing plaque and maintaining a healthy mouth The cavity is necessary. The cavity of dental caries is an external local infection process, which causes the hard tissue (massage) of the dental block to become fragile and causes the formation of dental cavity. The main cause of dental disease seems to be Gram (+) bacteria.穿 变 # 硪 磨. Periodontal disease is a disease that affects the gums and supporting tissues of the dental block. The earliest periodontal disease is gingivitis, which is characterized by redness of the gums. If it is treated properly, then this period The disease will develop into periodontitis, which will permanently affect the gums (please read the precautions on the back and fill out this page)

Printed by the Employee Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 1224508

V. Description of the invention (〇2 Injury printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. In the final periodontitis, the bones and tissues of the bones and tissues of the periodontitis were broken. With the development of the disease / disease, the guttata pine may fall off or need to be removed. The main disease of periodontal disease is because of the bacteria F. Fructus sclerosis and sinking the teeth without removing the right side: Toxins produced by bacteria destroy the surrounding; = supporting tissues, loose tooth silver, and the teeth are separated, forming a full of bacteria ... Periodontal disease can be often and carefully — iu to brush your teeth and move the R plaque with dental floss' Also use interdental brushes or interdental brushes, interdental stimulants, and / or saliva, as appropriate. However, the daily hygiene procedures are still insufficient, and supplemented with professional cleaning by a dental surgeon, which can be removed. j 杪 陈 日 ⑦ The formed petrochemical deposits are removed by brushing with teeth. > The standard treatment of periodontal disease includes root smoothing, scraping and scraping, and most of them include removing plaque and making pockets around the teeth. Harden & lighten and smooth the roots so that the gums reattach to the teeth Contact with each other to eliminate the sack. However, more serious cases may require surgery. In addition, bad breath or bad breath is caused by the development and release of several volatile compounds, mainly volatile sulfur compounds ( vsc), such as sulfur hydrogen and methyl materials. The oral cavity contains microorganisms, i is often anaerobic and gram (_ bacteria, which are related to halitosis. There are several treatments to combat halitosis, and some systems are "" 6 with σ It is mainly formed compounds, while others are based on natural compounds (Cangzhao Spanish Patent Application No. ρ97〇1 545). Although there are several methods to prevent and treat g spots and bad breath, other antibacterial agents are still needed. Spot formation and / or harmful microorganisms are present in the mouth. The paper size applies Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the note on the back first? Matters # Fill this page) 1111111.

Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 V. Method of Invention Description (03). Mouth 胪 & Ben Qiming answers the aforementioned needs, using olive oil to prepare the township-friendly health, in order to eliminate or reduce plaque in the mouth and / or harmful, bacteria such as bacteria in the alpha cavity is completely or partially reduced The result is reduced oral cavity crane teeth, periodontal disease and its early symptoms (dental gingivitis), and bad breath caused by VSCs produced by microorganisms present in the mouth. ☆, tincture oil is a product widely used in food, but its treatment and beauty use are also known (refer to Western blotch patent application number 98〇1543 Bu oil *, 弋 98 eight dilute D system is a single unsaturated Fatty acids, it seems to be the source and reason of several advantages. As everyone knows, rehydration helps prevent arteriosclerosis, increase the cholesterol concentration of areal density lipoprotein, and reduce the cholesterol concentration of low density lipoprotein. Therefore it provides an appropriate way to prevent avascular disease. Olive oil also contains vitamins (A, E, F, and κ) and polyphenols, which appear to provide resistance to the antioxidants (vitamins A and κ and polyphenols) present in olive oil. Organisms with anti-tang mechanism to prevent aging, prevent arteriosclerosis, breast cancer, liver disease and inflammation. The stomach is relatively tolerant to olive oil, which has a positive effect on gastritis and ulcers. It is CoUgOg, which activates pancreatic hormones. And bile secretion, and reduce the occurrence of gallstone disease. In addition, its superior digestive ability results in the complete absorption of nutrients, especially vitamins and inorganic salts, and provides the skeletal system required The mineralization effect of olive oil is excellent, and it is suitable for both young and old age when it is prone to mineralization problems. Olive oil also has a positive effect on the brain and central nervous system. The paper size applies to Chinese national standards (CNS ) A4 size (210 X 297 mm) -I 1— ^ 1 1 §§ 1 I = -OJ «.1 1 ϋ ϋ I i Please read the notes on the back first and fill in this page} ^ 1. Ϊ́2245〇δ V. Description of the Invention (〇4) Protecting the body and preventing infection 'Helps to form scars on internal and external tissues. In addition to the treatment indicators mentioned above, olive oil has a cosmetic purpose and is currently used to protect the skin' to prevent the appearance of sensitive lines. It can also be used as a sedative for dry and peeling skin. It can also be used to restore the luster and strength of improperly treated hair and eyelashes, and restore the vitality of fragile hair. It is also known in the China Sea region that olive oil has antiseptic and bactericidal properties ("' , Plant ritual preservatives, etc.). When the fish or cheese product containing Dali fine cricket was originally immersed in olive oil, the actual count of bacteria was found to be zero after soaking in olive oil for several hours. It has been found that olive oil can be used to reduce or eliminate plaque and / or bacteria in the mouth. (Please read the notes on the back to fill out this page.) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economics. The use of olive oil in the preparation of oral hygiene mouth is used to eliminate or reduce plaque and / or bacteria in the oral cavity. The term "eliminate or reduce plaque and / or bacteria in the oral cavity" used in this rabbit is intended Refers to the degree of plaque and / or bacterial strains present in the mouth that are completely or partially reduced to the extent that (1) no dental disease occurs, or (丨 丨) does not produce an amount of VSC high enough to release bad breath (the VSC —Generally 75 parts per billion). Olive oil is a commercially available product, which is produced by grinding the slow-growing fruits of the olive tree (0 / ea d / ropea L ·). The olive oil that may be present in oral hygiene products to eliminate or reduce plaque and / or bacteria in the mouth may be any olive oil, such as commercially available olive oil, unprocessed olive oil, refined olive 7 111 — I 11 — — — — — — — — #! This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) α ^ 45〇8 5. Description of the invention (〇5 Employees' Cooperatives, Intellectual Property Bureau, Ministry of Economic Affairs Printing oil and olive oil (a mixture of unprocessed and refined olive oil, the maximum acidity is 1 'peroxide concentration is lower than i 5, preferably lower than i 0). Any product that can be used for oral cleaning and / or disinfection in any form, such as teeth f, mouthwash, oral spray, chewing gum, etc. In the development of the present invention, it is necessary to analyze the microorganisms that cause dental disease and produce vsc The analysis of plaque spots often showed that there are several kinds of lipophilic microorganisms, that is, cells covered with lipid-rich cells or substances showing affinity for lipids, such as actinomycetes accompanied by actinomycetes, viscous actinomycetes Bacteria Actinomycetes, Porrhymona gingivalis, Streptococcus salivarius, Streptococcus sanguis, and perforation # 广 · 彦, some of which are due to the causes of vsc and periodontal bands, while others are mainly variably linked It is the cause of dental caries. The identification of the same periodontal disease species is the key factor in the diagnosis and detection of the disease. The most commonly identified periodontal disease is Porphyromonas gingivalis ^ Prevotella intermedia > Bacteria, bacillus-like bacteria, carbon dioxide phagocytic genus. In detail, confirm the following: • Zhuliang k-day week I test. • Actinomycetes accompanied by actinomycetes Porphyromonas gingivalis ^ ^ Prevotella intermedt anti-corruption Eikenella \-produces adolescence Anterior periodontitis patients: those who suffer from abrasion and depletion, read the nets and diphtheria carbon phagocytosis, and • those who produce juvenile periodontitis: radioactive adolescents congeal continuation # 广, 8 test as nuclear菌 a -------- ^ --------- (Please read the notes on the back to fill in this page first) #! This paper size is applicable to China National Standard (CNS) A4 specification (21〇X 297g t) 1224508 Employee Cooperatives of Intellectual Property Bureau, Ministry of Economic Affairs A7 B7 _ braking five invention is described in (06)

Porphyromonas gingivalis anti-prev〇ulla in Urmedia., Anti-produce rapid development of periodontitis. · Putting abrasion disease, abandoning axe, and Eiken bacillus anti-bacteria. A common property of the aforementioned periodontal disease-causing bacteria is that they are Gram-negative (Gram (_)) bacteria when stained with crystal violet. Several tests using several products have shown that olive oil is surprisingly particularly suitable for products that reduce or eliminate plaque and / or bacteria in the oral cavity, some of which cause dental caries, while others cause vsc because of reduced The occurrence of gingivitis, periodontitis, and dental caries greatly improves oral health and reduces bad breath caused by VSC. Several tests have shown that olive oil can be used as a bacteriostatic agent in oral hygiene products formulations at intermediate olive oil content, generally ranging from 6% to 60% of the total weight, or formulated in oral hygiene at high olive oil content. As a fungicide, it is generally 15% to 70% of the total weight of the formulation. Olive oil can be used as a bacteriostatic or fungicide at a specific concentration. What constitutes the essence of the present invention is the obvious ability to find that olive oil completely or partially reduces the population of bacteria present in the mouth and / or plaque, mainly anaerobic bacteria and gram microbes that cause dental disease and bad breath. Although not intended to be bound by a particular theory, the high lipid content of Gram's cell walls seems to make these cell walls hydrophobic and soluble in lipid media. This may explain why oil-rich media can more effectively eliminate Gram bacteria than aqueous media. It seems that Gram bacteria have a higher affinity for olive oil than aqueous media, so they can attach or be trapped in this oil ’and be eliminated by leaching at the same time.

This paper size applies the Zhongguanjia standard (cNs ^ TS " mo XWI ϋ ϋ_1 · ϋ «ϋ H 一 ϋ 11 ^ 1 · ϋ ϋ i ^ i 1 I (Please read the note on the back first? Matters # Fill this page) #! 9 Α7 V. Description of the invention (〇7 Β7 When printed by using the olive oil to prepare oral hygiene products to eliminate or reduce plaque and / or bacteria in the mouth, the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs provides several advantages, Such as:-Good, non-abrasive cleaning of the oral cavity and dental blocks by removing lipid organisms;-Reduce the absolute amount of plaque, both above and below the gums, and greatly improve periodontal health (reduce dental caries, gingivitis and (Improving periodontitis); and-reducing the occurrence of bad breath by reducing vs. C-producing microorganisms, by blocking or inactivating the microorganisms and / or neutralizing VSCs generated by the generators, so that the sense of smell cannot be detected The present invention further provides an oral hygiene article suitable for eliminating or reducing lamban and / or bacteria existing in the oral cavity, which contains olive oil, hereinafter referred to as the oral hygiene article of the present invention. The oral hygiene article The content of olive oil is preferably from i weight percent to 70 weight percent with respect to the weight of the product. The oral hygiene product of the present invention can take any form, such as toothpaste, mouthwash, spray, chewing gum, etc., and the formulation should include each form The required ingredients, additives and excipients. Example: When the oral hygiene products are in the form of toothpaste, in addition to olive oil, it may contain specific compounds, provide specific properties, and appropriate additives and excipients. , Such as fluoride sources, grinding agents, surface tension agents, moisturizing agents, fragrances, flavoring agents, colorants, whitening agents, etc. ^ Use rice grinding or polishing agents as friction agents, and toothbrushes At the same time, it can eliminate sticky food residues without damaging the enamel quality or the dentin that is sometimes exposed in the teeth. Traditionally, calcium salts such as calcium carbonate and pyrophosphate are used. This paper size applies to Chinese national standards (CNS ) A4 size (210 X 297 mm) (Please read the notes on the back first and fill in this page)

ϋ · ϋ · ϋ I I —mmm _ I ml I ϋ I n I

A7 V. Description of the invention (〇8 B7 Dance, Dish Acid Office, Eyebrow item H ^ Calcium, Calcium Metaphosphate, or Sodium salt such as partial age '% Especially because of incompatibility between dance salt and fluoride, Recently, it should be used: Residual agent: there is a specific form of silicon dioxide. Traditionally, the 30% -oxidized crushed and stone-continued salt are obtained by two different methods: the U solution or the coagulation method. The demon solution method P 4 ^… * Silver dioxide of clothing has only thickening properties, while those obtained by gelation method also have ancient functions, and j has the function of thickener and polishing agent. However, due to technical limitations, 丨Shifa's female search products are quite flexible. With the new precipitation of SiO2 and oxalate, the structure of the silicon dioxide can be accurately controlled using control structure technology (CST) # 丹,. Mouth fruit is the availability of the culprit monoxide oxide 'It provides the flexibility of both thickener and abrasive properties. Surface tension agents are used in various concentrations depending on the degree of foaming required' Relative The total weight of the product is generally between 0.5% and 2% by weight. Specific limits, shellfish, lead to the emergence and development of periodontal disease. The most widely used users are Liuxueerjun® Crescent Sodium s-day sodium, sarcosinate sodium lauryl sodium and tegobeta ^ y The emollient is a must for toothpaste & ^ ^ ο β essential compound, which means to maintain the original consistency of the product 'prevent it from being in the camp ^, internal change, and improve the privacy of toothpaste in washing water The seven-headed priests widely spread Erxi, saying that the emollients that were used by rabbits were sorbitol, glycerin, polyethylene glycol, and polypropylene glycol.

The collector is hydrophilic. R Γ Raw rubber limbs prevent the separation of liquid and solid components in toothpaste. Examples of agglutinating agents are Pu'er thief, betel aerobic gum, hansen gum, gum arabic, and antlers and agar. After using the toothpaste, the aroma and taste of the r-supplier in the mouth are two important factors, which need to remain unchanged in the toothpaste during preparation, storage and transfer. This paper size applies to China National Standard (CNS) A4 specifications (210 χ 297 public love) _______________ (Please read the note on the back # (Fill this page) — — — — — — — Order -------- Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs can use any legitimately improved scent. Sweet taste 丨 or the flavor of the flavor is consistent. Because wetting is called ... ', the taste of the button is fragrant and _ teaches ... For this reason, toothpaste is often weighted by a concentration of-°°° 5 to 5% by weight. | It is strengthened by sodium saccharin with a weight ratio of 100 knives. Because the fish moisturizing agent and specific spot liquid are good for micro-life-generally needed in this product Add preservatives. I often use anti-dibenzoic acid, tapping and hope derivatives. Anti- "can use any recognized coloring agent. Toothpaste, depending on the function added to the toothpaste, contains other ingredients. ° ° Take it For the careful elimination of the properties of proteins deposited on uneven surfaces, proteolytic proteins such as papaya protein 1 chemical papaya protein 'can be added for dentifrices and whitening agents. Phase = extract solution to use its counterpart Cosmetic and therapeutic shellfish vitamins of the gums and tissues and special antioxidant vitamins such as Ε and other activated pitfish, "shellfish regeneration vitamins such as β5 彳" are included in the formulation to achieve more all-round protection; the same The product may include fat-soluble vitamins that have a recognized benefit to the oral cavity or hard tissues. The anti-caries caries may include fluoride compounds such as sodium or potassium fluoride, monofluorophosphine, etc. Because it has recognized anti-cancer properties and is not metabolized by the bacteria that cause caries, it is increasingly used in toothpaste.

The anti-cancer effect provided by the toothpaste (containing olive oil) based on the removal of olive oil to cause caries bacteria Wugui (Gram) can be added by xylitol (a sweet I flavoring agent that does not cause tooth decay naturally) _ · Generally relative to the total weight of the product, paper size stabs @ 国 绪 准 （CNS) A4 Specifications⑵〇χ 297mm Γ

Fill in person — — — — — — · 11111111 (Please read the notes on the back # | Fill this page first) ^ 1. 1224508 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. The invention description (10 is between 0.2 and 0.2) Percentage and 40% _ · ^ Effective source of fluoride, because it is completely black and sodium fluoride (the heaviest dosage is generally between 0. 5 and 10% by weight. In this case, in this case, an abrasion agent such as a besom ratio component can be used because sodium fluoride cannot allow the use of the other. To avoid calcium regardless of the source of the fluoride used, such as rat sodium or sodium monofluorophosphate '^ Can maintain the point of the toothpaste of the present invention ... the excellent non-abrasive, cleaning effect achieved, in the latter case, can be used as the king of King's mill | insecticide. Or you can use sodium monofluorodiso and fluorine The composition of sodium ions is used as the source of rat compounds. In the preferred embodiment, the mill I insecticide present in the teether and the tooth β is Cenozoic dioxide, which is generated by the computer. CST Dioxygen Silicone. The more oil it absorbs, the lower the abrasiveness. In addition, the 1st series is a better foaming and agglutinating agent. This olive oil is used in high-concentration-doors. It is said that the absorption capacity in an emulsified silicon is formulated with the product. The novel research on the surface tension bamboo idler 丨 mustangang knife agent helps to disperse the oil in solid and semi-solid or liquid formulations at the same time. The example of toothpaste provided by 11 Ming has the following composition: Ingredients Olive oil mill I Insect wetting agent Surface tension agent Thick sweet waterproofing agent Flavoring agent Preservative weight percentage (%) 1-70 10-2020-50 1-20.5-2 ra (required amount) ra Suitable Amount to 100 13 ------------ (Please read the notes on the back first? Fill out this page} II 1 ϋ I -ϋ ί One: 0, ϋ n ϋ ϋ • ^ 1. 12245〇8 A7 B7 V. Description of the invention (11) The various products provided by the present invention, such as toothpaste, mouthwash, spray gum, etc., can be made by using conventional techniques known to those skilled in the art: The following examples are used to Illustrate the present invention, not limit the definition of the present invention. &Quot; Example 1 Made of olive oil and toothpaste Prepare toothpaste with the preparations (1) and (2) listed in Table 1, and fully mix the appropriate amounts of various ingredients by customary methods. Table 1 Weight of toothpaste ingredients containing olive oil printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Percent (%) Formulation 1 Formulation Sorbitol 40.000 18.740 Silicon dioxide 18.000 27.000 Water 15.140 8.000 Xylitol 10.000 10.000 Salmon oil 5.000 30.000 Glycerin 5.000 1.000 Buffering agent (a) 3.200 1.600 Perfume 1.000 1.000 Gum (b) 1.000 1.000 One gas chemical 0.900 0.900 Sodium fluoride 0.320 0.320 Coloring agent 0.160 0.160 Sodium saccharin 0.130 0.130 Preservative (C) 0.100 0.100 Surface tension agent (d) 0.050 0.050 14 This paper size applies to Chinese National Standard (CNS) A4 specification (210 X 297 mm) —— — — — — I—-tra, — — — — — — — — — — (Please read the note on the back # (fill in this page) item before filling in too ^ 1. V. Description of the invention (I2) U) The buffering agent can be formed from citric acid / potassium citrate, or mono-phosphoric acid / Jiaoxi cattle Sjiuquan potassium, or anyone using it in toothpaste. (b) Gum may be gum arabic, xanthan gum, antlers or cellulose. (c) The preservative may be oxadiazolyl, imidazolyl, acid, and a salt thereof. (d) 〇livem® 300 (PEG-7 olive oil, Quimiobio), pEG-40 hydrogenated ramie oil, and tegobetaine. Example 2 Toothpaste containing olive oil Toothpaste having the formulations (1) and (2) shown in Table 2 was prepared, and appropriate amounts of various ingredients were thoroughly mixed by conventional methods. Table 1 Mouthwash containing olive oil Please read the notes on the back

Sell IIIII Order Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, Consumer Cooperatives, and the weight percentage (%) Preparation 1 Preparation 2 Water 78.469 8.970 Xylitol 10.000 10.000 Sodium saccharin 0.030 0.030 Lime oil 5.000 40.000 Glycerin 2.00 31.599 Fragrance 2.000 2.000 Buffer (A) 2.000 2.000 Preservatives (b) 0.400 0.400 Surface tension agents (C) 0.100 5.000 Colorants 0.001 0.001 15 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 1224508 Intellectual Property of the Ministry of Economic Affairs Printed by the Consumer Cooperatives of the Bureau A7 B7_______ 5. Description of the invention (13) (a) The buffer can be formed from citric acid / potassium citrate, or monopotassium phosphate / pyrolite for tetrapotassium acid, or anyone who uses it in mouthwash . (b) The preservative may be oxadiazinyl, imidazolidinyl, an acid, and a salt thereof. (c) 01ivem® 300, Peg-40 hydrogenated ramie oil, CAPB. Example 3 Bactericidal efficacy test of toothpaste containing olive oil This test was performed to measure the g-killing efficacy of toothpaste containing olive oil. This test was performed in accordance with D.G.H.M. Standard v.01.01.8 1 2 · 2 with necessary modifications. The tested microorganisms were the ATCC 6538 and the lingering ATCC 1023 1 8 by the gold side. The microbial suspension was prepared by growing on Dp Hpticase Soy Sauce (TSB) at 38 ° C for 24 hours. At 37. It was grown on Triptkase soybean fat (TSA) at 48 ° C for 48 hours to confirm a sufficient number of colony forming units (CFU) / ml (108) 09), and then the corresponding ten-fold dilution was extracted. 0.1 ml of the microbial suspension is thoroughly mixed with 10 ml of the sample to be tested, such as the toothpaste described in Example 1. After 0.5, 1, 2 and 5 minutes of contact, 0.1 ml was taken from each sample / inoculum and grown subsurface in 10 ml TSB at 37t over a period of 72 hours. The (+) reading indicates turbidity (growing), and the (-) indicates "not turbid" (not growing). For the control or prevention of final growth inhibition, all test tubes that did not show turbidity were inoculated with a microbial suspension (0 · ml in TBs 1 γιο3). If there is no turbidity after another 24 hours, the tested 16 ° This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) — — — — — — — ^ ------- -· (Please read the note on the back? Matters # «Fill this page first.] A7 B7 5. The invention description (M) is still active, because the inactivation is insufficient, and the test needs to be repeated using different media or inactivation forms. Table 3 shows the results obtained from the tests performed on different samples. Table 3 Bactericidal activity of toothpaste containing olive oil Inoculation concentration Time Sample concentration (CFU / ml) (minutes) 100% (V / V) Staphylococcus aureus 3.5X108 0.5 (+) Bacteria ATCC 6538 1 (+) 2 (+) 5 Candida albicans 3.5X108 0.5 ⑴ ATCC 102318 1 (+) 2 (+) -------- —— ^^ 一 _ (± 1_ Printed by the Consumers ’Cooperative of Intellectual Property Bureau, Ministry of Economic Affairs Showing the bactericidal ability of the tested samples Example 4 Clinical study of the degree of plaque and gingivitis 〃 This test was performed to evaluate plaque elimination and ㈣ reduce gingival bleeding which is the first sign of gingivitis. 60 people arbitrarily selected It is divided into a subgroup of 20 people per knife wind mother group. The first subgroup (group I) brushes its teeth with water, and the first group (group 11) applies the Chinese National Standard (CNS) A4 regulations at a 100% scale 1 () x 2-: 17 1224508 A7 V. Description of the invention (1 / Chery oil brushing teeth, and 筮 _ brushing (representing the other second and second group 111) ... divided into one row brushing subject: Guarantee 3V, = after the period 'Based on ;; 2 = er. —N staining) to obtain the plaque index. Gey Hei "the modification of the number, in addition, based on The symptoms of gingivitis ^ the first sign of a person and the bleeding phenomenon is measured. Evaluation is performed using a periodontal probe according to the following methods: See signs 0: no bleeding 1: bleeding 2: bleeding + redness 3: bleeding + redness + swelling 4: Bleeding + redness + edema 5: Spontaneous bleeding + redness + edema The results obtained are statistically compared with the group using water or Caihua oil: 'U &#; The low bleeding index and the degree of plaque elimination in the southern part of the tree. The results showed an improvement of 270%, and it showed that olive oil was a positive substance for eliminating plaque and fighting gingivitis-the first sign of periodontal disease. 5 Clinical study of plaque elimination on the gum This test is used to evaluate the efficacy of plaque elimination on the gum. Forty volunteers were divided into two subgroups. The oral hygiene method was mainly used daily with Bass brushing technology Twice in 3 minutes, with water 18 This paper size applies Chinese National Standard (CNS) A4 specification (210 X 297 mm) ------- Γ% Read the precautions on the back first and write this page}

ϋ ϋ I ϋ 1 ϋ =-· οϋa I Β1 II n ϋ I Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1224508 A7 B7 V. Description of the invention (1 Also after the population, use specific mouthwashes. Group A ( 20 people): •-Commercially available household toothpaste, containing sodium fluoride and sodium lauryl sulfate with% as surface tension agent; and-Listerine® mouthwash, containing ethanol. Group B (20 people) used the same technique , But using ...-specially formulated toothpaste, containing olive oil and sodium fluoride (Example 1, Table 1 'Reconciliation 1); and-specially formulated mouthwash, containing olive oil and surface tension (water solution (Or dispersion) (Example 2, Table 2, Formulation 1). Both groups were banned from any oral hygiene method for three days, and then (day) 'Each group began the activities shown. On the 15th day, proceed For measurement, fresh plaque was obtained in the incisors, canines, small white teeth (between the gums and the front tooth surface of the incisor floss) and the area between the tooth surfaces using a curette. The standard period for collecting plaque for each subject was丨 ^ 刀 隹 里 ° The tester does not know who the testee belongs to Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, the final results showed that the plaque reduction (97%) of the test group using tooth spring and mouthwash containing olive oil was much higher than that of the conventional person + catty and use. Sodium fluoride and sodium lauryl sulfate are used as surface tension agents for tooth spring < @ 者 (60% reduction in plaques). 19 Announcement Date of this application 1L-8 — Cases above the case number are to be filled by this Office Note) %%-2; A4 ¢ 4 Revised Mingqiao type patent specification on August 02, 1993! 2245〇8 Inventive New Name Invention Creation / Chinese English Name Last Name Nationality Residence, Home Name (Name) Toothpaste Containing Olive Oil

OLIVE OIL-CONTAINING TOOTHPASTE Alvarez Fernandez, Maria Spain

Arcos de la Frontera, 15, 28023 Madrid, SPAIN Biological cosmetics company BIOCOSMETICS, S 丄. Lu Binder, China Economic Cooperation Bureau, Ministry of Economic Affairs, Employee Consumption Cooperative, Printed Nationality Spain III. Applicant's residence (Office) Name of Representative

Arcos de la Frontera, 15, 28023 Madrid, SPAIN Alfredo Aguillera Gumpert This paper's dimensions apply to the Chinese National Standard (CNS) A4 (210X297 mm)

Claims (1)

1224508 Application No. 089123347 Application Completed on August 02, 1993 (01) The application for a patent encloses a method for preparing toothpaste for oral hygiene using olive oil, which adds appropriate amounts of suitable additives and excipients to an appropriate amount of an active ingredient, the active ingredient including olive Oil, xylitol and / or fluoride, in which olive oil has an anti-caries effect, so that the toothpaste can eliminate or reduce plaque and / or bacteria present in the mouth. For example, the method of claim 1, wherein the toothpaste contains xylitol between 0.2% and 40%, and / or fluorine between 0.15% and 0.33%, based on the total weight of the toothpaste.物 源。 Compound source. For example, the method of claim 1 wherein the toothpaste contains a fluoride source. For example, the method of claim 3, wherein the fluorination source is selected from sodium fluoride, sodium monofluorophosphate, and mixtures thereof. A toothpaste for oral hygiene comprising olive oil, xylitol and / or a fluoride source ', with the limitation that the toothpaste does not contain parsley oil. For example, the toothpaste of the scope of patent application No. 5 includes olive oil between 1% and 70%, 0.2% to 40% < xylitol, and / or based on the total weight of the toothpaste. Fluoride source between 0.15% and 0.33%. For example, the toothpaste in the scope of patent application No. 5 contains a fluoride source. For example, the toothpaste for scope 7 of the patent application, wherein the fluorination source is selected from the group consisting of fluoride, sodium monofluorophosphate and mixtures thereof. For example, the toothpaste of any one of claims 5 to 8 is used to eliminate or reduce plaque and / or bacteria existing in the oral cavity. 20