JPH03128313A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To provide a dentifrice composition containing albumen, exhibiting excellent enzyme-inhibiting action, antibacterial action and foaming action, having stability and safety and useful for the prevention of dental caries and prevention and therapy of periodontosis. CONSTITUTION:The objective dentifrice can be prepared by adding 0.05-20wt.%. preferably 0.1-10wt.% (in terms of dry weight based on the whole dentifrice composition) of albumen to a dentifrice composition at a proper stage in the conventional dentifrice preparation process. The dentifrice may be compounded usually with abrasive, surfactant, wetting agent, binder, flavor, sweetener, preservative, salt, antibacterial agent, enzyme, etc. It can be prepared in the form of toothpaste, tooth powder, wet dentifrice (semi-paste dentifrice), pasta, liquid dentifrice, etc. In the case of liquid dentifrice, it can be used in a portable state such as granule or tablet.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a dentifrice composition, and more particularly to a dentifrice composition containing egg white and having excellent enzyme inhibitory, antibacterial and foaming effects.

[Conventional technology and its problems]

Oral diseases such as cavities and periodontitis are generally caused by various bacteria in the oral cavity: their metabolites, deposits such as plaque and tartar; food debris; exfoliated epithelial cells, etc. It is thought that this is caused by poor hygiene and harmful effects on the teeth, gums, and oral mucosa.

Brushing your teeth has been a method of preventing cavities and periodontitis for a long time, but its importance has become even more important in recent years. Toothbrushing is originally an attempt to remove various deposits, food particles, etc. that cause cavities and periodontitis by brushing using a toothpaste mainly composed of abrasives and surfactants. With the elucidation of the pathogenesis of periodontitis and the like, there is a growing demand for toothpastes to have various pharmacological effects.

[Means to solve the problem]

Under these circumstances, the present inventors conducted studies to develop a safe dentifrice with excellent pharmacological effects, and found that a dentifrice composition with excellent enzyme inhibitory, antibacterial, and foaming effects can be obtained by incorporating egg white. The inventors discovered that the present invention can be obtained and completed the present invention.

That is, the present invention provides a dentifrice composition containing egg white.

The egg white to be added to the dentifrice composition of the present invention is preferably one derived from a chicken egg, particularly a dried product derived from a chicken egg and subjected to a desugar treatment. The desaccharified dried egg white may be commercially available, or may be prepared from egg white by a method known per se.

The amount of egg white blended into the dentifrice composition of the present invention is not particularly limited, but is 0.05 to 0.05% by dry weight based on the total dentifrice composition.
20% by weight, particularly 0.1 to 10% by weight (hereinafter simply abbreviated as %) is preferable.

The dentifrice composition of the present invention also includes ingredients that are included in ordinary dentifrices, such as abrasives, surfactants, humectants, binders, flavoring agents, sweeteners, preservatives, salt, antibacterial agents, Enzymes and the like can be added.

Examples of the polishing agent that can be used include calcium carbonate, calcium birophosphate, calcium diphosphate, silicic anhydride, aluminum hydroxide, and insoluble sodium metaphosphate. Examples of the surfactant include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium coconut monoglyceride sulfate, and sodium coconut monoglyceride sulfonate. Examples of wetting agents include sorbitol, glycerin, propylene glycol, and the like.

Examples of the binder include iris moss, carboxymethylcellulose (CMC), xanthan gum, methylcellulose, tragacanth gum, karaya gum, sodium carboxymethylcellulose, and hydroxyethylcellulose (l(BC)).As the flavoring agent, peppermint oil, Examples include spearmint oil, peppermint flavoring agents such as menthol, and various other spices. Examples of sweeteners include saccharin, and examples of preservatives include butyl roseoxybenzoate. can.

To manufacture the dentifrice composition of the present invention, egg white may be added at an appropriate stage of the general dentifrice manufacturing process.

The dentifrice composition of the present invention can be in the form of ordinary dentifrices, such as toothpaste, toothpaste, wet toothpaste (manual toothpaste), paste powder, and water toothpaste. In the case of water toothpaste, it may be in the form of granules, tablets, etc., and can be made portable by dissolving it in water before use [Example] Next, the present invention will be described in detail with reference to Examples.

Example 1 A dentifrice having the following composition was prepared.

aluminum hydroxide glycerin carboxymethylcellulose sodium saccharin sodium fragrance Desweetened dried egg whites water Example 2 A dentifrice having the following composition was prepared.

Dibasic calcium phosphate glycerol sodium chloride sodium lauryl sulfate carrageenan saccharin Butyl roseoxybenzoate Desweetened dried egg whites water 0.2 1.0 1.0 21.8 (%) 3 2 01O1 13, 99 Example 3 A dentifrice having the following composition was prepared.

calcium carbonate sorbit (%) 37.0 21.0 sodium lauryl sulfate saccharin Ethyl roseoxybenzoate Desweetened dried egg whites water Example 4 A dentifrice having the following composition was prepared.

1.3 0.1 0.01 3.0 36, 49 Dibasic calcium phosphate glycerin carrageenan (airinsh) sodium lauryl sulfate saccharin fragrance moss) (%) 40.0 16.0 0.9 1.2 0.09 1.1 Butyl roseoxybenzoate Desweetened dried egg whites water Example 5 A dentifrice having the following composition was prepared.

0,005 4.0 36.705 Insoluble sodium metaphosphate Dibasic calcium phosphate gum tragacanth saccharin sodium lauryl sulfate glycerin fragrance copper chlorophyllin sodium Desweetened dried egg whites water Example 6 A dentifrice having the following composition was prepared.

(%〉 24.0 12.0 1.4 0.1 1.5 25.0 1.0 0.1 4.0 30.9 Calcium pyrophosphate (%) 39.0 sodium lauryl sulfate Sodium lauroyl sarcosine glycerin carrageenan Sucrose fatty acid ester fragrance saccharin Desweetened dried egg whites water Example 7 A dentifrice having the following composition was prepared.

to 1.2 0.2 20.0 1.1 2.0 1.2 0.1 3.0 32.2 aluminum hydroxide (%) 42.0 carrageenan sodium lauryl sulfate Sodium monofluorophosphate saccharin sorbit fragrance Rium 0.8 0.6 0.76 0.05 22.0 1.0 Desweetened dried egg whites water Example 8 A dentifrice having the following composition was prepared.

3.0 29, 49 Silicic anhydride ultra fine silica (%) 9.0 2.0 sorbit glycerin Blue No. 1 saccharin fragrance Desweetened dried egg whites water Example 9 A dentifrice having the following composition was prepared.

42.0 3.0 0.1 0.07 0.7 4.0 3B, 03 calcium carbonate glycerin (%) 71°0 10.0 fragrance Methyl paraoxybenzoate sodium lauryl sulfate saccharin Desweetened dried egg whites water Example 10 A dentifrice having the following composition was prepared.

Aluminum hydroxide (ultrafine particles) Aluminum hydroxide (325 mesh) sodium fufluoride sodium lauryl sulfate saccharin fragrance Desweetened dried egg whites water Example 11 A dentifrice having the following composition was prepared.

) 1.0 0.005 1.3 0.1 4.0 12.595 (%) 87.5 6.0 0.1 1.8 0.2 1.2 3.0 0.2 (%) Dicalcium phosphate (dihydrate) Dibasic calcium phosphate (anhydrous salt) glycerin carrageenan sodium lauryl sulfate saccharin fragrance Desweetened dried egg whites water Test example 1 Using a dentifrice composition with the following composition, We considered this.

Composition> (1) Composition I Dicalcium phosphate glycerol Sodium lauryl sulfate Carrageenan 48.0 33.0 8.0 0.1 0.5 0.05 0.8 4.0 5.55 Enzyme inhibitory effect (% ) 36-440 3 Saccharin l Butyl oxybenzoate 0.05 Desugarized dried egg white
0-8*) Water
13.95 Special) In the above composition,
Dibasic calcium phosphate and desweetened dried egg white together account for 44%
It was adjusted so that

(2) Composition ■ A commercially available toothpaste containing the following ingredients was blended with desugared dried egg white to a concentration of 0 to 8%.

Ingredients contained in commercially available toothpaste: ground calcium carbonate, sorbitol solution, propylene glycol, sodium chloride, allantoin chlorhydroxyaluminum, epsilon aminocaproic acid, sodium lauryl sulfate, sodium carboxymethylcellulose, fragrance, sodium saccharin, butyl paraoxybenzoate, enzyme inhibitory activity Measurement method> The above dentifrice composition was added with Tris-HCl buffer (pH ?, 5
．． 1%NaCj! ), 15.625mg/
ml! The sample was taken as a sample. 500 samples
0.0 μl. la+g/- trypsin (manufactured by Sigma) 5
Add 0 μl and allow to react at room temperature for 5 minutes. Next, 500 μl of 2% azocasein (Sigma M1) was added, and 37
React at ℃ for 300 minutes. 2rnl of 5% trichloroacetic acid was added to the reaction solution, centrifuged at 3000 rpm for 15 minutes, and the supernatant was taken. D.

Absorbance was measured at 40Qnm.

The results show that the enzyme inhibitory activity when no egg white was added was 0.
It is expressed as a percentage and shown in Table 1.

Margin below table Example 12 A portable water toothpaste powder with the following composition was prepared.

(g) Purified salt 1.8 Desugarized dried egg white Q, 134 hinokitiol 0.05 peppermint
0.008 menthol
0.008 total 2.0 Oml! Dissolved in water, this portable water toothpaste granules can be used for approximately 10 hours.

Example 13 Prepare portable water toothpaste granules with the following composition: refined table salt Monosodium glutamate Desweetened dried egg whites did.

(g) 1.8 0.002 0.182 Peppermint 0.008 Menthol 0.008 Total
2.0125 This portable water toothpaste granule is about 100ml! Can be used by dissolving in water.

Example 14 Portable water toothpaste granules having the following composition were prepared.

(g) Refined table salt (fine powder) 1.7875
Desugared dried egg white 0.2 Plum flavor 0.012 Menthol
0.008 total
2.02 This portable water toothpaste granule can be used by dissolving it in about 100% water.

Example 15 Portable water toothpaste granules having the following composition were prepared.

(g) Refined table salt (fine powder) 1.7875
Desugared dried egg white 0.2 Plum flavor 0.016 Peppermint 0.008 total
2.024 This portable water toothpaste granule can be used by dissolving it in about 100% water.

〔Effect of the invention〕

The dentifrice composition of the present invention has excellent enzyme inhibitory, antibacterial and foaming effects, is stable and safe, and is extremely useful for the prevention and treatment of dental caries and periodontitis.

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Claims (1)

[Claims] 1. A dentifrice composition containing egg white.