CN107080731A - Probiotics periodontal nurses gel production technology - Google Patents
Probiotics periodontal nurses gel production technology Download PDFInfo
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- CN107080731A CN107080731A CN201710248334.4A CN201710248334A CN107080731A CN 107080731 A CN107080731 A CN 107080731A CN 201710248334 A CN201710248334 A CN 201710248334A CN 107080731 A CN107080731 A CN 107080731A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Oral & Maxillofacial Surgery (AREA)
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Abstract
Gel production technology is nursed the invention discloses probiotics periodontal, solution I is configured：Purified water heating adds sodium benzoate, Cetylpyridinium Chloride, sodium fluoride and Sucralose, non-crystallising sorbitol, nisin, light blue pigment, stirs 20 25 minutes；Configure solution II：RH40 rilanit specials, propane diols are heated to melting, add American mint essence, are uniformly mixing to obtain solution II；Configure solution III：By formula rate, after PEG 400, xanthans and sodium alginate stir, solution III is obtained.Solution II is added in solution I, stirred, solution III is added, stirs 25 30 minutes and forms semi-finished product, sample examination obtains Cetylpyridinium Chloride semi-finished product, and semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, it is unqualified discarded.Lactobacillus can strengthen inhibitory action of the sodium fluoride to Streptococcus mutans, reduce the bacterial plaque accumulation on tooth, and the generation of prevention of gingivitis and carious tooth improves oral cavity flora balance.
Description
Technical field
Gel production technology is nursed the present invention relates to a kind of probiotics periodontal.
Background technology
General utility functions imitate toothpaste addition antibiotic and suppress oral cavity germ entirely, and antibiotic is used for a long time, and germ easily produces
The raw resistance to the action of a drug, and general utility functions toothpaste is single to the care benefits of oral cavity and tooth, lacks comprehensive nursing function.Typically
Enzyme preparation toothpaste can not control the decay of enzymatic activity, it cannot be guaranteed that the activity of enzyme within the shelf-life, so as to can not reach really
Using effect, the protective effect to oral cavity and tooth is reduced.
Accordingly, it is desirable to provide a kind of new technical scheme solves the above problems.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of good probiotics periodontal nursing gel production work of nursing efficacy
Skill.
In order to solve the above technical problems, the present invention provides a kind of nursing efficacy good probiotics periodontal nursing gel production work
Skill, comprises the following steps：
（a）Configure solution I：Weight/mass percentage composition 70%-80% purified water is heated to 35-40 DEG C, weight/mass percentage composition is added
0.45%-0.55% sodium benzoate, weight/mass percentage composition 0.045%-0.055% Cetylpyridinium Chloride, weight/mass percentage composition 0.04%-
0.06% sodium fluoride and weight/mass percentage composition 0.045%-0.055% Sucralose, weight/mass percentage composition 9%-21% it is noncrystalline
D-sorbite（Content is 70%）, weight/mass percentage composition 0.0035%-0.0065% nisin, weight/mass percentage composition
0.00016%-0.0002% light blue pigments, stir 20-25 minutes, obtain solution I；
（b）Configure solution II：By weight/mass percentage composition 0.8%-1.2% RH40 rilanit specials, weight/mass percentage composition 0.8%-
1.2% propane diols is heated to melting, adds weight/mass percentage composition 0.08%-0.12% American mint essence, is uniformly mixing to obtain
Solution II；
（c）Configure solution III：By formula rate, by weight/mass percentage composition 4%-6% PEG-400, weight/mass percentage composition 0.2%-
After 0.4% xanthans and weight/mass percentage composition 0.2%-0.4% sodium alginate stir, solution III is obtained.PEG-400 is
Medical polyethylene glycol；
（d）Solution II is added in solution I, stirred, solution III is added, stirs 25-30 minutes and forms semi-finished product, take
Sample chemically examines to obtain Cetylpyridinium Chloride semi-finished product, and semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, 25-30 is stirred
Minute, sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, it is unqualified discarded.
Beneficial effects of the present invention：Lactobacillus can strengthen inhibitory action of the sodium fluoride to Streptococcus mutans, reduce tooth
On bacterial plaque accumulation, the generation of prevention of gingivitis and carious tooth, improve oral cavity flora balance.
Embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, the embodiment
It is only used for explaining the present invention, does not constitute the restriction to protection scope of the present invention.
Embodiment 1
A kind of probiotics periodontal nursing gel production technology of the present invention, comprises the following steps：
（a）By formula rate, the purified water of weight/mass percentage composition 74.625% is heated to 35-40 DEG C, weight/mass percentage composition is added
0.52% sodium benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.052%, the sodium fluoride of weight/mass percentage composition 0.047% and quality
Sucralose, the non-crystallising sorbitol of weight/mass percentage composition 17% of percentage composition 0.051%（Content is 70%）, quality percentage
Nisin, the light blue pigment of weight/mass percentage composition 0.00019% of content 0.0045%, stir 20-25 minutes, obtain solution
Ⅰ；
（b）The propane diols of the RH40 rilanit specials of weight/mass percentage composition 0.9%, weight/mass percentage composition 1.1% is heated to melting,
The American mint essence of weight/mass percentage composition 0.1% is added, solution II is uniformly mixing to obtain；
（c）By formula rate, by the PEG-400 of weight/mass percentage composition 5%, the xanthans of weight/mass percentage composition 0.28% and quality hundred
After the sodium alginate of point content 0.32% stirs, solution III is obtained；
（d）Solution II is added in solution I, stirred, solution III is added, stirs 25-30 minutes and forms semi-finished product, take
Sample chemically examines to obtain Cetylpyridinium Chloride semi-finished product, and semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, 25-30 is stirred
Minute, sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, it is unqualified discarded.
Embodiment 2
A kind of probiotics periodontal nursing gel production technology of the present invention, comprises the following steps：
（a）By formula rate, the purified water of weight/mass percentage composition 77.96% is heated to 35-40 DEG C, weight/mass percentage composition is added
0.55% sodium benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.055%, the sodium fluoride of weight/mass percentage composition 0.06% and quality
Sucralose, the non-crystallising sorbitol of weight/mass percentage composition 12% of percentage composition 0.055%（Content is 70%）, quality percentage
Nisin, the light blue pigment of weight/mass percentage composition 0.0002% of content 0.0065%, stir 20-25 minutes, obtain solution
Ⅰ；
（b）The propane diols of the RH40 rilanit specials of weight/mass percentage composition 1.2%, weight/mass percentage composition 1.2% is heated to melting,
The American mint essence of weight/mass percentage composition 0.12% is added, solution II is uniformly mixing to obtain；
（c）By formula rate, by the PEG-400 of weight/mass percentage composition 6%, the xanthans of weight/mass percentage composition 0.4% and quality hundred
After the sodium alginate of point content 0.4% stirs, solution III is obtained；
（d）Solution II is added in solution I, stirred, solution III is added, stirs 25-30 minutes and forms semi-finished product, take
Sample chemically examines to obtain Cetylpyridinium Chloride semi-finished product, and semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, 25-30 is stirred
Minute, sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, it is unqualified discarded.
Embodiment 3
A kind of probiotics periodontal nursing gel production technology of the present invention, comprises the following steps：
（a）By formula rate, the purified water of weight/mass percentage composition 72.336% is heated to 35-40 DEG C, weight/mass percentage composition is added
0.45% sodium benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.045%, the sodium fluoride of weight/mass percentage composition 0.04% and quality
Sucralose, the non-crystallising sorbitol of weight/mass percentage composition 21% of percentage composition 0.045%（Content is 70%）, quality percentage
Nisin, the light blue pigment of weight/mass percentage composition 0.00016%% of content 0.0035%, stir 20-25 minutes, obtain molten
Liquid I；
（b）The propane diols of the RH40 rilanit specials of weight/mass percentage composition 0.8%, weight/mass percentage composition 0.8% is heated to melting,
The American mint essence of weight/mass percentage composition 0.08% is added, solution II is uniformly mixing to obtain；
（c）By formula rate, by the PEG-400 of weight/mass percentage composition 4%, the xanthans of weight/mass percentage composition 0.2% and quality hundred
After the sodium alginate of point content 0.2% stirs, solution III is obtained；
（d）Solution II is added in solution I, stirred, solution III is added, stirs 25-30 minutes and forms semi-finished product, take
Sample chemically examines to obtain Cetylpyridinium Chloride semi-finished product, and semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, 25-30 is stirred
Minute, sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, it is unqualified discarded.
Probiotics periodontal nursing gel primary efficacy is nisin, sodium fluoride and Cetylpyridinium Chloride, nisin
The synergy of rhzomorph and sodium fluoride, preferably reaches the effect of preventing decayed tooth bacterium and maintains the balance of oral cavity flora, add
Cetylpyridinium Chloride, suppresses bacterial plaque and periodontal bacteria, particularly porphyromonas gingivalis, so that alleviate periodontitis, gingivitis.It is above-mentioned
Several compositions, can suppress most bacteriums in oral cavity, safeguard oral health.
Step（a）Middle configuration solution I, sodium benzoate：It is a kind of good food preservative, the effect extended the shelf life；
Cetylpyridinium Chloride：Belong to cationic surfactant, by reducing surface tension, increase the permeability of cell membrane, so as to suppress
With killing bacterium, it can be adsorbed in mucous membrane of mouth, and nonirritant to mucous membrane of mouth, not colored to facing, have antibacterial to bacterium
Effect, can reduce bacterial plaque and be formed, the health care in oral cavity is widely used in abroad；Sodium fluoride：It is to a variety of enzymes in oral cavity
There is inhibitory action, can reduce bacterial plaque with antibacterial, the solubility of hydroxyapatite in enamel can be reduced, increase the anti-caries of tooth
Power, can also promote the integrality of enamel, increase the hardness of enamel；Sucralose：It is a kind of sweetener, enhances mouthfeel effect
Really, its property is stable, water-soluble preferable；Non-crystallising sorbitol：It is both NMF and sweetener, moistening effect temperature
With taste is also fine；Nisin：It is a kind of natural products with very strong bactericidal effect, it disturbs bacterium in oral cavity
The normal function of cell membrane, destroys the integrality of cell, particularly some cariogenic bacterias, such as Streptococcus mutans, so as to maintain oral cavity
The balance of flora, the oral health of let us；Light blue pigment：It is a kind of colouring agent, allows product to have preferable visual impression.
Step（b）Middle configuration solution II, American mint essence can well dissolve in the presence of rilanit special, from property
Looked on shape clear, effect of moisturizing can preferably be played by adding propane diols.
Step（c）Middle configuration solution III, because xanthans and sodium alginate have emulsification so that above two is molten
Liquid becomes sticky, and adding PEG-400 can make each component reach good compatibility.
The probiotics periodontal nursing gel production technology of the present invention, by configuring three solution, obtains Cetylpyridinium Chloride semi-finished product,
Lactobacillus can strengthen inhibitory action of the sodium fluoride to Streptococcus mutans, reduce the bacterial plaque accumulation on tooth, prevention of gingivitis with
And the generation of carious tooth, improve oral cavity flora balance.
Claims (1)
1. probiotics periodontal nurses gel production technology, it is characterised in that comprise the following steps：
（a）Configure solution I：Weight/mass percentage composition 70%-80% purified water is heated to 35-40 DEG C, weight/mass percentage composition is added
0.45%-0.55% sodium benzoate, weight/mass percentage composition 0.045%-0.055% Cetylpyridinium Chloride, weight/mass percentage composition 0.04%-
0.06% sodium fluoride and weight/mass percentage composition 0.045%-0.055% Sucralose, weight/mass percentage composition 9%-21% it is noncrystalline
D-sorbite（Content is 70%）, weight/mass percentage composition 0.0035%-0.0065% nisin, weight/mass percentage composition
0.00016%-0.0002% light blue pigments, stir 20-25 minutes, obtain solution I；
（b）Configure solution II：By weight/mass percentage composition 0.8%-1.2% RH40 rilanit specials, weight/mass percentage composition 0.8%-
1.2% propane diols is heated to melting, adds weight/mass percentage composition 0.08%-0.12% American mint essence, is uniformly mixing to obtain
Solution II；
（c）Configure solution III：By formula rate, by weight/mass percentage composition 4%-6% PEG-400, weight/mass percentage composition 0.2%-
After 0.4% xanthans and weight/mass percentage composition 0.2%-0.4% sodium alginate stir, solution III is obtained；
（d）Solution II is added in solution I, stirred, solution III is added, stirs 25-30 minutes and forms semi-finished product, take
Sample chemically examines to obtain Cetylpyridinium Chloride semi-finished product, and semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, 25-30 is stirred
Minute, sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, it is unqualified discarded.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710248334.4A CN107080731A (en) | 2017-04-17 | 2017-04-17 | Probiotics periodontal nurses gel production technology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710248334.4A CN107080731A (en) | 2017-04-17 | 2017-04-17 | Probiotics periodontal nurses gel production technology |
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| CN107080731A true CN107080731A (en) | 2017-08-22 |
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| CN201710248334.4A Pending CN107080731A (en) | 2017-04-17 | 2017-04-17 | Probiotics periodontal nurses gel production technology |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753931A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| IT202100010802A1 (en) | 2021-05-03 | 2022-11-03 | Alfasigma Spa | SOLID MUCOADHESIVE FORMULATION INCLUDING PROBIOTICS FOR USE IN THE PREVENTION AND TREATMENT OF ORAL DYSBIOSIS. |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306202A (en) * | 2014-09-26 | 2015-01-28 | 福建爱洁丽日化有限公司 | Mouthwash for eliminating bad breath, inhibiting bacteria and preventing dental caries |
| CN104666185A (en) * | 2015-02-13 | 2015-06-03 | 成都润兴消毒药业有限公司 | Liquid toothpaste and preparation method thereof |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
-
2017
- 2017-04-17 CN CN201710248334.4A patent/CN107080731A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306202A (en) * | 2014-09-26 | 2015-01-28 | 福建爱洁丽日化有限公司 | Mouthwash for eliminating bad breath, inhibiting bacteria and preventing dental caries |
| CN104666185A (en) * | 2015-02-13 | 2015-06-03 | 成都润兴消毒药业有限公司 | Liquid toothpaste and preparation method thereof |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753931A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| IT202100010802A1 (en) | 2021-05-03 | 2022-11-03 | Alfasigma Spa | SOLID MUCOADHESIVE FORMULATION INCLUDING PROBIOTICS FOR USE IN THE PREVENTION AND TREATMENT OF ORAL DYSBIOSIS. |
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| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Jiang Jingjing Inventor after: Zhang Zhenping Inventor before: Jiang Jingjing Inventor before: Zhang Zhenping Inventor before: Zhou Jianbing |
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Application publication date: 20170822 |
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